Identification

• Cohort, name
  Genetics of Glucose regulation in Gestation and Growth
  
  Cohort, abbreviation
  Gen3G
  
  Cohort, country
  Canada
  
  Cohort, website
  NA
  
  Cohort, facebook-site
  https://www.facebook.com/EtudeGen3G
  
  Key reference
  PMID:PMID: 26842272
  
  Date of filling in this questionnaire:
  0000-00-00
  
  
• Principal investigator(s), name
  Pr Marie-France Hivert, Pr Patrice Perron, Pr Luigi Bouchard
  
  Principal investigator(s), e-mail address
  MHIVERT@PARTNERS.ORG, patrice.perron@usherbrooke.c
  
  Principal investigator(s), institution
  3001, 12e Avenue Nord, Sherbrooke, Québec, Canada, J1H 5N4
  
  Contact person(s), name
  Myriam Doyon
  
  Contact person(s), e-mail address
  myriam.doyon@usherbrooke.ca
  
  Contact person(s), institution address
  3001, 12e Avenue Nord, Sherbrooke, Québec, Canada, J1H 5N4
  
  

Basic description

• Main aim of cohort
  Increase our understanding of biological, environmental and genetic determinants of glucose regulation during pregnancy and their impact on fetal development.
  
  Recruited number of:
  854 children / 1024 mothers / 0 fathers / 0 grand parents / 0 other family members
  
  Approximate proportion of source population included
  20
  
  Source population
  Region-based
  
  
• Period of enrollment
  Start: 2010-01-22, End: 2013-06-25
  
  Enrollment period
  Pregnancy, week 6 to 14
  
  Enrollment criteria, please specify
  Pregnant women aged ≥18 years old who visited the blood sampling in pregnancy clinic in Sherbrooke for their first trimester clinical blood samples and their newborn.
  
  Exclusion criteria, please specify
  non singleton pregnancy, had known pre-pregnancy diabetes, took medication that influenced glucose tolerance, had glycated haemoglobin (HbA1c) ≥6.5% or 1 h glucose ≥10.3 mmol/L post-50 g GCT, as this was classified as overt diabetes based on 2008 CDA criteria,
  
  Planned age of children at end of follow-up
  Life-long / unrestricted

Questionnaire or registry data and biological samples

• Children
• Mothers
• Fathers

General information	---------- Child age (years) at assessment ----------
	<1	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	>18
Home address
School address

Birth outcomes
Birth weight	X
Birth length	X
Gestational age at birth	X
Apgar score	X
Congenital malformations	X
Stillbirth (>= 22 weeks)	X
Child’s sex	X
Head circumference	X
Biparietal diameter

Child exposures	---------- Child age (years) at assessment ----------
	<1	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	>18
Breast feeding				X
Diet
Dietary supplements				X		X					X
Childcare attendance
Active smoking
Passive smoking				X		X					X
Alcohol consumption
Physical activity				X		X					X
Substance use
Medicine intake				X		X					X
Vaccinations
Psychological distress (e.g. bullying)
Air pollution
Access to green spaces
Built environment
Noise
Radiation, electromagnetic fields
Water contamination
Pets
Farm animal exposure											X
Biomarkers of exposure
Mercury
Lead
Cadmium
Arsenic
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds
Bisphenol A
Other bisphenols
Parabens
Benzophenones
Triclosan
Phthalates
Cotinine

Child development and health	---------- Child age (years) at assessment ----------
	<1	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	>18
Anthropometry
Weight	X			X		X					X
Height	X			X		X					X
Head circumference	X
Abdominal circumference
Arm circumference	X			X		X					X
Wrist circumference				X		X					X
Waist circumference				X		X					X
Clinical examinations
Blood pressure				X		X					X
Carotida intima media thickness
Pulse wave velocity
Cardiac ultrasound				X
Renal ultrasound
Brain MRI											X
Other MRI
DEXA‐scan results						X					X
Skin folds	X			X		X					X
Bio impedence											X
Oscilometry
Spirometry
Skin prick test
Bronchial challenge test
Reversibility test
Dental observations
Mental and neurological development
Cognitive function											X
School performance
Language
ADHD
Autism
Sleep disturbances
Mental health						X					X
Respiratory health
Asthma											X
Allergy											X
Allergic rhinitis											X
Eczema											X
Respiratory tract infections											X
Senses
Vision
Hearing
Musculo-skeletal health
Back pain
Neck pain
Growing pains
Sexual maturation
Tanner stage											X
Pubertal development stage
Age at menarche											X
Age at voice change
2D/4D digit ratio
Nocturnal ejaculation
Acne
Other health outcomes
Cancer
Diabetes											X
Congenital anomalies	X
Biomarkers of health
Nephrology (e.g. creatinine, albumin)						X					X
Thyroid hormones
Inflammatory markers (e.g. C-reactive protein cytokines)						X					X
Immunologic markers (e.g. immunoglobulines)
Cortisol						X					X
Vitamines and micronutrients
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)						X					X
Metabolomics
DNA methylation	X					X
Transcriptomics (mRNA, miRNA)	X
Genome-wide association study (GWAS)	X

Child biological samples	---------- Child age (years) at sampling ----------
	At birth	0	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	>18
Whole blood	X
Serum	X
Plasma	X						X					X
Buffy coat	X						X					X
Urine							X					X
Hair							X					X
Teeth
Nails
Saliva					X		X					X
Purified DNA
Purified RNA	X
Red blood cells
Umbilical cord blood/tissue	X
Blood smear
Faeces/meconium							X					X
Exhaled breathe condensate
Sputum induction
Placenta	X

General information
	Pre-pregnancy	During pregnancy	<1	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18
Education													X
Income													X
Employment status								X					X
Job title								X					X
Single parenthood						X		X					X
Home address
Work address

Maternal characteristics related to the index pregnancy/child
Age at birth
Ethnicity	X
Country of birth	X
Planned pregnancy
Time to pregnancy
Fertility treatment
Prior spontaneous abortion (<22w)	X
Prior births	X
Ultrasound measurements	X
Doppler measurements
Preeclampsia	X
Gestational diabetes	X
Gestational hypertension	X
Gestational duration	X
Mode of delivery	X
Prenatal diagnostics	X
Medical termination of pregnancy	X

Maternal Exposures	---------- Timing of assessment ----------
	Pre-pregnancy	First trimester	Second trimester	Third trimester	Post pregnancy
Diet
Dietary supplements		X	X		X
Active smoking		X			X
Passive smoking
Alcohol consumption		X	X		X
Physical activity		X	X		X
Substance use					X
Medicine intake		X	X		X
Coffee drinking
Psychological distress (e.g. life-events, health behaviors, perceived stress)
Occupational exposures
Heavy lifts
Work hours					X
Air pollution
Access to green spaces
Built environment
Noise
Radiation, electromagnetic fields
Water contamination
Binge drinking
Pets
Farm animal exposure
Biomarkers of exposure
Mercury
Lead
Cadmium
Arsenic
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds
Bisphenol A
Other bisphenols
Parabens
Benzophenones
Triclosan
Phthalates
Cotinine

Maternal health	---------- Timing of assessment ----------
	Pre-pregnancy	First trimester	Second trimester	Third trimester	Post pregnancy
Anthropometry
Weight	X	X	X	X	X
Height		X
Waist circumference		X			X
Clinical examinations
Blood pressure		X	X		X
Carotida intima media thickness
Pulse wave velocity
DEXA scans
Bioimpedence		X	X		X
Mental and neurological development
Mental health					X
Cognitive function (e.g. intelligence quotient)					X
Respiratory health
Asthma					X
Allergy					X
Musculo‐skeletal disease
Back pain
Neck pain
Arthritis
Other health outcomes
Cancer
Diabetes					X
Cardio‐vascular disease
Family history of chronic disease
Infectious disease
Fever
Autoimmune disease
Urinary symptoms					X
Sexual problems
Sleep disturbance
Biomarkers of health
Nephrology (e.g. creatinine, albumin)					X
Thyroid hormones
Inflammatory markers (e.g. C-reactive protein cytokines)		X	X		X
Immunologic markers (e.g. immunoglobulines)
Cortisol
Vitamines and micronutrients
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)		X	X		X
Metabolomics			X
DNA methylation
Transcriptomics (mRNA, miRNA)				X
Genome-wide association study (GWAS)		X

Maternal biological samples	---------- Timing of sampling ----------
	Pre-pregnancy	First trimester	Second trimester	Third trimester	Post pregnancy
Breast milk
Whole blood
Serum
Plasma		X	X		X
Buffy coat		X	X		X
Urine					X
Hair
Nails
Saliva
Purified DNA
Purified RNA
Red blood cells
Faeces					X

General information
	Pre-pregnancy	During pregnancy	<1	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18
Education
Income
Employment status
Job title													X
Single parenthood
Home address
Work address

Paternal characteristics related to the index pregnancy/child
Fertility treatment
Age at child's birth
Ethnicity
Country of birth

Paternal exposures	---------- Timing of assessment ----------
	Pre-pregnancy	During pregnancy	Post pregnancy
Diet
Dietary supplements
Active smoking
Passive smoking
Alcohol consumption
Physical activity
Substance use
Medicine intake
Coffee drinking
Psychological distress (e.g. life-events, health behaviors, perceived stress)
Occupational exposures
Heavy lifts
Work hours
Air pollution
Access to green spaces
Built environment
Noise
Radiation, electromagnetic fields
Water contamination
Binge drinking
Pets
Farm animal exposure
Biomarkers of exposure
Mercury
Lead
Cadmium
Arsenic
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds
Bisphenol A
Other bisphenols
Parabens
Benzophenones
Triclosan
Phthalates
Cotinine

Paternal health	---------- Timing of assessment ----------
	Pre-pregnancy	During pregnancy	Post pregnancy
Anthropometry
Weight			X
Height			X
Waist circumference
Clinical examinations
Blood pressure
Carotida intima media thickness
Pulse wave velocity
DEXA scans
Bio impedence
Mental and neurological development
Mental health
Cognitive function (e.g. intelligence quotient)
Respiratory health
Asthma
Allergy
Musculo‐skeletal disease
Back pain
Neck pain
Arthritis
Other health outcomes
Cancer
Diabetes			X
Cardio‐vascular disease
Family history of chronic disease
Infectious disease
Fever
Autoimmune disease
Urinary symptoms
Sexual problems
Sleep disturbance
Biomarkers of health
Nephrology (e.g. creatinine, albumin)
Thyroid hormones
Inflammatory markers (e.g. C-reactive protein cytokines)
Immunologic markers (e.g. immunoglobulines)
Cortisol
Vitamines and micronutrients
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)
Metabolomics
DNA methylation
Transcriptomics (mRNA, miRNA)
Genome-wide association study (GWAS)

Paternal biological samples	---------- Timing of sampling ----------
	Pre-pregnancy	During pregnancy	Post pregnancy
Semen
Whole blood
Serum
Plasma
Buffy coat
Urine
Hair
Nails
Saliva
Purified DNA
Purified RNA
Red blood cells
Faeces

Comments and ideas

Comments and ideas