Identification

• Cohort, name
  LIFE Child
  
  Cohort, abbreviation
  
  
  Cohort, country
  Germany (Deutschland)
  
  Cohort, website
  http://www.life.uni-leipzig.de/
  
  Date of filling in this questionnaire:
  2012-01-12
  
  
• Principal investigator(s), name
  Wieland Kiess, Antje Körner
  
  Principal investigator(s), e-mail address
  wieland.kiess@medizin.uni-leipzig.de
  
  Principal investigator(s), institution
  University of Leipzig, Germany
  
  Contact person(s), name
  Anne Jurkutat
  
  Contact person(s), e-mail address
  ajurkutat@life.uni-leipzig.de
  
  Contact person(s), institution address
  Leipzig Research Center for Civilization Diseases, Philipp-Rosenthal-Str. 27, 04103 Leipzig, Germany
  
  

Basic description

• Main aim of cohort
  healthy child development from pregnancy to adulthood + development of civilization diseases (e.g. obesity)
  
  Recruited number of:
  3500 children / 2500 mothers / 1000 fathers / 0 grand parents / 0 other family members
  
  Approximate proportion of source population included
  0
  
  Source population
  Region-based
  
  
• Period of enrollment
  Start: 2011-08-01, End: 0000-00-00
  
  Enrollment period
  Pregnancy, week 24 to 36
  
  Exclusion criteria, please specify
  severe chronic, chromosomal, or syndromal diseases
  
  Planned age of children at end of follow-up
  18 years

Questionnaire or registry data and biological samples

• Children
• Mothers
• Fathers

General information	---------- Child age (years) at assessment ----------
	<1	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	>18
Home address
School address

Birth outcomes
Birth weight	X
Birth length	X
Gestational age at birth	X
Apgar score	X
Congenital malformations	X
Stillbirth (>= 22 weeks)
Child’s sex	X
Head circumference	X
Biparietal diameter	X

Child exposures	---------- Child age (years) at assessment ----------
	<1	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	>18
Breast feeding	X
Diet	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X
Dietary supplements
Childcare attendance	X	X	X	X	X	X	X
Active smoking												X	X	X	X	X	X	X	X
Passive smoking	X
Alcohol consumption												X	X	X	X	X	X	X	X
Physical activity	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X
Substance use												X	X	X	X	X	X	X	X
Medicine intake	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X
Vaccinations	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X
Psychological distress (e.g. bullying)
Air pollution
Access to green spaces
Built environment
Noise
Radiation, electromagnetic fields
Water contamination
Pets	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X
Farm animal exposure
Biomarkers of exposure
Mercury
Lead
Cadmium
Arsenic
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds
Bisphenol A
Other bisphenols
Parabens
Benzophenones
Triclosan
Phthalates
Cotinine

Child development and health	---------- Child age (years) at assessment ----------
	<1	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	>18
Anthropometry
Weight	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X
Height	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X
Head circumference	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X
Abdominal circumference	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X
Arm circumference								X	X	X	X	X	X	X	X	X	X	X	X
Wrist circumference								X	X	X	X	X	X	X	X	X	X	X	X
Waist circumference								X	X	X	X	X	X	X	X	X	X	X	X
Clinical examinations
Blood pressure	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X
Carotida intima media thickness
Pulse wave velocity
Cardiac ultrasound
Renal ultrasound
Brain MRI
Other MRI
DEXA‐scan results
Skin folds	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X
Bio impedence							X	X	X	X	X	X	X	X	X	X	X	X	X
Oscilometry
Spirometry							X	X	X	X	X	X	X	X	X	X	X	X	X
Skin prick test
Bronchial challenge test
Reversibility test
Dental observations		X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X
Mental and neurological development
Cognitive function	X	X	X	X	X	X
School performance									X	X	X	X	X	X	X	X	X	X	X
Language		X	X	X	X	X
ADHD
Autism
Sleep disturbances	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X
Mental health	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X
Respiratory health
Asthma	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X
Allergy	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X
Allergic rhinitis	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X
Eczema	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X
Respiratory tract infections	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X
Senses
Vision				X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X
Hearing
Musculo-skeletal health
Back pain
Neck pain
Growing pains
Sexual maturation
Tanner stage	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X
Pubertal development stage
Age at menarche								X
Age at voice change
2D/4D digit ratio			X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X
Nocturnal ejaculation
Acne
Other health outcomes
Cancer	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X
Diabetes	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X
Congenital anomalies	X
Biomarkers of health
Nephrology (e.g. creatinine, albumin)	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X
Thyroid hormones	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X
Inflammatory markers (e.g. C-reactive protein cytokines)	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X
Immunologic markers (e.g. immunoglobulines)	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X
Cortisol
Vitamines and micronutrients	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X
Gonadal axis hormones (e.g. testosterone, estradiol)		X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X
Metabolomics
DNA methylation
Transcriptomics (mRNA, miRNA)
Genome-wide association study (GWAS)

Child biological samples	---------- Child age (years) at sampling ----------
	At birth	0	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	>18
Whole blood
Serum	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X
Plasma	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X
Buffy coat
Urine		X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X
Hair		X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X
Teeth
Nails
Saliva
Purified DNA		X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X
Purified RNA		X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X
Red blood cells		X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X
Umbilical cord blood/tissue	X
Blood smear
Faeces/meconium		X	X	X	X	X	X
Exhaled breathe condensate
Sputum induction
Placenta	X

General information
	Pre-pregnancy	During pregnancy	<1	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18
Education		X
Income		X
Employment status
Job title
Single parenthood
Home address
Work address

Maternal characteristics related to the index pregnancy/child
Age at birth	X
Ethnicity	X
Country of birth
Planned pregnancy	X
Time to pregnancy	X
Fertility treatment
Prior spontaneous abortion (<22w)	X
Prior births	X
Ultrasound measurements
Doppler measurements
Preeclampsia	X
Gestational diabetes
Gestational hypertension
Gestational duration	X
Mode of delivery
Prenatal diagnostics	X
Medical termination of pregnancy	X

Maternal Exposures	---------- Timing of assessment ----------
	Pre-pregnancy	First trimester	Second trimester	Third trimester	Post pregnancy
Diet			X
Dietary supplements			X
Active smoking			X
Passive smoking			X
Alcohol consumption			X
Physical activity
Substance use			X
Medicine intake			X
Coffee drinking			X
Psychological distress (e.g. life-events, health behaviors, perceived stress)			X
Occupational exposures
Heavy lifts
Work hours
Air pollution
Access to green spaces
Built environment
Noise
Radiation, electromagnetic fields
Water contamination
Binge drinking
Pets
Farm animal exposure
Biomarkers of exposure
Mercury
Lead
Cadmium
Arsenic
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds
Bisphenol A
Other bisphenols
Parabens
Benzophenones
Triclosan
Phthalates
Cotinine

Maternal health	---------- Timing of assessment ----------
	Pre-pregnancy	First trimester	Second trimester	Third trimester	Post pregnancy
Anthropometry
Weight			X	X	X
Height			X	X	X
Waist circumference
Clinical examinations
Blood pressure			X	X
Carotida intima media thickness
Pulse wave velocity
DEXA scans
Bioimpedence
Mental and neurological development
Mental health	X		X	X
Cognitive function (e.g. intelligence quotient)
Respiratory health
Asthma
Allergy
Musculo‐skeletal disease	X
Back pain
Neck pain
Arthritis
Other health outcomes
Cancer	X		X	X
Diabetes	X		X	X
Cardio‐vascular disease	X		X	X
Family history of chronic disease
Infectious disease	X		X	X
Fever
Autoimmune disease	X
Urinary symptoms
Sexual problems
Sleep disturbance
Biomarkers of health
Nephrology (e.g. creatinine, albumin)
Thyroid hormones
Inflammatory markers (e.g. C-reactive protein cytokines)
Immunologic markers (e.g. immunoglobulines)
Cortisol
Vitamines and micronutrients
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)
Metabolomics
DNA methylation
Transcriptomics (mRNA, miRNA)
Genome-wide association study (GWAS)

Maternal biological samples	---------- Timing of sampling ----------
	Pre-pregnancy	First trimester	Second trimester	Third trimester	Post pregnancy
Breast milk					X
Whole blood
Serum			X	X
Plasma
Buffy coat
Urine			X	X
Hair			X	X
Nails
Saliva
Purified DNA			X	X
Purified RNA
Red blood cells
Faeces

General information
	Pre-pregnancy	During pregnancy	<1	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18
Education
Income
Employment status
Job title
Single parenthood
Home address
Work address

Paternal characteristics related to the index pregnancy/child
Fertility treatment
Age at child's birth	X
Ethnicity	X
Country of birth

Paternal exposures	---------- Timing of assessment ----------
	Pre-pregnancy	During pregnancy	Post pregnancy
Diet
Dietary supplements
Active smoking
Passive smoking
Alcohol consumption
Physical activity
Substance use
Medicine intake
Coffee drinking
Psychological distress (e.g. life-events, health behaviors, perceived stress)
Occupational exposures
Heavy lifts
Work hours
Air pollution
Access to green spaces
Built environment
Noise
Radiation, electromagnetic fields
Water contamination
Binge drinking
Pets
Farm animal exposure
Biomarkers of exposure
Mercury
Lead
Cadmium
Arsenic
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds
Bisphenol A
Other bisphenols
Parabens
Benzophenones
Triclosan
Phthalates
Cotinine

Paternal health	---------- Timing of assessment ----------
	Pre-pregnancy	During pregnancy	Post pregnancy
Anthropometry
Weight		X
Height		X
Waist circumference
Clinical examinations
Blood pressure		X
Carotida intima media thickness
Pulse wave velocity
DEXA scans
Bio impedence
Mental and neurological development
Mental health		X
Cognitive function (e.g. intelligence quotient)
Respiratory health
Asthma
Allergy
Musculo‐skeletal disease		X
Back pain
Neck pain
Arthritis
Other health outcomes
Cancer		X
Diabetes		X
Cardio‐vascular disease
Family history of chronic disease
Infectious disease		X
Fever
Autoimmune disease		X
Urinary symptoms
Sexual problems
Sleep disturbance
Biomarkers of health
Nephrology (e.g. creatinine, albumin)
Thyroid hormones
Inflammatory markers (e.g. C-reactive protein cytokines)
Immunologic markers (e.g. immunoglobulines)
Cortisol
Vitamines and micronutrients
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)
Metabolomics
DNA methylation
Transcriptomics (mRNA, miRNA)
Genome-wide association study (GWAS)

Paternal biological samples	---------- Timing of sampling ----------
	Pre-pregnancy	During pregnancy	Post pregnancy
Semen
Whole blood
Serum		X
Plasma
Buffy coat
Urine		X
Hair		X
Nails
Saliva
Purified DNA		X
Purified RNA
Red blood cells
Faeces

Comments and ideas

Comments and ideas