• Cohort, name
    Piccolipiù

    Cohort, abbreviation


    Cohort, country
    Italy (Italia)

    Cohort, website
    http://www.piccolipiu.it

    Cohort, facebook-site
    http://https://www.facebook.com/progetto.piccolipiu

    Key reference
    Farchi S, Forastiere F, Vecchi Brumatti et al. Piccolipiù, a multicenter birth cohort in Italy: protocol of the study. BMC Pediatr. 2014 Feb 7;14:36

    Date of filling in this questionnaire:
    2018-04-18

  • Principal investigator(s), name
    Daniela Porta

    Principal investigator(s), e-mail address
    d.porta@deplazio.it

    Principal investigator(s), institution
    Department of Epidemiology of the Regional Health Service - Lazio

    Contact person(s), name
    Daniela Porta

    Contact person(s), e-mail address
    d.porta@deplazio.it

    Contact person(s), institution address
    Department of Epidemiology of the Regional Health Service - Lazio

  • Main aim of cohort
    To estimate the association between perinatal and early life factors, and environmental, social, occupational, factors and asthma and respiratory symptoms, obesity and metabolic disorders, cognitive development; to build a biobank with samples of serum and plasma from maternal and cord blood; umbilical cord; heel blood spot. The cohort is based on five cities of Northern and Central italy

    Recruited number of:
    3338 children / 3338 mothers / 3300 fathers / 0 grand parents / 0 other family members

    Approximate proportion of source population included
    60

    Source population
    Nation-based

  • Period of enrollment
    Start: 2011-10-26, End: 2015-03-20

    Enrollment period
    At birth  to

    Enrollment criteria, please specify
    families included in the study: - mothers aged >=18yrs; - mothers delivering in four hospitals of four italian cities (Turin, Florence, Trieste and Rome); - mothers and fathers signing informed consent; - good knowledge of italian language

    Exclusion criteria, please specify
    -multiple births; -families temporarly living in the considered cities

    Planned age of children at end of follow-up
    18 years
General information ---------- Child age (years) at assessment ----------
<1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
Home addressXXXX
School addressXXXX
Birth outcomes
Birth weightX
Birth lengthX
Gestational age at birthX
Apgar scoreX
Congenital malformationsX
Stillbirth (>= 22 weeks)
Child’s sexX
Head circumference
Biparietal diameter
Child exposures ---------- Child age (years) at assessment ----------
<1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
Breast feedingXXX
DietXXXXX
Dietary supplementsXXX
Childcare attendanceXXXX
Active smoking
Passive smokingXXXX
Alcohol consumption
Physical activityXX
Substance use
Medicine intakeXXXX
VaccinationsX
Psychological distress (e.g. bullying)X
Air pollutionXXXX
Access to green spaces
Built environment
Noise
Radiation, electromagnetic fields
Water contamination
PetsXXX
Farm animal exposure
Biomarkers of exposure
Mercury
Lead
Cadmium
Arsenic
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds
Bisphenol A
Other bisphenols
Parabens
Benzophenones
Triclosan
Phthalates
Cotinine
Child development and health ---------- Child age (years) at assessment ----------
<1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
Anthropometry
WeightXXXXX
HeightXXXXX
Head circumferenceX
Abdominal circumferenceX
Arm circumference
Wrist circumference
Waist circumference
Clinical examinations
Blood pressureX
Carotida intima media thickness
Pulse wave velocity
Cardiac ultrasound
Renal ultrasound
Brain MRI
Other MRI
DEXA‐scan results
Skin folds
Bio impedence
Oscilometry
SpirometryX
Skin prick testX
Bronchial challenge test
Reversibility test
Dental observations
Mental and neurological development
Cognitive functionX
School performance
Language
ADHDX
AutismX
Sleep disturbancesXXXXX
Mental health
Respiratory health
AsthmaXXXXX
AllergyX
Allergic rhinitisX
EczemaXXXXX
Respiratory tract infectionsXXXXX
Senses
Vision
Hearing
Musculo-skeletal health
Back pain
Neck pain
Growing pains
Sexual maturation
Tanner stage
Pubertal development stage
Age at menarche
Age at voice change
2D/4D digit ratio
Nocturnal ejaculation
Acne
Other health outcomes
Cancer
Diabetes
Congenital anomaliesXX
Biomarkers of health
Nephrology (e.g. creatinine, albumin)
Thyroid hormones
Inflammatory markers (e.g. C-reactive protein cytokines)
Immunologic markers (e.g. immunoglobulines)
Cortisol
Vitamines and micronutrients
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)
Metabolomics
DNA methylation
Transcriptomics (mRNA, miRNA)
Genome-wide association study (GWAS)
Child biological samples ---------- Child age (years) at sampling ----------
At birth 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
Whole bloodX
SerumX
Plasma
Buffy coat
Urine
Hair
Teeth
Nails
Saliva
Purified DNA
Purified RNA
Red blood cells
Umbilical cord blood/tissueX
Blood smear
Faeces/meconium
Exhaled breathe condensate
Sputum induction
Placenta
General information
Pre-pregnancy During pregnancy <1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
EducationX
Income
Employment status
Job title
Single parenthoodX
Home address
Work address
Maternal characteristics related to the index pregnancy/child
Age at birthX
EthnicityX
Country of birth
Planned pregnancyX
Time to pregnancyX
Fertility treatmentX
Prior spontaneous abortion (<22w)X
Prior birthsX
Ultrasound measurements
Doppler measurements
PreeclampsiaX
Gestational diabetes
Gestational hypertension
Gestational durationX
Mode of deliveryX
Prenatal diagnosticsX
Medical termination of pregnancyX
Maternal Exposures ---------- Timing of assessment ----------
Pre-pregnancy First trimester Second trimester Third trimester Post pregnancy
DietXXXX
Dietary supplementsXXXX
Active smokingXXXXX
Passive smokingXXXXX
Alcohol consumptionXXXXX
Physical activityXXXXX
Substance use
Medicine intakeXXXXX
Coffee drinkingXXXXX
Psychological distress (e.g. life-events, health behaviors, perceived stress)XXXX
Occupational exposuresXXXXX
Heavy liftsXXXXX
Work hours
Air pollutionXXXXX
Access to green spaces
Built environment
Noise
Radiation, electromagnetic fields
Water contaminationXXXXX
Binge drinkingX
Pets
Farm animal exposure
Biomarkers of exposure
Mercury
Lead
Cadmium
Arsenic
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds
Bisphenol A
Other bisphenols
Parabens
Benzophenones
Triclosan
Phthalates
Cotinine
Maternal health ---------- Timing of assessment ----------
Pre-pregnancy First trimester Second trimester Third trimester Post pregnancy
Anthropometry
WeightXXXXX
HeightXXXXX
Waist circumference
Clinical examinations
Blood pressure
Carotida intima media thickness
Pulse wave velocity
DEXA scans
Bioimpedence
Mental and neurological development
Mental healthX
Cognitive function (e.g. intelligence quotient)
Respiratory health
Asthma
Allergy
Musculo‐skeletal diseaseXXXX
Back pain
Neck pain
Arthritis
Other health outcomes
CancerXXX
DiabetesXXXX
Cardio‐vascular diseaseXXXX
Family history of chronic disease
Infectious diseaseXXXX
FeverX
Autoimmune diseaseXXXX
Urinary symptoms
Sexual problems
Sleep disturbance
Biomarkers of health
Nephrology (e.g. creatinine, albumin)
Thyroid hormones
Inflammatory markers (e.g. C-reactive protein cytokines)
Immunologic markers (e.g. immunoglobulines)
Cortisol
Vitamines and micronutrients
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)
Metabolomics
DNA methylation
Transcriptomics (mRNA, miRNA)
Genome-wide association study (GWAS)
Maternal biological samples ---------- Timing of sampling ----------
Pre-pregnancy First trimester Second trimester Third trimester Post pregnancy
Breast milk
Whole bloodX
SerumX
Plasma
Buffy coat
Urine
Hair
Nails
Saliva
Purified DNA
Purified RNA
Red blood cells
Faeces
General information
Pre-pregnancy During pregnancy <1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
EducationX
Income
Employment status
Job title
Single parenthood
Home address
Work address
Paternal characteristics related to the index pregnancy/child
Fertility treatment
Age at child's birthX
EthnicityX
Country of birth
Paternal exposures ---------- Timing of assessment ----------
Pre-pregnancy During pregnancy Post pregnancy
Diet
Dietary supplements
Active smokingXXX
Passive smoking
Alcohol consumption
Physical activity
Substance use
Medicine intake
Coffee drinking
Psychological distress (e.g. life-events, health behaviors, perceived stress)
Occupational exposuresXXX
Heavy lifts
Work hours
Air pollution
Access to green spaces
Built environment
Noise
Radiation, electromagnetic fields
Water contamination
Binge drinking
Pets
Farm animal exposure
Biomarkers of exposure
Mercury
Lead
Cadmium
Arsenic
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds
Bisphenol A
Other bisphenols
Parabens
Benzophenones
Triclosan
Phthalates
Cotinine
Paternal health ---------- Timing of assessment ----------
Pre-pregnancy During pregnancy Post pregnancy
Anthropometry
WeightXX
HeightXX
Waist circumference
Clinical examinations
Blood pressure
Carotida intima media thickness
Pulse wave velocity
DEXA scans
Bio impedence
Mental and neurological development
Mental healthX
Cognitive function (e.g. intelligence quotient)
Respiratory health
Asthma
Allergy
Musculo‐skeletal diseaseX
Back pain
Neck pain
Arthritis
Other health outcomes
CancerX
DiabetesX
Cardio‐vascular diseaseX
Family history of chronic disease
Infectious diseaseX
Fever
Autoimmune diseaseX
Urinary symptoms
Sexual problems
Sleep disturbance
Biomarkers of health
Nephrology (e.g. creatinine, albumin)
Thyroid hormones
Inflammatory markers (e.g. C-reactive protein cytokines)
Immunologic markers (e.g. immunoglobulines)
Cortisol
Vitamines and micronutrients
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)
Metabolomics
DNA methylation
Transcriptomics (mRNA, miRNA)
Genome-wide association study (GWAS)
Paternal biological samples ---------- Timing of sampling ----------
Pre-pregnancy During pregnancy Post pregnancy
Semen
Whole blood
Serum
Plasma
Buffy coat
Urine
Hair
Nails
Saliva
Purified DNA
Purified RNA
Red blood cells
Faeces
Comments and ideas
Piccolipiù cohort has been funded by Minister of Health to create a biobank and to prospectively follow the infants ideally up to adulthood