• Cohort, name
    Polish Mother and Child Cohort Study

    Cohort, abbreviation
    REPRO_PL

    Cohort, country
    Poland (Polska)

    Cohort, website
    http://www.repropl.com/

    Key reference
    Polanska K, Hanke W, Gromadzinska J, Ligocka D, Gulczynska E, Sobala W, Wasowicz W. Polish mother and child cohort study — defining the problem, the aim of the study and methodological assumptions. International Journal of Occupational Medicine and Environmental Health 2009;22(4):383–391

    Date of filling in this questionnaire:
    2017-08-03

  • Principal investigator(s), name
    Wojciech Hanke

    Principal investigator(s), e-mail address
    wojciech.hanke@imp.lodz.pl

    Principal investigator(s), institution
    Nofer Institute of Occupational Medicine, 91-348 Lodz, Poland, Teresy 8 ST.

    Contact person(s), name
    Kinga Polanska

    Contact person(s), e-mail address
    kinga.polanska@imp.lodz.pl

    Contact person(s), institution address
    Nofer Institute of Occupational Medicine, 91-348 Lodz, Poland, Teresy 8 St.

  • Main aim of cohort
    The aim of the study is to evaluate the impact of exposure to different environmental factors during pregnancy and after birth on pregnancy outcome and children’s health. Specific research hypotheses refer to the role of heavy metals, exposure to polycyclic aromatic hydrocar­bons, and environmental tobacco smoke in the aetiology of intrauterine growth retardation, preterm delivery and the risk of respiratory diseases, allergy and poor mental and physical development. It is also intended to explain the role of oxidative stress and nutritional status of the pregnant women. The impact of occupational exposures and stressful situations on pregnancy outcome will be evaluated from question­naire data.

    Recruited number of:
    1800 children / 1800 mothers / 0 fathers / 0 grand parents / 0 other family members

    Approximate proportion of source population included
    0

    Source population
    Nation-based

  • Period of enrollment
    Start: 2007-01-01, End: 2011-12-31

    Enrollment period
    Pregnancy, week 8 to 12

    Enrollment criteria, please specify
    1) women between 8–12 weeks of single pregnancy 2) pregnancy not assisted with reproductive technology 3) pregnancy not expected to be finished as spontaneous abortion

    Exclusion criteria, please specify
    1) women with the serious chronic diseases specified in study protocol such as diabetes, hypertension, nephropathy, epilepsy and cancer 2) suspicion of serious child malformations

    Planned age of children at end of follow-up
    life-long (current stage - 7-8 years of age) years
General information ---------- Child age (years) at assessment ----------
<1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
Home addressXXXX
School address
Birth outcomes
Birth weightX
Birth lengthX
Gestational age at birthX
Apgar scoreX
Congenital malformationsX
Stillbirth (>= 22 weeks)X
Child’s sexX
Head circumferenceX
Biparietal diameterX
Child exposures ---------- Child age (years) at assessment ----------
<1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
Breast feedingXXX
DietXXXX
Dietary supplementsXXXX
Childcare attendanceXXX
Active smoking
Passive smokingXXXX
Alcohol consumption
Physical activityXXXX
Substance use
Medicine intakeXXXX
VaccinationsXXXX
Psychological distress (e.g. bullying)X
Air pollutionXXXX
Access to green spacesX
Built environmentX
NoiseXXXX
Radiation, electromagnetic fieldsX
Water contamination
PetsXXXX
Farm animal exposureXXXX
Biomarkers of exposure
Mercury
Lead
Cadmium
Arsenic
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds
Bisphenol AX
Other bisphenols
Parabens
Benzophenones
Triclosan
PhthalatesXX
CotinineXXX
Child development and health ---------- Child age (years) at assessment ----------
<1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
Anthropometry
WeightXXXX
HeightXXXX
Head circumferenceXXX
Abdominal circumferenceXXX
Arm circumferenceXXX
Wrist circumference
Waist circumferenceX
Clinical examinations
Blood pressureX
Carotida intima media thickness
Pulse wave velocity
Cardiac ultrasound
Renal ultrasound
Brain MRI
Other MRI
DEXA‐scan results
Skin folds
Bio impedence
Oscilometry
SpirometryX
Skin prick testX
Bronchial challenge test
Reversibility test
Dental observationsX
Mental and neurological development
Cognitive functionXXX
School performance
LanguageXXX
ADHDX
Autism
Sleep disturbances
Mental healthXXXX
Respiratory health
AsthmaX
AllergyXXXX
Allergic rhinitisXXXX
EczemaXXXX
Respiratory tract infectionsXXXX
Senses
VisionX
HearingX
Musculo-skeletal health
Back painX
Neck painX
Growing pains
Sexual maturation
Tanner stage
Pubertal development stage
Age at menarche
Age at voice change
2D/4D digit ratio
Nocturnal ejaculation
Acne
Other health outcomes
CancerXXXX
DiabetesXXXX
Congenital anomaliesX
Biomarkers of health
Nephrology (e.g. creatinine, albumin)
Thyroid hormones
Inflammatory markers (e.g. C-reactive protein cytokines)
Immunologic markers (e.g. immunoglobulines)
Cortisol
Vitamines and micronutrients
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)
Metabolomics
DNA methylation
Transcriptomics (mRNA, miRNA)
Genome-wide association study (GWAS)
Child biological samples ---------- Child age (years) at sampling ----------
At birth 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
Whole bloodX
Serum
PlasmaX
Buffy coatX
UrineXXX
Hair
Teeth
Nails
SalivaXXX
Purified DNA
Purified RNA
Red blood cells
Umbilical cord blood/tissueX
Blood smear
Faeces/meconium
Exhaled breathe condensate
Sputum induction
Placenta
General information
Pre-pregnancy During pregnancy <1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
EducationXXXX
IncomeXXXX
Employment statusXXXX
Job titleXXXX
Single parenthoodXXXX
Home addressXXXX
Work address
Maternal characteristics related to the index pregnancy/child
Age at birthX
EthnicityX
Country of birthX
Planned pregnancyX
Time to pregnancy
Fertility treatment
Prior spontaneous abortion (<22w)X
Prior birthsX
Ultrasound measurementsX
Doppler measurements
PreeclampsiaX
Gestational diabetesX
Gestational hypertensionX
Gestational durationX
Mode of deliveryX
Prenatal diagnosticsX
Medical termination of pregnancyX
Maternal Exposures ---------- Timing of assessment ----------
Pre-pregnancy First trimester Second trimester Third trimester Post pregnancy
DietXXX
Dietary supplementsXXXX
Active smokingXXXXX
Passive smokingXXXXX
Alcohol consumptionX
Physical activityXXX
Substance useX
Medicine intakeXXXX
Coffee drinkingX
Psychological distress (e.g. life-events, health behaviors, perceived stress)XX
Occupational exposuresXXXXX
Heavy liftsXXX
Work hoursXXX
Air pollutionXXXX
Access to green spaces
Built environment
NoiseX
Radiation, electromagnetic fieldsX
Water contamination
Binge drinkingX
PetsXXXXX
Farm animal exposureXXXXX
Biomarkers of exposure
MercuryX
LeadXX
CadmiumXX
Arsenic
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds
Bisphenol A
Other bisphenols
Parabens
Benzophenones
Triclosan
PhthalatesX
CotinineXXXX
Maternal health ---------- Timing of assessment ----------
Pre-pregnancy First trimester Second trimester Third trimester Post pregnancy
Anthropometry
WeightXXXX
HeightX
Waist circumference
Clinical examinations
Blood pressure
Carotida intima media thickness
Pulse wave velocity
DEXA scans
Bioimpedence
Mental and neurological development
Mental health
Cognitive function (e.g. intelligence quotient)
Respiratory health
AsthmaX
AllergyX
Musculo‐skeletal disease
Back pain
Neck pain
Arthritis
Other health outcomes
CancerXXX
DiabetesXXX
Cardio‐vascular diseaseXXX
Family history of chronic disease
Infectious diseaseXXX
FeverXXX
Autoimmune diseaseXXX
Urinary symptoms
Sexual problems
Sleep disturbance
Biomarkers of health
Nephrology (e.g. creatinine, albumin)
Thyroid hormones
Inflammatory markers (e.g. C-reactive protein cytokines)
Immunologic markers (e.g. immunoglobulines)
Cortisol
Vitamines and micronutrientsXXX
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)
Metabolomics
DNA methylationX
Transcriptomics (mRNA, miRNA)
Genome-wide association study (GWAS)
Maternal biological samples ---------- Timing of sampling ----------
Pre-pregnancy First trimester Second trimester Third trimester Post pregnancy
Breast milkX
Whole bloodX
Serum
PlasmaXXX
Buffy coatXXX
UrineXX
HairX
Nails
SalivaXXXX
Purified DNAXXX
Purified RNA
Red blood cells
Faeces
General information
Pre-pregnancy During pregnancy <1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
EducationXXX
IncomeXXX
Employment statusX
Job title
Single parenthoodX
Home addressXXX
Work address
Paternal characteristics related to the index pregnancy/child
Fertility treatment
Age at child's birthX
EthnicityX
Country of birthX
Paternal exposures ---------- Timing of assessment ----------
Pre-pregnancy During pregnancy Post pregnancy
Diet
Dietary supplements
Active smokingXX
Passive smoking
Alcohol consumption
Physical activity
Substance use
Medicine intake
Coffee drinking
Psychological distress (e.g. life-events, health behaviors, perceived stress)
Occupational exposures
Heavy lifts
Work hours
Air pollutionXX
Access to green spaces
Built environment
NoiseX
Radiation, electromagnetic fieldsX
Water contamination
Binge drinking
PetsXXX
Farm animal exposureXXX
Biomarkers of exposure
Mercury
Lead
Cadmium
Arsenic
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds
Bisphenol A
Other bisphenols
Parabens
Benzophenones
Triclosan
Phthalates
Cotinine
Paternal health ---------- Timing of assessment ----------
Pre-pregnancy During pregnancy Post pregnancy
Anthropometry
Weight
Height
Waist circumference
Clinical examinations
Blood pressure
Carotida intima media thickness
Pulse wave velocity
DEXA scans
Bio impedence
Mental and neurological development
Mental health
Cognitive function (e.g. intelligence quotient)
Respiratory health
AsthmaX
AllergyX
Musculo‐skeletal disease
Back pain
Neck pain
Arthritis
Other health outcomes
Cancer
Diabetes
Cardio‐vascular disease
Family history of chronic disease
Infectious disease
Fever
Autoimmune disease
Urinary symptoms
Sexual problems
Sleep disturbance
Biomarkers of health
Nephrology (e.g. creatinine, albumin)
Thyroid hormones
Inflammatory markers (e.g. C-reactive protein cytokines)
Immunologic markers (e.g. immunoglobulines)
Cortisol
Vitamines and micronutrients
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)
Metabolomics
DNA methylation
Transcriptomics (mRNA, miRNA)
Genome-wide association study (GWAS)
Paternal biological samples ---------- Timing of sampling ----------
Pre-pregnancy During pregnancy Post pregnancy
Semen
Whole blood
Serum
Plasma
Buffy coat
Urine
Hair
Nails
Saliva
Purified DNA
Purified RNA
Red blood cells
Faeces
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