Birthcohort | Birthcohorts

Cohort, name
Survey of Newborns in Pomerania

Cohort, abbreviation
SNiP-Study

Cohort, country
Germany (Deutschland)

Cohort, website
http://www2.medizin.uni-greifswald.de/kind_med/index.php?id=631

Date of filling in this questionnaire:
2018-05-07
Principal investigator(s), name
Prof. M. Heckmann

Principal investigator(s), e-mail address
matthias.heckmann@med.uni-greifswald.de

Principal investigator(s), institution
University of Greifswald

Contact person(s), name
PhD Dr. Anja Lange

Contact person(s), e-mail address
anja.lange@med.uni-greifswald.de

Contact person(s), institution address
University of Greifswald, F. Sauerbruchstr., 17475 Greifswald, Germany

Main aim of cohort
The objectives of Survey of Newborns in Pomerania (SNiP) were to establish: (a) a population-based birth cohort providing detailed information about neonatal health, morbidity and mortality, (b) a biobank with newborn DNA and serum from cord blood, placenta tissue samples and DNA obtained from oral mucosal swabs of the mothers, (c) a prospective study design by re-examination of the SNiP population prior to attendance at primary school.

Recruited number of:
5801 children / 5801 mothers / 0 fathers / 0 grand parents / 0 other family members

Approximate proportion of source population included
75

Source population
Region-based
Period of enrollment
Start: 2002-01-01, End: 2008-11-30

Enrollment period
At birth to

Enrollment criteria, please specify
The inclusion criteria to participate in the study were: * giving birth during the study period, and * being registered as a permanent resident of the study area defined by ZIP-codes 17389 to 17999.

Exclusion criteria, please specify
The exclusion criteria to participate in the study were: * insufficient German language skills, * being a minor, * gaving up a newborn for adoption * death

Planned age of children at end of follow-up
Life-long / unrestricted

Questionnaire or registry data and biological samples

General information	---------- Child age (years) at assessment ----------
	<1	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	>18
Home address	X										X	X	X	X	X	X
School address

Birth outcomes
Birth weight	X
Birth length	X
Gestational age at birth	X
Apgar score	X
Congenital malformations	X
Stillbirth (>= 22 weeks)	X
Child’s sex	X
Head circumference	X
Biparietal diameter

Child exposures	---------- Child age (years) at assessment ----------
	<1	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	>18
Breast feeding	X
Diet									X	X	X	X	X	X	X	X
Dietary supplements									X	X	X	X	X	X	X
Childcare attendance
Active smoking											X	X	X	X	X	X
Passive smoking											X	X	X	X	X	X
Alcohol consumption											X	X	X	X	X	X
Physical activity											X	X	X	X	X	X
Substance use											X	X	X	X	X	X
Medicine intake	X										X	X	X	X	X	X
Vaccinations
Psychological distress (e.g. bullying)											X	X	X	X	X	X
Air pollution
Access to green spaces
Built environment
Noise
Radiation, electromagnetic fields	X
Water contamination
Pets											X	X	X	X	X	X
Farm animal exposure											X	X	X	X	X	X
Biomarkers of exposure
Mercury
Lead
Cadmium
Arsenic
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds
Bisphenol A
Other bisphenols
Parabens
Benzophenones
Triclosan
Phthalates
Cotinine

Child development and health	---------- Child age (years) at assessment ----------
	<1	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	>18
Anthropometry
Weight	X								X	X	X	X	X	X	X	X
Height	X								X	X	X	X	X	X	X	X
Head circumference	X
Abdominal circumference
Arm circumference
Wrist circumference
Waist circumference
Clinical examinations
Blood pressure
Carotida intima media thickness
Pulse wave velocity
Cardiac ultrasound
Renal ultrasound	X
Brain MRI
Other MRI
DEXA‐scan results
Skin folds
Bio impedence
Oscilometry
Spirometry
Skin prick test
Bronchial challenge test
Reversibility test
Dental observations
Mental and neurological development
Cognitive function
School performance									X	X	X	X	X	X	X
Language
ADHD									X	X	X	X	X	X	X
Autism									X	X	X	X	X	X	X
Sleep disturbances									X	X	X	X	X	X	X
Mental health
Respiratory health
Asthma									X	X	X	X	X	X	X
Allergy									X	X	X	X	X	X	X
Allergic rhinitis									X	X	X	X	X	X	X
Eczema									X	X	X	X	X	X	X
Respiratory tract infections									X	X	X	X	X	X	X
Senses
Vision									X	X	X	X	X	X	X
Hearing									X	X	X	X	X	X	X
Musculo-skeletal health
Back pain
Neck pain
Growing pains
Sexual maturation
Tanner stage
Pubertal development stage
Age at menarche
Age at voice change
2D/4D digit ratio
Nocturnal ejaculation
Acne
Other health outcomes
Cancer										X	X	X	X	X	X	X
Diabetes										X	X	X	X	X	X	X
Congenital anomalies	X									X	X	X	X	X	X	X
Biomarkers of health
Nephrology (e.g. creatinine, albumin)
Thyroid hormones
Inflammatory markers (e.g. C-reactive protein cytokines)
Immunologic markers (e.g. immunoglobulines)
Cortisol
Vitamines and micronutrients
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)
Metabolomics
DNA methylation
Transcriptomics (mRNA, miRNA)
Genome-wide association study (GWAS)

Child biological samples	---------- Child age (years) at sampling ----------
	At birth	0	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	>18
Whole blood
Serum	X
Plasma	X
Buffy coat
Urine
Hair
Teeth
Nails
Saliva
Purified DNA	X
Purified RNA
Red blood cells
Umbilical cord blood/tissue	X
Blood smear
Faeces/meconium
Exhaled breathe condensate
Sputum induction
Placenta	X

General information
	Pre-pregnancy	During pregnancy	<1	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18
Education		X											X	X	X	X	X	X
Income		X											X	X	X	X	X	X
Employment status		X											X	X	X	X	X	X
Job title
Single parenthood		X											X	X	X	X	X	X
Home address		X											X	X	X	X	X	X
Work address

Maternal characteristics related to the index pregnancy/child
Age at birth	X
Ethnicity	X
Country of birth	X
Planned pregnancy	X
Time to pregnancy
Fertility treatment
Prior spontaneous abortion (<22w)	X
Prior births	X
Ultrasound measurements
Doppler measurements
Preeclampsia	X
Gestational diabetes	X
Gestational hypertension	X
Gestational duration	X
Mode of delivery	X
Prenatal diagnostics	X
Medical termination of pregnancy

Maternal Exposures	---------- Timing of assessment ----------
	Pre-pregnancy	First trimester	Second trimester	Third trimester	Post pregnancy
Diet					X
Dietary supplements					X
Active smoking					X
Passive smoking
Alcohol consumption					X
Physical activity
Substance use					X
Medicine intake
Coffee drinking
Psychological distress (e.g. life-events, health behaviors, perceived stress)					X
Occupational exposures
Heavy lifts
Work hours
Air pollution
Access to green spaces
Built environment
Noise
Radiation, electromagnetic fields
Water contamination
Binge drinking
Pets					X
Farm animal exposure					X
Biomarkers of exposure
Mercury
Lead
Cadmium
Arsenic
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds
Bisphenol A
Other bisphenols
Parabens
Benzophenones
Triclosan
Phthalates
Cotinine

Maternal health	---------- Timing of assessment ----------
	Pre-pregnancy	First trimester	Second trimester	Third trimester	Post pregnancy
Anthropometry
Weight					X
Height					X
Waist circumference
Clinical examinations
Blood pressure
Carotida intima media thickness
Pulse wave velocity
DEXA scans
Bioimpedence
Mental and neurological development
Mental health					X
Cognitive function (e.g. intelligence quotient)
Respiratory health
Asthma					X
Allergy					X
Musculo‐skeletal disease
Back pain
Neck pain
Arthritis
Other health outcomes
Cancer					X
Diabetes					X
Cardio‐vascular disease					X
Family history of chronic disease
Infectious disease					X
Fever					X
Autoimmune disease					X
Urinary symptoms					X
Sexual problems
Sleep disturbance
Biomarkers of health
Nephrology (e.g. creatinine, albumin)
Thyroid hormones
Inflammatory markers (e.g. C-reactive protein cytokines)
Immunologic markers (e.g. immunoglobulines)
Cortisol
Vitamines and micronutrients
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)
Metabolomics
DNA methylation
Transcriptomics (mRNA, miRNA)
Genome-wide association study (GWAS)

Maternal biological samples	---------- Timing of sampling ----------
	Pre-pregnancy	First trimester	Second trimester	Third trimester	Post pregnancy
Breast milk
Whole blood
Serum
Plasma
Buffy coat
Urine					X
Hair
Nails
Saliva
Purified DNA					X
Purified RNA
Red blood cells
Faeces

General information
	Pre-pregnancy	During pregnancy	<1	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18
Education
Income
Employment status
Job title
Single parenthood
Home address
Work address

Paternal characteristics related to the index pregnancy/child
Fertility treatment
Age at child's birth
Ethnicity
Country of birth

Paternal exposures	---------- Timing of assessment ----------
	Pre-pregnancy	During pregnancy	Post pregnancy
Diet
Dietary supplements
Active smoking
Passive smoking
Alcohol consumption
Physical activity
Substance use
Medicine intake
Coffee drinking
Psychological distress (e.g. life-events, health behaviors, perceived stress)
Occupational exposures
Heavy lifts
Work hours
Air pollution
Access to green spaces
Built environment
Noise
Radiation, electromagnetic fields
Water contamination
Binge drinking
Pets
Farm animal exposure
Biomarkers of exposure
Mercury
Lead
Cadmium
Arsenic
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds
Bisphenol A
Other bisphenols
Parabens
Benzophenones
Triclosan
Phthalates
Cotinine

Paternal health	---------- Timing of assessment ----------
	Pre-pregnancy	During pregnancy	Post pregnancy
Anthropometry
Weight
Height
Waist circumference
Clinical examinations
Blood pressure
Carotida intima media thickness
Pulse wave velocity
DEXA scans
Bio impedence
Mental and neurological development
Mental health
Cognitive function (e.g. intelligence quotient)
Respiratory health
Asthma
Allergy
Musculo‐skeletal disease
Back pain
Neck pain
Arthritis
Other health outcomes
Cancer
Diabetes
Cardio‐vascular disease
Family history of chronic disease
Infectious disease
Fever
Autoimmune disease
Urinary symptoms
Sexual problems
Sleep disturbance
Biomarkers of health
Nephrology (e.g. creatinine, albumin)
Thyroid hormones
Inflammatory markers (e.g. C-reactive protein cytokines)
Immunologic markers (e.g. immunoglobulines)
Cortisol
Vitamines and micronutrients
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)
Metabolomics
DNA methylation
Transcriptomics (mRNA, miRNA)
Genome-wide association study (GWAS)

Paternal biological samples	---------- Timing of sampling ----------
	Pre-pregnancy	During pregnancy	Post pregnancy
Semen
Whole blood
Serum
Plasma
Buffy coat
Urine
Hair
Nails
Saliva
Purified DNA
Purified RNA
Red blood cells
Faeces

Comments and ideas

Comments and ideas
Study Design was published: 1)Ebner A, Thyrian JR, Lange A, Lingnau ML, Scheler-Hofmann M, Rosskopf D, Zygmunt M, Haas JP, Hoffmann W, Fusch C. Survey of Neonates in Pomerania (SNiP): a population-based birth study--objectives, design and population coverage. Paediatr Perinat Epidemiol. 2010 Mar;24(2):190-9. doi: 10.1111/j.1365-3016.2009.01078.x. PMID: 20415776. 2) Kantorczyk E, Domanski G, Lange AE, Ittermann T, Allenberg H, Zygmunt M, Heckmann M. Survey of Neonates in Pomerania (SNiP): Study design and cohort update. Paediatr Perinat Epidemiol. 2020 Mar;34(2):204-213. doi: 10.1111/ppe.12645. Epub 2020 Jan 31. PMID: 32003026.