- Cohort, name
PRegnancy and Infant DEvelopment Study
Cohort, abbreviation
PRIDE Study
Cohort, country
Netherlands (Nederland)
Cohort, website
http://www.pridestudy.nl
Cohort, facebook-site
http://www.facebook.com/pridestudynl
Key reference
Van Gelder MMHJ, Merkus PJFM, van Drongelen J, Swarts JW, van de Belt TH, Roeleveld N. The PRIDE Study: Evaluation of online methods of data collection. Paediatr Perinat Epidemiol 2020;34(5):484-494. DOI: 10.1111/ppe.12618.
Date of filling in this questionnaire:
2021-07-13 - Principal investigator(s), name
Marleen van Gelder, PhD; Nel Roeleveld, PhD MSc
Principal investigator(s), e-mail address
Marleen.vanGelder@radboudumc.nl
Principal investigator(s), institution
Radboud university medical center, Nijmegen, The Netherlands
Contact person(s), name
Marleen M.H.J. van Gelder, PhD
Contact person(s), e-mail address
Marleen.vanGelder@radboudumc.nl
Contact person(s), institution address
Radboud university medical center, Nijmegen, The Netherlands
- Main aim of cohort
The PRIDE Study (PRIDE: PRegnancy and Infant DEvelopment) is a large prospective cohort study that enrolls women in early pregnancy to study a broad range of research questions pertaining to maternal and child health, preconception, prenatal, and perinatal care, and adverse developmental effects in offspring. Recruitment is ongoing
Recruited number of:
11800 children / 11800 mothers / 5000 fathers / 0 grand parents / 0 other family members
Approximate proportion of source population included
0
Source population
Nation-based - Period of enrollment
Start: 2011-07-01, End: 0000-00-00
Enrollment period
Pregnancy, week 6 to 16
Enrollment criteria, please specify
First prenatal care visit at midwife, gynaecologist, or general practitioner Being able to read and write Dutch
Exclusion criteria, please specify
Maternal age < 18 years Gestational age > 16 weeks
Planned age of children at end of follow-up
21 years
General information | ---------- Child age (years) at assessment ---------- | |||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
<1 | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | >18 | |
Home address | X | |||||||||||||||||||
School address |
Birth outcomes | |
---|---|
Birth weight | X |
Birth length | X |
Gestational age at birth | X |
Apgar score | X |
Congenital malformations | X |
Stillbirth (>= 22 weeks) | X |
Child’s sex | X |
Head circumference | X |
Biparietal diameter |
Child exposures | ---------- Child age (years) at assessment ---------- | |||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
<1 | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | >18 | |
Breast feeding | X | X | ||||||||||||||||||
Diet | X | X | X | X | X | X | X | |||||||||||||
Dietary supplements | X | X | X | X | X | X | X | |||||||||||||
Childcare attendance | X | |||||||||||||||||||
Active smoking | ||||||||||||||||||||
Passive smoking | X | X | X | X | X | X | X | X | ||||||||||||
Alcohol consumption | ||||||||||||||||||||
Physical activity | ||||||||||||||||||||
Substance use | ||||||||||||||||||||
Medicine intake | X | X | X | X | X | X | X | |||||||||||||
Vaccinations | X | X | X | X | X | X | X | |||||||||||||
Psychological distress (e.g. bullying) | ||||||||||||||||||||
Air pollution | X | X | X | X | ||||||||||||||||
Access to green spaces | X | X | X | X | ||||||||||||||||
Built environment | X | X | X | X | ||||||||||||||||
Noise | ||||||||||||||||||||
Radiation, electromagnetic fields | X | X | X | |||||||||||||||||
Water contamination | ||||||||||||||||||||
Pets | X | X | X | X | X | X | X | X | ||||||||||||
Farm animal exposure | ||||||||||||||||||||
Biomarkers of exposure | ||||||||||||||||||||
Mercury | ||||||||||||||||||||
Lead | ||||||||||||||||||||
Cadmium | ||||||||||||||||||||
Arsenic | ||||||||||||||||||||
Other metals | ||||||||||||||||||||
Polychlorinated biphenyl esters | ||||||||||||||||||||
Dicloro difenil tricloroetano | ||||||||||||||||||||
Hexachlorobenzene | ||||||||||||||||||||
Brominated flame retardants | ||||||||||||||||||||
Perflouralkyl compounds | ||||||||||||||||||||
Bisphenol A | ||||||||||||||||||||
Other bisphenols | ||||||||||||||||||||
Parabens | ||||||||||||||||||||
Benzophenones | ||||||||||||||||||||
Triclosan | ||||||||||||||||||||
Phthalates | ||||||||||||||||||||
Cotinine |
Child development and health | ---------- Child age (years) at assessment ---------- | |||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
<1 | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | >18 | |
Anthropometry | ||||||||||||||||||||
Weight | X | X | X | X | X | X | X | X | ||||||||||||
Height | X | X | X | X | X | X | X | X | ||||||||||||
Head circumference | X | |||||||||||||||||||
Abdominal circumference | ||||||||||||||||||||
Arm circumference | ||||||||||||||||||||
Wrist circumference | ||||||||||||||||||||
Waist circumference | ||||||||||||||||||||
Clinical examinations | ||||||||||||||||||||
Blood pressure | ||||||||||||||||||||
Carotida intima media thickness | ||||||||||||||||||||
Pulse wave velocity | ||||||||||||||||||||
Cardiac ultrasound | ||||||||||||||||||||
Renal ultrasound | ||||||||||||||||||||
Brain MRI | ||||||||||||||||||||
Other MRI | ||||||||||||||||||||
DEXA‐scan results | ||||||||||||||||||||
Skin folds | ||||||||||||||||||||
Bio impedence | ||||||||||||||||||||
Oscilometry | ||||||||||||||||||||
Spirometry | ||||||||||||||||||||
Skin prick test | ||||||||||||||||||||
Bronchial challenge test | ||||||||||||||||||||
Reversibility test | ||||||||||||||||||||
Dental observations | ||||||||||||||||||||
Mental and neurological development | ||||||||||||||||||||
Cognitive function | X | X | X | X | X | X | X | |||||||||||||
School performance | ||||||||||||||||||||
Language | ||||||||||||||||||||
ADHD | X | X | X | X | X | X | ||||||||||||||
Autism | X | X | X | X | X | X | ||||||||||||||
Sleep disturbances | X | X | X | X | X | X | X | |||||||||||||
Mental health | X | X | X | X | X | X | ||||||||||||||
Respiratory health | ||||||||||||||||||||
Asthma | X | X | X | X | X | X | ||||||||||||||
Allergy | X | X | X | X | X | X | X | |||||||||||||
Allergic rhinitis | X | X | X | X | X | X | X | |||||||||||||
Eczema | X | X | X | X | X | X | X | |||||||||||||
Respiratory tract infections | X | X | X | X | X | X | X | |||||||||||||
Senses | ||||||||||||||||||||
Vision | X | X | ||||||||||||||||||
Hearing | X | X | ||||||||||||||||||
Musculo-skeletal health | ||||||||||||||||||||
Back pain | ||||||||||||||||||||
Neck pain | ||||||||||||||||||||
Growing pains | ||||||||||||||||||||
Sexual maturation | ||||||||||||||||||||
Tanner stage | ||||||||||||||||||||
Pubertal development stage | ||||||||||||||||||||
Age at menarche | ||||||||||||||||||||
Age at voice change | ||||||||||||||||||||
2D/4D digit ratio | ||||||||||||||||||||
Nocturnal ejaculation | ||||||||||||||||||||
Acne | ||||||||||||||||||||
Other health outcomes | ||||||||||||||||||||
Cancer | X | X | X | X | X | X | X | X | ||||||||||||
Diabetes | X | X | X | X | X | X | X | X | ||||||||||||
Congenital anomalies | X | X | ||||||||||||||||||
Biomarkers of health | ||||||||||||||||||||
Nephrology (e.g. creatinine, albumin) | ||||||||||||||||||||
Thyroid hormones | ||||||||||||||||||||
Inflammatory markers (e.g. C-reactive protein cytokines) | ||||||||||||||||||||
Immunologic markers (e.g. immunoglobulines) | ||||||||||||||||||||
Cortisol | ||||||||||||||||||||
Vitamines and micronutrients | ||||||||||||||||||||
Gonadal axis hormones (e.g. testosterone, estradiol) | ||||||||||||||||||||
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides) | ||||||||||||||||||||
Metabolomics | ||||||||||||||||||||
DNA methylation | ||||||||||||||||||||
Transcriptomics (mRNA, miRNA) | ||||||||||||||||||||
Genome-wide association study (GWAS) |
Child biological samples | ---------- Child age (years) at sampling ---------- | ||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
At birth | 0 | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | >18 | |
Whole blood | |||||||||||||||||||||
Serum | |||||||||||||||||||||
Plasma | |||||||||||||||||||||
Buffy coat | |||||||||||||||||||||
Urine | |||||||||||||||||||||
Hair | |||||||||||||||||||||
Teeth | |||||||||||||||||||||
Nails | |||||||||||||||||||||
Saliva | |||||||||||||||||||||
Purified DNA | |||||||||||||||||||||
Purified RNA | |||||||||||||||||||||
Red blood cells | |||||||||||||||||||||
Umbilical cord blood/tissue | |||||||||||||||||||||
Blood smear | |||||||||||||||||||||
Faeces/meconium | X | X | |||||||||||||||||||
Exhaled breathe condensate | |||||||||||||||||||||
Sputum induction | |||||||||||||||||||||
Placenta |
General information | |||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Pre-pregnancy | During pregnancy | <1 | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | |
Education | X | ||||||||||||||||||||
Income | X | ||||||||||||||||||||
Employment status | X | X | X | ||||||||||||||||||
Job title | X | X | X | ||||||||||||||||||
Single parenthood | X | ||||||||||||||||||||
Home address | X | X | X | X | X | X | X | X | X | ||||||||||||
Work address |
Maternal characteristics related to the index pregnancy/child | |
---|---|
Age at birth | X |
Ethnicity | X |
Country of birth | X |
Planned pregnancy | X |
Time to pregnancy | X |
Fertility treatment | X |
Prior spontaneous abortion (<22w) | X |
Prior births | X |
Ultrasound measurements | X |
Doppler measurements | |
Preeclampsia | X |
Gestational diabetes | X |
Gestational hypertension | X |
Gestational duration | X |
Mode of delivery | X |
Prenatal diagnostics | X |
Medical termination of pregnancy | X |
Maternal Exposures | ---------- Timing of assessment ---------- | ||||
---|---|---|---|---|---|
Pre-pregnancy | First trimester | Second trimester | Third trimester | Post pregnancy | |
Diet | X | ||||
Dietary supplements | X | X | X | X | |
Active smoking | X | X | X | X | |
Passive smoking | X | X | X | X | |
Alcohol consumption | X | X | X | X | |
Physical activity | X | X | X | ||
Substance use | X | X | X | X | |
Medicine intake | X | X | X | X | |
Coffee drinking | X | X | X | ||
Psychological distress (e.g. life-events, health behaviors, perceived stress) | X | X | X | X | |
Occupational exposures | X | X | X | X | |
Heavy lifts | X | ||||
Work hours | X | X | X | X | |
Air pollution | X | X | X | X | |
Access to green spaces | X | X | X | X | |
Built environment | X | X | X | X | |
Noise | |||||
Radiation, electromagnetic fields | X | X | X | X | |
Water contamination | |||||
Binge drinking | X | X | X | X | |
Pets | X | X | |||
Farm animal exposure | |||||
Biomarkers of exposure | |||||
Mercury | |||||
Lead | |||||
Cadmium | |||||
Arsenic | |||||
Other metals | |||||
Polychlorinated biphenyl esters | |||||
Dicloro difenil tricloroetano | |||||
Hexachlorobenzene | |||||
Brominated flame retardants | |||||
Perflouralkyl compounds | |||||
Bisphenol A | |||||
Other bisphenols | |||||
Parabens | |||||
Benzophenones | |||||
Triclosan | |||||
Phthalates | |||||
Cotinine |
Maternal health | ---------- Timing of assessment ---------- | ||||
---|---|---|---|---|---|
Pre-pregnancy | First trimester | Second trimester | Third trimester | Post pregnancy | |
Anthropometry | |||||
Weight | X | X | X | X | X |
Height | X | ||||
Waist circumference | |||||
Clinical examinations | |||||
Blood pressure | X | X | X | ||
Carotida intima media thickness | |||||
Pulse wave velocity | |||||
DEXA scans | |||||
Bioimpedence | |||||
Mental and neurological development | |||||
Mental health | X | X | X | X | |
Cognitive function (e.g. intelligence quotient) | |||||
Respiratory health | |||||
Asthma | X | X | X | X | X |
Allergy | X | X | X | X | X |
Musculo‐skeletal disease | |||||
Back pain | X | X | X | X | |
Neck pain | X | X | X | X | |
Arthritis | X | X | X | X | |
Other health outcomes | |||||
Cancer | X | X | X | X | |
Diabetes | X | X | X | X | |
Cardio‐vascular disease | X | X | X | X | |
Family history of chronic disease | X | ||||
Infectious disease | X | X | X | ||
Fever | X | X | X | ||
Autoimmune disease | X | X | X | X | |
Urinary symptoms | X | X | X | ||
Sexual problems | |||||
Sleep disturbance | X | X | X | X | |
Biomarkers of health | |||||
Nephrology (e.g. creatinine, albumin) | |||||
Thyroid hormones | |||||
Inflammatory markers (e.g. C-reactive protein cytokines) | |||||
Immunologic markers (e.g. immunoglobulines) | |||||
Cortisol | X | ||||
Vitamines and micronutrients | |||||
Gonadal axis hormones (e.g. testosterone, estradiol) | |||||
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides) | |||||
Metabolomics | |||||
DNA methylation | |||||
Transcriptomics (mRNA, miRNA) | |||||
Genome-wide association study (GWAS) |
Maternal biological samples | ---------- Timing of sampling ---------- | ||||
---|---|---|---|---|---|
Pre-pregnancy | First trimester | Second trimester | Third trimester | Post pregnancy | |
Breast milk | |||||
Whole blood | X | ||||
Serum | X | ||||
Plasma | X | ||||
Buffy coat | |||||
Urine | |||||
Hair | |||||
Nails | |||||
Saliva | X | ||||
Purified DNA | X | ||||
Purified RNA | |||||
Red blood cells | |||||
Faeces | X | X | X |
General information | |||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Pre-pregnancy | During pregnancy | <1 | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | |
Education | X | X | |||||||||||||||||||
Income | X | ||||||||||||||||||||
Employment status | X | ||||||||||||||||||||
Job title | X | ||||||||||||||||||||
Single parenthood | |||||||||||||||||||||
Home address | |||||||||||||||||||||
Work address |
Paternal characteristics related to the index pregnancy/child | |
---|---|
Fertility treatment | |
Age at child's birth | X |
Ethnicity | X |
Country of birth | X |
Paternal exposures | ---------- Timing of assessment ---------- | ||
---|---|---|---|
Pre-pregnancy | During pregnancy | Post pregnancy | |
Diet | |||
Dietary supplements | |||
Active smoking | X | X | |
Passive smoking | X | X | |
Alcohol consumption | X | X | |
Physical activity | X | X | |
Substance use | X | X | |
Medicine intake | X | X | |
Coffee drinking | X | X | |
Psychological distress (e.g. life-events, health behaviors, perceived stress) | |||
Occupational exposures | X | X | |
Heavy lifts | |||
Work hours | X | X | |
Air pollution | |||
Access to green spaces | |||
Built environment | |||
Noise | |||
Radiation, electromagnetic fields | |||
Water contamination | |||
Binge drinking | X | X | |
Pets | |||
Farm animal exposure | |||
Biomarkers of exposure | |||
Mercury | |||
Lead | |||
Cadmium | |||
Arsenic | |||
Other metals | |||
Polychlorinated biphenyl esters | |||
Dicloro difenil tricloroetano | |||
Hexachlorobenzene | |||
Brominated flame retardants | |||
Perflouralkyl compounds | |||
Bisphenol A | |||
Other bisphenols | |||
Parabens | |||
Benzophenones | |||
Triclosan | |||
Phthalates | |||
Cotinine |
Paternal health | ---------- Timing of assessment ---------- | ||
---|---|---|---|
Pre-pregnancy | During pregnancy | Post pregnancy | |
Anthropometry | |||
Weight | X | X | |
Height | X | X | |
Waist circumference | |||
Clinical examinations | |||
Blood pressure | |||
Carotida intima media thickness | |||
Pulse wave velocity | |||
DEXA scans | |||
Bio impedence | |||
Mental and neurological development | |||
Mental health | |||
Cognitive function (e.g. intelligence quotient) | |||
Respiratory health | |||
Asthma | X | X | |
Allergy | X | X | |
Musculo‐skeletal disease | |||
Back pain | |||
Neck pain | |||
Arthritis | |||
Other health outcomes | |||
Cancer | X | X | |
Diabetes | X | X | |
Cardio‐vascular disease | X | X | |
Family history of chronic disease | |||
Infectious disease | X | ||
Fever | X | ||
Autoimmune disease | X | X | |
Urinary symptoms | |||
Sexual problems | |||
Sleep disturbance | |||
Biomarkers of health | |||
Nephrology (e.g. creatinine, albumin) | |||
Thyroid hormones | |||
Inflammatory markers (e.g. C-reactive protein cytokines) | |||
Immunologic markers (e.g. immunoglobulines) | |||
Cortisol | |||
Vitamines and micronutrients | |||
Gonadal axis hormones (e.g. testosterone, estradiol) | |||
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides) | |||
Metabolomics | |||
DNA methylation | |||
Transcriptomics (mRNA, miRNA) | |||
Genome-wide association study (GWAS) |
Paternal biological samples | ---------- Timing of sampling ---------- | ||
---|---|---|---|
Pre-pregnancy | During pregnancy | Post pregnancy | |
Semen | |||
Whole blood | |||
Serum | |||
Plasma | |||
Buffy coat | |||
Urine | |||
Hair | |||
Nails | |||
Saliva | |||
Purified DNA | |||
Purified RNA | |||
Red blood cells | |||
Faeces |
Comments and ideas