Identification

• Cohort, name
  European Longitudinal Study of Pregnancy and Childhood
  
  Cohort, abbreviation
  ELSPAC
  
  Cohort, country
  Czech Republic (Česko)
  
  Cohort, website
  http://www.elspac.cz
  
  Date of filling in this questionnaire:
  2018-07-03
  
  
• Principal investigator(s), name
  prof. Jana Klanova
  
  Principal investigator(s), e-mail address
  klanova@recetox.muni.cz
  
  Principal investigator(s), institution
  RECETOX MU
  
  Contact person(s), institution address
  Kamenice 753/5, pavilon A29, 625 00 Brno
  
  

Basic description

• Main aim of cohort
  ELSPAC was designed as a population-based prospective longitudinal birth cohort study to investigate the effects of biological, psychosocial, economic and environmental factors on pregnancy, delivery and subsequent child´s development and health. The Czech team was interested also in the effects of the profound socioeconomic changes related to the societal transformation after the fall of Communism in 1989.
  
  Recruited number of:
  7589 children / 5151 mothers / 4653 fathers / 0 grand parents / 0 other family members
  
  Approximate proportion of source population included
  96
  
  Source population
  Region-based
  
  
• Period of enrollment
  Start: 1991-03-01, End: 1992-06-30
  
  Enrollment period
  Pregnancy, week 20 to birth
  
  Enrollment criteria, please specify
  Residency in the two selected regions of the Czech republic (Brno, Znojmo). Expected date of delivery between 1 March 1991 and 30 June 1992.
  
  Planned age of children at end of follow-up
  19 yearsLife-long / unrestricted

Questionnaire or registry data and biological samples

• Children
• Mothers
• Fathers

General information	---------- Child age (years) at assessment ----------
	<1	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	>18
Home address	X	X	X	X		X		X				X				X			X
School address								X				X				X

Birth outcomes
Birth weight	X
Birth length	X
Gestational age at birth	X
Apgar score	X
Congenital malformations	X
Stillbirth (>= 22 weeks)
Child’s sex	X
Head circumference	X
Biparietal diameter

Child exposures	---------- Child age (years) at assessment ----------
	<1	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	>18
Breast feeding	X	X	X
Diet		X	X	X		X		X				X				X			X
Dietary supplements
Childcare attendance
Active smoking												X				X			X
Passive smoking	X	X	X	X		X		X
Alcohol consumption												X				X			X
Physical activity								X				X				X			X
Substance use												X				X			X
Medicine intake	X	X	X	X				X				X				X			X
Vaccinations	X	X	X	X
Psychological distress (e.g. bullying)												X				X			X
Air pollution
Access to green spaces
Built environment
Noise
Radiation, electromagnetic fields
Water contamination
Pets	X	X	X	X								X				X			X
Farm animal exposure
Biomarkers of exposure
Mercury
Lead
Cadmium
Arsenic
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds
Bisphenol A
Other bisphenols
Parabens
Benzophenones
Triclosan
Phthalates
Cotinine

Child development and health	---------- Child age (years) at assessment ----------
	<1	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	>18
Anthropometry
Weight		X	X	X		X		X				X				X			X
Height		X	X	X		X		X				X				X			X
Head circumference		X
Abdominal circumference
Arm circumference
Wrist circumference
Waist circumference
Clinical examinations
Blood pressure									X			X
Carotida intima media thickness
Pulse wave velocity
Cardiac ultrasound
Renal ultrasound
Brain MRI
Other MRI
DEXA‐scan results
Skin folds
Bio impedence
Oscilometry
Spirometry									X			X		X		X
Skin prick test
Bronchial challenge test
Reversibility test
Dental observations									X			X		X		X
Mental and neurological development
Cognitive function		X	X	X		X
School performance								X				X				X			X
Language
ADHD
Autism
Sleep disturbances
Mental health
Respiratory health
Asthma				X		X		X				X				X			X
Allergy				X		X		X				X				X			X
Allergic rhinitis				X		X		X				X				X			X
Eczema		X	X	X		X		X				X				X			X
Respiratory tract infections		X	X	X		X		X				X				X			X
Senses
Vision		X	X	X		X		X				X				X			X
Hearing		X	X	X		X		X				X				X			X
Musculo-skeletal health
Back pain
Neck pain
Growing pains
Sexual maturation
Tanner stage
Pubertal development stage												X				X			X
Age at menarche												X				X			X
Age at voice change
2D/4D digit ratio
Nocturnal ejaculation
Acne
Other health outcomes
Cancer
Diabetes												X				X			X
Congenital anomalies		X	X	X
Biomarkers of health
Nephrology (e.g. creatinine, albumin)
Thyroid hormones
Inflammatory markers (e.g. C-reactive protein cytokines)
Immunologic markers (e.g. immunoglobulines)
Cortisol
Vitamines and micronutrients
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)
Metabolomics
DNA methylation												X
Transcriptomics (mRNA, miRNA)
Genome-wide association study (GWAS)

Child biological samples	---------- Child age (years) at sampling ----------
	At birth	0	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	>18
Whole blood
Serum
Plasma
Buffy coat
Urine
Hair
Teeth
Nails
Saliva
Purified DNA
Purified RNA
Red blood cells
Umbilical cord blood/tissue
Blood smear
Faeces/meconium
Exhaled breathe condensate
Sputum induction
Placenta

General information
	Pre-pregnancy	During pregnancy	<1	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18
Education		X	X	X	X	X		X
Income
Employment status		X	X	X	X	X		X			X				X			X			X
Job title
Single parenthood
Home address	X	X	X	X	X			X		X				X				X			X
Work address

Maternal characteristics related to the index pregnancy/child
Age at birth	X
Ethnicity	X
Country of birth	X
Planned pregnancy	X
Time to pregnancy	X
Fertility treatment	X
Prior spontaneous abortion (<22w)	X
Prior births
Ultrasound measurements
Doppler measurements
Preeclampsia	X
Gestational diabetes	X
Gestational hypertension	X
Gestational duration	X
Mode of delivery	X
Prenatal diagnostics
Medical termination of pregnancy	X

Maternal Exposures	---------- Timing of assessment ----------
	Pre-pregnancy	First trimester	Second trimester	Third trimester	Post pregnancy
Diet			X		X
Dietary supplements
Active smoking			X		X
Passive smoking			X		X
Alcohol consumption			X		X
Physical activity			X		X
Substance use					X
Medicine intake			X		X
Coffee drinking			X		X
Psychological distress (e.g. life-events, health behaviors, perceived stress)			X		X
Occupational exposures			X		X
Heavy lifts			X		X
Work hours
Air pollution
Access to green spaces
Built environment
Noise
Radiation, electromagnetic fields
Water contamination
Binge drinking			X		X
Pets			X		X
Farm animal exposure
Biomarkers of exposure
Mercury
Lead
Cadmium
Arsenic
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds
Bisphenol A
Other bisphenols
Parabens
Benzophenones
Triclosan
Phthalates
Cotinine

Maternal health	---------- Timing of assessment ----------
	Pre-pregnancy	First trimester	Second trimester	Third trimester	Post pregnancy
Anthropometry
Weight	X		X		X
Height	X		X		X
Waist circumference	X		X		X
Clinical examinations
Blood pressure
Carotida intima media thickness
Pulse wave velocity
DEXA scans
Bioimpedence
Mental and neurological development
Mental health
Cognitive function (e.g. intelligence quotient)
Respiratory health
Asthma			X		X
Allergy			X		X
Musculo‐skeletal disease
Back pain			X		X
Neck pain			X		X
Arthritis			X		X
Other health outcomes
Cancer
Diabetes			X		X
Cardio‐vascular disease			X		X
Family history of chronic disease			X		X
Infectious disease
Fever			X		X
Autoimmune disease
Urinary symptoms			X		X
Sexual problems			X		X
Sleep disturbance
Biomarkers of health
Nephrology (e.g. creatinine, albumin)
Thyroid hormones
Inflammatory markers (e.g. C-reactive protein cytokines)
Immunologic markers (e.g. immunoglobulines)
Cortisol
Vitamines and micronutrients
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)
Metabolomics
DNA methylation
Transcriptomics (mRNA, miRNA)
Genome-wide association study (GWAS)

Maternal biological samples	---------- Timing of sampling ----------
	Pre-pregnancy	First trimester	Second trimester	Third trimester	Post pregnancy
Breast milk
Whole blood
Serum
Plasma
Buffy coat
Urine
Hair
Nails
Saliva
Purified DNA
Purified RNA
Red blood cells
Faeces

General information
	Pre-pregnancy	During pregnancy	<1	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18
Education		X	X	X	X	X				X				X				X			X
Income
Employment status		X	X	X	X	X				X				X				X			X
Job title
Single parenthood
Home address		X	X	X	X	X				X				X				X			X
Work address

Paternal characteristics related to the index pregnancy/child
Fertility treatment
Age at child's birth	X
Ethnicity	X
Country of birth	X

Paternal exposures	---------- Timing of assessment ----------
	Pre-pregnancy	During pregnancy	Post pregnancy
Diet		X	X
Dietary supplements
Active smoking		X	X
Passive smoking		X	X
Alcohol consumption		X	X
Physical activity		X	X
Substance use		X	X
Medicine intake
Coffee drinking		X	X
Psychological distress (e.g. life-events, health behaviors, perceived stress)		X	X
Occupational exposures		X	X
Heavy lifts
Work hours
Air pollution
Access to green spaces
Built environment
Noise
Radiation, electromagnetic fields
Water contamination
Binge drinking		X	X
Pets		X	X
Farm animal exposure
Biomarkers of exposure
Mercury
Lead
Cadmium
Arsenic
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds
Bisphenol A
Other bisphenols
Parabens
Benzophenones
Triclosan
Phthalates
Cotinine

Paternal health	---------- Timing of assessment ----------
	Pre-pregnancy	During pregnancy	Post pregnancy
Anthropometry
Weight		X	X
Height		X	X
Waist circumference
Clinical examinations
Blood pressure
Carotida intima media thickness
Pulse wave velocity
DEXA scans
Bio impedence
Mental and neurological development
Mental health
Cognitive function (e.g. intelligence quotient)
Respiratory health
Asthma		X	X
Allergy		X	X
Musculo‐skeletal disease
Back pain		X	X
Neck pain		X	X
Arthritis		X	X
Other health outcomes
Cancer
Diabetes		X	X
Cardio‐vascular disease		X	X
Family history of chronic disease		X	X
Infectious disease
Fever
Autoimmune disease
Urinary symptoms
Sexual problems		X	X
Sleep disturbance
Biomarkers of health
Nephrology (e.g. creatinine, albumin)
Thyroid hormones
Inflammatory markers (e.g. C-reactive protein cytokines)
Immunologic markers (e.g. immunoglobulines)
Cortisol
Vitamines and micronutrients
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)
Metabolomics
DNA methylation
Transcriptomics (mRNA, miRNA)
Genome-wide association study (GWAS)

Paternal biological samples	---------- Timing of sampling ----------
	Pre-pregnancy	During pregnancy	Post pregnancy
Semen
Whole blood
Serum
Plasma
Buffy coat
Urine
Hair
Nails
Saliva
Purified DNA
Purified RNA
Red blood cells
Faeces

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