• Cohort, name
    Amsterdam Born Children and their Development

    Cohort, abbreviation
    ABCD

    Cohort, country
    Netherlands (Nederland)

    Cohort, website
    http://www.abcd-studie.nl

    Cohort, facebook-site
    http://www.facebook.com/ABCDstudie/

    Key reference
    van Eijsden M, Vrijkotte TG, Gemke RJ, van der Wal MF. Cohort profile: the Amsterdam Born Children and their Development (ABCD) study. Int J Epidemiol. 2011 Oct;40(5):1176-86.

    Date of filling in this questionnaire:
    2017-09-29

  • Principal investigator(s), name
    Tanja G.M. Vrijkotte

    Principal investigator(s), e-mail address
    t.vrijkotte@amc.uva.nl

    Principal investigator(s), institution
    Academic Medical Centre/Department of Public Health/University of Amsterdam

    Contact person(s), name
    Noekie van Lieshout

    Contact person(s), e-mail address
    abcd@amc.nl

    Contact person(s), institution address
    Academic Medical Centre/Department of Public Health/University of Amsterdam

  • Main aim of cohort
    Prospective cohort study on the association between lifestyle, psychosocial conditions, and nutritional status during pregnancy, and the childs health at birth (birth weight, pregnancy duration, perinatal mortality) and in later life (growth, physical development, behhaviour and cognitive functioning).

    Recruited number of:
    6161 children / 8266 mothers / 2270 fathers / 0 grand parents / 0 other family members

    Approximate proportion of source population included
    67

    Source population
    Region-based

  • Period of enrollment
    Start: 2003-01-01, End: 2004-03-01

    Enrollment period
    Pregnancy, week 14 to 18

    Planned age of children at end of follow-up
    25 years
General information ---------- Child age (years) at assessment ----------
<1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
Home addressXXXXXXXXXXXXXX
School addressXXX
Birth outcomes
Birth weightX
Birth length
Gestational age at birthX
Apgar scoreX
Congenital malformationsX
Stillbirth (>= 22 weeks)X
Child’s sexX
Head circumferenceX
Biparietal diameter
Child exposures ---------- Child age (years) at assessment ----------
<1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
Breast feedingXXX
DietXXX
Dietary supplementsXXX
Childcare attendanceX
Active smokingX
Passive smokingXXX
Alcohol consumptionX
Physical activityXXX
Substance useX
Medicine intakeXXX
Vaccinations
Psychological distress (e.g. bullying)XX
Air pollutionX
Access to green spacesX
Built environmentX
Noise
Radiation, electromagnetic fieldsXX
Water contamination
PetsX
Farm animal exposure
Biomarkers of exposure
Mercury
Lead
Cadmium
Arsenic
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds
Bisphenol A
Other bisphenols
Parabens
Benzophenones
Triclosan
Phthalates
Cotinine
Child development and health ---------- Child age (years) at assessment ----------
<1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
Anthropometry
WeightXXXXXXXXX
HeightXXXXXXXXX
Head circumferenceXX
Abdominal circumferenceXX
Arm circumferenceXX
Wrist circumference
Waist circumferenceXX
Clinical examinations
Blood pressureXX
Carotida intima media thicknessX
Pulse wave velocity
Cardiac ultrasound
Renal ultrasound
Brain MRI
Other MRI
DEXA‐scan results
Skin folds
Bio impedenceXX
Oscilometry
Spirometry
Skin prick test
Bronchial challenge test
Reversibility test
Dental observations
Mental and neurological development
Cognitive functionXX
School performanceXX
LanguageX
ADHDXX
AutismXX
Sleep disturbancesXXX
Mental healthXXX
Respiratory health
AsthmaXXX
AllergyX
Allergic rhinitis
EczemaX
Respiratory tract infections
Senses
Vision
Hearing
Musculo-skeletal health
Back pain
Neck pain
Growing pains
Sexual maturation
Tanner stageX
Pubertal development stageX
Age at menarcheX
Age at voice changeX
2D/4D digit ratio
Nocturnal ejaculation
AcneX
Other health outcomes
CancerXXX
DiabetesXXX
Congenital anomaliesXXX
Biomarkers of health
Nephrology (e.g. creatinine, albumin)X
Thyroid hormones
Inflammatory markers (e.g. C-reactive protein cytokines)
Immunologic markers (e.g. immunoglobulines)
Cortisol
Vitamines and micronutrients
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)XX
Metabolomics
DNA methylation
Transcriptomics (mRNA, miRNA)
Genome-wide association study (GWAS)X
Child biological samples ---------- Child age (years) at sampling ----------
At birth 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
Whole bloodXX
Serum
Plasma
Buffy coat
Urine
Hair
Teeth
Nails
SalivaX
Purified DNAX
Purified RNA
Red blood cells
Umbilical cord blood/tissue
Blood smear
Faeces/meconium
Exhaled breathe condensate
Sputum induction
Placenta
General information
Pre-pregnancy During pregnancy <1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
EducationXXX
IncomeXX
Employment statusX
Job titleX
Single parenthoodXXX
Home addressXXX
Work address
Maternal characteristics related to the index pregnancy/child
Age at birthX
EthnicityX
Country of birthX
Planned pregnancyX
Time to pregnancyX
Fertility treatmentX
Prior spontaneous abortion (<22w)X
Prior birthsX
Ultrasound measurements
Doppler measurements
PreeclampsiaX
Gestational diabetesX
Gestational hypertensionX
Gestational durationX
Mode of deliveryX
Prenatal diagnosticsX
Medical termination of pregnancyX
Maternal Exposures ---------- Timing of assessment ----------
Pre-pregnancy First trimester Second trimester Third trimester Post pregnancy
DietXXXX
Dietary supplementsXXXX
Active smokingXXXXX
Passive smokingXXXXX
Alcohol consumptionXXXXX
Physical activityXXXX
Substance useXXXXX
Medicine intakeXXXXX
Coffee drinkingXXXX
Psychological distress (e.g. life-events, health behaviors, perceived stress)XXXXX
Occupational exposuresXXXXX
Heavy liftsXXXX
Work hoursXXX
Air pollutionXX
Access to green spaces
Built environment
Noise
Radiation, electromagnetic fields
Water contaminationX
Binge drinkingXXXXX
Pets
Farm animal exposure
Biomarkers of exposure
Mercury
Lead
Cadmium
Arsenic
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds
Bisphenol A
Other bisphenols
Parabens
Benzophenones
Triclosan
Phthalates
Cotinine
Maternal health ---------- Timing of assessment ----------
Pre-pregnancy First trimester Second trimester Third trimester Post pregnancy
Anthropometry
WeightXXX
HeightXXX
Waist circumference
Clinical examinations
Blood pressureXXXX
Carotida intima media thickness
Pulse wave velocity
DEXA scans
Bioimpedence
Mental and neurological development
Mental healthXXX
Cognitive function (e.g. intelligence quotient)
Respiratory health
AsthmaX
AllergyX
Musculo‐skeletal diseaseXXXXX
Back pain
Neck pain
Arthritis
Other health outcomes
CancerXXXXX
DiabetesXXXXX
Cardio‐vascular diseaseXXXXX
Family history of chronic diseaseX
Infectious diseaseXXXXX
Fever
Autoimmune diseaseXXXXX
Urinary symptoms
Sexual problems
Sleep disturbanceX
Biomarkers of health
Nephrology (e.g. creatinine, albumin)
Thyroid hormonesX
Inflammatory markers (e.g. C-reactive protein cytokines)X
Immunologic markers (e.g. immunoglobulines)
CortisolX
Vitamines and micronutrientsX
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)
Metabolomics
DNA methylation
Transcriptomics (mRNA, miRNA)
Genome-wide association study (GWAS)
Maternal biological samples ---------- Timing of sampling ----------
Pre-pregnancy First trimester Second trimester Third trimester Post pregnancy
Breast milk
Whole blood
SerumX
PlasmaX
Buffy coat
Urine
Hair
Nails
Saliva
Purified DNA
Purified RNA
Red blood cells
Faeces
General information
Pre-pregnancy During pregnancy <1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
EducationXX
Income
Employment status
Job title
Single parenthood
Home address
Work address
Paternal characteristics related to the index pregnancy/child
Fertility treatment
Age at child's birthX
EthnicityX
Country of birth
Paternal exposures ---------- Timing of assessment ----------
Pre-pregnancy During pregnancy Post pregnancy
Diet
Dietary supplements
Active smoking
Passive smoking
Alcohol consumption
Physical activity
Substance use
Medicine intake
Coffee drinking
Psychological distress (e.g. life-events, health behaviors, perceived stress)
Occupational exposuresX
Heavy lifts
Work hours
Air pollution
Access to green spaces
Built environment
Noise
Radiation, electromagnetic fields
Water contamination
Binge drinking
Pets
Farm animal exposure
Biomarkers of exposure
Mercury
Lead
Cadmium
Arsenic
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds
Bisphenol A
Other bisphenols
Parabens
Benzophenones
Triclosan
Phthalates
Cotinine
Paternal health ---------- Timing of assessment ----------
Pre-pregnancy During pregnancy Post pregnancy
Anthropometry
WeightX
HeightX
Waist circumference
Clinical examinations
Blood pressure
Carotida intima media thickness
Pulse wave velocity
DEXA scans
Bio impedence
Mental and neurological development
Mental healthX
Cognitive function (e.g. intelligence quotient)
Respiratory health
Asthma
Allergy
Musculo‐skeletal disease
Back pain
Neck pain
Arthritis
Other health outcomes
CancerX
DiabetesX
Cardio‐vascular diseaseX
Family history of chronic disease
Infectious disease
Fever
Autoimmune disease
Urinary symptoms
Sexual problems
Sleep disturbance
Biomarkers of health
Nephrology (e.g. creatinine, albumin)
Thyroid hormones
Inflammatory markers (e.g. C-reactive protein cytokines)
Immunologic markers (e.g. immunoglobulines)
Cortisol
Vitamines and micronutrients
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)
Metabolomics
DNA methylation
Transcriptomics (mRNA, miRNA)
Genome-wide association study (GWAS)
Paternal biological samples ---------- Timing of sampling ----------
Pre-pregnancy During pregnancy Post pregnancy
Semen
Whole blood
Serum
Plasma
Buffy coat
Urine
Hair
Nails
Saliva
Purified DNA
Purified RNA
Red blood cells
Faeces
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