• Cohort, name
    Nascita e INFanzia: gli Effetti dell’Ambiente

    Cohort, abbreviation
    NINFEA

    Cohort, country
    Italy (Italia)

    Cohort, website
    http://www.progettoninfea.it

    Cohort, facebook-site
    http://it-it.facebook.com/pages/Progetto-NINFEA/210478081656?sk=wall

    Key reference
    Richiardi L, Baussano I, Vizzini L, Douwes J, Pearce N, Merletti F; NINFEA cohort. Feasibility of recruiting a birth cohort through the Internet: the experience of the NINFEA cohort. Eur J Epidemiol. 2007;22(12):831-7.

    Date of filling in this questionnaire:
    0000-00-00

  • Principal investigator(s), name
    Lorenzo Richiardi

    Principal investigator(s), e-mail address
    lorenzo.richiardi@unito.it

    Principal investigator(s), institution
    Cancer Epidemioloy Unit, University of Turin. Via Santena 7, 10126. Turin

    Contact person(s), name
    Lorenzo Richiardi

    Contact person(s), e-mail address
    lorenzo.richiardi@unito.it

    Contact person(s), institution address
    Cancer Epidemioloy Unit, University of Turin. Via Santena 7, 10126. Turin

  • Main aim of cohort
    NINFEA is an internet-based multi-purpose mother-child cohort set up to investigate the effects of exposures acting during pre-natal and early post-natal life on infant, child and adult health.

    Recruited number of:
    6832 children / 6798 mothers / 0 fathers / 0 grand parents / 0 other family members

    Approximate proportion of source population included
    0

    Source population
    Nation-based

  • Period of enrollment
    Start: 2005-06-30, End: 2016-06-30

    Enrollment period
    Pregnancy, week 1 to end of pregnancy

    Enrollment criteria, please specify
    Members of the cohort are children born to women who have access to the internet, have enough knowledge of the Italian language to complete the online questionnaires, become aware of the study and volunteer to participate.

    Planned age of children at end of follow-up
    18 yearsLife-long / unrestricted
General information ---------- Child age (years) at assessment ----------
<1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
Home addressXXXXX
School address
Birth outcomes
Birth weightX
Birth lengthX
Gestational age at birthX
Apgar scoreX
Congenital malformationsX
Stillbirth (>= 22 weeks)X
Child’s sexX
Head circumference
Biparietal diameter
Child exposures ---------- Child age (years) at assessment ----------
<1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
Breast feedingXX
DietXX
Dietary supplements
Childcare attendanceXX
Active smoking
Passive smokingXXXX
Alcohol consumption
Physical activityX
Substance use
Medicine intakeXX
VaccinationsXXX
Psychological distress (e.g. bullying)
Air pollutionXXXXX
Access to green spacesXXXXX
Built environment
NoiseXX
Radiation, electromagnetic fields
Water contamination
PetsXX
Farm animal exposure
Biomarkers of exposure
Mercury
Lead
Cadmium
Arsenic
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds
Bisphenol A
Other bisphenols
Parabens
Benzophenones
Triclosan
Phthalates
Cotinine
Child development and health ---------- Child age (years) at assessment ----------
<1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
Anthropometry
WeightXXXXX
HeightXXXXX
Head circumferenceXX
Abdominal circumference
Arm circumference
Wrist circumference
Waist circumference
Clinical examinations
Blood pressure
Carotida intima media thickness
Pulse wave velocity
Cardiac ultrasound
Renal ultrasound
Brain MRI
Other MRI
DEXA‐scan results
Skin folds
Bio impedence
Oscilometry
Spirometry
Skin prick test
Bronchial challenge test
Reversibility test
Dental observations
Mental and neurological development
Cognitive function
School performanceXX
Language
ADHDXX
Autism
Sleep disturbancesXX
Mental health
Respiratory health
AsthmaXXXX
Allergy
Allergic rhinitisXXXX
EczemaXX
Respiratory tract infectionsXX
Senses
Vision
Hearing
Musculo-skeletal health
Back pain
Neck pain
Growing pains
Sexual maturation
Tanner stage
Pubertal development stage
Age at menarcheX
Age at voice changeX
2D/4D digit ratio
Nocturnal ejaculation
Acne
Other health outcomes
Cancer
DiabetesX
Congenital anomaliesX
Biomarkers of health
Nephrology (e.g. creatinine, albumin)
Thyroid hormones
Inflammatory markers (e.g. C-reactive protein cytokines)
Immunologic markers (e.g. immunoglobulines)
Cortisol
Vitamines and micronutrients
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)
Metabolomics
DNA methylationX
Transcriptomics (mRNA, miRNA)
Genome-wide association study (GWAS)
Child biological samples ---------- Child age (years) at sampling ----------
At birth 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
Whole blood
Serum
Plasma
Buffy coat
Urine
Hair
Teeth
Nails
SalivaX
Purified DNA
Purified RNA
Red blood cells
Umbilical cord blood/tissue
Blood smear
Faeces/meconium
Exhaled breathe condensate
Sputum induction
Placenta
General information
Pre-pregnancy During pregnancy <1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
EducationX
Income
Employment statusXXXXX
Job titleXXXX
Single parenthood
Home addressXXXXXX
Work address
Maternal characteristics related to the index pregnancy/child
Age at birthX
Ethnicity
Country of birthX
Planned pregnancyX
Time to pregnancyX
Fertility treatmentX
Prior spontaneous abortion (<22w)
Prior birthsX
Ultrasound measurements
Doppler measurements
PreeclampsiaX
Gestational diabetesX
Gestational hypertensionX
Gestational durationX
Mode of deliveryX
Prenatal diagnosticsX
Medical termination of pregnancy
Maternal Exposures ---------- Timing of assessment ----------
Pre-pregnancy First trimester Second trimester Third trimester Post pregnancy
DietX
Dietary supplementsXXX
Active smokingXXXXX
Passive smokingXX
Alcohol consumptionXXX
Physical activityXX
Substance useXX
Medicine intakeXXX
Coffee drinkingX
Psychological distress (e.g. life-events, health behaviors, perceived stress)
Occupational exposuresXXX
Heavy lifts
Work hoursX
Air pollutionXXX
Access to green spacesXXX
Built environment
NoiseXXX
Radiation, electromagnetic fields
Water contamination
Binge drinkingXXX
PetsXXX
Farm animal exposure
Biomarkers of exposure
Mercury
LeadX
Cadmium
Arsenic
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds
Bisphenol A
Other bisphenols
Parabens
Benzophenones
Triclosan
Phthalates
Cotinine
Maternal health ---------- Timing of assessment ----------
Pre-pregnancy First trimester Second trimester Third trimester Post pregnancy
Anthropometry
WeightXXXX
HeightX
Waist circumference
Clinical examinations
Blood pressure
Carotida intima media thickness
Pulse wave velocity
DEXA scans
Bioimpedence
Mental and neurological development
Mental healthXXXXX
Cognitive function (e.g. intelligence quotient)
Respiratory health
AsthmaXXXX
AllergyXXXX
Musculo‐skeletal disease
Back painXXXX
Neck pain
ArthritisXXXX
Other health outcomes
CancerX
DiabetesXXXX
Cardio‐vascular diseaseXXXX
Family history of chronic disease
Infectious diseaseXXX
FeverXXX
Autoimmune diseaseXXXX
Urinary symptomsXXX
Sexual problems
Sleep disturbanceXXX
Biomarkers of health
Nephrology (e.g. creatinine, albumin)
Thyroid hormones
Inflammatory markers (e.g. C-reactive protein cytokines)
Immunologic markers (e.g. immunoglobulines)
Cortisol
Vitamines and micronutrients
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)
Metabolomics
DNA methylation
Transcriptomics (mRNA, miRNA)
Genome-wide association study (GWAS)
Maternal biological samples ---------- Timing of sampling ----------
Pre-pregnancy First trimester Second trimester Third trimester Post pregnancy
Breast milk
Whole blood
Serum
Plasma
Buffy coat
Urine
Hair
Nails
SalivaX
Purified DNA
Purified RNA
Red blood cells
Faeces
General information
Pre-pregnancy During pregnancy <1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
EducationX
Income
Employment statusXX
Job titleX
Single parenthood
Home address
Work address
Paternal characteristics related to the index pregnancy/child
Fertility treatmentX
Age at child's birth
Ethnicity
Country of birth
Paternal exposures ---------- Timing of assessment ----------
Pre-pregnancy During pregnancy Post pregnancy
Diet
Dietary supplements
Active smokingX
Passive smoking
Alcohol consumption
Physical activity
Substance use
Medicine intake
Coffee drinking
Psychological distress (e.g. life-events, health behaviors, perceived stress)
Occupational exposures
Heavy lifts
Work hours
Air pollution
Access to green spaces
Built environment
Noise
Radiation, electromagnetic fields
Water contamination
Binge drinking
Pets
Farm animal exposure
Biomarkers of exposure
Mercury
Lead
Cadmium
Arsenic
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds
Bisphenol A
Other bisphenols
Parabens
Benzophenones
Triclosan
Phthalates
Cotinine
Paternal health ---------- Timing of assessment ----------
Pre-pregnancy During pregnancy Post pregnancy
Anthropometry
WeightXX
HeightX
Waist circumference
Clinical examinations
Blood pressure
Carotida intima media thickness
Pulse wave velocity
DEXA scans
Bio impedence
Mental and neurological development
Mental health
Cognitive function (e.g. intelligence quotient)
Respiratory health
AsthmaX
Allergy
Musculo‐skeletal disease
Back pain
Neck pain
Arthritis
Other health outcomes
Cancer
Diabetes
Cardio‐vascular disease
Family history of chronic disease
Infectious disease
Fever
Autoimmune disease
Urinary symptoms
Sexual problems
Sleep disturbance
Biomarkers of health
Nephrology (e.g. creatinine, albumin)
Thyroid hormones
Inflammatory markers (e.g. C-reactive protein cytokines)
Immunologic markers (e.g. immunoglobulines)
Cortisol
Vitamines and micronutrients
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)
Metabolomics
DNA methylation
Transcriptomics (mRNA, miRNA)
Genome-wide association study (GWAS)
Paternal biological samples ---------- Timing of sampling ----------
Pre-pregnancy During pregnancy Post pregnancy
Semen
Whole blood
Serum
Plasma
Buffy coat
Urine
Hair
Nails
Saliva
Purified DNA
Purified RNA
Red blood cells
Faeces
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