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Birthcohort

Identification
  • Cohort, name
    Survey of Newborns in Pomerania

    Cohort, abbreviation
    SNiP-Study

    Cohort, country
    Germany (Deutschland)

    Cohort, website
    http://www2.medizin.uni-greifswald.de/kind_med/index.php?id=631

    Date of filling in this questionnaire:
    2018-05-07

  • Principal investigator(s), name
    Prof. M. Heckmann

    Principal investigator(s), e-mail address
    matthias.heckmann@med.uni-greifswald.de

    Principal investigator(s), institution
    University of Greifswald

    Contact person(s), name
    PhD Dr. Anja Lange

    Contact person(s), e-mail address
    anja.lange@med.uni-greifswald.de

    Contact person(s), institution address
    University of Greifswald, F. Sauerbruchstr., 17475 Greifswald, Germany

Basic description
  • Main aim of cohort
    The objectives of Survey of Newborns in Pomerania (SNiP) were to establish: (a) a population-based birth cohort providing detailed information about neonatal health, morbidity and mortality, (b) a biobank with newborn DNA and serum from cord blood, placenta tissue samples and DNA obtained from oral mucosal swabs of the mothers, (c) a prospective study design by re-examination of the SNiP population prior to attendance at primary school.

    Recruited number of:
    5801 children / 5801 mothers / 0 fathers / 0 grand parents / 0 other family members

    Approximate proportion of source population included
    75

    Source population
    Region-based

  • Period of enrollment
    Start: 2002-01-01, End: 2008-11-30

    Enrollment period
    At birth  to

    Enrollment criteria, please specify
    The inclusion criteria to participate in the study were: * giving birth during the study period, and * being registered as a permanent resident of the study area defined by ZIP-codes 17389 to 17999.

    Exclusion criteria, please specify
    The exclusion criteria to participate in the study were: * insufficient German language skills, * being a minor, * gaving up a newborn for adoption * death

    Planned age of children at end of follow-up
    Life-long / unrestricted
Questionnaire or registry data and biological samples
  • Children
  • Mothers
  • Fathers
General information ---------- Child age (years) at assessment ----------
<1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 >18
Home addressXXXXXXX
School address
Birth outcomes
Birth weightX
Birth lengthX
Gestational age at birthX
Apgar scoreX
Congenital malformationsX
Stillbirth (>= 22 weeks)X
Child’s sexX
Head circumferenceX
Biparietal diameter
Child exposures ---------- Child age (years) at assessment ----------
<1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 >18
Breast feedingX
DietXXXXXXXX
Dietary supplementsXXXXXXX
Childcare attendance
Active smokingXXXXXX
Passive smokingXXXXXX
Alcohol consumptionXXXXXX
Physical activityXXXXXX
Substance useXXXXXX
Medicine intakeXXXXXXX
Vaccinations
Psychological distress (e.g. bullying)XXXXXX
Air pollution
Access to green spaces
Built environment
Noise
Radiation, electromagnetic fieldsX
Water contamination
PetsXXXXXX
Farm animal exposureXXXXXX
Biomarkers of exposure
Mercury
Lead
Cadmium
Arsenic
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds
Bisphenol A
Other bisphenols
Parabens
Benzophenones
Triclosan
Phthalates
Cotinine
Child development and health ---------- Child age (years) at assessment ----------
<1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 >18
Anthropometry
WeightXXXXXXXXX
HeightXXXXXXXXX
Head circumferenceX
Abdominal circumference
Arm circumference
Wrist circumference
Waist circumference
Clinical examinations
Blood pressure
Carotida intima media thickness
Pulse wave velocity
Cardiac ultrasound
Renal ultrasoundX
Brain MRI
Other MRI
DEXA‐scan results
Skin folds
Bio impedence
Oscilometry
Spirometry
Skin prick test
Bronchial challenge test
Reversibility test
Dental observations
Mental and neurological development
Cognitive function
School performanceXXXXXXX
Language
ADHDXXXXXXX
AutismXXXXXXX
Sleep disturbancesXXXXXXX
Mental health
Respiratory health
AsthmaXXXXXXX
AllergyXXXXXXX
Allergic rhinitisXXXXXXX
EczemaXXXXXXX
Respiratory tract infectionsXXXXXXX
Senses
VisionXXXXXXX
HearingXXXXXXX
Musculo-skeletal health
Back pain
Neck pain
Growing pains
Sexual maturation
Tanner stage
Pubertal development stage
Age at menarche
Age at voice change
2D/4D digit ratio
Nocturnal ejaculation
Acne
Other health outcomes
CancerXXXXXXX
DiabetesXXXXXXX
Congenital anomaliesXXXXXXXX
Biomarkers of health
Nephrology (e.g. creatinine, albumin)
Thyroid hormones
Inflammatory markers (e.g. C-reactive protein cytokines)
Immunologic markers (e.g. immunoglobulines)
Cortisol
Vitamines and micronutrients
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)
Metabolomics
DNA methylation
Transcriptomics (mRNA, miRNA)
Genome-wide association study (GWAS)
Child biological samples ---------- Child age (years) at sampling ----------
At birth 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 >18
Whole blood
SerumX
PlasmaX
Buffy coat
Urine
Hair
Teeth
Nails
Saliva
Purified DNAX
Purified RNA
Red blood cells
Umbilical cord blood/tissueX
Blood smear
Faeces/meconium
Exhaled breathe condensate
Sputum induction
PlacentaX
General information
Pre-pregnancy During pregnancy <1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
EducationXXXXXXX
IncomeXXXXXXX
Employment statusXXXXXXX
Job title
Single parenthoodXXXXXXX
Home addressXXXXXXX
Work address
Maternal characteristics related to the index pregnancy/child
Age at birthX
EthnicityX
Country of birthX
Planned pregnancyX
Time to pregnancy
Fertility treatment
Prior spontaneous abortion (<22w)X
Prior birthsX
Ultrasound measurements
Doppler measurements
PreeclampsiaX
Gestational diabetesX
Gestational hypertensionX
Gestational durationX
Mode of deliveryX
Prenatal diagnosticsX
Medical termination of pregnancy
Maternal Exposures ---------- Timing of assessment ----------
Pre-pregnancy First trimester Second trimester Third trimester Post pregnancy
DietX
Dietary supplementsX
Active smokingX
Passive smoking
Alcohol consumptionX
Physical activity
Substance useX
Medicine intake
Coffee drinking
Psychological distress (e.g. life-events, health behaviors, perceived stress)X
Occupational exposures
Heavy lifts
Work hours
Air pollution
Access to green spaces
Built environment
Noise
Radiation, electromagnetic fields
Water contamination
Binge drinking
PetsX
Farm animal exposureX
Biomarkers of exposure
Mercury
Lead
Cadmium
Arsenic
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds
Bisphenol A
Other bisphenols
Parabens
Benzophenones
Triclosan
Phthalates
Cotinine
Maternal health ---------- Timing of assessment ----------
Pre-pregnancy First trimester Second trimester Third trimester Post pregnancy
Anthropometry
WeightX
HeightX
Waist circumference
Clinical examinations
Blood pressure
Carotida intima media thickness
Pulse wave velocity
DEXA scans
Bioimpedence
Mental and neurological development
Mental healthX
Cognitive function (e.g. intelligence quotient)
Respiratory health
AsthmaX
AllergyX
Musculo‐skeletal disease
Back pain
Neck pain
Arthritis
Other health outcomes
CancerX
DiabetesX
Cardio‐vascular diseaseX
Family history of chronic disease
Infectious diseaseX
FeverX
Autoimmune diseaseX
Urinary symptomsX
Sexual problems
Sleep disturbance
Biomarkers of health
Nephrology (e.g. creatinine, albumin)
Thyroid hormones
Inflammatory markers (e.g. C-reactive protein cytokines)
Immunologic markers (e.g. immunoglobulines)
Cortisol
Vitamines and micronutrients
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)
Metabolomics
DNA methylation
Transcriptomics (mRNA, miRNA)
Genome-wide association study (GWAS)
Maternal biological samples ---------- Timing of sampling ----------
Pre-pregnancy First trimester Second trimester Third trimester Post pregnancy
Breast milk
Whole blood
Serum
Plasma
Buffy coat
UrineX
Hair
Nails
Saliva
Purified DNAX
Purified RNA
Red blood cells
Faeces
General information
Pre-pregnancy During pregnancy <1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
Education
Income
Employment status
Job title
Single parenthood
Home address
Work address
Paternal characteristics related to the index pregnancy/child
Fertility treatment
Age at child's birth
Ethnicity
Country of birth
Paternal exposures ---------- Timing of assessment ----------
Pre-pregnancy During pregnancy Post pregnancy
Diet
Dietary supplements
Active smoking
Passive smoking
Alcohol consumption
Physical activity
Substance use
Medicine intake
Coffee drinking
Psychological distress (e.g. life-events, health behaviors, perceived stress)
Occupational exposures
Heavy lifts
Work hours
Air pollution
Access to green spaces
Built environment
Noise
Radiation, electromagnetic fields
Water contamination
Binge drinking
Pets
Farm animal exposure
Biomarkers of exposure
Mercury
Lead
Cadmium
Arsenic
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds
Bisphenol A
Other bisphenols
Parabens
Benzophenones
Triclosan
Phthalates
Cotinine
Paternal health ---------- Timing of assessment ----------
Pre-pregnancy During pregnancy Post pregnancy
Anthropometry
Weight
Height
Waist circumference
Clinical examinations
Blood pressure
Carotida intima media thickness
Pulse wave velocity
DEXA scans
Bio impedence
Mental and neurological development
Mental health
Cognitive function (e.g. intelligence quotient)
Respiratory health
Asthma
Allergy
Musculo‐skeletal disease
Back pain
Neck pain
Arthritis
Other health outcomes
Cancer
Diabetes
Cardio‐vascular disease
Family history of chronic disease
Infectious disease
Fever
Autoimmune disease
Urinary symptoms
Sexual problems
Sleep disturbance
Biomarkers of health
Nephrology (e.g. creatinine, albumin)
Thyroid hormones
Inflammatory markers (e.g. C-reactive protein cytokines)
Immunologic markers (e.g. immunoglobulines)
Cortisol
Vitamines and micronutrients
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)
Metabolomics
DNA methylation
Transcriptomics (mRNA, miRNA)
Genome-wide association study (GWAS)
Paternal biological samples ---------- Timing of sampling ----------
Pre-pregnancy During pregnancy Post pregnancy
Semen
Whole blood
Serum
Plasma
Buffy coat
Urine
Hair
Nails
Saliva
Purified DNA
Purified RNA
Red blood cells
Faeces
Comments and ideas
Comments and ideas
Study Design was published: 1)Ebner A, Thyrian JR, Lange A, Lingnau ML, Scheler-Hofmann M, Rosskopf D, Zygmunt M, Haas JP, Hoffmann W, Fusch C. Survey of Neonates in Pomerania (SNiP): a population-based birth study--objectives, design and population coverage. Paediatr Perinat Epidemiol. 2010 Mar;24(2):190-9. doi: 10.1111/j.1365-3016.2009.01078.x. PMID: 20415776. 2) Kantorczyk E, Domanski G, Lange AE, Ittermann T, Allenberg H, Zygmunt M, Heckmann M. Survey of Neonates in Pomerania (SNiP): Study design and cohort update. Paediatr Perinat Epidemiol. 2020 Mar;34(2):204-213. doi: 10.1111/ppe.12645. Epub 2020 Jan 31. PMID: 32003026.

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