- Cohort, name
BabyCare
Cohort, abbreviation
babycarecohort
Cohort, country
Germany (Deutschland)
Cohort, website
https://www.baby-care.de
Date of filling in this questionnaire:
2012-05-03 - Principal investigator(s), name
Dr. Wolf Kirschner
Principal investigator(s), e-mail address
wolf.kirschner@fb-e.de
Principal investigator(s), institution
Forschung Beratung + Evaluation c/o Charité
Contact person(s), e-mail address
wolf.kirschner@fb-e.de
Contact person(s), institution address
Augustenburger Platz 1 13353 Berlin
- Main aim of cohort
BabyCare is a program for the prevention of preterm birth (PB) started in 2000 in Germany in collaboration of FB+E an the clinics of obstetrics in Berlin (Charité) an Munich (Prof. Dudenhausen, Prof. Friese). The program comprises health information and education and health promotion including an important role for nutrition especially in relation to folic acid, iodine and iron. Beside a book the main instrument is a self administered questionnaire (see below), comprising all risk and protective factors of preterm birth and a diety history protocol. This questionnaire is filled in by participating pregnant women on the average in the 14th week of gestation. Up to now, more than 150.000 pregnant women have participated and more than 30.000 questionnaires comprising all relevant risk and protective factors of PD are available. From the women filling in the questionnaire we have the signed approval of 85% to do follow-up surveys. Thus about 25.000 mothers and children are available for cohort studies.We have already carried out one follow-up study in 2004 for methodological reasons and the next is planned at the end of this year. To emphasize momentarily a cohort does not yet exist, but there is the opportunity for research on about 25000 mothers and 26000 children aged now 0 to 12 years. For about 12.000 participants besides the questionnaire data the birth outcome (birth at week of gestation) is also available and documented by the gynaecologist.
Recruited number of:
26 children / 25 mothers / 0 fathers / 0 grand parents / 0 other family members
Approximate proportion of source population included
0
Source population
Nation-based - Period of enrollment
Start: 0000-00-00, End: 0000-00-00
Enrollment period
Pregnancy, week 14 to 21
Enrollment criteria, please specify
Some 100 or so insurance providers and 1 000 of the 7 000 gynaecologists in Germany are co-operating with BabyCare and insurees and patients are invited to participate. Please find further infromation on our website www.baby-care.de in the field press/scientific publications.
Exclusion criteria, please specify
None
Planned age of children at end of follow-up
Life-long / unrestricted
| General information | ---------- Child age (years) at assessment ---------- | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| <1 | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | |
| Home address | |||||||||||||||||||
| School address | |||||||||||||||||||
| Birth outcomes | |
|---|---|
| Birth weight | |
| Birth length | |
| Gestational age at birth | |
| Apgar score | |
| Congenital malformations | |
| Stillbirth (>= 22 weeks) | |
| Child’s sex | |
| Head circumference | |
| Biparietal diameter | |
| Child exposures | ---------- Child age (years) at assessment ---------- | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| <1 | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | |
| Breast feeding | |||||||||||||||||||
| Diet | |||||||||||||||||||
| Dietary supplements | |||||||||||||||||||
| Childcare attendance | |||||||||||||||||||
| Active smoking | |||||||||||||||||||
| Passive smoking | |||||||||||||||||||
| Alcohol consumption | |||||||||||||||||||
| Physical activity | |||||||||||||||||||
| Substance use | |||||||||||||||||||
| Medicine intake | |||||||||||||||||||
| Vaccinations | |||||||||||||||||||
| Psychological distress (e.g. bullying) | |||||||||||||||||||
| Air pollution | |||||||||||||||||||
| Access to green spaces | |||||||||||||||||||
| Built environment | |||||||||||||||||||
| Noise | |||||||||||||||||||
| Radiation, electromagnetic fields | |||||||||||||||||||
| Water contamination | |||||||||||||||||||
| Pets | |||||||||||||||||||
| Farm animal exposure | |||||||||||||||||||
| Biomarkers of exposure | |||||||||||||||||||
| Mercury | |||||||||||||||||||
| Lead | |||||||||||||||||||
| Cadmium | |||||||||||||||||||
| Arsenic | |||||||||||||||||||
| Other metals | |||||||||||||||||||
| Polychlorinated biphenyl esters | |||||||||||||||||||
| Dicloro difenil tricloroetano | |||||||||||||||||||
| Hexachlorobenzene | |||||||||||||||||||
| Brominated flame retardants | |||||||||||||||||||
| Perflouralkyl compounds | |||||||||||||||||||
| Bisphenol A | |||||||||||||||||||
| Other bisphenols | |||||||||||||||||||
| Parabens | |||||||||||||||||||
| Benzophenones | |||||||||||||||||||
| Triclosan | |||||||||||||||||||
| Phthalates | |||||||||||||||||||
| Cotinine | |||||||||||||||||||
| Child development and health | ---------- Child age (years) at assessment ---------- | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| <1 | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | |
| Anthropometry | |||||||||||||||||||
| Weight | |||||||||||||||||||
| Height | |||||||||||||||||||
| Head circumference | |||||||||||||||||||
| Abdominal circumference | |||||||||||||||||||
| Arm circumference | |||||||||||||||||||
| Wrist circumference | |||||||||||||||||||
| Waist circumference | |||||||||||||||||||
| Clinical examinations | |||||||||||||||||||
| Blood pressure | |||||||||||||||||||
| Carotida intima media thickness | |||||||||||||||||||
| Pulse wave velocity | |||||||||||||||||||
| Cardiac ultrasound | |||||||||||||||||||
| Renal ultrasound | |||||||||||||||||||
| Brain MRI | |||||||||||||||||||
| Other MRI | |||||||||||||||||||
| DEXA‐scan results | |||||||||||||||||||
| Skin folds | |||||||||||||||||||
| Bio impedence | |||||||||||||||||||
| Oscilometry | |||||||||||||||||||
| Spirometry | |||||||||||||||||||
| Skin prick test | |||||||||||||||||||
| Bronchial challenge test | |||||||||||||||||||
| Reversibility test | |||||||||||||||||||
| Dental observations | |||||||||||||||||||
| Mental and neurological development | |||||||||||||||||||
| Cognitive function | |||||||||||||||||||
| School performance | |||||||||||||||||||
| Language | |||||||||||||||||||
| ADHD | |||||||||||||||||||
| Autism | |||||||||||||||||||
| Sleep disturbances | |||||||||||||||||||
| Mental health | |||||||||||||||||||
| Respiratory health | |||||||||||||||||||
| Asthma | |||||||||||||||||||
| Allergy | |||||||||||||||||||
| Allergic rhinitis | |||||||||||||||||||
| Eczema | |||||||||||||||||||
| Respiratory tract infections | |||||||||||||||||||
| Senses | |||||||||||||||||||
| Vision | |||||||||||||||||||
| Hearing | |||||||||||||||||||
| Musculo-skeletal health | |||||||||||||||||||
| Back pain | |||||||||||||||||||
| Neck pain | |||||||||||||||||||
| Growing pains | |||||||||||||||||||
| Sexual maturation | |||||||||||||||||||
| Tanner stage | |||||||||||||||||||
| Pubertal development stage | |||||||||||||||||||
| Age at menarche | |||||||||||||||||||
| Age at voice change | |||||||||||||||||||
| 2D/4D digit ratio | |||||||||||||||||||
| Nocturnal ejaculation | |||||||||||||||||||
| Acne | |||||||||||||||||||
| Other health outcomes | |||||||||||||||||||
| Cancer | |||||||||||||||||||
| Diabetes | |||||||||||||||||||
| Congenital anomalies | |||||||||||||||||||
| Biomarkers of health | |||||||||||||||||||
| Nephrology (e.g. creatinine, albumin) | |||||||||||||||||||
| Thyroid hormones | |||||||||||||||||||
| Inflammatory markers (e.g. C-reactive protein cytokines) | |||||||||||||||||||
| Immunologic markers (e.g. immunoglobulines) | |||||||||||||||||||
| Cortisol | |||||||||||||||||||
| Vitamines and micronutrients | |||||||||||||||||||
| Gonadal axis hormones (e.g. testosterone, estradiol) | |||||||||||||||||||
| Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides) | |||||||||||||||||||
| Metabolomics | |||||||||||||||||||
| DNA methylation | |||||||||||||||||||
| Transcriptomics (mRNA, miRNA) | |||||||||||||||||||
| Genome-wide association study (GWAS) | |||||||||||||||||||
| Child biological samples | ---------- Child age (years) at sampling ---------- | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| At birth | 0 | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | |
| Whole blood | ||||||||||||||||||||
| Serum | ||||||||||||||||||||
| Plasma | ||||||||||||||||||||
| Buffy coat | ||||||||||||||||||||
| Urine | ||||||||||||||||||||
| Hair | ||||||||||||||||||||
| Teeth | ||||||||||||||||||||
| Nails | ||||||||||||||||||||
| Saliva | ||||||||||||||||||||
| Purified DNA | ||||||||||||||||||||
| Purified RNA | ||||||||||||||||||||
| Red blood cells | ||||||||||||||||||||
| Umbilical cord blood/tissue | ||||||||||||||||||||
| Blood smear | ||||||||||||||||||||
| Faeces/meconium | ||||||||||||||||||||
| Exhaled breathe condensate | ||||||||||||||||||||
| Sputum induction | ||||||||||||||||||||
| Placenta | ||||||||||||||||||||
| General information | |||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Pre-pregnancy | During pregnancy | <1 | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | |
| Education | X | X | |||||||||||||||||||
| Income | X | X | |||||||||||||||||||
| Employment status | |||||||||||||||||||||
| Job title | |||||||||||||||||||||
| Single parenthood | X | X | |||||||||||||||||||
| Home address | |||||||||||||||||||||
| Work address | |||||||||||||||||||||
| Maternal characteristics related to the index pregnancy/child | |
|---|---|
| Age at birth | |
| Ethnicity | |
| Country of birth | |
| Planned pregnancy | |
| Time to pregnancy | |
| Fertility treatment | |
| Prior spontaneous abortion (<22w) | |
| Prior births | |
| Ultrasound measurements | |
| Doppler measurements | |
| Preeclampsia | |
| Gestational diabetes | |
| Gestational hypertension | |
| Gestational duration | |
| Mode of delivery | |
| Prenatal diagnostics | |
| Medical termination of pregnancy | |
| Maternal Exposures | ---------- Timing of assessment ---------- | ||||
|---|---|---|---|---|---|
| Pre-pregnancy | First trimester | Second trimester | Third trimester | Post pregnancy | |
| Diet | X | X | |||
| Dietary supplements | X | X | |||
| Active smoking | X | X | |||
| Passive smoking | X | X | |||
| Alcohol consumption | X | X | |||
| Physical activity | X | X | |||
| Substance use | X | X | |||
| Medicine intake | X | X | |||
| Coffee drinking | X | X | |||
| Psychological distress (e.g. life-events, health behaviors, perceived stress) | X | X | |||
| Occupational exposures | X | X | |||
| Heavy lifts | X | X | |||
| Work hours | |||||
| Air pollution | |||||
| Access to green spaces | |||||
| Built environment | |||||
| Noise | |||||
| Radiation, electromagnetic fields | |||||
| Water contamination | |||||
| Binge drinking | X | X | |||
| Pets | |||||
| Farm animal exposure | |||||
| Biomarkers of exposure | |||||
| Mercury | |||||
| Lead | |||||
| Cadmium | |||||
| Arsenic | |||||
| Other metals | |||||
| Polychlorinated biphenyl esters | |||||
| Dicloro difenil tricloroetano | |||||
| Hexachlorobenzene | |||||
| Brominated flame retardants | |||||
| Perflouralkyl compounds | |||||
| Bisphenol A | |||||
| Other bisphenols | |||||
| Parabens | |||||
| Benzophenones | |||||
| Triclosan | |||||
| Phthalates | |||||
| Cotinine | |||||
| Maternal health | ---------- Timing of assessment ---------- | ||||
|---|---|---|---|---|---|
| Pre-pregnancy | First trimester | Second trimester | Third trimester | Post pregnancy | |
| Anthropometry | |||||
| Weight | X | X | |||
| Height | X | X | |||
| Waist circumference | |||||
| Clinical examinations | |||||
| Blood pressure | X | X | |||
| Carotida intima media thickness | |||||
| Pulse wave velocity | |||||
| DEXA scans | |||||
| Bioimpedence | |||||
| Mental and neurological development | |||||
| Mental health | X | X | |||
| Cognitive function (e.g. intelligence quotient) | |||||
| Respiratory health | |||||
| Asthma | |||||
| Allergy | |||||
| Musculo‐skeletal disease | X | X | |||
| Back pain | |||||
| Neck pain | |||||
| Arthritis | |||||
| Other health outcomes | |||||
| Cancer | X | X | |||
| Diabetes | X | X | |||
| Cardio‐vascular disease | X | X | |||
| Family history of chronic disease | |||||
| Infectious disease | X | X | |||
| Fever | |||||
| Autoimmune disease | X | X | |||
| Urinary symptoms | |||||
| Sexual problems | |||||
| Sleep disturbance | |||||
| Biomarkers of health | |||||
| Nephrology (e.g. creatinine, albumin) | |||||
| Thyroid hormones | |||||
| Inflammatory markers (e.g. C-reactive protein cytokines) | |||||
| Immunologic markers (e.g. immunoglobulines) | |||||
| Cortisol | |||||
| Vitamines and micronutrients | |||||
| Gonadal axis hormones (e.g. testosterone, estradiol) | |||||
| Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides) | |||||
| Metabolomics | |||||
| DNA methylation | |||||
| Transcriptomics (mRNA, miRNA) | |||||
| Genome-wide association study (GWAS) | |||||
| Maternal biological samples | ---------- Timing of sampling ---------- | ||||
|---|---|---|---|---|---|
| Pre-pregnancy | First trimester | Second trimester | Third trimester | Post pregnancy | |
| Breast milk | |||||
| Whole blood | |||||
| Serum | |||||
| Plasma | |||||
| Buffy coat | |||||
| Urine | |||||
| Hair | |||||
| Nails | |||||
| Saliva | |||||
| Purified DNA | |||||
| Purified RNA | |||||
| Red blood cells | |||||
| Faeces | |||||
| General information | |||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Pre-pregnancy | During pregnancy | <1 | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | |
| Education | |||||||||||||||||||||
| Income | |||||||||||||||||||||
| Employment status | |||||||||||||||||||||
| Job title | |||||||||||||||||||||
| Single parenthood | |||||||||||||||||||||
| Home address | |||||||||||||||||||||
| Work address | |||||||||||||||||||||
| Paternal characteristics related to the index pregnancy/child | |
|---|---|
| Fertility treatment | |
| Age at child's birth | |
| Ethnicity | |
| Country of birth | |
| Paternal exposures | ---------- Timing of assessment ---------- | ||
|---|---|---|---|
| Pre-pregnancy | During pregnancy | Post pregnancy | |
| Diet | |||
| Dietary supplements | |||
| Active smoking | |||
| Passive smoking | |||
| Alcohol consumption | |||
| Physical activity | |||
| Substance use | |||
| Medicine intake | |||
| Coffee drinking | |||
| Psychological distress (e.g. life-events, health behaviors, perceived stress) | |||
| Occupational exposures | |||
| Heavy lifts | |||
| Work hours | |||
| Air pollution | |||
| Access to green spaces | |||
| Built environment | |||
| Noise | |||
| Radiation, electromagnetic fields | |||
| Water contamination | |||
| Binge drinking | |||
| Pets | |||
| Farm animal exposure | |||
| Biomarkers of exposure | |||
| Mercury | |||
| Lead | |||
| Cadmium | |||
| Arsenic | |||
| Other metals | |||
| Polychlorinated biphenyl esters | |||
| Dicloro difenil tricloroetano | |||
| Hexachlorobenzene | |||
| Brominated flame retardants | |||
| Perflouralkyl compounds | |||
| Bisphenol A | |||
| Other bisphenols | |||
| Parabens | |||
| Benzophenones | |||
| Triclosan | |||
| Phthalates | |||
| Cotinine | |||
| Paternal health | ---------- Timing of assessment ---------- | ||
|---|---|---|---|
| Pre-pregnancy | During pregnancy | Post pregnancy | |
| Anthropometry | |||
| Weight | |||
| Height | |||
| Waist circumference | |||
| Clinical examinations | |||
| Blood pressure | |||
| Carotida intima media thickness | |||
| Pulse wave velocity | |||
| DEXA scans | |||
| Bio impedence | |||
| Mental and neurological development | |||
| Mental health | |||
| Cognitive function (e.g. intelligence quotient) | |||
| Respiratory health | |||
| Asthma | |||
| Allergy | |||
| Musculo‐skeletal disease | |||
| Back pain | |||
| Neck pain | |||
| Arthritis | |||
| Other health outcomes | |||
| Cancer | |||
| Diabetes | |||
| Cardio‐vascular disease | |||
| Family history of chronic disease | |||
| Infectious disease | |||
| Fever | |||
| Autoimmune disease | |||
| Urinary symptoms | |||
| Sexual problems | |||
| Sleep disturbance | |||
| Biomarkers of health | |||
| Nephrology (e.g. creatinine, albumin) | |||
| Thyroid hormones | |||
| Inflammatory markers (e.g. C-reactive protein cytokines) | |||
| Immunologic markers (e.g. immunoglobulines) | |||
| Cortisol | |||
| Vitamines and micronutrients | |||
| Gonadal axis hormones (e.g. testosterone, estradiol) | |||
| Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides) | |||
| Metabolomics | |||
| DNA methylation | |||
| Transcriptomics (mRNA, miRNA) | |||
| Genome-wide association study (GWAS) | |||
| Paternal biological samples | ---------- Timing of sampling ---------- | ||
|---|---|---|---|
| Pre-pregnancy | During pregnancy | Post pregnancy | |
| Semen | |||
| Whole blood | |||
| Serum | |||
| Plasma | |||
| Buffy coat | |||
| Urine | |||
| Hair | |||
| Nails | |||
| Saliva | |||
| Purified DNA | |||
| Purified RNA | |||
| Red blood cells | |||
| Faeces | |||
Comments and ideas
As the dataset comprises nutritional an supplemental data cohort research can be especially focused on associations between nutrition in pregnancy and health status of children. Our first research question will be if there is an association between the use of folic acid and the incidence of asthma. However the cohort is open for all interesting research questions.
As the dataset comprises nutritional an supplemental data cohort research can be especially focused on associations between nutrition in pregnancy and health status of children. Our first research question will be if there is an association between the use of folic acid and the incidence of asthma. However the cohort is open for all interesting research questions.