- Cohort, name
Lifelines NEXT
Cohort, abbreviation
LLNEXT
Cohort, country
Netherlands (Nederland)
Cohort, website
http://www.lifelines.nl/next
Cohort, facebook-site
www.facebook.com/lifelinesnext
Date of filling in this questionnaire:
2021-06-30 - Principal investigator(s), name
Prof. Dr. S.A. Scherjon
Principal investigator(s), e-mail address
s.a.scherjon@umcg.nl
Principal investigator(s), institution
University Medical Center Groningen (UMCG)
Contact person(s), name
Jackie Dekens
Contact person(s), e-mail address
j.a.m.dekens@umcg.nl
Contact person(s), institution address
Universitiy Medical Center Groningen (UMCG)
- Main aim of cohort
To investigate the effects of early life factors and pre-conceptional transgenerational events on healthy ageing and chronic disease in (early) childhood. To relate immunological, metabolic, environmental, (epi)genomic and social factors in early life development to microbiome.
Recruited number of:
800 children / 1060 mothers / 525 fathers / 0 grand parents / 0 other family members
Approximate proportion of source population included
0
Source population
Nation-based - Period of enrollment
Start: 2016-10-01, End: 0000-00-00
Enrollment period
Pregnancy, week 8 to 32
Enrollment criteria, please specify
pregnant Lifelines participant
Planned age of children at end of follow-up
Life-long / unrestricted
General information | ---------- Child age (years) at assessment ---------- | |||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
<1 | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | >18 | |
Home address | X | X | ||||||||||||||||||
School address |
Birth outcomes | |
---|---|
Birth weight | X |
Birth length | X |
Gestational age at birth | X |
Apgar score | X |
Congenital malformations | |
Stillbirth (>= 22 weeks) | |
Child’s sex | X |
Head circumference | X |
Biparietal diameter |
Child exposures | ---------- Child age (years) at assessment ---------- | |||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
<1 | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | >18 | |
Breast feeding | X | X | ||||||||||||||||||
Diet | X | X | ||||||||||||||||||
Dietary supplements | X | X | ||||||||||||||||||
Childcare attendance | X | X | ||||||||||||||||||
Active smoking | ||||||||||||||||||||
Passive smoking | X | X | ||||||||||||||||||
Alcohol consumption | ||||||||||||||||||||
Physical activity | ||||||||||||||||||||
Substance use | ||||||||||||||||||||
Medicine intake | X | X | ||||||||||||||||||
Vaccinations | X | X | ||||||||||||||||||
Psychological distress (e.g. bullying) | ||||||||||||||||||||
Air pollution | ||||||||||||||||||||
Access to green spaces | ||||||||||||||||||||
Built environment | ||||||||||||||||||||
Noise | ||||||||||||||||||||
Radiation, electromagnetic fields | ||||||||||||||||||||
Water contamination | ||||||||||||||||||||
Pets | X | X | ||||||||||||||||||
Farm animal exposure | X | X | ||||||||||||||||||
Biomarkers of exposure | ||||||||||||||||||||
Mercury | ||||||||||||||||||||
Lead | ||||||||||||||||||||
Cadmium | ||||||||||||||||||||
Arsenic | ||||||||||||||||||||
Other metals | ||||||||||||||||||||
Polychlorinated biphenyl esters | ||||||||||||||||||||
Dicloro difenil tricloroetano | ||||||||||||||||||||
Hexachlorobenzene | ||||||||||||||||||||
Brominated flame retardants | ||||||||||||||||||||
Perflouralkyl compounds | ||||||||||||||||||||
Bisphenol A | ||||||||||||||||||||
Other bisphenols | ||||||||||||||||||||
Parabens | ||||||||||||||||||||
Benzophenones | ||||||||||||||||||||
Triclosan | ||||||||||||||||||||
Phthalates | ||||||||||||||||||||
Cotinine |
Child development and health | ---------- Child age (years) at assessment ---------- | |||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
<1 | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | >18 | |
Anthropometry | ||||||||||||||||||||
Weight | X | X | ||||||||||||||||||
Height | X | X | ||||||||||||||||||
Head circumference | ||||||||||||||||||||
Abdominal circumference | ||||||||||||||||||||
Arm circumference | ||||||||||||||||||||
Wrist circumference | ||||||||||||||||||||
Waist circumference | ||||||||||||||||||||
Clinical examinations | ||||||||||||||||||||
Blood pressure | ||||||||||||||||||||
Carotida intima media thickness | ||||||||||||||||||||
Pulse wave velocity | ||||||||||||||||||||
Cardiac ultrasound | ||||||||||||||||||||
Renal ultrasound | ||||||||||||||||||||
Brain MRI | ||||||||||||||||||||
Other MRI | ||||||||||||||||||||
DEXA‐scan results | ||||||||||||||||||||
Skin folds | ||||||||||||||||||||
Bio impedence | ||||||||||||||||||||
Oscilometry | ||||||||||||||||||||
Spirometry | X | |||||||||||||||||||
Skin prick test | ||||||||||||||||||||
Bronchial challenge test | ||||||||||||||||||||
Reversibility test | ||||||||||||||||||||
Dental observations | ||||||||||||||||||||
Mental and neurological development | ||||||||||||||||||||
Cognitive function | X | X | ||||||||||||||||||
School performance | ||||||||||||||||||||
Language | ||||||||||||||||||||
ADHD | ||||||||||||||||||||
Autism | ||||||||||||||||||||
Sleep disturbances | X | X | ||||||||||||||||||
Mental health | X | X | ||||||||||||||||||
Respiratory health | ||||||||||||||||||||
Asthma | X | X | ||||||||||||||||||
Allergy | X | X | ||||||||||||||||||
Allergic rhinitis | X | X | ||||||||||||||||||
Eczema | X | X | ||||||||||||||||||
Respiratory tract infections | X | X | ||||||||||||||||||
Senses | ||||||||||||||||||||
Vision | ||||||||||||||||||||
Hearing | ||||||||||||||||||||
Musculo-skeletal health | ||||||||||||||||||||
Back pain | ||||||||||||||||||||
Neck pain | ||||||||||||||||||||
Growing pains | ||||||||||||||||||||
Sexual maturation | ||||||||||||||||||||
Tanner stage | ||||||||||||||||||||
Pubertal development stage | ||||||||||||||||||||
Age at menarche | ||||||||||||||||||||
Age at voice change | ||||||||||||||||||||
2D/4D digit ratio | ||||||||||||||||||||
Nocturnal ejaculation | ||||||||||||||||||||
Acne | ||||||||||||||||||||
Other health outcomes | ||||||||||||||||||||
Cancer | ||||||||||||||||||||
Diabetes | ||||||||||||||||||||
Congenital anomalies | ||||||||||||||||||||
Biomarkers of health | ||||||||||||||||||||
Nephrology (e.g. creatinine, albumin) | ||||||||||||||||||||
Thyroid hormones | ||||||||||||||||||||
Inflammatory markers (e.g. C-reactive protein cytokines) | ||||||||||||||||||||
Immunologic markers (e.g. immunoglobulines) | ||||||||||||||||||||
Cortisol | ||||||||||||||||||||
Vitamines and micronutrients | ||||||||||||||||||||
Gonadal axis hormones (e.g. testosterone, estradiol) | ||||||||||||||||||||
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides) | ||||||||||||||||||||
Metabolomics | ||||||||||||||||||||
DNA methylation | ||||||||||||||||||||
Transcriptomics (mRNA, miRNA) | ||||||||||||||||||||
Genome-wide association study (GWAS) |
Child biological samples | ---------- Child age (years) at sampling ---------- | ||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
At birth | 0 | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | >18 | |
Whole blood | X | X | X | ||||||||||||||||||
Serum | X | X | X | ||||||||||||||||||
Plasma | X | X | X | ||||||||||||||||||
Buffy coat | X | X | X | ||||||||||||||||||
Urine | X | X | |||||||||||||||||||
Hair | |||||||||||||||||||||
Teeth | |||||||||||||||||||||
Nails | |||||||||||||||||||||
Saliva | |||||||||||||||||||||
Purified DNA | X | X | X | ||||||||||||||||||
Purified RNA | |||||||||||||||||||||
Red blood cells | X | X | X | ||||||||||||||||||
Umbilical cord blood/tissue | X | ||||||||||||||||||||
Blood smear | |||||||||||||||||||||
Faeces/meconium | X | X | X | ||||||||||||||||||
Exhaled breathe condensate | |||||||||||||||||||||
Sputum induction | |||||||||||||||||||||
Placenta | X |
General information | |||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Pre-pregnancy | During pregnancy | <1 | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | |
Education | X | ||||||||||||||||||||
Income | X | ||||||||||||||||||||
Employment status | X | ||||||||||||||||||||
Job title | X | ||||||||||||||||||||
Single parenthood | X | ||||||||||||||||||||
Home address | |||||||||||||||||||||
Work address |
Maternal characteristics related to the index pregnancy/child | |
---|---|
Age at birth | X |
Ethnicity | X |
Country of birth | X |
Planned pregnancy | |
Time to pregnancy | |
Fertility treatment | |
Prior spontaneous abortion (<22w) | |
Prior births | X |
Ultrasound measurements | |
Doppler measurements | |
Preeclampsia | |
Gestational diabetes | X |
Gestational hypertension | X |
Gestational duration | X |
Mode of delivery | X |
Prenatal diagnostics | |
Medical termination of pregnancy |
Maternal Exposures | ---------- Timing of assessment ---------- | ||||
---|---|---|---|---|---|
Pre-pregnancy | First trimester | Second trimester | Third trimester | Post pregnancy | |
Diet | X | X | X | X | |
Dietary supplements | X | ||||
Active smoking | X | ||||
Passive smoking | X | ||||
Alcohol consumption | X | ||||
Physical activity | X | ||||
Substance use | X | ||||
Medicine intake | X | X | X | ||
Coffee drinking | X | ||||
Psychological distress (e.g. life-events, health behaviors, perceived stress) | X | X | |||
Occupational exposures | X | ||||
Heavy lifts | X | ||||
Work hours | X | ||||
Air pollution | X | ||||
Access to green spaces | |||||
Built environment | |||||
Noise | |||||
Radiation, electromagnetic fields | |||||
Water contamination | |||||
Binge drinking | |||||
Pets | X | X | X | ||
Farm animal exposure | X | X | |||
Biomarkers of exposure | |||||
Mercury | |||||
Lead | |||||
Cadmium | |||||
Arsenic | |||||
Other metals | |||||
Polychlorinated biphenyl esters | |||||
Dicloro difenil tricloroetano | |||||
Hexachlorobenzene | |||||
Brominated flame retardants | |||||
Perflouralkyl compounds | |||||
Bisphenol A | |||||
Other bisphenols | |||||
Parabens | |||||
Benzophenones | |||||
Triclosan | |||||
Phthalates | |||||
Cotinine |
Maternal health | ---------- Timing of assessment ---------- | ||||
---|---|---|---|---|---|
Pre-pregnancy | First trimester | Second trimester | Third trimester | Post pregnancy | |
Anthropometry | |||||
Weight | X | ||||
Height | X | ||||
Waist circumference | X | ||||
Clinical examinations | |||||
Blood pressure | X | ||||
Carotida intima media thickness | |||||
Pulse wave velocity | X | ||||
DEXA scans | |||||
Bioimpedence | |||||
Mental and neurological development | |||||
Mental health | X | X | X | ||
Cognitive function (e.g. intelligence quotient) | X | ||||
Respiratory health | |||||
Asthma | X | ||||
Allergy | X | ||||
Musculo‐skeletal disease | |||||
Back pain | X | ||||
Neck pain | X | ||||
Arthritis | X | ||||
Other health outcomes | |||||
Cancer | X | ||||
Diabetes | X | ||||
Cardio‐vascular disease | X | ||||
Family history of chronic disease | X | ||||
Infectious disease | X | ||||
Fever | X | ||||
Autoimmune disease | X | ||||
Urinary symptoms | X | ||||
Sexual problems | X | ||||
Sleep disturbance | X | ||||
Biomarkers of health | |||||
Nephrology (e.g. creatinine, albumin) | X | ||||
Thyroid hormones | X | ||||
Inflammatory markers (e.g. C-reactive protein cytokines) | |||||
Immunologic markers (e.g. immunoglobulines) | |||||
Cortisol | |||||
Vitamines and micronutrients | |||||
Gonadal axis hormones (e.g. testosterone, estradiol) | |||||
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides) | |||||
Metabolomics | |||||
DNA methylation | |||||
Transcriptomics (mRNA, miRNA) | |||||
Genome-wide association study (GWAS) |
Maternal biological samples | ---------- Timing of sampling ---------- | ||||
---|---|---|---|---|---|
Pre-pregnancy | First trimester | Second trimester | Third trimester | Post pregnancy | |
Breast milk | X | ||||
Whole blood | |||||
Serum | X | ||||
Plasma | X | ||||
Buffy coat | |||||
Urine | X | ||||
Hair | X | ||||
Nails | |||||
Saliva | |||||
Purified DNA | X | ||||
Purified RNA | X | ||||
Red blood cells | |||||
Faeces | X | X | X |
General information | |||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Pre-pregnancy | During pregnancy | <1 | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | |
Education | X | ||||||||||||||||||||
Income | X | ||||||||||||||||||||
Employment status | X | ||||||||||||||||||||
Job title | X | ||||||||||||||||||||
Single parenthood | |||||||||||||||||||||
Home address | |||||||||||||||||||||
Work address |
Paternal characteristics related to the index pregnancy/child | |
---|---|
Fertility treatment | |
Age at child's birth | X |
Ethnicity | X |
Country of birth | X |
Paternal exposures | ---------- Timing of assessment ---------- | ||
---|---|---|---|
Pre-pregnancy | During pregnancy | Post pregnancy | |
Diet | X | ||
Dietary supplements | X | ||
Active smoking | X | ||
Passive smoking | X | ||
Alcohol consumption | X | ||
Physical activity | X | ||
Substance use | X | ||
Medicine intake | X | ||
Coffee drinking | X | ||
Psychological distress (e.g. life-events, health behaviors, perceived stress) | X | ||
Occupational exposures | X | ||
Heavy lifts | X | ||
Work hours | X | ||
Air pollution | X | ||
Access to green spaces | |||
Built environment | |||
Noise | |||
Radiation, electromagnetic fields | |||
Water contamination | |||
Binge drinking | |||
Pets | X | ||
Farm animal exposure | X | ||
Biomarkers of exposure | |||
Mercury | |||
Lead | |||
Cadmium | |||
Arsenic | |||
Other metals | |||
Polychlorinated biphenyl esters | |||
Dicloro difenil tricloroetano | |||
Hexachlorobenzene | |||
Brominated flame retardants | |||
Perflouralkyl compounds | |||
Bisphenol A | |||
Other bisphenols | |||
Parabens | |||
Benzophenones | |||
Triclosan | |||
Phthalates | |||
Cotinine |
Paternal health | ---------- Timing of assessment ---------- | ||
---|---|---|---|
Pre-pregnancy | During pregnancy | Post pregnancy | |
Anthropometry | |||
Weight | X | ||
Height | X | ||
Waist circumference | X | ||
Clinical examinations | |||
Blood pressure | X | ||
Carotida intima media thickness | |||
Pulse wave velocity | X | ||
DEXA scans | |||
Bio impedence | |||
Mental and neurological development | |||
Mental health | X | ||
Cognitive function (e.g. intelligence quotient) | X | ||
Respiratory health | |||
Asthma | X | ||
Allergy | X | ||
Musculo‐skeletal disease | |||
Back pain | X | ||
Neck pain | X | ||
Arthritis | X | ||
Other health outcomes | |||
Cancer | X | ||
Diabetes | X | ||
Cardio‐vascular disease | X | ||
Family history of chronic disease | X | ||
Infectious disease | X | ||
Fever | X | ||
Autoimmune disease | X | ||
Urinary symptoms | X | ||
Sexual problems | X | ||
Sleep disturbance | X | ||
Biomarkers of health | |||
Nephrology (e.g. creatinine, albumin) | X | ||
Thyroid hormones | X | ||
Inflammatory markers (e.g. C-reactive protein cytokines) | |||
Immunologic markers (e.g. immunoglobulines) | |||
Cortisol | |||
Vitamines and micronutrients | |||
Gonadal axis hormones (e.g. testosterone, estradiol) | |||
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides) | X | ||
Metabolomics | |||
DNA methylation | |||
Transcriptomics (mRNA, miRNA) | |||
Genome-wide association study (GWAS) |
Paternal biological samples | ---------- Timing of sampling ---------- | ||
---|---|---|---|
Pre-pregnancy | During pregnancy | Post pregnancy | |
Semen | |||
Whole blood | |||
Serum | X | ||
Plasma | X | ||
Buffy coat | |||
Urine | X | ||
Hair | X | ||
Nails | |||
Saliva | |||
Purified DNA | X | ||
Purified RNA | X | ||
Red blood cells | |||
Faeces |
Comments and ideas
Cohort description : European Journal of Epidemiology https://doi.org/10.1007/s10654-020-00614-7
Cohort description : European Journal of Epidemiology https://doi.org/10.1007/s10654-020-00614-7