• Cohort, name
    Danish National Birth Cohort

    Cohort, abbreviation
    DNBC (int'l), BSIG (Danish)

    Cohort, country
    Denmark (Danmark)

    Cohort, website
    http://www.dnbc.dk

    Cohort, facebook-site
    https://www.facebook.com/bedresundhedigenerationer/

    Key reference
    Olsen J, Melbye M, Olsen SF, Sørensen TIA, Aaby P, Nybo Andersen AM et al. The Danish National Birth Cohort. Its background, structure and aim. Scand J Public Health, 2001; 29(4):300-307.

    Date of filling in this questionnaire:
    2018-03-10

  • Principal investigator(s), name
    Anne-Marie Nybo Andersen

    Principal investigator(s), e-mail address
    amny@sund.ku.dk

    Principal investigator(s), institution
    Department of Public Health, University of Copenhagen, Oster Farimagsgade 5A, DK-1014 Cph K

    Contact person(s), name
    Inger Kristine Meder

    Contact person(s), e-mail address
    bsmb@ssi.dk

    Contact person(s), institution address
    DNBC secretariat, Statens Serum Institut, Artillerivej 5, DK-2300 Copenhagen S

  • Main aim of cohort
    Main aim: pregnancy complications and diseases in offspring as a function of factors operating in pregnancy/fetal and early life. Fetal growth as an outcome and as a determinant of later health. Main exposures: Infection, alcohol, tobacco, environments, medication, psycho-social factors. Nutrition in pregnancy, in general but with focus upon fish intake. Outcome measures: Life-long follow-up of children: mortality and morbidity

    Recruited number of:
    95000 children / 100418 mothers / 0 fathers / 0 grand parents / 0 other family members

    Approximate proportion of source population included
    35

    Source population
    Nation-based

  • Period of enrollment
    Start: 1996-01-01, End: 2002-10-01

    Enrollment period
    Pregnancy, week 6 to 24

    Enrollment criteria, please specify
    All pregnant women in Denmark who, at their first visit to the GP, wanted to carry their pregnancy to term and who spoke Danish well enough to take part in the telephone interviews.

    Exclusion criteria, please specify
    No other exclusion criteria were used.

    Planned age of children at end of follow-up
    Life-long / unrestricted
General information ---------- Child age (years) at assessment ----------
<1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
Home address
School addressX
Birth outcomes
Birth weightX
Birth lengthX
Gestational age at birthX
Apgar scoreX
Congenital malformationsX
Stillbirth (>= 22 weeks)X
Child’s sexX
Head circumference
Biparietal diameter
Child exposures ---------- Child age (years) at assessment ----------
<1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
Breast feedingXX
DietXXXXX
Dietary supplementsX
Childcare attendanceXXXXXXX
Active smokingXX
Passive smokingXXXX
Alcohol consumptionXX
Physical activityXXXX
Substance useXX
Medicine intakeXXX
VaccinationsXXX
Psychological distress (e.g. bullying)XX
Air pollution
Access to green spaces
Built environmentX
NoiseX
Radiation, electromagnetic fieldsX
Water contaminationXX
PetsX
Farm animal exposureXX
Biomarkers of exposure
Mercury
Lead
Cadmium
Arsenic
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds
Bisphenol A
Other bisphenols
Parabens
Benzophenones
Triclosan
Phthalates
Cotinine
Child development and health ---------- Child age (years) at assessment ----------
<1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
Anthropometry
WeightXXXX
HeightXXXX
Head circumferenceX
Abdominal circumference
Arm circumference
Wrist circumference
Waist circumference
Clinical examinations
Blood pressure
Carotida intima media thickness
Pulse wave velocity
Cardiac ultrasound
Renal ultrasound
Brain MRI
Other MRI
DEXA‐scan results
Skin folds
Bio impedence
Oscilometry
Spirometry
Skin prick test
Bronchial challenge test
Reversibility test
Dental observations
Mental and neurological development
Cognitive function
School performanceX
LanguageXX
ADHD
Autism
Sleep disturbancesXX
Mental healthXXXXXXXXXX
Respiratory health
AsthmaXX
AllergyXX
Allergic rhinitis
Eczema
Respiratory tract infections
Senses
VisionX
HearingXX
Musculo-skeletal health
Back painXX
Neck painXX
Growing painsX
Sexual maturation
Tanner stageXXXXXX
Pubertal development stageXXXXXX
Age at menarcheXXXXXX
Age at voice changeXXXXXX
2D/4D digit ratioXXXXXX
Nocturnal ejaculationXXXXXX
AcneXXXXXX
Other health outcomes
CancerXXXXXXXXXXXX
DiabetesXXXXXXXXXXXX
Congenital anomaliesXXXXXXXXXXXX
Biomarkers of health
Nephrology (e.g. creatinine, albumin)
Thyroid hormones
Inflammatory markers (e.g. C-reactive protein cytokines)
Immunologic markers (e.g. immunoglobulines)
Cortisol
Vitamines and micronutrients
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)
Metabolomics
DNA methylation
Transcriptomics (mRNA, miRNA)
Genome-wide association study (GWAS)
Child biological samples ---------- Child age (years) at sampling ----------
At birth 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
Whole bloodX
SerumX
Plasma
Buffy coat
Urine
Hair
Teeth
Nails
Saliva
Purified DNAX
Purified RNA
Red blood cells
Umbilical cord blood/tissueX
Blood smear
Faeces/meconium
Exhaled breathe condensate
Sputum induction
Placenta
General information
Pre-pregnancy During pregnancy <1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
EducationX
Income
Employment status
Job title
Single parenthood
Home address
Work address
Maternal characteristics related to the index pregnancy/child
Age at birthX
Ethnicity
Country of birth
Planned pregnancyX
Time to pregnancyX
Fertility treatmentX
Prior spontaneous abortion (<22w)X
Prior birthsX
Ultrasound measurements
Doppler measurements
PreeclampsiaX
Gestational diabetes
Gestational hypertension
Gestational durationX
Mode of deliveryX
Prenatal diagnosticsX
Medical termination of pregnancyX
Maternal Exposures ---------- Timing of assessment ----------
Pre-pregnancy First trimester Second trimester Third trimester Post pregnancy
DietXX
Dietary supplementsXX
Active smokingXXXX
Passive smoking
Alcohol consumptionXXXX
Physical activityXX
Substance useXX
Medicine intakeXXXX
Coffee drinkingXX
Psychological distress (e.g. life-events, health behaviors, perceived stress)
Occupational exposuresX
Heavy liftsXX
Work hours
Air pollutionX
Access to green spaces
Built environment
Noise
Radiation, electromagnetic fields
Water contaminationXX
Binge drinkingXXXX
Pets
Farm animal exposure
Biomarkers of exposure
Mercury
Lead
Cadmium
Arsenic
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds
Bisphenol A
Other bisphenols
Parabens
Benzophenones
Triclosan
Phthalates
Cotinine
Maternal health ---------- Timing of assessment ----------
Pre-pregnancy First trimester Second trimester Third trimester Post pregnancy
Anthropometry
WeightXX
HeightXX
Waist circumference
Clinical examinations
Blood pressure
Carotida intima media thickness
Pulse wave velocity
DEXA scans
Bioimpedence
Mental and neurological development
Mental healthXXXXX
Cognitive function (e.g. intelligence quotient)
Respiratory health
Asthma
Allergy
Musculo‐skeletal diseaseXXXXX
Back pain
Neck pain
Arthritis
Other health outcomes
CancerXXXXX
DiabetesXXXXX
Cardio‐vascular diseaseXXXXX
Family history of chronic disease
Infectious diseaseXXX
FeverXX
Autoimmune diseaseXXXXX
Urinary symptoms
Sexual problems
Sleep disturbance
Biomarkers of health
Nephrology (e.g. creatinine, albumin)
Thyroid hormones
Inflammatory markers (e.g. C-reactive protein cytokines)
Immunologic markers (e.g. immunoglobulines)
Cortisol
Vitamines and micronutrients
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)
Metabolomics
DNA methylation
Transcriptomics (mRNA, miRNA)
Genome-wide association study (GWAS)
Maternal biological samples ---------- Timing of sampling ----------
Pre-pregnancy First trimester Second trimester Third trimester Post pregnancy
Breast milk
Whole bloodX
SerumX
Plasma
Buffy coat
Urine
Hair
Nails
Saliva
Purified DNAX
Purified RNA
Red blood cells
Faeces
General information
Pre-pregnancy During pregnancy <1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
Education
Income
Employment status
Job title
Single parenthood
Home address
Work address
Paternal characteristics related to the index pregnancy/child
Fertility treatment
Age at child's birthX
Ethnicity
Country of birth
Paternal exposures ---------- Timing of assessment ----------
Pre-pregnancy During pregnancy Post pregnancy
Diet
Dietary supplements
Active smokingXX
Passive smoking
Alcohol consumption
Physical activity
Substance use
Medicine intake
Coffee drinking
Psychological distress (e.g. life-events, health behaviors, perceived stress)
Occupational exposuresX
Heavy lifts
Work hours
Air pollution
Access to green spaces
Built environment
Noise
Radiation, electromagnetic fields
Water contamination
Binge drinking
Pets
Farm animal exposure
Biomarkers of exposure
Mercury
Lead
Cadmium
Arsenic
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds
Bisphenol A
Other bisphenols
Parabens
Benzophenones
Triclosan
Phthalates
Cotinine
Paternal health ---------- Timing of assessment ----------
Pre-pregnancy During pregnancy Post pregnancy
Anthropometry
WeightX
HeightX
Waist circumference
Clinical examinations
Blood pressure
Carotida intima media thickness
Pulse wave velocity
DEXA scans
Bio impedence
Mental and neurological development
Mental healthXXX
Cognitive function (e.g. intelligence quotient)
Respiratory health
Asthma
Allergy
Musculo‐skeletal disease
Back pain
Neck pain
Arthritis
Other health outcomes
CancerXXX
DiabetesXXX
Cardio‐vascular diseaseXXX
Family history of chronic disease
Infectious disease
Fever
Autoimmune diseaseXXX
Urinary symptoms
Sexual problems
Sleep disturbance
Biomarkers of health
Nephrology (e.g. creatinine, albumin)
Thyroid hormones
Inflammatory markers (e.g. C-reactive protein cytokines)
Immunologic markers (e.g. immunoglobulines)
Cortisol
Vitamines and micronutrients
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)
Metabolomics
DNA methylation
Transcriptomics (mRNA, miRNA)
Genome-wide association study (GWAS)
Paternal biological samples ---------- Timing of sampling ----------
Pre-pregnancy During pregnancy Post pregnancy
Semen
Whole blood
Serum
Plasma
Buffy coat
Urine
Hair
Nails
Saliva
Purified DNA
Purified RNA
Red blood cells
Faeces
Comments and ideas
From the Danish National Patient Registry we have access to information on all discharge diagnoses from in- and outpatient contacts since 1977 on mother, father and child. Note that data on sexual maturation is collected among a sub-cohort of 22.500 participants only with a response rate of approx. 60%.