Birthcohort | Birthcohorts

Cohort, name
EDEN - Study on the pre and early postnatal determinants of child health and development

Cohort, abbreviation
EDEN - France

Cohort, country
France

Cohort, website
http://eden.vjf.inserm.fr/index.php/fr/

Key reference
Heude B, Forhan A, Slama R, Douhaud L, Bedel S, Saurel MJ, Hankard R, Thiebaugeorges O, De Agostini M, Annesi-Maesano I, Kaminski M, Charles MA and the EDEN mother-child cohort study group. Cohort Profile: The EDEN mother-child cohort on the prenatal and early postnatal determinants of child health and development. IJE. 2016 Apr;45(2):353-63

Date of filling in this questionnaire:
2017-04-04
Principal investigator(s), name
Heude Barbara

Principal investigator(s), e-mail address
barbara.heude@inserm.fr

Principal investigator(s), institution
CRESS INSERM UMR 1153 Team 6 ORCHAD - 16 Av Paul vaillant Couturier 94807 Villejuif France

Contact person(s), name
Anne Forhan

Contact person(s), e-mail address
etude.eden@inserm.fr

Main aim of cohort
To study of the pre et post natal determinant of the child’s development and health

Recruited number of:
1900 children / 2000 mothers / 1800 fathers / 0 grand parents / 0 other family members

Approximate proportion of source population included
53

Source population
Other, please describeTwo maternity centres
Period of enrollment
Start: 2003-01-01, End: 2005-01-01

Enrollment period
Pregnancy, week <24 to

Enrollment criteria, please specify
major (≥18 years) being able to write and read French presenting in the maternity centre before 24 weeks of amenorrhea

Exclusion criteria, please specify
multiple pregnancy known pregestational diabetes planning to move house during the following years

Planned age of children at end of follow-up
8 years

Questionnaire or registry data and biological samples

General information	---------- Child age (years) at assessment ----------
	<1	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	>18
Home address
School address

Birth outcomes
Birth weight	X
Birth length	X
Gestational age at birth	X
Apgar score	X
Congenital malformations	X
Stillbirth (>= 22 weeks)	X
Child’s sex	X
Head circumference
Biparietal diameter

Child exposures	---------- Child age (years) at assessment ----------
	<1	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	>18
Breast feeding	X	X	X
Diet	X	X	X	X	X	X			X
Dietary supplements
Childcare attendance	X	X	X	X	X
Active smoking
Passive smoking	X	X	X	X	X	X			X
Alcohol consumption
Physical activity		X	X	X		X			X
Substance use
Medicine intake	X	X	X	X	X	X			X
Vaccinations	X	X		X		X
Psychological distress (e.g. bullying)
Air pollution
Access to green spaces
Built environment
Noise
Radiation, electromagnetic fields
Water contamination
Pets
Farm animal exposure
Biomarkers of exposure
Mercury
Lead
Cadmium
Arsenic
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds
Bisphenol A
Other bisphenols
Parabens
Benzophenones
Triclosan
Phthalates
Cotinine

Child development and health	---------- Child age (years) at assessment ----------
	<1	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	>18
Anthropometry
Weight	X	X	X	X	X	X			X
Height	X	X	X	X	X	X			X
Head circumference	X	X	X	X	X	X
Abdominal circumference
Arm circumference
Wrist circumference
Waist circumference
Clinical examinations
Blood pressure						X
Carotida intima media thickness
Pulse wave velocity
Cardiac ultrasound
Renal ultrasound
Brain MRI
Other MRI
DEXA‐scan results
Skin folds
Bio impedence
Oscilometry
Spirometry
Skin prick test
Bronchial challenge test
Reversibility test
Dental observations
Mental and neurological development
Cognitive function				X		X
School performance									X
Language			X	X		X
ADHD
Autism
Sleep disturbances	X	X	X	X		X			X
Mental health		X	X	X		X			X
Respiratory health
Asthma
Allergy
Allergic rhinitis
Eczema
Respiratory tract infections
Senses
Vision
Hearing
Musculo-skeletal health
Back pain
Neck pain
Growing pains
Sexual maturation
Tanner stage
Pubertal development stage
Age at menarche
Age at voice change
2D/4D digit ratio
Nocturnal ejaculation
Acne
Other health outcomes
Cancer
Diabetes
Congenital anomalies
Biomarkers of health
Nephrology (e.g. creatinine, albumin)
Thyroid hormones
Inflammatory markers (e.g. C-reactive protein cytokines)
Immunologic markers (e.g. immunoglobulines)
Cortisol
Vitamines and micronutrients
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)
Metabolomics
DNA methylation
Transcriptomics (mRNA, miRNA)
Genome-wide association study (GWAS)

Child biological samples	---------- Child age (years) at sampling ----------
	At birth	0	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	>18
Whole blood							X
Serum	X						X
Plasma
Buffy coat
Urine							X
Hair	X		X	X
Teeth
Nails
Saliva
Purified DNA	X						X
Purified RNA
Red blood cells
Umbilical cord blood/tissue	X
Blood smear
Faeces/meconium
Exhaled breathe condensate
Sputum induction
Placenta

General information
	Pre-pregnancy	During pregnancy	<1	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18
Education		X
Income		X
Employment status	X
Job title
Single parenthood		X
Home address
Work address

Maternal characteristics related to the index pregnancy/child
Age at birth	X
Ethnicity
Country of birth
Planned pregnancy	X
Time to pregnancy	X
Fertility treatment	X
Prior spontaneous abortion (<22w)	X
Prior births	X
Ultrasound measurements
Doppler measurements
Preeclampsia	X
Gestational diabetes
Gestational hypertension
Gestational duration	X
Mode of delivery	X
Prenatal diagnostics	X
Medical termination of pregnancy	X

Maternal Exposures	---------- Timing of assessment ----------
	Pre-pregnancy	First trimester	Second trimester	Third trimester	Post pregnancy
Diet	X			X
Dietary supplements	X
Active smoking	X	X	X	X	X
Passive smoking		X	X	X	X
Alcohol consumption	X	X	X	X	X
Physical activity			X
Substance use		X	X	X	X
Medicine intake	X	X	X	X	X
Coffee drinking	X			X
Psychological distress (e.g. life-events, health behaviors, perceived stress)			X		X
Occupational exposures	X		X
Heavy lifts
Work hours
Air pollution			X		X
Access to green spaces
Built environment
Noise
Radiation, electromagnetic fields
Water contamination	X	X
Binge drinking	X			X	X
Pets
Farm animal exposure
Biomarkers of exposure
Mercury					X
Lead			X
Cadmium
Arsenic
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds
Bisphenol A				X
Other bisphenols
Parabens
Benzophenones
Triclosan
Phthalates
Cotinine

Maternal health	---------- Timing of assessment ----------
	Pre-pregnancy	First trimester	Second trimester	Third trimester	Post pregnancy
Anthropometry
Weight	X	X	X	X	X
Height	X
Waist circumference
Clinical examinations
Blood pressure			X
Carotida intima media thickness
Pulse wave velocity
DEXA scans
Bioimpedence
Mental and neurological development
Mental health			X		X
Cognitive function (e.g. intelligence quotient)
Respiratory health
Asthma
Allergy
Musculo‐skeletal disease
Back pain
Neck pain
Arthritis
Other health outcomes
Cancer	X
Diabetes			X	X
Cardio‐vascular disease	X			X	X
Family history of chronic disease
Infectious disease		X	X	X	X
Fever
Autoimmune disease
Urinary symptoms
Sexual problems
Sleep disturbance
Biomarkers of health
Nephrology (e.g. creatinine, albumin)
Thyroid hormones
Inflammatory markers (e.g. C-reactive protein cytokines)
Immunologic markers (e.g. immunoglobulines)
Cortisol
Vitamines and micronutrients
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)
Metabolomics
DNA methylation
Transcriptomics (mRNA, miRNA)
Genome-wide association study (GWAS)

Maternal biological samples	---------- Timing of sampling ----------
	Pre-pregnancy	First trimester	Second trimester	Third trimester	Post pregnancy
Breast milk					X
Whole blood			X
Serum			X
Plasma
Buffy coat
Urine			X
Hair					X
Nails
Saliva			X
Purified DNA			X
Purified RNA
Red blood cells
Faeces

General information
	Pre-pregnancy	During pregnancy	<1	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18
Education		X
Income
Employment status
Job title
Single parenthood
Home address
Work address

Paternal characteristics related to the index pregnancy/child
Fertility treatment
Age at child's birth	X
Ethnicity
Country of birth

Paternal exposures	---------- Timing of assessment ----------
	Pre-pregnancy	During pregnancy	Post pregnancy
Diet
Dietary supplements
Active smoking	X	X	X
Passive smoking
Alcohol consumption	X
Physical activity			X
Substance use	X		X
Medicine intake
Coffee drinking
Psychological distress (e.g. life-events, health behaviors, perceived stress)
Occupational exposures	X
Heavy lifts
Work hours
Air pollution
Access to green spaces
Built environment
Noise
Radiation, electromagnetic fields
Water contamination
Binge drinking
Pets
Farm animal exposure
Biomarkers of exposure
Mercury
Lead
Cadmium
Arsenic
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds
Bisphenol A
Other bisphenols
Parabens
Benzophenones
Triclosan
Phthalates
Cotinine

Paternal health	---------- Timing of assessment ----------
	Pre-pregnancy	During pregnancy	Post pregnancy
Anthropometry
Weight		X
Height		X
Waist circumference
Clinical examinations
Blood pressure
Carotida intima media thickness
Pulse wave velocity
DEXA scans
Bio impedence
Mental and neurological development
Mental health
Cognitive function (e.g. intelligence quotient)
Respiratory health
Asthma
Allergy
Musculo‐skeletal disease
Back pain
Neck pain
Arthritis
Other health outcomes
Cancer	X
Diabetes	X
Cardio‐vascular disease
Family history of chronic disease
Infectious disease
Fever
Autoimmune disease
Urinary symptoms
Sexual problems
Sleep disturbance
Biomarkers of health
Nephrology (e.g. creatinine, albumin)
Thyroid hormones
Inflammatory markers (e.g. C-reactive protein cytokines)
Immunologic markers (e.g. immunoglobulines)
Cortisol
Vitamines and micronutrients
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)
Metabolomics
DNA methylation
Transcriptomics (mRNA, miRNA)
Genome-wide association study (GWAS)

Paternal biological samples	---------- Timing of sampling ----------
	Pre-pregnancy	During pregnancy	Post pregnancy
Semen
Whole blood			X
Serum
Plasma
Buffy coat
Urine
Hair
Nails
Saliva
Purified DNA		X
Purified RNA
Red blood cells
Faeces

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