Identification

• Cohort, name
  PRegnancy and Infant DEvelopment Study
  
  Cohort, abbreviation
  PRIDE Study
  
  Cohort, country
  Netherlands (Nederland)
  
  Cohort, website
  http://www.pridestudy.nl
  
  Cohort, facebook-site
  http://www.facebook.com/pridestudynl
  
  Key reference
  Van Gelder MMHJ, Bretveld RW, Roukema J, Steenhoek M, van Drongelen J, Spaanderman MEA, van Rumpt D, Zielhuis GA, Verhaak CM, Roeleveld N. Rationale and design of the PRegnancy and Infant DEvelopment (PRIDE) Study. Paediatric and Perinatal Epidemiology 2013;27(1):34-43.
  
  Date of filling in this questionnaire:
  2017-01-30
  
  
• Principal investigator(s), name
  Nel Roeleveld, PhD MSc
  
  Principal investigator(s), e-mail address
  Nel.Roeleveld@radboudumc.nl
  
  Principal investigator(s), institution
  Radboud university medical center, Nijmegen, The Netherlands
  
  Contact person(s), name
  Marleen M.H.J. van Gelder, PhD
  
  Contact person(s), e-mail address
  info@pridestudy.nl
  
  Contact person(s), institution address
  Radboud university medical center, Nijmegen, The Netherlands
  
  

Basic description

• Main aim of cohort
  The PRIDE Study (PRIDE: PRegnancy and Infant DEvelopment) is a large prospective cohort study that aims at including ≥100,000 pregnant women in early pregnancy to study a broad range of research questions pertaining to maternal and child health, preconception, prenatal, and perinatal care, and adverse developmental effects in offspring.
  
  Recruited number of:
  3200 children / 5300 mothers / 2100 fathers / 0 grand parents / 0 other family members
  
  Approximate proportion of source population included
  0
  
  Source population
  Nation-based
  
  
• Period of enrollment
  Start: 2011-07-01, End: 2019-12-31
  
  Enrollment period
  Pregnancy, week 6 to 15
  
  Enrollment criteria, please specify
  First prenatal care visit at midwife, gynaecologist, or general practitioner Being able to read and write Dutch
  
  Exclusion criteria, please specify
  Maternal age < 18 years Gestational age > 16 weeks
  
  Planned age of children at end of follow-up
  21 years

Questionnaire or registry data and biological samples

• Children
• Mothers
• Fathers

General information	---------- Child age (years) at assessment ----------
	<1	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18
Home address	X
School address

Birth outcomes
Birth weight	X
Birth length	X
Gestational age at birth	X
Apgar score	X
Congenital malformations	X
Stillbirth (>= 22 weeks)	X
Child’s sex	X
Head circumference	X
Biparietal diameter

Child exposures	---------- Child age (years) at assessment ----------
	<1	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18
Breast feeding	X
Diet	X	X	X	X	X	X	X
Dietary supplements	X	X	X	X	X	X	X
Childcare attendance	X
Active smoking
Passive smoking	X	X	X	X	X	X	X
Alcohol consumption
Physical activity
Substance use
Medicine intake	X	X	X	X	X	X	X
Vaccinations	X	X	X	X	X	X	X
Psychological distress (e.g. bullying)
Air pollution		X		X		X
Access to green spaces		X		X		X
Built environment		X		X		X
Noise
Radiation, electromagnetic fields		X		X		X
Water contamination
Pets	X	X	X	X	X	X
Farm animal exposure
Biomarkers of exposure
Mercury
Lead
Cadmium
Arsenic
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds
Bisphenol A
Other bisphenols
Parabens
Benzophenones
Triclosan
Phthalates
Cotinine

Child development and health	---------- Child age (years) at assessment ----------
	<1	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18
Anthropometry
Weight	X	X	X	X	X	X	X
Height	X	X	X	X	X	X	X
Head circumference	X
Abdominal circumference
Arm circumference
Wrist circumference
Waist circumference
Clinical examinations
Blood pressure
Carotida intima media thickness
Pulse wave velocity
Cardiac ultrasound
Renal ultrasound
Brain MRI
Other MRI
DEXA‐scan results
Skin folds
Bio impedence
Oscilometry
Spirometry
Skin prick test
Bronchial challenge test
Reversibility test
Dental observations
Mental and neurological development
Cognitive function	X	X	X	X	X	X	X
School performance
Language
ADHD		X	X	X	X	X	X
Autism		X	X	X	X	X	X
Sleep disturbances	X	X	X	X	X	X	X
Mental health		X	X	X	X	X	X
Respiratory health
Asthma		X	X	X	X	X	X
Allergy	X	X	X	X	X	X	X
Allergic rhinitis	X	X	X	X	X	X	X
Eczema	X	X	X	X	X	X	X
Respiratory tract infections	X	X	X	X	X	X	X
Senses
Vision		X		X
Hearing		X		X
Musculo-skeletal health
Back pain
Neck pain
Growing pains
Sexual maturation
Tanner stage
Pubertal development stage
Age at menarche
Age at voice change
2D/4D digit ratio
Nocturnal ejaculation
Acne
Other health outcomes
Cancer	X	X	X	X	X	X	X
Diabetes	X	X	X	X	X	X	X
Congenital anomalies	X
Biomarkers of health
Nephrology (e.g. creatinine, albumin)
Thyroid hormones
Inflammatory markers (e.g. C-reactive protein cytokines)
Immunologic markers (e.g. immunoglobulines)
Cortisol
Vitamines and micronutrients
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)
Metabolomics
DNA methylation
Transcriptomics (mRNA, miRNA)
Genome-wide association study (GWAS)

Child biological samples	---------- Child age (years) at sampling ----------
	At birth	0	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18
Whole blood
Serum
Plasma
Buffy coat
Urine
Hair
Teeth
Nails
Saliva
Purified DNA
Purified RNA
Red blood cells
Umbilical cord blood/tissue
Blood smear
Faeces/meconium
Exhaled breathe condensate
Sputum induction
Placenta

General information
	Pre-pregnancy	During pregnancy	<1	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18
Education		X
Income		X
Employment status	X	X	X
Job title	X	X	X
Single parenthood		X
Home address		X	X	X	X	X	X	X	X
Work address

Maternal characteristics related to the index pregnancy/child
Age at birth	X
Ethnicity	X
Country of birth	X
Planned pregnancy	X
Time to pregnancy	X
Fertility treatment	X
Prior spontaneous abortion (<22w)	X
Prior births	X
Ultrasound measurements	X
Doppler measurements
Preeclampsia	X
Gestational diabetes	X
Gestational hypertension	X
Gestational duration	X
Mode of delivery	X
Prenatal diagnostics	X
Medical termination of pregnancy	X

Maternal Exposures	---------- Timing of assessment ----------
	Pre-pregnancy	First trimester	Second trimester	Third trimester	Post pregnancy
Diet		X
Dietary supplements		X	X	X	X
Active smoking		X	X	X	X
Passive smoking		X	X	X	X
Alcohol consumption		X	X	X	X
Physical activity		X	X	X
Substance use		X	X	X	X
Medicine intake		X	X	X	X
Coffee drinking		X	X	X
Psychological distress (e.g. life-events, health behaviors, perceived stress)		X	X	X	X
Occupational exposures		X	X	X	X
Heavy lifts			X
Work hours		X	X	X	X
Air pollution		X	X	X	X
Access to green spaces		X	X	X	X
Built environment		X	X	X	X
Noise
Radiation, electromagnetic fields		X	X	X	X
Water contamination
Binge drinking		X	X	X	X
Pets			X		X
Farm animal exposure
Biomarkers of exposure
Mercury
Lead
Cadmium
Arsenic
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds
Bisphenol A
Other bisphenols
Parabens
Benzophenones
Triclosan
Phthalates
Cotinine

Maternal health	---------- Timing of assessment ----------
	Pre-pregnancy	First trimester	Second trimester	Third trimester	Post pregnancy
Anthropometry
Weight		X	X	X	X
Height		X
Waist circumference
Clinical examinations
Blood pressure		X	X	X
Carotida intima media thickness
Pulse wave velocity
DEXA scans
Bioimpedence
Mental and neurological development
Mental health		X	X	X	X
Cognitive function (e.g. intelligence quotient)
Respiratory health
Asthma	X	X	X	X	X
Allergy	X	X	X	X	X
Musculo‐skeletal disease
Back pain		X	X	X	X
Neck pain		X	X	X	X
Arthritis		X	X	X	X
Other health outcomes
Cancer		X	X	X	X
Diabetes		X	X	X	X
Cardio‐vascular disease		X	X	X	X
Family history of chronic disease		X
Infectious disease		X	X	X
Fever		X	X	X
Autoimmune disease		X	X	X	X
Urinary symptoms		X		X	X
Sexual problems
Sleep disturbance		X	X	X	X
Biomarkers of health
Nephrology (e.g. creatinine, albumin)
Thyroid hormones
Inflammatory markers (e.g. C-reactive protein cytokines)
Immunologic markers (e.g. immunoglobulines)
Cortisol			X
Vitamines and micronutrients
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)
Metabolomics
DNA methylation
Transcriptomics (mRNA, miRNA)
Genome-wide association study (GWAS)

Maternal biological samples	---------- Timing of sampling ----------
	Pre-pregnancy	First trimester	Second trimester	Third trimester	Post pregnancy
Breast milk
Whole blood		X
Serum		X
Plasma		X
Buffy coat
Urine
Hair
Nails
Saliva			X
Purified DNA		X
Purified RNA
Red blood cells
Faeces			X	X	X

General information
	Pre-pregnancy	During pregnancy	<1	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18
Education	X	X
Income		X
Employment status		X
Job title		X
Single parenthood
Home address
Work address

Paternal characteristics related to the index pregnancy/child
Fertility treatment
Age at child's birth	X
Ethnicity	X
Country of birth	X

Paternal exposures	---------- Timing of assessment ----------
	Pre-pregnancy	During pregnancy	Post pregnancy
Diet
Dietary supplements
Active smoking	X	X
Passive smoking	X	X
Alcohol consumption	X	X
Physical activity	X	X
Substance use	X	X
Medicine intake	X	X
Coffee drinking	X	X
Psychological distress (e.g. life-events, health behaviors, perceived stress)
Occupational exposures	X	X
Heavy lifts
Work hours	X	X
Air pollution
Access to green spaces
Built environment
Noise
Radiation, electromagnetic fields
Water contamination
Binge drinking	X	X
Pets
Farm animal exposure
Biomarkers of exposure
Mercury
Lead
Cadmium
Arsenic
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds
Bisphenol A
Other bisphenols
Parabens
Benzophenones
Triclosan
Phthalates
Cotinine

Paternal health	---------- Timing of assessment ----------
	Pre-pregnancy	During pregnancy	Post pregnancy
Anthropometry
Weight	X	X
Height	X	X
Waist circumference
Clinical examinations
Blood pressure
Carotida intima media thickness
Pulse wave velocity
DEXA scans
Bio impedence
Mental and neurological development
Mental health
Cognitive function (e.g. intelligence quotient)
Respiratory health
Asthma	X	X
Allergy	X	X
Musculo‐skeletal disease
Back pain
Neck pain
Arthritis
Other health outcomes
Cancer	X	X
Diabetes	X	X
Cardio‐vascular disease	X	X
Family history of chronic disease
Infectious disease	X
Fever	X
Autoimmune disease	X	X
Urinary symptoms
Sexual problems
Sleep disturbance
Biomarkers of health
Nephrology (e.g. creatinine, albumin)
Thyroid hormones
Inflammatory markers (e.g. C-reactive protein cytokines)
Immunologic markers (e.g. immunoglobulines)
Cortisol
Vitamines and micronutrients
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)
Metabolomics
DNA methylation
Transcriptomics (mRNA, miRNA)
Genome-wide association study (GWAS)

Paternal biological samples	---------- Timing of sampling ----------
	Pre-pregnancy	During pregnancy	Post pregnancy
Semen
Whole blood
Serum
Plasma
Buffy coat
Urine
Hair
Nails
Saliva
Purified DNA
Purified RNA
Red blood cells
Faeces

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