Identification

• Cohort, name
  Bern-Basel Infant Lung Development Cohort
  
  Cohort, abbreviation
  BILD
  
  Cohort, country
  Switzerland (Schweiz)
  
  Cohort, website
  www.bild-cohort.ch
  
  Key reference
  Fuchs O, Latzin P, Kuehni CE, Frey U. Cohort profile: the Bern infant lung development cohort. Int J Epidemiol. 2012 Apr;41(2):366-76. doi: 10.1093/ije/dyq239. Epub 2011 Jan 13. PMID: 21233140; PMCID: PMC7108546.
  
  Date of filling in this questionnaire:
  2011-10-31
  
  
• Principal investigator(s), name
  Urs Frey
  
  Principal investigator(s), e-mail address
  urs.frey@ukbb.ch
  
  Principal investigator(s), institution
  University Children's Hospital (UKBB) Basel, Switzerland and University Children's Hospital Bern, Switzerland
  
  Contact person(s), name
  Urs Frey
  
  Contact person(s), e-mail address
  urs.frey@ukbb.ch
  
  Contact person(s), institution address
  University Children's Hospital (UKBB) Basel, Switzerland
  
  

Basic description

• Main aim of cohort
  The aim of this study is to research the causes of impaired lung growth and asthma development in term- and preterm infants, as well as in infants with a predisposition to asthma. We are particularly interested in the harmful influence of environmental pollution, and whether or not certain predispositions (prematurity, maternal asthma or genetic variations) may make infants more vulnerable to air pollution. With the results of this study we hope to develop prevention measures or new therapeutic concepts for the future.
  
  Recruited number of:
  1600 children / 200 mothers / 0 fathers / 0 grand parents / 0 other family members
  
  Approximate proportion of source population included
  0
  
  Source population
  Region-based
  
  
• Period of enrollment
  Start: 1999-00-00, End: 2021-11-30
  
  Enrollment period
  Pre pregnancy  to
  
  Enrollment criteria, please specify
  White ethnicity, ability of parents to speak one of the major Swiss languages (German, French), no severe maternal health problems, no maternal drug abuse other than nicotine, no known major birth defects or airway malformation. In addition, for healty infants: term delivery (at least 37 weeks), no perinatal disease of the newborn such as respiratory distress, need of oxygen or other major respiratory diseases diagnosed after birth.
  
  Exclusion criteria, please specify
  Need for respiratory support >three days postnatally, severe malformations or known diseases, maternal drug abuse, known severe maternal disease, severe problems of communication (with child or caregivers).
  
  Planned age of children at end of follow-up
  12 years

Questionnaire or registry data and biological samples

• Children
• Mothers
• Fathers

General information	---------- Child age (years) at assessment ----------
	<1	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	>18
Home address	X	X
School address

Birth outcomes
Birth weight	X
Birth length	X
Gestational age at birth	X
Apgar score	X
Congenital malformations
Stillbirth (>= 22 weeks)
Child’s sex	X
Head circumference
Biparietal diameter

Child exposures	---------- Child age (years) at assessment ----------
	<1	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	>18
Breast feeding	X	X
Diet	X	X					X						X
Dietary supplements
Childcare attendance	X	X	X	X	X	X	X
Active smoking													X
Passive smoking	X	X	X	X	X	X	X						X
Alcohol consumption													X
Physical activity							X						X
Substance use
Medicine intake							X						X
Vaccinations	X	X
Psychological distress (e.g. bullying)
Air pollution	X	X	X	X	X	X	X						X
Access to green spaces
Built environment
Noise
Radiation, electromagnetic fields
Water contamination
Pets	X	X	X	X	X	X	X						X
Farm animal exposure	X	X	X	X	X	X	X						X
Biomarkers of exposure
Mercury
Lead
Cadmium
Arsenic
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds
Bisphenol A
Other bisphenols
Parabens
Benzophenones
Triclosan
Phthalates
Cotinine

Child development and health	---------- Child age (years) at assessment ----------
	<1	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	>18
Anthropometry
Weight	X	X					X						X
Height	X	X					X						X
Head circumference	X						X
Abdominal circumference
Arm circumference
Wrist circumference
Waist circumference
Clinical examinations
Blood pressure							X						X
Carotida intima media thickness
Pulse wave velocity
Cardiac ultrasound
Renal ultrasound
Brain MRI
Other MRI
DEXA‐scan results
Skin folds
Bio impedence
Oscilometry
Spirometry							X						X
Skin prick test							X						X
Bronchial challenge test
Reversibility test
Dental observations
Mental and neurological development
Cognitive function
School performance
Language
ADHD
Autism
Sleep disturbances
Mental health
Respiratory health
Asthma							X						X
Allergy							X						X
Allergic rhinitis							X						X
Eczema							X						X
Respiratory tract infections	X	X	X				X						X
Senses
Vision
Hearing
Musculo-skeletal health
Back pain
Neck pain
Growing pains
Sexual maturation
Tanner stage
Pubertal development stage
Age at menarche
Age at voice change
2D/4D digit ratio
Nocturnal ejaculation
Acne
Other health outcomes
Cancer
Diabetes
Congenital anomalies
Biomarkers of health
Nephrology (e.g. creatinine, albumin)
Thyroid hormones
Inflammatory markers (e.g. C-reactive protein cytokines)							X
Immunologic markers (e.g. immunoglobulines)							X
Cortisol
Vitamines and micronutrients
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)
Metabolomics
DNA methylation
Transcriptomics (mRNA, miRNA)
Genome-wide association study (GWAS)

Child biological samples	---------- Child age (years) at sampling ----------
	At birth	0	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	>18
Whole blood	X
Serum	X
Plasma
Buffy coat
Urine	X	X						X
Hair
Teeth
Nails
Saliva
Purified DNA	X							X
Purified RNA
Red blood cells
Umbilical cord blood/tissue	X
Blood smear
Faeces/meconium
Exhaled breathe condensate
Sputum induction
Placenta

General information
	Pre-pregnancy	During pregnancy	<1	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18
Education
Income
Employment status
Job title
Single parenthood
Home address
Work address

Maternal characteristics related to the index pregnancy/child
Age at birth	X
Ethnicity	X
Country of birth
Planned pregnancy
Time to pregnancy
Fertility treatment
Prior spontaneous abortion (<22w)
Prior births	X
Ultrasound measurements
Doppler measurements
Preeclampsia
Gestational diabetes
Gestational hypertension
Gestational duration	X
Mode of delivery	X
Prenatal diagnostics
Medical termination of pregnancy

Maternal Exposures	---------- Timing of assessment ----------
	Pre-pregnancy	First trimester	Second trimester	Third trimester	Post pregnancy
Diet		X	X	X
Dietary supplements		X	X	X
Active smoking		X	X	X	X
Passive smoking		X	X	X	X
Alcohol consumption		X	X	X
Physical activity
Substance use
Medicine intake		X	X	X
Coffee drinking		X	X	X
Psychological distress (e.g. life-events, health behaviors, perceived stress)
Occupational exposures
Heavy lifts
Work hours
Air pollution		X	X	X
Access to green spaces
Built environment
Noise
Radiation, electromagnetic fields
Water contamination		X	X	X
Binge drinking
Pets
Farm animal exposure
Biomarkers of exposure
Mercury
Lead
Cadmium
Arsenic
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds
Bisphenol A
Other bisphenols
Parabens
Benzophenones
Triclosan
Phthalates
Cotinine

Maternal health	---------- Timing of assessment ----------
	Pre-pregnancy	First trimester	Second trimester	Third trimester	Post pregnancy
Anthropometry
Weight
Height
Waist circumference
Clinical examinations
Blood pressure
Carotida intima media thickness
Pulse wave velocity
DEXA scans
Bioimpedence
Mental and neurological development
Mental health
Cognitive function (e.g. intelligence quotient)
Respiratory health
Asthma
Allergy
Musculo‐skeletal disease
Back pain
Neck pain
Arthritis
Other health outcomes
Cancer
Diabetes
Cardio‐vascular disease
Family history of chronic disease
Infectious disease		X	X	X	X
Fever		X	X	X
Autoimmune disease
Urinary symptoms
Sexual problems
Sleep disturbance
Biomarkers of health
Nephrology (e.g. creatinine, albumin)
Thyroid hormones
Inflammatory markers (e.g. C-reactive protein cytokines)
Immunologic markers (e.g. immunoglobulines)
Cortisol
Vitamines and micronutrients
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)
Metabolomics
DNA methylation
Transcriptomics (mRNA, miRNA)
Genome-wide association study (GWAS)

Maternal biological samples	---------- Timing of sampling ----------
	Pre-pregnancy	First trimester	Second trimester	Third trimester	Post pregnancy
Breast milk
Whole blood
Serum
Plasma
Buffy coat
Urine
Hair
Nails
Saliva
Purified DNA
Purified RNA
Red blood cells
Faeces

General information
	Pre-pregnancy	During pregnancy	<1	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18
Education
Income
Employment status
Job title
Single parenthood
Home address
Work address

Paternal characteristics related to the index pregnancy/child
Fertility treatment
Age at child's birth	X
Ethnicity	X
Country of birth

Paternal exposures	---------- Timing of assessment ----------
	Pre-pregnancy	During pregnancy	Post pregnancy
Diet
Dietary supplements
Active smoking		X	X
Passive smoking
Alcohol consumption
Physical activity
Substance use
Medicine intake
Coffee drinking
Psychological distress (e.g. life-events, health behaviors, perceived stress)
Occupational exposures
Heavy lifts
Work hours
Air pollution
Access to green spaces
Built environment
Noise
Radiation, electromagnetic fields
Water contamination
Binge drinking
Pets
Farm animal exposure
Biomarkers of exposure
Mercury
Lead
Cadmium
Arsenic
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds
Bisphenol A
Other bisphenols
Parabens
Benzophenones
Triclosan
Phthalates
Cotinine

Paternal health	---------- Timing of assessment ----------
	Pre-pregnancy	During pregnancy	Post pregnancy
Anthropometry
Weight
Height
Waist circumference
Clinical examinations
Blood pressure
Carotida intima media thickness
Pulse wave velocity
DEXA scans
Bio impedence
Mental and neurological development
Mental health
Cognitive function (e.g. intelligence quotient)
Respiratory health
Asthma
Allergy
Musculo‐skeletal disease
Back pain
Neck pain
Arthritis
Other health outcomes
Cancer
Diabetes
Cardio‐vascular disease
Family history of chronic disease
Infectious disease
Fever
Autoimmune disease
Urinary symptoms
Sexual problems
Sleep disturbance
Biomarkers of health
Nephrology (e.g. creatinine, albumin)
Thyroid hormones
Inflammatory markers (e.g. C-reactive protein cytokines)
Immunologic markers (e.g. immunoglobulines)
Cortisol
Vitamines and micronutrients
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)
Metabolomics
DNA methylation
Transcriptomics (mRNA, miRNA)
Genome-wide association study (GWAS)

Paternal biological samples	---------- Timing of sampling ----------
	Pre-pregnancy	During pregnancy	Post pregnancy
Semen
Whole blood
Serum
Plasma
Buffy coat
Urine
Hair
Nails
Saliva
Purified DNA
Purified RNA
Red blood cells
Faeces

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