Birthcohort | Birthcohorts

Cohort, name
Danish National Birth Cohort

Cohort, abbreviation
DNBC (int'l), BSIG (Danish)

Cohort, country
Denmark (Danmark)

Cohort, website
http://www.dnbc.dk

Cohort, facebook-site
https://www.facebook.com/bedresundhedigenerationer/

Key reference
Olsen J, Melbye M, Olsen SF, Sørensen TIA, Aaby P, Nybo Andersen AM et al. The Danish National Birth Cohort. Its background, structure and aim. Scand J Public Health, 2001; 29(4):300-307.

Date of filling in this questionnaire:
2018-03-10
Principal investigator(s), name
Anne-Marie Nybo Andersen

Principal investigator(s), e-mail address
amny@sund.ku.dk

Principal investigator(s), institution
Department of Public Health, University of Copenhagen, Oster Farimagsgade 5A, DK-1014 Cph K

Contact person(s), name
Inger Kristine Meder

Contact person(s), e-mail address
bsmb@ssi.dk

Contact person(s), institution address
DNBC secretariat, Statens Serum Institut, Artillerivej 5, DK-2300 Copenhagen S

Main aim of cohort
Main aim: pregnancy complications and diseases in offspring as a function of factors operating in pregnancy/fetal and early life. Fetal growth as an outcome and as a determinant of later health. Main exposures: Infection, alcohol, tobacco, environments, medication, psycho-social factors. Nutrition in pregnancy, in general but with focus upon fish intake. Outcome measures: Life-long follow-up of children: mortality and morbidity

Recruited number of:
95000 children / 100418 mothers / 0 fathers / 0 grand parents / 0 other family members

Approximate proportion of source population included
35

Source population
Nation-based
Period of enrollment
Start: 1996-01-01, End: 2002-10-01

Enrollment period
Pregnancy, week 6 to 24

Enrollment criteria, please specify
All pregnant women in Denmark who, at their first visit to the GP, wanted to carry their pregnancy to term and who spoke Danish well enough to take part in the telephone interviews.

Exclusion criteria, please specify
No other exclusion criteria were used.

Planned age of children at end of follow-up
Life-long / unrestricted

Questionnaire or registry data and biological samples

General information	---------- Child age (years) at assessment ----------
	<1	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	>18
Home address
School address												X

Birth outcomes
Birth weight	X
Birth length	X
Gestational age at birth	X
Apgar score	X
Congenital malformations	X
Stillbirth (>= 22 weeks)	X
Child’s sex	X
Head circumference
Biparietal diameter

Child exposures	---------- Child age (years) at assessment ----------
	<1	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	>18
Breast feeding	X	X
Diet	X	X						X				X			X
Dietary supplements															X
Childcare attendance	X	X	X	X	X	X	X
Active smoking												X							X
Passive smoking	X	X						X				X
Alcohol consumption												X							X
Physical activity								X				X			X				X
Substance use												X							X
Medicine intake	X							X				X
Vaccinations		X						X				X
Psychological distress (e.g. bullying)												X							X
Air pollution
Access to green spaces
Built environment												X
Noise																			X
Radiation, electromagnetic fields								X
Water contamination								X				X
Pets												X
Farm animal exposure								X				X
Biomarkers of exposure
Mercury
Lead
Cadmium
Arsenic
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds
Bisphenol A
Other bisphenols
Parabens
Benzophenones
Triclosan
Phthalates
Cotinine

Child development and health	---------- Child age (years) at assessment ----------
	<1	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	>18
Anthropometry
Weight								X				X			X				X
Height								X				X			X				X
Head circumference	X
Abdominal circumference
Arm circumference
Wrist circumference
Waist circumference
Clinical examinations
Blood pressure
Carotida intima media thickness
Pulse wave velocity
Cardiac ultrasound
Renal ultrasound
Brain MRI
Other MRI
DEXA‐scan results
Skin folds
Bio impedence
Oscilometry
Spirometry
Skin prick test
Bronchial challenge test
Reversibility test
Dental observations
Mental and neurological development
Cognitive function
School performance												X
Language		X						X
ADHD
Autism
Sleep disturbances												X							X
Mental health	X	X	X	X	X	X	X	X				X							X
Respiratory health
Asthma								X				X
Allergy								X				X
Allergic rhinitis
Eczema
Respiratory tract infections
Senses
Vision												X
Hearing												X							X
Musculo-skeletal health
Back pain												X							X
Neck pain												X							X
Growing pains												X
Sexual maturation
Tanner stage													X	X	X	X	X	X
Pubertal development stage													X	X	X	X	X	X
Age at menarche													X	X	X	X	X	X
Age at voice change													X	X	X	X	X	X
2D/4D digit ratio													X	X	X	X	X	X
Nocturnal ejaculation													X	X	X	X	X	X
Acne													X	X	X	X	X	X
Other health outcomes
Cancer	X	X	X	X	X	X	X	X	X	X	X	X
Diabetes	X	X	X	X	X	X	X	X	X	X	X	X
Congenital anomalies	X	X	X	X	X	X	X	X	X	X	X	X
Biomarkers of health
Nephrology (e.g. creatinine, albumin)
Thyroid hormones
Inflammatory markers (e.g. C-reactive protein cytokines)
Immunologic markers (e.g. immunoglobulines)
Cortisol
Vitamines and micronutrients
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)
Metabolomics
DNA methylation
Transcriptomics (mRNA, miRNA)
Genome-wide association study (GWAS)

Child biological samples	---------- Child age (years) at sampling ----------
	At birth	0	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	>18
Whole blood	X
Serum	X
Plasma
Buffy coat
Urine
Hair
Teeth
Nails
Saliva
Purified DNA	X
Purified RNA
Red blood cells
Umbilical cord blood/tissue	X
Blood smear
Faeces/meconium
Exhaled breathe condensate
Sputum induction
Placenta

General information
	Pre-pregnancy	During pregnancy	<1	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18
Education		X
Income
Employment status
Job title
Single parenthood
Home address
Work address

Maternal characteristics related to the index pregnancy/child
Age at birth	X
Ethnicity
Country of birth
Planned pregnancy	X
Time to pregnancy	X
Fertility treatment	X
Prior spontaneous abortion (<22w)	X
Prior births	X
Ultrasound measurements
Doppler measurements
Preeclampsia	X
Gestational diabetes
Gestational hypertension
Gestational duration	X
Mode of delivery	X
Prenatal diagnostics	X
Medical termination of pregnancy	X

Maternal Exposures	---------- Timing of assessment ----------
	Pre-pregnancy	First trimester	Second trimester	Third trimester	Post pregnancy
Diet		X	X
Dietary supplements		X	X
Active smoking		X	X	X	X
Passive smoking
Alcohol consumption		X	X	X	X
Physical activity		X	X
Substance use		X	X
Medicine intake		X	X	X	X
Coffee drinking		X		X
Psychological distress (e.g. life-events, health behaviors, perceived stress)
Occupational exposures		X
Heavy lifts		X	X
Work hours
Air pollution		X
Access to green spaces
Built environment
Noise
Radiation, electromagnetic fields
Water contamination		X			X
Binge drinking		X	X	X	X
Pets
Farm animal exposure
Biomarkers of exposure
Mercury
Lead
Cadmium
Arsenic
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds
Bisphenol A
Other bisphenols
Parabens
Benzophenones
Triclosan
Phthalates
Cotinine

Maternal health	---------- Timing of assessment ----------
	Pre-pregnancy	First trimester	Second trimester	Third trimester	Post pregnancy
Anthropometry
Weight		X			X
Height		X			X
Waist circumference
Clinical examinations
Blood pressure
Carotida intima media thickness
Pulse wave velocity
DEXA scans
Bioimpedence
Mental and neurological development
Mental health	X	X	X	X	X
Cognitive function (e.g. intelligence quotient)
Respiratory health
Asthma
Allergy
Musculo‐skeletal disease	X	X	X	X	X
Back pain
Neck pain
Arthritis
Other health outcomes
Cancer	X	X	X	X	X
Diabetes	X	X	X	X	X
Cardio‐vascular disease	X	X	X	X	X
Family history of chronic disease
Infectious disease		X	X	X
Fever		X	X
Autoimmune disease	X	X	X	X	X
Urinary symptoms
Sexual problems
Sleep disturbance
Biomarkers of health
Nephrology (e.g. creatinine, albumin)
Thyroid hormones
Inflammatory markers (e.g. C-reactive protein cytokines)
Immunologic markers (e.g. immunoglobulines)
Cortisol
Vitamines and micronutrients
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)
Metabolomics
DNA methylation
Transcriptomics (mRNA, miRNA)
Genome-wide association study (GWAS)

Maternal biological samples	---------- Timing of sampling ----------
	Pre-pregnancy	First trimester	Second trimester	Third trimester	Post pregnancy
Breast milk
Whole blood		X
Serum		X
Plasma
Buffy coat
Urine
Hair
Nails
Saliva
Purified DNA		X
Purified RNA
Red blood cells
Faeces

General information
	Pre-pregnancy	During pregnancy	<1	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18
Education
Income
Employment status
Job title
Single parenthood
Home address
Work address

Paternal characteristics related to the index pregnancy/child
Fertility treatment
Age at child's birth	X
Ethnicity
Country of birth

Paternal exposures	---------- Timing of assessment ----------
	Pre-pregnancy	During pregnancy	Post pregnancy
Diet
Dietary supplements
Active smoking		X	X
Passive smoking
Alcohol consumption
Physical activity
Substance use
Medicine intake
Coffee drinking
Psychological distress (e.g. life-events, health behaviors, perceived stress)
Occupational exposures		X
Heavy lifts
Work hours
Air pollution
Access to green spaces
Built environment
Noise
Radiation, electromagnetic fields
Water contamination
Binge drinking
Pets
Farm animal exposure
Biomarkers of exposure
Mercury
Lead
Cadmium
Arsenic
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds
Bisphenol A
Other bisphenols
Parabens
Benzophenones
Triclosan
Phthalates
Cotinine

Paternal health	---------- Timing of assessment ----------
	Pre-pregnancy	During pregnancy	Post pregnancy
Anthropometry
Weight			X
Height			X
Waist circumference
Clinical examinations
Blood pressure
Carotida intima media thickness
Pulse wave velocity
DEXA scans
Bio impedence
Mental and neurological development
Mental health	X	X	X
Cognitive function (e.g. intelligence quotient)
Respiratory health
Asthma
Allergy
Musculo‐skeletal disease
Back pain
Neck pain
Arthritis
Other health outcomes
Cancer	X	X	X
Diabetes	X	X	X
Cardio‐vascular disease	X	X	X
Family history of chronic disease
Infectious disease
Fever
Autoimmune disease	X	X	X
Urinary symptoms
Sexual problems
Sleep disturbance
Biomarkers of health
Nephrology (e.g. creatinine, albumin)
Thyroid hormones
Inflammatory markers (e.g. C-reactive protein cytokines)
Immunologic markers (e.g. immunoglobulines)
Cortisol
Vitamines and micronutrients
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)
Metabolomics
DNA methylation
Transcriptomics (mRNA, miRNA)
Genome-wide association study (GWAS)

Paternal biological samples	---------- Timing of sampling ----------
	Pre-pregnancy	During pregnancy	Post pregnancy
Semen
Whole blood
Serum
Plasma
Buffy coat
Urine
Hair
Nails
Saliva
Purified DNA
Purified RNA
Red blood cells
Faeces

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