• Cohort, name
    Avon Longitudinal Study of Parents & Children/Children of the 90s

    Cohort, abbreviation
    ALSPAC

    Cohort, country
    United Kingdom

    Cohort, website
    http://www.alspac.bristol.ac.uk

    Cohort, facebook-site
    http://www.facebook.com/#!/childrenofthe90s

    Key reference
    Golding,J.; Pembrey,M.; Jones,R. ALSPAC--the Avon Longitudinal Study of Parents and Children. I. Study methodology. Paediatr Perinat Epidemiol. 2001 Jan;15(1):74-87.

    Date of filling in this questionnaire:
    2011-12-20

  • Principal investigator(s), name
    George Davey Smith, Nic Timpson

    Principal investigator(s), e-mail address
    KZ.Davey-Smith@bristol.ac.uk; N.J.Timspson@bristo

    Principal investigator(s), institution
    University of Bristol

    Contact person(s), name
    John Henderson (a.j.henderson@bristol.ac.uk)

    Contact person(s), e-mail address
    alspac-data@bristol.ac.uk; alspac-secretaries@bristol.ac.uk

    Contact person(s), institution address
    ALSPAC, Oakfield House, Oakfield Grove, Bristol, BS8 2BN, UK

  • Main aim of cohort
    The main aim of the study is to identify features of the environment, genotypes and the interaction between the two that influence the health, development and well-being of children throughout the life course. Main exposures: Features of the diet, psychosocial influences including type of housing, as well as violence in the home, types of neighbourhood and linkage to features such as major roads and sources of pollution. Main outcomes: Growth including measures of weight, height, waist circumference, leg length etc; health particularly including atopic disorders such as asthma eczema and hay fever, gastrointestinal disturbance, febrile convulsions, cardiovascular markers, and so on. Most health outcome measures are in terms of traits although diagnosis also exist; behavioural and psychiatric disorders – including hyperactivity, conduct disorder, anxiety; neurocognitive outcomes including IQ, attention span, vision and hearing, speech and language.

    Recruited number of:
    14000 children / 14000 mothers / 20000 fathers / 0 grand parents / 1000 other family members

    Approximate proportion of source population included
    0

    Source population
    Region-based

  • Period of enrollment
    Start: 1990-01-01, End: 1992-00-00

    Enrollment period
    Pregnancy, week  to

    Enrollment criteria, please specify
    Pregnant woman resident in what was Avon, South West England (covered by the three local health authorities) with an expected data of delivery between April 1991 and Dec 1992.

    Planned age of children at end of follow-up
    Life-long / unrestricted
General information ---------- Child age (years) at assessment ----------
<1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
Home addressXXXXXXXXXXXXXXXXXXX
School address
Birth outcomes
Birth weightX
Birth lengthX
Gestational age at birthX
Apgar scoreX
Congenital malformationsX
Stillbirth (>= 22 weeks)X
Child’s sexX
Head circumferenceX
Biparietal diameter
Child exposures ---------- Child age (years) at assessment ----------
<1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
Breast feedingXX
DietXXXXXXXX
Dietary supplementsXXXX
Childcare attendanceXXXXXX
Active smokingXXXXXX
Passive smokingXXXXX
Alcohol consumptionXXXXX
Physical activityXXXX
Substance useXXXXX
Medicine intakeXXXXXXXXXXXXX
VaccinationsXXXX
Psychological distress (e.g. bullying)X
Air pollutionX
Access to green spaces
Built environment
Noise
Radiation, electromagnetic fields
Water contamination
Pets
Farm animal exposure
Biomarkers of exposure
MercuryX
LeadX
CadmiumX
ArsenicX
Other metalsX
Polychlorinated biphenyl estersX
Dicloro difenil tricloroetanoX
HexachlorobenzeneX
Brominated flame retardantsX
Perflouralkyl compoundsX
Bisphenol AX
Other bisphenolsX
ParabensX
BenzophenonesX
TriclosanX
PhthalatesX
Cotinine
Child development and health ---------- Child age (years) at assessment ----------
<1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
Anthropometry
WeightXXXXXXXX
HeightXXXX
Head circumferenceXXXXX
Abdominal circumference
Arm circumference
Wrist circumference
Waist circumferenceXX
Clinical examinations
Blood pressureXXXXXX
Carotida intima media thicknessXX
Pulse wave velocityX
Cardiac ultrasoundX
Renal ultrasound
Brain MRI
Other MRI
DEXA‐scan resultsXXXXX
Skin folds
Bio impedence
Oscilometry
SpirometryXXX
Skin prick testX
Bronchial challenge testX
Reversibility test
Dental observations
Mental and neurological development
Cognitive functionXXX
School performanceX
LanguageX
ADHD
Autism
Sleep disturbances
Mental healthXXXX
Respiratory health
AsthmaXXXXX
AllergyXXXX
Allergic rhinitisXXXX
EczemaXXXX
Respiratory tract infections
Senses
VisionXXX
HearingXXXXX
Musculo-skeletal health
Back pain
Neck pain
Growing pains
Sexual maturation
Tanner stageXXXXXXXX
Pubertal development stageXXXXXXXX
Age at menarcheXXXXXX
Age at voice changeXXXXXXXX
2D/4D digit ratioX
Nocturnal ejaculation
AcneXXXX
Other health outcomes
Cancer
Diabetes
Congenital anomaliesX
Biomarkers of health
Nephrology (e.g. creatinine, albumin)
Thyroid hormones
Inflammatory markers (e.g. C-reactive protein cytokines)
Immunologic markers (e.g. immunoglobulines)
Cortisol
Vitamines and micronutrients
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)X
MetabolomicsX
DNA methylationX
Transcriptomics (mRNA, miRNA)
Genome-wide association study (GWAS)X
Child biological samples ---------- Child age (years) at sampling ----------
At birth 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
Whole blood
Serum
Plasma
Buffy coat
Urine
Hair
TeethXXXX
Nails
Saliva
Purified DNA
Purified RNA
Red blood cells
Umbilical cord blood/tissueX
Blood smear
Faeces/meconium
Exhaled breathe condensate
Sputum induction
PlacentaX
General information
Pre-pregnancy During pregnancy <1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
EducationX
Income
Employment status
Job title
Single parenthood
Home address
Work address
Maternal characteristics related to the index pregnancy/child
Age at birthX
EthnicityX
Country of birth
Planned pregnancyX
Time to pregnancyX
Fertility treatmentX
Prior spontaneous abortion (<22w)X
Prior birthsX
Ultrasound measurements
Doppler measurements
PreeclampsiaX
Gestational diabetes
Gestational hypertension
Gestational durationX
Mode of deliveryX
Prenatal diagnosticsX
Medical termination of pregnancyX
Maternal Exposures ---------- Timing of assessment ----------
Pre-pregnancy First trimester Second trimester Third trimester Post pregnancy
DietXX
Dietary supplementsXXX
Active smokingXXXXX
Passive smokingXX
Alcohol consumptionXXXXX
Physical activityXXX
Substance useXXXXX
Medicine intakeXXX
Coffee drinkingXXXX
Psychological distress (e.g. life-events, health behaviors, perceived stress)
Occupational exposuresXX
Heavy liftsXXX
Work hours
Air pollution
Access to green spaces
Built environment
Noise
Radiation, electromagnetic fields
Water contamination
Binge drinkingXXXXX
Pets
Farm animal exposure
Biomarkers of exposure
Mercury
Lead
Cadmium
Arsenic
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds
Bisphenol A
Other bisphenols
Parabens
Benzophenones
Triclosan
Phthalates
Cotinine
Maternal health ---------- Timing of assessment ----------
Pre-pregnancy First trimester Second trimester Third trimester Post pregnancy
Anthropometry
WeightXX
HeightXX
Waist circumference
Clinical examinations
Blood pressureXXXXX
Carotida intima media thickness
Pulse wave velocity
DEXA scans
Bioimpedence
Mental and neurological development
Mental healthXXX
Cognitive function (e.g. intelligence quotient)
Respiratory health
Asthma
Allergy
Musculo‐skeletal diseaseXX
Back pain
Neck pain
Arthritis
Other health outcomes
CancerXX
DiabetesXX
Cardio‐vascular diseaseX
Family history of chronic disease
Infectious diseaseXX
FeverX
Autoimmune disease
Urinary symptoms
Sexual problems
Sleep disturbance
Biomarkers of health
Nephrology (e.g. creatinine, albumin)
Thyroid hormones
Inflammatory markers (e.g. C-reactive protein cytokines)
Immunologic markers (e.g. immunoglobulines)
Cortisol
Vitamines and micronutrients
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)
Metabolomics
DNA methylation
Transcriptomics (mRNA, miRNA)
Genome-wide association study (GWAS)
Maternal biological samples ---------- Timing of sampling ----------
Pre-pregnancy First trimester Second trimester Third trimester Post pregnancy
Breast milk
Whole blood
Serum
Plasma
Buffy coat
UrineXXX
Hair
Nails
Saliva
Purified DNA
Purified RNA
Red blood cells
Faeces
General information
Pre-pregnancy During pregnancy <1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
EducationX
Income
Employment status
Job title
Single parenthood
Home address
Work address
Paternal characteristics related to the index pregnancy/child
Fertility treatment
Age at child's birthX
EthnicityX
Country of birth
Paternal exposures ---------- Timing of assessment ----------
Pre-pregnancy During pregnancy Post pregnancy
DietXX
Dietary supplements
Active smokingXXX
Passive smokingXXX
Alcohol consumptionXXX
Physical activityX
Substance useXXX
Medicine intake
Coffee drinking
Psychological distress (e.g. life-events, health behaviors, perceived stress)X
Occupational exposuresXXX
Heavy lifts
Work hours
Air pollution
Access to green spaces
Built environment
Noise
Radiation, electromagnetic fields
Water contamination
Binge drinking
Pets
Farm animal exposure
Biomarkers of exposure
Mercury
Lead
Cadmium
Arsenic
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds
Bisphenol A
Other bisphenols
Parabens
Benzophenones
Triclosan
Phthalates
Cotinine
Paternal health ---------- Timing of assessment ----------
Pre-pregnancy During pregnancy Post pregnancy
Anthropometry
WeightXX
HeightXX
Waist circumference
Clinical examinations
Blood pressure
Carotida intima media thickness
Pulse wave velocity
DEXA scans
Bio impedence
Mental and neurological development
Mental health
Cognitive function (e.g. intelligence quotient)
Respiratory health
Asthma
Allergy
Musculo‐skeletal disease
Back pain
Neck pain
Arthritis
Other health outcomes
Cancer
Diabetes
Cardio‐vascular disease
Family history of chronic disease
Infectious disease
Fever
Autoimmune disease
Urinary symptoms
Sexual problems
Sleep disturbance
Biomarkers of health
Nephrology (e.g. creatinine, albumin)
Thyroid hormones
Inflammatory markers (e.g. C-reactive protein cytokines)
Immunologic markers (e.g. immunoglobulines)
Cortisol
Vitamines and micronutrients
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)
Metabolomics
DNA methylation
Transcriptomics (mRNA, miRNA)
Genome-wide association study (GWAS)
Paternal biological samples ---------- Timing of sampling ----------
Pre-pregnancy During pregnancy Post pregnancy
Semen
Whole blood
Serum
Plasma
Buffy coat
Urine
HairX
NailsX
Saliva
Purified DNA
Purified RNA
Red blood cells
Faeces
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