Identification

• Cohort, name
  The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study
  
  Cohort, abbreviation
  The TMM BirThree Cohort Study
  
  Cohort, country
  Japan (日本)
  
  Date of filling in this questionnaire:
  2018-04-23
  
  
• Principal investigator(s), name
  Professor Shinichi Kuriyama
  
  Principal investigator(s), e-mail address
  obara-t@megabank.tohoku.ac.jp
  
  Principal investigator(s), institution
  Tohoku Medical Megabank Organization, Tohoku University
  
  Contact person(s), name
  Associate Professor Taku Obara
  
  Contact person(s), e-mail address
  obara-t@megabank.tohoku.ac.jp
  
  

Basic description

• Main aim of cohort
  The aims of our study are to monitor persons’ health status and implement suitable intervention after a big disaster and to challenge missing heritability by considering relatively sufficient required factors, including familial genetic information, exposures in early life, and life-course environmental factors.
  
  Recruited number of:
  24000 children / 22000 mothers / 9000 fathers / 8000 grand parents / 11000 other family members
  
  Approximate proportion of source population included
  0
  
  Source population
  Other, please describePopulation-based
  
  
• Period of enrollment
  Start: 2013-07-19, End: 2017-03-31
  
  Enrollment period
  Pregnancy, week  to
  
  Enrollment criteria, please specify
  recruited from pregnancy to a month after delivery
  
  Planned age of children at end of follow-up
  

Questionnaire or registry data and biological samples

• Children
• Mothers
• Fathers

General information	---------- Child age (years) at assessment ----------
	<1	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	>18
Home address	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X
School address

Birth outcomes
Birth weight	X
Birth length	X
Gestational age at birth	X
Apgar score	X
Congenital malformations	X
Stillbirth (>= 22 weeks)	X
Child’s sex	X
Head circumference	X
Biparietal diameter

Child exposures	---------- Child age (years) at assessment ----------
	<1	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	>18
Breast feeding	X	X	X	X
Diet	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X
Dietary supplements	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X
Childcare attendance	X	X	X	X	X	X
Active smoking														X	X	X	X	X	X
Passive smoking	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X
Alcohol consumption														X	X	X	X	X	X
Physical activity	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X
Substance use
Medicine intake	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X
Vaccinations						X
Psychological distress (e.g. bullying)					X	X	X	X	X	X	X	X	X	X	X	X	X	X	X
Air pollution
Access to green spaces
Built environment	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X
Noise
Radiation, electromagnetic fields
Water contamination
Pets	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X
Farm animal exposure
Biomarkers of exposure
Mercury
Lead
Cadmium
Arsenic
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds
Bisphenol A
Other bisphenols
Parabens
Benzophenones
Triclosan
Phthalates
Cotinine

Child development and health	---------- Child age (years) at assessment ----------
	<1	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	>18
Anthropometry
Weight	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X
Height	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X
Head circumference	X	X		X		X
Abdominal circumference
Arm circumference
Wrist circumference
Waist circumference
Clinical examinations
Blood pressure											X						X
Carotida intima media thickness
Pulse wave velocity
Cardiac ultrasound
Renal ultrasound
Brain MRI
Other MRI
DEXA‐scan results
Skin folds
Bio impedence											X						X
Oscilometry
Spirometry											X						X
Skin prick test
Bronchial challenge test
Reversibility test
Dental observations						X					X						X
Mental and neurological development
Cognitive function
School performance
Language
ADHD
Autism						X
Sleep disturbances	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X
Mental health	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X
Respiratory health
Asthma	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X
Allergy	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X
Allergic rhinitis	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X
Eczema	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X
Respiratory tract infections	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X
Senses
Vision						X					X						X
Hearing						X					X						X
Musculo-skeletal health
Back pain
Neck pain
Growing pains
Sexual maturation
Tanner stage
Pubertal development stage
Age at menarche
Age at voice change
2D/4D digit ratio
Nocturnal ejaculation
Acne
Other health outcomes
Cancer	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X
Diabetes	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X
Congenital anomalies	X
Biomarkers of health
Nephrology (e.g. creatinine, albumin)
Thyroid hormones						X											X
Inflammatory markers (e.g. C-reactive protein cytokines)
Immunologic markers (e.g. immunoglobulines)
Cortisol
Vitamines and micronutrients
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)
Metabolomics	X
DNA methylation
Transcriptomics (mRNA, miRNA)	X
Genome-wide association study (GWAS)	X

Child biological samples	---------- Child age (years) at sampling ----------
	At birth	0	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	>18
Whole blood
Serum	X
Plasma	X						X					X						X
Buffy coat	X						X					X						X
Urine							X					X						X
Hair
Teeth
Nails
Saliva
Purified DNA	X						X					X						X
Purified RNA
Red blood cells
Umbilical cord blood/tissue
Blood smear
Faeces/meconium
Exhaled breathe condensate
Sputum induction
Placenta

General information
	Pre-pregnancy	During pregnancy	<1	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18
Education				X
Income		X						X
Employment status		X	X	X	X	X	X	X
Job title		X	X	X				X
Single parenthood
Home address		X	X	X	X	X	X	X
Work address

Maternal characteristics related to the index pregnancy/child
Age at birth
Ethnicity
Country of birth	X
Planned pregnancy
Time to pregnancy	X
Fertility treatment	X
Prior spontaneous abortion (<22w)
Prior births	X
Ultrasound measurements	X
Doppler measurements
Preeclampsia	X
Gestational diabetes	X
Gestational hypertension	X
Gestational duration	X
Mode of delivery	X
Prenatal diagnostics	X
Medical termination of pregnancy	X

Maternal Exposures	---------- Timing of assessment ----------
	Pre-pregnancy	First trimester	Second trimester	Third trimester	Post pregnancy
Diet		X	X
Dietary supplements		X	X
Active smoking		X	X		X
Passive smoking		X	X		X
Alcohol consumption		X	X		X
Physical activity		X	X
Substance use
Medicine intake		X	X
Coffee drinking		X	X
Psychological distress (e.g. life-events, health behaviors, perceived stress)		X	X
Occupational exposures		X	X
Heavy lifts		X	X
Work hours		X	X
Air pollution
Access to green spaces
Built environment
Noise		X	X		X
Radiation, electromagnetic fields
Water contamination
Binge drinking
Pets			X		X
Farm animal exposure
Biomarkers of exposure
Mercury
Lead
Cadmium
Arsenic
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds
Bisphenol A
Other bisphenols
Parabens
Benzophenones
Triclosan
Phthalates
Cotinine

Maternal health	---------- Timing of assessment ----------
	Pre-pregnancy	First trimester	Second trimester	Third trimester	Post pregnancy
Anthropometry
Weight		X	X		X
Height		X	X		X
Waist circumference		X	X		X
Clinical examinations
Blood pressure		X	X		X
Carotida intima media thickness		X	X		X
Pulse wave velocity
DEXA scans
Bioimpedence		X	X		X
Mental and neurological development
Mental health		X	X		X
Cognitive function (e.g. intelligence quotient)
Respiratory health
Asthma					X
Allergy					X
Musculo‐skeletal disease
Back pain
Neck pain
Arthritis
Other health outcomes
Cancer					X
Diabetes					X
Cardio‐vascular disease					X
Family history of chronic disease					X
Infectious disease		X	X		X
Fever
Autoimmune disease					X
Urinary symptoms
Sexual problems
Sleep disturbance		X	X		X
Biomarkers of health
Nephrology (e.g. creatinine, albumin)		X	X		X
Thyroid hormones
Inflammatory markers (e.g. C-reactive protein cytokines)
Immunologic markers (e.g. immunoglobulines)
Cortisol
Vitamines and micronutrients
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)
Metabolomics		X	X
DNA methylation
Transcriptomics (mRNA, miRNA)		X	X
Genome-wide association study (GWAS)		X	X

Maternal biological samples	---------- Timing of sampling ----------
	Pre-pregnancy	First trimester	Second trimester	Third trimester	Post pregnancy
Breast milk					X
Whole blood
Serum		X	X		X
Plasma		X	X		X
Buffy coat		X	X		X
Urine		X	X		X
Hair
Nails
Saliva
Purified DNA		X	X		X
Purified RNA
Red blood cells
Faeces

General information
	Pre-pregnancy	During pregnancy	<1	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18
Education		X
Income								X
Employment status		X		X	X	X	X	X
Job title		X						X
Single parenthood
Home address		X	X	X	X	X	X	X
Work address

Paternal characteristics related to the index pregnancy/child
Fertility treatment
Age at child's birth
Ethnicity
Country of birth	X

Paternal exposures	---------- Timing of assessment ----------
	Pre-pregnancy	During pregnancy	Post pregnancy
Diet		X	X
Dietary supplements		X	X
Active smoking		X
Passive smoking		X
Alcohol consumption		X
Physical activity		X	X
Substance use
Medicine intake		X	X
Coffee drinking		X	X
Psychological distress (e.g. life-events, health behaviors, perceived stress)		X	X
Occupational exposures		X
Heavy lifts		X
Work hours		X
Air pollution
Access to green spaces			X
Built environment		X	X
Noise		X
Radiation, electromagnetic fields
Water contamination
Binge drinking
Pets		X
Farm animal exposure
Biomarkers of exposure
Mercury
Lead
Cadmium
Arsenic
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds
Bisphenol A
Other bisphenols
Parabens
Benzophenones
Triclosan
Phthalates
Cotinine

Paternal health	---------- Timing of assessment ----------
	Pre-pregnancy	During pregnancy	Post pregnancy
Anthropometry
Weight		X	X
Height		X	X
Waist circumference		X	X
Clinical examinations
Blood pressure		X	X
Carotida intima media thickness		X	X
Pulse wave velocity
DEXA scans
Bio impedence		X	X
Mental and neurological development
Mental health		X	X
Cognitive function (e.g. intelligence quotient)		X	X
Respiratory health
Asthma		X	X
Allergy		X	X
Musculo‐skeletal disease
Back pain
Neck pain
Arthritis
Other health outcomes
Cancer		X	X
Diabetes		X	X
Cardio‐vascular disease		X	X
Family history of chronic disease		X	X
Infectious disease		X	X
Fever
Autoimmune disease		X	X
Urinary symptoms
Sexual problems
Sleep disturbance		X	X
Biomarkers of health
Nephrology (e.g. creatinine, albumin)		X	X
Thyroid hormones			X
Inflammatory markers (e.g. C-reactive protein cytokines)			X
Immunologic markers (e.g. immunoglobulines)
Cortisol
Vitamines and micronutrients
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)
Metabolomics		X
DNA methylation
Transcriptomics (mRNA, miRNA)		X
Genome-wide association study (GWAS)		X

Paternal biological samples	---------- Timing of sampling ----------
	Pre-pregnancy	During pregnancy	Post pregnancy
Semen
Whole blood
Serum		X	X
Plasma		X	X
Buffy coat		X	X
Urine		X	X
Hair
Nails
Saliva
Purified DNA		X	X
Purified RNA
Red blood cells
Faeces

Comments and ideas

Comments and ideas