• Cohort, name
    PRegnancy and Infant DEvelopment Study

    Cohort, abbreviation
    PRIDE Study

    Cohort, country
    Netherlands (Nederland)

    Cohort, website
    http://www.pridestudy.nl

    Cohort, facebook-site
    http://www.facebook.com/pridestudynl

    Key reference
    Van Gelder MMHJ, Bretveld RW, Roukema J, Steenhoek M, van Drongelen J, Spaanderman MEA, van Rumpt D, Zielhuis GA, Verhaak CM, Roeleveld N. Rationale and design of the PRegnancy and Infant DEvelopment (PRIDE) Study. Paediatric and Perinatal Epidemiology 2013;27(1):34-43.

    Date of filling in this questionnaire:
    2017-01-30

  • Principal investigator(s), name
    Nel Roeleveld, PhD MSc

    Principal investigator(s), e-mail address
    Nel.Roeleveld@radboudumc.nl

    Principal investigator(s), institution
    Radboud university medical center, Nijmegen, The Netherlands

    Contact person(s), name
    Marleen M.H.J. van Gelder, PhD

    Contact person(s), e-mail address
    info@pridestudy.nl

    Contact person(s), institution address
    Radboud university medical center, Nijmegen, The Netherlands

  • Main aim of cohort
    The PRIDE Study (PRIDE: PRegnancy and Infant DEvelopment) is a large prospective cohort study that aims at including ≥100,000 pregnant women in early pregnancy to study a broad range of research questions pertaining to maternal and child health, preconception, prenatal, and perinatal care, and adverse developmental effects in offspring.

    Recruited number of:
    3200 children / 5300 mothers / 2100 fathers / 0 grand parents / 0 other family members

    Approximate proportion of source population included
    0

    Source population
    Nation-based

  • Period of enrollment
    Start: 2011-07-01, End: 2019-12-31

    Enrollment period
    Pregnancy, week 6 to 15

    Enrollment criteria, please specify
    First prenatal care visit at midwife, gynaecologist, or general practitioner Being able to read and write Dutch

    Exclusion criteria, please specify
    Maternal age < 18 years Gestational age > 16 weeks

    Planned age of children at end of follow-up
    21 years
General information ---------- Child age (years) at assessment ----------
<1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
Home addressX
School address
Birth outcomes
Birth weightX
Birth lengthX
Gestational age at birthX
Apgar scoreX
Congenital malformationsX
Stillbirth (>= 22 weeks)X
Child’s sexX
Head circumferenceX
Biparietal diameter
Child exposures ---------- Child age (years) at assessment ----------
<1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
Breast feedingX
DietXXXXXXX
Dietary supplementsXXXXXXX
Childcare attendanceX
Active smoking
Passive smokingXXXXXXX
Alcohol consumption
Physical activity
Substance use
Medicine intakeXXXXXXX
VaccinationsXXXXXXX
Psychological distress (e.g. bullying)
Air pollutionXXX
Access to green spacesXXX
Built environmentXXX
Noise
Radiation, electromagnetic fieldsXXX
Water contamination
PetsXXXXXX
Farm animal exposure
Biomarkers of exposure
Mercury
Lead
Cadmium
Arsenic
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds
Bisphenol A
Other bisphenols
Parabens
Benzophenones
Triclosan
Phthalates
Cotinine
Child development and health ---------- Child age (years) at assessment ----------
<1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
Anthropometry
WeightXXXXXXX
HeightXXXXXXX
Head circumferenceX
Abdominal circumference
Arm circumference
Wrist circumference
Waist circumference
Clinical examinations
Blood pressure
Carotida intima media thickness
Pulse wave velocity
Cardiac ultrasound
Renal ultrasound
Brain MRI
Other MRI
DEXA‐scan results
Skin folds
Bio impedence
Oscilometry
Spirometry
Skin prick test
Bronchial challenge test
Reversibility test
Dental observations
Mental and neurological development
Cognitive functionXXXXXXX
School performance
Language
ADHDXXXXXX
AutismXXXXXX
Sleep disturbancesXXXXXXX
Mental healthXXXXXX
Respiratory health
AsthmaXXXXXX
AllergyXXXXXXX
Allergic rhinitisXXXXXXX
EczemaXXXXXXX
Respiratory tract infectionsXXXXXXX
Senses
VisionXX
HearingXX
Musculo-skeletal health
Back pain
Neck pain
Growing pains
Sexual maturation
Tanner stage
Pubertal development stage
Age at menarche
Age at voice change
2D/4D digit ratio
Nocturnal ejaculation
Acne
Other health outcomes
CancerXXXXXXX
DiabetesXXXXXXX
Congenital anomaliesX
Biomarkers of health
Nephrology (e.g. creatinine, albumin)
Thyroid hormones
Inflammatory markers (e.g. C-reactive protein cytokines)
Immunologic markers (e.g. immunoglobulines)
Cortisol
Vitamines and micronutrients
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)
Metabolomics
DNA methylation
Transcriptomics (mRNA, miRNA)
Genome-wide association study (GWAS)
Child biological samples ---------- Child age (years) at sampling ----------
At birth 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
Whole blood
Serum
Plasma
Buffy coat
Urine
Hair
Teeth
Nails
Saliva
Purified DNA
Purified RNA
Red blood cells
Umbilical cord blood/tissue
Blood smear
Faeces/meconium
Exhaled breathe condensate
Sputum induction
Placenta
General information
Pre-pregnancy During pregnancy <1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
EducationX
IncomeX
Employment statusXXX
Job titleXXX
Single parenthoodX
Home addressXXXXXXXX
Work address
Maternal characteristics related to the index pregnancy/child
Age at birthX
EthnicityX
Country of birthX
Planned pregnancyX
Time to pregnancyX
Fertility treatmentX
Prior spontaneous abortion (<22w)X
Prior birthsX
Ultrasound measurementsX
Doppler measurements
PreeclampsiaX
Gestational diabetesX
Gestational hypertensionX
Gestational durationX
Mode of deliveryX
Prenatal diagnosticsX
Medical termination of pregnancyX
Maternal Exposures ---------- Timing of assessment ----------
Pre-pregnancy First trimester Second trimester Third trimester Post pregnancy
DietX
Dietary supplementsXXXX
Active smokingXXXX
Passive smokingXXXX
Alcohol consumptionXXXX
Physical activityXXX
Substance useXXXX
Medicine intakeXXXX
Coffee drinkingXXX
Psychological distress (e.g. life-events, health behaviors, perceived stress)XXXX
Occupational exposuresXXXX
Heavy liftsX
Work hoursXXXX
Air pollutionXXXX
Access to green spacesXXXX
Built environmentXXXX
Noise
Radiation, electromagnetic fieldsXXXX
Water contamination
Binge drinkingXXXX
PetsXX
Farm animal exposure
Biomarkers of exposure
Mercury
Lead
Cadmium
Arsenic
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds
Bisphenol A
Other bisphenols
Parabens
Benzophenones
Triclosan
Phthalates
Cotinine
Maternal health ---------- Timing of assessment ----------
Pre-pregnancy First trimester Second trimester Third trimester Post pregnancy
Anthropometry
WeightXXXX
HeightX
Waist circumference
Clinical examinations
Blood pressureXXX
Carotida intima media thickness
Pulse wave velocity
DEXA scans
Bioimpedence
Mental and neurological development
Mental healthXXXX
Cognitive function (e.g. intelligence quotient)
Respiratory health
AsthmaXXXXX
AllergyXXXXX
Musculo‐skeletal disease
Back painXXXX
Neck painXXXX
ArthritisXXXX
Other health outcomes
CancerXXXX
DiabetesXXXX
Cardio‐vascular diseaseXXXX
Family history of chronic diseaseX
Infectious diseaseXXX
FeverXXX
Autoimmune diseaseXXXX
Urinary symptomsXXX
Sexual problems
Sleep disturbanceXXXX
Biomarkers of health
Nephrology (e.g. creatinine, albumin)
Thyroid hormones
Inflammatory markers (e.g. C-reactive protein cytokines)
Immunologic markers (e.g. immunoglobulines)
CortisolX
Vitamines and micronutrients
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)
Metabolomics
DNA methylation
Transcriptomics (mRNA, miRNA)
Genome-wide association study (GWAS)
Maternal biological samples ---------- Timing of sampling ----------
Pre-pregnancy First trimester Second trimester Third trimester Post pregnancy
Breast milk
Whole bloodX
SerumX
PlasmaX
Buffy coat
Urine
Hair
Nails
SalivaX
Purified DNAX
Purified RNA
Red blood cells
FaecesXXX
General information
Pre-pregnancy During pregnancy <1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
EducationXX
IncomeX
Employment statusX
Job titleX
Single parenthood
Home address
Work address
Paternal characteristics related to the index pregnancy/child
Fertility treatment
Age at child's birthX
EthnicityX
Country of birthX
Paternal exposures ---------- Timing of assessment ----------
Pre-pregnancy During pregnancy Post pregnancy
Diet
Dietary supplements
Active smokingXX
Passive smokingXX
Alcohol consumptionXX
Physical activityXX
Substance useXX
Medicine intakeXX
Coffee drinkingXX
Psychological distress (e.g. life-events, health behaviors, perceived stress)
Occupational exposuresXX
Heavy lifts
Work hoursXX
Air pollution
Access to green spaces
Built environment
Noise
Radiation, electromagnetic fields
Water contamination
Binge drinkingXX
Pets
Farm animal exposure
Biomarkers of exposure
Mercury
Lead
Cadmium
Arsenic
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds
Bisphenol A
Other bisphenols
Parabens
Benzophenones
Triclosan
Phthalates
Cotinine
Paternal health ---------- Timing of assessment ----------
Pre-pregnancy During pregnancy Post pregnancy
Anthropometry
WeightXX
HeightXX
Waist circumference
Clinical examinations
Blood pressure
Carotida intima media thickness
Pulse wave velocity
DEXA scans
Bio impedence
Mental and neurological development
Mental health
Cognitive function (e.g. intelligence quotient)
Respiratory health
AsthmaXX
AllergyXX
Musculo‐skeletal disease
Back pain
Neck pain
Arthritis
Other health outcomes
CancerXX
DiabetesXX
Cardio‐vascular diseaseXX
Family history of chronic disease
Infectious diseaseX
FeverX
Autoimmune diseaseXX
Urinary symptoms
Sexual problems
Sleep disturbance
Biomarkers of health
Nephrology (e.g. creatinine, albumin)
Thyroid hormones
Inflammatory markers (e.g. C-reactive protein cytokines)
Immunologic markers (e.g. immunoglobulines)
Cortisol
Vitamines and micronutrients
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)
Metabolomics
DNA methylation
Transcriptomics (mRNA, miRNA)
Genome-wide association study (GWAS)
Paternal biological samples ---------- Timing of sampling ----------
Pre-pregnancy During pregnancy Post pregnancy
Semen
Whole blood
Serum
Plasma
Buffy coat
Urine
Hair
Nails
Saliva
Purified DNA
Purified RNA
Red blood cells
Faeces
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