Identification

• Cohort, name
  MiPPAD birth cohort of Benin
  
  Cohort, abbreviation
  MiPPAD-Benin
  
  Cohort, country
  Benin (B
  
  Date of filling in this questionnaire:
  2025-07-04
  
  
• Principal investigator(s), name
  Florence Bodeau-Livinec
  
  Principal investigator(s), e-mail address
  florence.bodeau-livinec@ehesp.fr
  
  Principal investigator(s), institution
  Ecole des Hautes Etudes en Santé Publique, France
  
  Contact person(s), name
  Florence Bodeau-Livinec
  
  Contact person(s), e-mail address
  florence.bodeau-livinec@ehesp.fr
  
  

Basic description

• Main aim of cohort
  Study on the determinants of child health and development in the context of malaria
  
  Recruited number of:
  1136 children / 1183 mothers / 1183 fathers / 0 grand parents / 0 other family members
  
  Approximate proportion of source population included
  0
  
  Source population
  Other, please describeDistrict of Allada, Benin
  
  
• Period of enrollment
  Start: 2009-06-01, End: 2011-12-01
  
  Enrollment period
  Pregnancy, week 12 to 28
  
  Enrollment criteria, please specify
  Permanent residence in the study area, gestational age <=28 weeks, negative HIV-testing at recruitment, absence of history of allergy to sulfa drugs or mefloquine, absence of history of severe renal, hepatic, psychiatric, or neurological disease, and of mefloquine or halofantrine treatment in the preceding 4 weeks.
  
  Planned age of children at end of follow-up
  Life-long / unrestricted

Questionnaire or registry data and biological samples

• Children
• Mothers
• Fathers

General information	---------- Child age (years) at assessment ----------
	<1	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	>18
Home address
School address

Birth outcomes
Birth weight	X
Birth length	X
Gestational age at birth	X
Apgar score
Congenital malformations	X
Stillbirth (>= 22 weeks)	X
Child’s sex	X
Head circumference	X
Biparietal diameter

Child exposures	---------- Child age (years) at assessment ----------
	<1	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	>18
Breast feeding		X
Diet		X					X							X		X
Dietary supplements	X	X
Childcare attendance
Active smoking
Passive smoking		X
Alcohol consumption																X
Physical activity																X
Substance use
Medicine intake	X	X
Vaccinations		X
Psychological distress (e.g. bullying)							X							X		X
Air pollution							X			X				X		X
Access to green spaces
Built environment		X					X			X				X
Noise		X					X
Radiation, electromagnetic fields
Water contamination		X					X
Pets
Farm animal exposure		X					X							X
Biomarkers of exposure
Mercury
Lead		X					X							X
Cadmium
Arsenic
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano														X
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds
Bisphenol A
Other bisphenols
Parabens
Benzophenones
Triclosan
Phthalates
Cotinine

Child development and health	---------- Child age (years) at assessment ----------
	<1	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	>18
Anthropometry
Weight	X	X					X							X
Height	X	X					X							X
Head circumference	X	X					X							X
Abdominal circumference							X							X
Arm circumference							X							X
Wrist circumference							X							X
Waist circumference							X							X
Clinical examinations
Blood pressure														X
Carotida intima media thickness
Pulse wave velocity
Cardiac ultrasound
Renal ultrasound
Brain MRI
Other MRI
DEXA‐scan results
Skin folds
Bio impedence							X							X
Oscilometry
Spirometry
Skin prick test
Bronchial challenge test
Reversibility test
Dental observations
Mental and neurological development
Cognitive function		X					X							X		X
School performance							X							X		X
Language							X							X
ADHD							X							X
Autism							X							X		X
Sleep disturbances														X		X
Mental health														X		X
Respiratory health
Asthma										X				X		X
Allergy																X
Allergic rhinitis																X
Eczema																X
Respiratory tract infections
Senses
Vision														X
Hearing
Musculo-skeletal health
Back pain
Neck pain
Growing pains
Sexual maturation
Tanner stage														X		X
Pubertal development stage														X		X
Age at menarche														X		X
Age at voice change														X		X
2D/4D digit ratio
Nocturnal ejaculation
Acne
Other health outcomes
Cancer
Diabetes
Congenital anomalies	X
Biomarkers of health
Nephrology (e.g. creatinine, albumin)
Thyroid hormones														X
Inflammatory markers (e.g. C-reactive protein cytokines)		X					X							X
Immunologic markers (e.g. immunoglobulines)														X
Cortisol
Vitamines and micronutrients	X	X					X							X
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)														X
Metabolomics
DNA methylation
Transcriptomics (mRNA, miRNA)
Genome-wide association study (GWAS)			X

Child biological samples	---------- Child age (years) at sampling ----------
	At birth	0	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	>18
Whole blood			X					X							X
Serum			X					X							X
Plasma			X					X							X
Buffy coat															X
Urine								X							X
Hair
Teeth
Nails
Saliva
Purified DNA
Purified RNA
Red blood cells															X
Umbilical cord blood/tissue
Blood smear	X	X	X	X				X							X
Faeces/meconium
Exhaled breathe condensate
Sputum induction
Placenta

General information
	Pre-pregnancy	During pregnancy	<1	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18
Education		X	X	X					X							X		X
Income																X
Employment status		X		X					X							X		X
Job title				X					X							X		X
Single parenthood				X												X		X
Home address									X
Work address

Maternal characteristics related to the index pregnancy/child
Age at birth	X
Ethnicity
Country of birth	X
Planned pregnancy
Time to pregnancy
Fertility treatment
Prior spontaneous abortion (<22w)	X
Prior births	X
Ultrasound measurements
Doppler measurements
Preeclampsia	X
Gestational diabetes	X
Gestational hypertension	X
Gestational duration	X
Mode of delivery	X
Prenatal diagnostics
Medical termination of pregnancy

Maternal Exposures	---------- Timing of assessment ----------
	Pre-pregnancy	First trimester	Second trimester	Third trimester	Post pregnancy
Diet					X
Dietary supplements		X	X	X
Active smoking					X
Passive smoking					X
Alcohol consumption
Physical activity
Substance use
Medicine intake		X	X	X
Coffee drinking
Psychological distress (e.g. life-events, health behaviors, perceived stress)					X
Occupational exposures					X
Heavy lifts
Work hours
Air pollution					X
Access to green spaces
Built environment
Noise
Radiation, electromagnetic fields
Water contamination					X
Binge drinking
Pets
Farm animal exposure					X
Biomarkers of exposure
Mercury
Lead					X
Cadmium
Arsenic
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds
Bisphenol A
Other bisphenols
Parabens
Benzophenones
Triclosan
Phthalates
Cotinine

Maternal health	---------- Timing of assessment ----------
	Pre-pregnancy	First trimester	Second trimester	Third trimester	Post pregnancy
Anthropometry
Weight			X	X	X
Height			X	X	X
Waist circumference
Clinical examinations
Blood pressure			X	X
Carotida intima media thickness
Pulse wave velocity
DEXA scans
Bioimpedence					X
Mental and neurological development
Mental health					X
Cognitive function (e.g. intelligence quotient)					X
Respiratory health
Asthma					X
Allergy
Musculo‐skeletal disease
Back pain
Neck pain
Arthritis
Other health outcomes
Cancer					X
Diabetes					X
Cardio‐vascular disease					X
Family history of chronic disease					X
Infectious disease			X	X	X
Fever			X	X
Autoimmune disease					X
Urinary symptoms
Sexual problems
Sleep disturbance
Biomarkers of health
Nephrology (e.g. creatinine, albumin)
Thyroid hormones
Inflammatory markers (e.g. C-reactive protein cytokines)			X	X
Immunologic markers (e.g. immunoglobulines)
Cortisol
Vitamines and micronutrients			X	X
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)
Metabolomics
DNA methylation
Transcriptomics (mRNA, miRNA)
Genome-wide association study (GWAS)

Maternal biological samples	---------- Timing of sampling ----------
	Pre-pregnancy	First trimester	Second trimester	Third trimester	Post pregnancy
Breast milk
Whole blood			X	X	X
Serum			X	X	X
Plasma			X	X	X
Buffy coat
Urine
Hair
Nails
Saliva
Purified DNA
Purified RNA
Red blood cells
Faeces

General information
	Pre-pregnancy	During pregnancy	<1	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18
Education				X					X							X
Income																X
Employment status				X					X							X
Job title				X					X							X
Single parenthood
Home address									X
Work address

Paternal characteristics related to the index pregnancy/child
Fertility treatment
Age at child's birth	X
Ethnicity
Country of birth	X

Paternal exposures	---------- Timing of assessment ----------
	Pre-pregnancy	During pregnancy	Post pregnancy
Diet
Dietary supplements
Active smoking
Passive smoking
Alcohol consumption
Physical activity
Substance use
Medicine intake
Coffee drinking
Psychological distress (e.g. life-events, health behaviors, perceived stress)
Occupational exposures
Heavy lifts
Work hours
Air pollution
Access to green spaces
Built environment
Noise
Radiation, electromagnetic fields
Water contamination
Binge drinking
Pets
Farm animal exposure
Biomarkers of exposure
Mercury
Lead
Cadmium
Arsenic
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds
Bisphenol A
Other bisphenols
Parabens
Benzophenones
Triclosan
Phthalates
Cotinine

Paternal health	---------- Timing of assessment ----------
	Pre-pregnancy	During pregnancy	Post pregnancy
Anthropometry
Weight			X
Height			X
Waist circumference
Clinical examinations
Blood pressure
Carotida intima media thickness
Pulse wave velocity
DEXA scans
Bio impedence
Mental and neurological development
Mental health			X
Cognitive function (e.g. intelligence quotient)
Respiratory health
Asthma
Allergy
Musculo‐skeletal disease
Back pain
Neck pain
Arthritis
Other health outcomes
Cancer			X
Diabetes			X
Cardio‐vascular disease
Family history of chronic disease			X
Infectious disease
Fever
Autoimmune disease
Urinary symptoms
Sexual problems
Sleep disturbance
Biomarkers of health
Nephrology (e.g. creatinine, albumin)
Thyroid hormones
Inflammatory markers (e.g. C-reactive protein cytokines)
Immunologic markers (e.g. immunoglobulines)
Cortisol
Vitamines and micronutrients
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)
Metabolomics
DNA methylation
Transcriptomics (mRNA, miRNA)
Genome-wide association study (GWAS)

Paternal biological samples	---------- Timing of sampling ----------
	Pre-pregnancy	During pregnancy	Post pregnancy
Semen
Whole blood
Serum
Plasma
Buffy coat
Urine
Hair
Nails
Saliva
Purified DNA
Purified RNA
Red blood cells
Faeces

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Comments and ideas