Identification

• Cohort, name
  Dutch famine birth cohort study
  
  Cohort, abbreviation
  DFBCS
  
  Cohort, country
  Netherlands (Nederland)
  
  Cohort, website
  http://www.hongerwinter.nl
  
  Date of filling in this questionnaire:
  2018-04-12
  
  
• Principal investigator(s), name
  Tessa Roseboom
  
  Principal investigator(s), e-mail address
  t.j.roseboom@amc.uva.nl
  
  Principal investigator(s), institution
  Academic Medical Centre, Amsterdam, the Netherlands
  
  Contact person(s), name
  Tessa Roseboom
  
  Contact person(s), e-mail address
  t.j.roseboom@amc.uva.nl
  
  Contact person(s), institution address
  Academic Medical Centre, Amsterdam, the Netherlands
  
  

Basic description

• Main aim of cohort
  To study the effects of prenatal exposure to the dutch famine on health in later life
  
  Recruited number of:
  741 children / 741 mothers / 0 fathers / 0 grand parents / 0 other family members
  
  Approximate proportion of source population included
  30
  
  Source population
  Other, please describeSingletons born alive between November 1943 and February 1947 in the Wilhelmina Gasthuis in Amsterdam
  
  
• Period of enrollment
  Start: 1943-11-01, End: 1947-02-01
  
  Enrollment period
  Pregnancy, week  to
  
  Enrollment criteria, please specify
  - Term singletons - born alive - between November 1943 and February 1947 - in the Wilhelmina Gasthuis in Amsterdam - available detailed birth record
  
  Exclusion criteria, please specify
  - missing medical records - gestational age less than 259 days
  
  Planned age of children at end of follow-up
  Life-long / unrestricted

Questionnaire or registry data and biological samples

• Children
• Mothers
• Fathers

General information	---------- Child age (years) at assessment ----------
	<1	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	>18
Home address																				X
School address

Birth outcomes
Birth weight	X
Birth length	X
Gestational age at birth	X
Apgar score
Congenital malformations	X
Stillbirth (>= 22 weeks)
Child’s sex	X
Head circumference	X
Biparietal diameter

Child exposures	---------- Child age (years) at assessment ----------
	<1	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	>18
Breast feeding	X
Diet	X																			X
Dietary supplements																				X
Childcare attendance
Active smoking																				X
Passive smoking
Alcohol consumption																				X
Physical activity																				X
Substance use
Medicine intake																				X
Vaccinations
Psychological distress (e.g. bullying)																				X
Air pollution
Access to green spaces
Built environment
Noise
Radiation, electromagnetic fields
Water contamination
Pets
Farm animal exposure
Biomarkers of exposure
Mercury
Lead
Cadmium
Arsenic
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds
Bisphenol A
Other bisphenols
Parabens
Benzophenones
Triclosan
Phthalates
Cotinine

Child development and health	---------- Child age (years) at assessment ----------
	<1	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	>18
Anthropometry
Weight																				X
Height																				X
Head circumference																				X
Abdominal circumference																				X
Arm circumference																				X
Wrist circumference
Waist circumference																				X
Clinical examinations
Blood pressure																				X
Carotida intima media thickness																				X
Pulse wave velocity																				X
Cardiac ultrasound																				X
Renal ultrasound
Brain MRI																				X
Other MRI
DEXA‐scan results
Skin folds																				X
Bio impedence																				X
Oscilometry
Spirometry
Skin prick test
Bronchial challenge test
Reversibility test
Dental observations
Mental and neurological development
Cognitive function																				X
School performance
Language
ADHD
Autism
Sleep disturbances																				X
Mental health																				X
Respiratory health
Asthma																				X
Allergy																				X
Allergic rhinitis
Eczema
Respiratory tract infections
Senses
Vision																				X
Hearing																				X
Musculo-skeletal health
Back pain																				X
Neck pain																				X
Growing pains
Sexual maturation
Tanner stage
Pubertal development stage
Age at menarche																				X
Age at voice change
2D/4D digit ratio
Nocturnal ejaculation
Acne
Other health outcomes
Cancer																				X
Diabetes																				X
Congenital anomalies																				X
Biomarkers of health
Nephrology (e.g. creatinine, albumin)																				X
Thyroid hormones																				X
Inflammatory markers (e.g. C-reactive protein cytokines)																				X
Immunologic markers (e.g. immunoglobulines)
Cortisol																				X
Vitamines and micronutrients
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)																				X
Metabolomics																				X
DNA methylation																				X
Transcriptomics (mRNA, miRNA)																				X
Genome-wide association study (GWAS)

Child biological samples	---------- Child age (years) at sampling ----------
	At birth	0	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	>18
Whole blood																					X
Serum																					X
Plasma																					X
Buffy coat																					X
Urine
Hair
Teeth
Nails
Saliva
Purified DNA																					X
Purified RNA
Red blood cells
Umbilical cord blood/tissue
Blood smear
Faeces/meconium
Exhaled breathe condensate
Sputum induction
Placenta

General information
	Pre-pregnancy	During pregnancy	<1	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18
Education		X
Income
Employment status		X
Job title		X
Single parenthood		X
Home address
Work address

Maternal characteristics related to the index pregnancy/child
Age at birth	X
Ethnicity
Country of birth
Planned pregnancy
Time to pregnancy
Fertility treatment
Prior spontaneous abortion (<22w)
Prior births	X
Ultrasound measurements
Doppler measurements
Preeclampsia	X
Gestational diabetes	X
Gestational hypertension	X
Gestational duration	X
Mode of delivery	X
Prenatal diagnostics
Medical termination of pregnancy

Maternal Exposures	---------- Timing of assessment ----------
	Pre-pregnancy	First trimester	Second trimester	Third trimester	Post pregnancy
Diet	X	X	X	X
Dietary supplements
Active smoking
Passive smoking
Alcohol consumption
Physical activity
Substance use
Medicine intake
Coffee drinking
Psychological distress (e.g. life-events, health behaviors, perceived stress)
Occupational exposures
Heavy lifts
Work hours
Air pollution
Access to green spaces
Built environment
Noise
Radiation, electromagnetic fields
Water contamination
Binge drinking
Pets
Farm animal exposure
Biomarkers of exposure
Mercury
Lead
Cadmium
Arsenic
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds
Bisphenol A
Other bisphenols
Parabens
Benzophenones
Triclosan
Phthalates
Cotinine

Maternal health	---------- Timing of assessment ----------
	Pre-pregnancy	First trimester	Second trimester	Third trimester	Post pregnancy
Anthropometry
Weight		X	X	X
Height
Waist circumference
Clinical examinations
Blood pressure				X
Carotida intima media thickness
Pulse wave velocity
DEXA scans
Bioimpedence
Mental and neurological development
Mental health
Cognitive function (e.g. intelligence quotient)
Respiratory health
Asthma
Allergy
Musculo‐skeletal disease
Back pain
Neck pain
Arthritis
Other health outcomes
Cancer
Diabetes
Cardio‐vascular disease					X
Family history of chronic disease					X
Infectious disease
Fever				X
Autoimmune disease
Urinary symptoms
Sexual problems
Sleep disturbance
Biomarkers of health
Nephrology (e.g. creatinine, albumin)
Thyroid hormones
Inflammatory markers (e.g. C-reactive protein cytokines)
Immunologic markers (e.g. immunoglobulines)
Cortisol
Vitamines and micronutrients
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)
Metabolomics
DNA methylation
Transcriptomics (mRNA, miRNA)
Genome-wide association study (GWAS)

Maternal biological samples	---------- Timing of sampling ----------
	Pre-pregnancy	First trimester	Second trimester	Third trimester	Post pregnancy
Breast milk
Whole blood
Serum
Plasma
Buffy coat
Urine
Hair
Nails
Saliva
Purified DNA
Purified RNA
Red blood cells
Faeces

General information
	Pre-pregnancy	During pregnancy	<1	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18
Education		X
Income
Employment status		X
Job title		X
Single parenthood
Home address
Work address

Paternal characteristics related to the index pregnancy/child
Fertility treatment
Age at child's birth	X
Ethnicity
Country of birth

Paternal exposures	---------- Timing of assessment ----------
	Pre-pregnancy	During pregnancy	Post pregnancy
Diet
Dietary supplements
Active smoking
Passive smoking
Alcohol consumption
Physical activity
Substance use
Medicine intake
Coffee drinking
Psychological distress (e.g. life-events, health behaviors, perceived stress)
Occupational exposures
Heavy lifts
Work hours
Air pollution
Access to green spaces
Built environment
Noise
Radiation, electromagnetic fields
Water contamination
Binge drinking
Pets
Farm animal exposure
Biomarkers of exposure
Mercury
Lead
Cadmium
Arsenic
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds
Bisphenol A
Other bisphenols
Parabens
Benzophenones
Triclosan
Phthalates
Cotinine

Paternal health	---------- Timing of assessment ----------
	Pre-pregnancy	During pregnancy	Post pregnancy
Anthropometry
Weight
Height
Waist circumference
Clinical examinations
Blood pressure
Carotida intima media thickness
Pulse wave velocity
DEXA scans
Bio impedence
Mental and neurological development
Mental health
Cognitive function (e.g. intelligence quotient)
Respiratory health
Asthma
Allergy
Musculo‐skeletal disease
Back pain
Neck pain
Arthritis
Other health outcomes
Cancer
Diabetes			X
Cardio‐vascular disease			X
Family history of chronic disease			X
Infectious disease
Fever
Autoimmune disease
Urinary symptoms
Sexual problems
Sleep disturbance
Biomarkers of health
Nephrology (e.g. creatinine, albumin)
Thyroid hormones
Inflammatory markers (e.g. C-reactive protein cytokines)
Immunologic markers (e.g. immunoglobulines)
Cortisol
Vitamines and micronutrients
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)
Metabolomics
DNA methylation
Transcriptomics (mRNA, miRNA)
Genome-wide association study (GWAS)

Paternal biological samples	---------- Timing of sampling ----------
	Pre-pregnancy	During pregnancy	Post pregnancy
Semen
Whole blood
Serum
Plasma
Buffy coat
Urine
Hair
Nails
Saliva
Purified DNA
Purified RNA
Red blood cells
Faeces

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Comments and ideas