- Cohort, name
Tasmanian Infant Health Survey
Cohort, abbreviation
TIHS
Cohort, country
Australia
Cohort, website
http://www.mcri.edu.au/projects/I4C/default.asp
Key reference
Lancet. 1991 May 25;337(8752):1244-7
Date of filling in this questionnaire:
2021-12-23 - Principal investigator(s), name
Terry Dwyer, Anne-Louise Ponsonby
Principal investigator(s), e-mail address
terry.dwyer@mcri.edu.au, annelouise.ponsonby@flore
Principal investigator(s), institution
Murdoch Childrens Research Institute, the Florey Institute
Contact person(s), name
Anne-Louise Ponsonby
Contact person(s), e-mail address
annelouise.ponsonby@florey.edu.au
- Main aim of cohort
The Tasmanian Infant Health Prospective cohort (TIHS) was created to investigate the cause of Sudden Infant Death Syndrome (SIDS) in Tasmania, Australia. Main pre-natal factors assessed retrospectively were maternal food frequency in third trimester, maternal supplementation including folate, smoking and alcohol intake and prenatal care. Infant factors/exposures anthropometry, gestation, airborne allergens-(aerosols-including hairspray, insecticides and cleaning/laundry sprays, humidity, interior mould, humidity, ventilation, heating, cooking facilities and max-min temperatures, post natal parental smoking, infant and family illnesses, baby-care, residential density, indoor pets, type infant feeding, infant sleeping patterns, clothing, bedding and time spent outdoors, immunization, SES factors, early development and neurological factors assessed at 5 weeks. Immunization, illness history and use of health services recorded in telephone interview conducted after 10weeks. Primary outcome: SIDS mortality, Secondary outcomes Atopy-Asthma (aged 7-8 and 16) hayfever, eczema, IgE food allergy and positive responses for other skin-tests aged 7-8 and RASTs aged 16. Respiratory problems such as cyanosis in infancy, bone density age 7 and 16, adiposity, cancer, diabetes, also blood pressure, fitness and physical activity at ages 7-8 and 16.
Recruited number of:
10569 children / 8729 mothers / 8729 fathers / 0 grand parents / 0 other family members
Approximate proportion of source population included
0
Source population
Other, please describe - Period of enrollment
Start: 1988-01-01, End: 1995-01-01
Enrollment period
Pre pregnancy to
Enrollment criteria, please specify
Infants at higher risk of SIDS according to a perinatal SIDS risk factor scoring system.
Exclusion criteria, please specify
Children with major congenital anomalies or serious disease.
Planned age of children at end of follow-up
General information | ---------- Child age (years) at assessment ---------- | |||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
<1 | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | >18 | |
Home address | ||||||||||||||||||||
School address |
Birth outcomes | |
---|---|
Birth weight | X |
Birth length | X |
Gestational age at birth | X |
Apgar score | X |
Congenital malformations | X |
Stillbirth (>= 22 weeks) | |
Child’s sex | X |
Head circumference | X |
Biparietal diameter | X |
Child exposures | ---------- Child age (years) at assessment ---------- | |||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
<1 | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | >18 | |
Breast feeding | X | |||||||||||||||||||
Diet | X | |||||||||||||||||||
Dietary supplements | X | |||||||||||||||||||
Childcare attendance | X | |||||||||||||||||||
Active smoking | ||||||||||||||||||||
Passive smoking | X | |||||||||||||||||||
Alcohol consumption | ||||||||||||||||||||
Physical activity | X | |||||||||||||||||||
Substance use | ||||||||||||||||||||
Medicine intake | X | |||||||||||||||||||
Vaccinations | X | |||||||||||||||||||
Psychological distress (e.g. bullying) | ||||||||||||||||||||
Air pollution | X | |||||||||||||||||||
Access to green spaces | X | |||||||||||||||||||
Built environment | X | |||||||||||||||||||
Noise | X | |||||||||||||||||||
Radiation, electromagnetic fields | X | |||||||||||||||||||
Water contamination | X | |||||||||||||||||||
Pets | X | |||||||||||||||||||
Farm animal exposure | X | |||||||||||||||||||
Biomarkers of exposure | ||||||||||||||||||||
Mercury | ||||||||||||||||||||
Lead | ||||||||||||||||||||
Cadmium | ||||||||||||||||||||
Arsenic | ||||||||||||||||||||
Other metals | ||||||||||||||||||||
Polychlorinated biphenyl esters | ||||||||||||||||||||
Dicloro difenil tricloroetano | ||||||||||||||||||||
Hexachlorobenzene | ||||||||||||||||||||
Brominated flame retardants | ||||||||||||||||||||
Perflouralkyl compounds | ||||||||||||||||||||
Bisphenol A | ||||||||||||||||||||
Other bisphenols | ||||||||||||||||||||
Parabens | ||||||||||||||||||||
Benzophenones | ||||||||||||||||||||
Triclosan | ||||||||||||||||||||
Phthalates | ||||||||||||||||||||
Cotinine | X |
Child development and health | ---------- Child age (years) at assessment ---------- | |||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
<1 | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | >18 | |
Anthropometry | ||||||||||||||||||||
Weight | X | X | ||||||||||||||||||
Height | X | X | ||||||||||||||||||
Head circumference | X | X | ||||||||||||||||||
Abdominal circumference | X | X | ||||||||||||||||||
Arm circumference | X | X | ||||||||||||||||||
Wrist circumference | X | |||||||||||||||||||
Waist circumference | X | X | ||||||||||||||||||
Clinical examinations | ||||||||||||||||||||
Blood pressure | X | |||||||||||||||||||
Carotida intima media thickness | ||||||||||||||||||||
Pulse wave velocity | X | |||||||||||||||||||
Cardiac ultrasound | ||||||||||||||||||||
Renal ultrasound | ||||||||||||||||||||
Brain MRI | ||||||||||||||||||||
Other MRI | ||||||||||||||||||||
DEXA‐scan results | X | |||||||||||||||||||
Skin folds | X | |||||||||||||||||||
Bio impedence | ||||||||||||||||||||
Oscilometry | ||||||||||||||||||||
Spirometry | X | |||||||||||||||||||
Skin prick test | X | |||||||||||||||||||
Bronchial challenge test | ||||||||||||||||||||
Reversibility test | ||||||||||||||||||||
Dental observations | ||||||||||||||||||||
Mental and neurological development | ||||||||||||||||||||
Cognitive function | ||||||||||||||||||||
School performance | ||||||||||||||||||||
Language | ||||||||||||||||||||
ADHD | X | |||||||||||||||||||
Autism | X | |||||||||||||||||||
Sleep disturbances | ||||||||||||||||||||
Mental health | ||||||||||||||||||||
Respiratory health | ||||||||||||||||||||
Asthma | X | |||||||||||||||||||
Allergy | X | |||||||||||||||||||
Allergic rhinitis | X | |||||||||||||||||||
Eczema | X | |||||||||||||||||||
Respiratory tract infections | X | |||||||||||||||||||
Senses | ||||||||||||||||||||
Vision | ||||||||||||||||||||
Hearing | ||||||||||||||||||||
Musculo-skeletal health | ||||||||||||||||||||
Back pain | ||||||||||||||||||||
Neck pain | ||||||||||||||||||||
Growing pains | ||||||||||||||||||||
Sexual maturation | ||||||||||||||||||||
Tanner stage | ||||||||||||||||||||
Pubertal development stage | ||||||||||||||||||||
Age at menarche | ||||||||||||||||||||
Age at voice change | ||||||||||||||||||||
2D/4D digit ratio | ||||||||||||||||||||
Nocturnal ejaculation | ||||||||||||||||||||
Acne | ||||||||||||||||||||
Other health outcomes | ||||||||||||||||||||
Cancer | X | |||||||||||||||||||
Diabetes | ||||||||||||||||||||
Congenital anomalies | ||||||||||||||||||||
Biomarkers of health | ||||||||||||||||||||
Nephrology (e.g. creatinine, albumin) | ||||||||||||||||||||
Thyroid hormones | ||||||||||||||||||||
Inflammatory markers (e.g. C-reactive protein cytokines) | ||||||||||||||||||||
Immunologic markers (e.g. immunoglobulines) | ||||||||||||||||||||
Cortisol | ||||||||||||||||||||
Vitamines and micronutrients | ||||||||||||||||||||
Gonadal axis hormones (e.g. testosterone, estradiol) | ||||||||||||||||||||
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides) | ||||||||||||||||||||
Metabolomics | ||||||||||||||||||||
DNA methylation | ||||||||||||||||||||
Transcriptomics (mRNA, miRNA) | ||||||||||||||||||||
Genome-wide association study (GWAS) |
Child biological samples | ---------- Child age (years) at sampling ---------- | ||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
At birth | 0 | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | >18 | |
Whole blood | |||||||||||||||||||||
Serum | |||||||||||||||||||||
Plasma | |||||||||||||||||||||
Buffy coat | |||||||||||||||||||||
Urine | |||||||||||||||||||||
Hair | |||||||||||||||||||||
Teeth | |||||||||||||||||||||
Nails | |||||||||||||||||||||
Saliva | |||||||||||||||||||||
Purified DNA | |||||||||||||||||||||
Purified RNA | |||||||||||||||||||||
Red blood cells | |||||||||||||||||||||
Umbilical cord blood/tissue | |||||||||||||||||||||
Blood smear | |||||||||||||||||||||
Faeces/meconium | |||||||||||||||||||||
Exhaled breathe condensate | |||||||||||||||||||||
Sputum induction | |||||||||||||||||||||
Placenta |
General information | |||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Pre-pregnancy | During pregnancy | <1 | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | |
Education | |||||||||||||||||||||
Income | |||||||||||||||||||||
Employment status | |||||||||||||||||||||
Job title | |||||||||||||||||||||
Single parenthood | |||||||||||||||||||||
Home address | |||||||||||||||||||||
Work address |
Maternal characteristics related to the index pregnancy/child | |
---|---|
Age at birth | |
Ethnicity | |
Country of birth | |
Planned pregnancy | |
Time to pregnancy | |
Fertility treatment | |
Prior spontaneous abortion (<22w) | |
Prior births | |
Ultrasound measurements | |
Doppler measurements | |
Preeclampsia | |
Gestational diabetes | |
Gestational hypertension | |
Gestational duration | |
Mode of delivery | |
Prenatal diagnostics | |
Medical termination of pregnancy |
Maternal Exposures | ---------- Timing of assessment ---------- | ||||
---|---|---|---|---|---|
Pre-pregnancy | First trimester | Second trimester | Third trimester | Post pregnancy | |
Diet | |||||
Dietary supplements | |||||
Active smoking | |||||
Passive smoking | |||||
Alcohol consumption | |||||
Physical activity | |||||
Substance use | |||||
Medicine intake | |||||
Coffee drinking | |||||
Psychological distress (e.g. life-events, health behaviors, perceived stress) | |||||
Occupational exposures | |||||
Heavy lifts | |||||
Work hours | |||||
Air pollution | |||||
Access to green spaces | |||||
Built environment | |||||
Noise | |||||
Radiation, electromagnetic fields | |||||
Water contamination | |||||
Binge drinking | |||||
Pets | |||||
Farm animal exposure | |||||
Biomarkers of exposure | |||||
Mercury | |||||
Lead | |||||
Cadmium | |||||
Arsenic | |||||
Other metals | |||||
Polychlorinated biphenyl esters | |||||
Dicloro difenil tricloroetano | |||||
Hexachlorobenzene | |||||
Brominated flame retardants | |||||
Perflouralkyl compounds | |||||
Bisphenol A | |||||
Other bisphenols | |||||
Parabens | |||||
Benzophenones | |||||
Triclosan | |||||
Phthalates | |||||
Cotinine |
Maternal health | ---------- Timing of assessment ---------- | ||||
---|---|---|---|---|---|
Pre-pregnancy | First trimester | Second trimester | Third trimester | Post pregnancy | |
Anthropometry | |||||
Weight | |||||
Height | |||||
Waist circumference | |||||
Clinical examinations | |||||
Blood pressure | |||||
Carotida intima media thickness | |||||
Pulse wave velocity | |||||
DEXA scans | |||||
Bioimpedence | |||||
Mental and neurological development | |||||
Mental health | |||||
Cognitive function (e.g. intelligence quotient) | |||||
Respiratory health | |||||
Asthma | |||||
Allergy | |||||
Musculo‐skeletal disease | |||||
Back pain | |||||
Neck pain | |||||
Arthritis | |||||
Other health outcomes | |||||
Cancer | |||||
Diabetes | |||||
Cardio‐vascular disease | |||||
Family history of chronic disease | |||||
Infectious disease | |||||
Fever | |||||
Autoimmune disease | |||||
Urinary symptoms | |||||
Sexual problems | |||||
Sleep disturbance | |||||
Biomarkers of health | |||||
Nephrology (e.g. creatinine, albumin) | |||||
Thyroid hormones | |||||
Inflammatory markers (e.g. C-reactive protein cytokines) | |||||
Immunologic markers (e.g. immunoglobulines) | |||||
Cortisol | |||||
Vitamines and micronutrients | |||||
Gonadal axis hormones (e.g. testosterone, estradiol) | |||||
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides) | |||||
Metabolomics | |||||
DNA methylation | |||||
Transcriptomics (mRNA, miRNA) | |||||
Genome-wide association study (GWAS) |
Maternal biological samples | ---------- Timing of sampling ---------- | ||||
---|---|---|---|---|---|
Pre-pregnancy | First trimester | Second trimester | Third trimester | Post pregnancy | |
Breast milk | |||||
Whole blood | |||||
Serum | |||||
Plasma | |||||
Buffy coat | |||||
Urine | |||||
Hair | |||||
Nails | |||||
Saliva | |||||
Purified DNA | |||||
Purified RNA | |||||
Red blood cells | |||||
Faeces |
General information | |||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Pre-pregnancy | During pregnancy | <1 | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | |
Education | |||||||||||||||||||||
Income | |||||||||||||||||||||
Employment status | |||||||||||||||||||||
Job title | |||||||||||||||||||||
Single parenthood | |||||||||||||||||||||
Home address | |||||||||||||||||||||
Work address |
Paternal characteristics related to the index pregnancy/child | |
---|---|
Fertility treatment | |
Age at child's birth | |
Ethnicity | |
Country of birth |
Paternal exposures | ---------- Timing of assessment ---------- | ||
---|---|---|---|
Pre-pregnancy | During pregnancy | Post pregnancy | |
Diet | |||
Dietary supplements | |||
Active smoking | |||
Passive smoking | |||
Alcohol consumption | |||
Physical activity | |||
Substance use | |||
Medicine intake | |||
Coffee drinking | |||
Psychological distress (e.g. life-events, health behaviors, perceived stress) | |||
Occupational exposures | |||
Heavy lifts | |||
Work hours | |||
Air pollution | |||
Access to green spaces | |||
Built environment | |||
Noise | |||
Radiation, electromagnetic fields | |||
Water contamination | |||
Binge drinking | |||
Pets | |||
Farm animal exposure | |||
Biomarkers of exposure | |||
Mercury | |||
Lead | |||
Cadmium | |||
Arsenic | |||
Other metals | |||
Polychlorinated biphenyl esters | |||
Dicloro difenil tricloroetano | |||
Hexachlorobenzene | |||
Brominated flame retardants | |||
Perflouralkyl compounds | |||
Bisphenol A | |||
Other bisphenols | |||
Parabens | |||
Benzophenones | |||
Triclosan | |||
Phthalates | |||
Cotinine |
Paternal health | ---------- Timing of assessment ---------- | ||
---|---|---|---|
Pre-pregnancy | During pregnancy | Post pregnancy | |
Anthropometry | |||
Weight | |||
Height | |||
Waist circumference | |||
Clinical examinations | |||
Blood pressure | |||
Carotida intima media thickness | |||
Pulse wave velocity | |||
DEXA scans | |||
Bio impedence | |||
Mental and neurological development | |||
Mental health | |||
Cognitive function (e.g. intelligence quotient) | |||
Respiratory health | |||
Asthma | |||
Allergy | |||
Musculo‐skeletal disease | |||
Back pain | |||
Neck pain | |||
Arthritis | |||
Other health outcomes | |||
Cancer | |||
Diabetes | |||
Cardio‐vascular disease | |||
Family history of chronic disease | |||
Infectious disease | |||
Fever | |||
Autoimmune disease | |||
Urinary symptoms | |||
Sexual problems | |||
Sleep disturbance | |||
Biomarkers of health | |||
Nephrology (e.g. creatinine, albumin) | |||
Thyroid hormones | |||
Inflammatory markers (e.g. C-reactive protein cytokines) | |||
Immunologic markers (e.g. immunoglobulines) | |||
Cortisol | |||
Vitamines and micronutrients | |||
Gonadal axis hormones (e.g. testosterone, estradiol) | |||
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides) | |||
Metabolomics | |||
DNA methylation | |||
Transcriptomics (mRNA, miRNA) | |||
Genome-wide association study (GWAS) |
Paternal biological samples | ---------- Timing of sampling ---------- | ||
---|---|---|---|
Pre-pregnancy | During pregnancy | Post pregnancy | |
Semen | |||
Whole blood | |||
Serum | |||
Plasma | |||
Buffy coat | |||
Urine | |||
Hair | |||
Nails | |||
Saliva | |||
Purified DNA | |||
Purified RNA | |||
Red blood cells | |||
Faeces |
Comments and ideas
Papers using data from the Tasmanian Infant Health Survey are listed below, grouped by child development/health outcome: Asthma/allergic disease: • Couper D, Ponsonby AL, Dwyer T. Determinants of dust mite allergen concentrations in infant bedrooms in Tasmania. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. Jun 1998;28(6):715-23. • Ponsonby AL, Couper D, Dwyer T, Carmichael A, Kemp A. Relationship between early life respiratory illness, family size over time, and the development of asthma and hay fever: a seven year follow up study. Thorax. Aug 1999;54(8):664-9. • Ponsonby AL, Couper D, Dwyer T, Carmichael A, Kemp A, Cochrane J. The relation between infant indoor environment and subsequent asthma. Epidemiology (Cambridge, Mass). Mar 2000;11(2):128-35. • Ponsonby AL, Dwyer T, Kemp A, Couper D, Cochrane J, Carmichael A. A prospective study of the association between home gas appliance use during infancy and subsequent dust mite sensitization and lung function in childhood. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. Oct 2001;31(10):1544-52. • Ponsonby AL, Kemp A, Dwyer T, Carmichael A, Couper D, Cochrane J. Feather bedding and house dust mite sensitization and airway disease in childhood. Journal of clinical epidemiology. Jun 2002;55(6):556-62. • Trevillian LF, Ponsonby AL, Dwyer T, et al. An association between plastic mattress covers and sheepskin underbedding use in infancy and house dust mite sensitization in childhood: a prospective study. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. Apr 2003;33(4):483-9. • Trevillian LF, Ponsonby AL, Dwyer T, et al. A prospective association between cocoon use in infancy and childhood asthma. Paediatric and perinatal epidemiology. Jul 2004;18(4):281-9. • Andreasyan K, Ponsonby AL, Dwyer T, Dear K, Cochrane J. Infant feeding and childhood atopy: does early introduction of non-milk fluids matter? Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology. May 2007;18(3):250-7. SIDS: • Dwyer T, Ponsonby AL, Couper D. Tobacco smoke exposure at one month of age and subsequent risk of SIDS--a prospective study. American journal of epidemiology. Apr 1 1999;149(7):593-602. Birth anthropometry: • Andreasyan K, Ponsonby AL, Dwyer T, et al. Higher maternal dietary protein intake in late pregnancy is associated with a lower infant ponderal index at birth. European journal of clinical nutrition. Apr 2007;61(4):498-508. • Ellis JA, Ponsonby AL, Pezic A, et al. APOE genotype and cardio-respiratory fitness interact to determine adiposity in 8-year-old children from the Tasmanian Infant Health Survey. PloS one. 2011;6(11):e26679. • Tikellis G, Ponsonby AL, Wells JC, Pezic A, Cochrane J, Dwyer T. Maternal and infant factors associated with neonatal adiposity: results from the Tasmanian Infant Health Survey (TIHS). International journal of obesity (2005). Apr 2012;36(4):496-504. d Cancer: • Paltiel O, Tikellis G, Linet M, et al. Birthweight and Childhood Cancer: Preliminary Findings from the International Childhood Cancer Cohort Consortium (I4C). Paediatric and perinatal epidemiology. Jul 2015;29(4):335-45.
Papers using data from the Tasmanian Infant Health Survey are listed below, grouped by child development/health outcome: Asthma/allergic disease: • Couper D, Ponsonby AL, Dwyer T. Determinants of dust mite allergen concentrations in infant bedrooms in Tasmania. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. Jun 1998;28(6):715-23. • Ponsonby AL, Couper D, Dwyer T, Carmichael A, Kemp A. Relationship between early life respiratory illness, family size over time, and the development of asthma and hay fever: a seven year follow up study. Thorax. Aug 1999;54(8):664-9. • Ponsonby AL, Couper D, Dwyer T, Carmichael A, Kemp A, Cochrane J. The relation between infant indoor environment and subsequent asthma. Epidemiology (Cambridge, Mass). Mar 2000;11(2):128-35. • Ponsonby AL, Dwyer T, Kemp A, Couper D, Cochrane J, Carmichael A. A prospective study of the association between home gas appliance use during infancy and subsequent dust mite sensitization and lung function in childhood. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. Oct 2001;31(10):1544-52. • Ponsonby AL, Kemp A, Dwyer T, Carmichael A, Couper D, Cochrane J. Feather bedding and house dust mite sensitization and airway disease in childhood. Journal of clinical epidemiology. Jun 2002;55(6):556-62. • Trevillian LF, Ponsonby AL, Dwyer T, et al. An association between plastic mattress covers and sheepskin underbedding use in infancy and house dust mite sensitization in childhood: a prospective study. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. Apr 2003;33(4):483-9. • Trevillian LF, Ponsonby AL, Dwyer T, et al. A prospective association between cocoon use in infancy and childhood asthma. Paediatric and perinatal epidemiology. Jul 2004;18(4):281-9. • Andreasyan K, Ponsonby AL, Dwyer T, Dear K, Cochrane J. Infant feeding and childhood atopy: does early introduction of non-milk fluids matter? Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology. May 2007;18(3):250-7. SIDS: • Dwyer T, Ponsonby AL, Couper D. Tobacco smoke exposure at one month of age and subsequent risk of SIDS--a prospective study. American journal of epidemiology. Apr 1 1999;149(7):593-602. Birth anthropometry: • Andreasyan K, Ponsonby AL, Dwyer T, et al. Higher maternal dietary protein intake in late pregnancy is associated with a lower infant ponderal index at birth. European journal of clinical nutrition. Apr 2007;61(4):498-508. • Ellis JA, Ponsonby AL, Pezic A, et al. APOE genotype and cardio-respiratory fitness interact to determine adiposity in 8-year-old children from the Tasmanian Infant Health Survey. PloS one. 2011;6(11):e26679. • Tikellis G, Ponsonby AL, Wells JC, Pezic A, Cochrane J, Dwyer T. Maternal and infant factors associated with neonatal adiposity: results from the Tasmanian Infant Health Survey (TIHS). International journal of obesity (2005). Apr 2012;36(4):496-504. d Cancer: • Paltiel O, Tikellis G, Linet M, et al. Birthweight and Childhood Cancer: Preliminary Findings from the International Childhood Cancer Cohort Consortium (I4C). Paediatric and perinatal epidemiology. Jul 2015;29(4):335-45.