• Cohort, name
    DOrtmund Nutritional and Anthropometric Longitudinally Designed Study

    Cohort, abbreviation
    DONALD

    Cohort, country
    Germany (Deutschland)

    Cohort, website
    http://www.fke-do.de

    Key reference
    Kroke A, Manz F, Kersting M, Remer T, Sichert-Hellert W, Alexy U, Lentze MJ. The DONALD Study History, current status and perspectives. Eur J Nutr 2004; 43:45-54

    Date of filling in this questionnaire:
    2011-11-21

  • Principal investigator(s), name
    Anette Buyken, Thomas Remer, Ute Alexy, Mathilde Kersting

    Principal investigator(s), e-mail address
    buyken@fke-do.de; fke@fke-do.de

    Principal investigator(s), institution
    Research Insitute of Child Nutrition

    Contact person(s), name
    Anette Buyken

    Contact person(s), e-mail address
    buyken@fke-do.de

    Contact person(s), institution address
    Research Institute of Child Nutrition

  • Main aim of cohort
    Open cohort study, not a birth cohort. Annual recruitment of 30-40 infants aged 3-6 months. Environmental exposure is not the main focus of the study. However, all contaminants that are nutrition-related can be evaluated if respective data on food contamination are available.

    Recruited number of:
    1300 children / 1300 mothers / 1300 fathers / 0 grand parents / 0 other family members

    Approximate proportion of source population included
    0

    Source population
    Other, please describeStudy participants are recruited in the city of Dortmund and surrounding communities via personal contacts, maternity wards or paediatric practices.

  • Period of enrollment
    Start: 1985-01-01, End: 0000-01-01

    Enrollment period
    Later, month 3 to 6

    Enrollment criteria, please specify
    Healthy (no prevalent diseases affecting growth and/or diet) German babies (age 3–6 month) whose mothers and/or fathers are willing to participate in a long-term study and of whom at least one parent has sufficient knowledge of the German language.

    Planned age of children at end of follow-up
General information ---------- Child age (years) at assessment ----------
<1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
Home address
School address
Birth outcomes
Birth weightX
Birth lengthX
Gestational age at birthX
Apgar scoreX
Congenital malformations
Stillbirth (>= 22 weeks)
Child’s sexX
Head circumference
Biparietal diameter
Child exposures ---------- Child age (years) at assessment ----------
<1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
Breast feedingXXX
DietXXXXXXXXXXXXXXXXXXX
Dietary supplements
Childcare attendanceXXXX
Active smokingXXX
Passive smokingXXXX
Alcohol consumptionXX
Physical activityXXXXXXXXXXXXXXXXXXX
Substance use
Medicine intakeXXXXXXXXXXXXXXXXXXX
Vaccinations
Psychological distress (e.g. bullying)
Air pollution
Access to green spaces
Built environment
Noise
Radiation, electromagnetic fields
Water contamination
Pets
Farm animal exposure
Biomarkers of exposure
Mercury
Lead
Cadmium
Arsenic
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds
Bisphenol A
Other bisphenols
Parabens
Benzophenones
Triclosan
Phthalates
Cotinine
Child development and health ---------- Child age (years) at assessment ----------
<1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
Anthropometry
WeightXXXXXXXXXXXXXXXXXXX
HeightXXXXXXXXXXXXXXXXXXX
Head circumferenceXXXXXXXXXXXXXXXXXXX
Abdominal circumference
Arm circumference
Wrist circumference
Waist circumference
Clinical examinations
Blood pressureXXXXXXX
Carotida intima media thickness
Pulse wave velocity
Cardiac ultrasound
Renal ultrasound
Brain MRI
Other MRI
DEXA‐scan results
Skin folds
Bio impedence
Oscilometry
Spirometry
Skin prick test
Bronchial challenge test
Reversibility test
Dental observations
Mental and neurological development
Cognitive function
School performance
Language
ADHD
Autism
Sleep disturbancesXXXXX
Mental health
Respiratory health
Asthma
Allergy
Allergic rhinitis
Eczema
Respiratory tract infections
Senses
Vision
Hearing
Musculo-skeletal health
Back pain
Neck pain
Growing pains
Sexual maturation
Tanner stage
Pubertal development stage
Age at menarche
Age at voice change
2D/4D digit ratio
Nocturnal ejaculation
Acne
Other health outcomes
CancerXXX
DiabetesXXX
Congenital anomalies
Biomarkers of health
Nephrology (e.g. creatinine, albumin)
Thyroid hormones
Inflammatory markers (e.g. C-reactive protein cytokines)
Immunologic markers (e.g. immunoglobulines)
Cortisol
Vitamines and micronutrients
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)
Metabolomics
DNA methylation
Transcriptomics (mRNA, miRNA)
Genome-wide association study (GWAS)
Child biological samples ---------- Child age (years) at sampling ----------
At birth 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
Whole bloodX
SerumX
Plasma
Buffy coat
UrineXXXXXXXXXXXXXXXX
Hair
Teeth
Nails
Saliva
Purified DNA
Purified RNA
Red blood cells
Umbilical cord blood/tissue
Blood smear
Faeces/meconium
Exhaled breathe condensate
Sputum induction
Placenta
General information
Pre-pregnancy During pregnancy <1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
Education
Income
Employment status
Job title
Single parenthood
Home address
Work address
Maternal characteristics related to the index pregnancy/child
Age at birthX
Ethnicity
Country of birth
Planned pregnancy
Time to pregnancy
Fertility treatment
Prior spontaneous abortion (<22w)
Prior birthsX
Ultrasound measurements
Doppler measurements
Preeclampsia
Gestational diabetes
Gestational hypertension
Gestational durationX
Mode of delivery
Prenatal diagnostics
Medical termination of pregnancy
Maternal Exposures ---------- Timing of assessment ----------
Pre-pregnancy First trimester Second trimester Third trimester Post pregnancy
DietX
Dietary supplementsX
Active smokingXX
Passive smokingX
Alcohol consumptionX
Physical activityX
Substance use
Medicine intakeX
Coffee drinking
Psychological distress (e.g. life-events, health behaviors, perceived stress)
Occupational exposures
Heavy lifts
Work hours
Air pollution
Access to green spaces
Built environment
Noise
Radiation, electromagnetic fields
Water contamination
Binge drinking
Pets
Farm animal exposure
Biomarkers of exposure
Mercury
Lead
Cadmium
Arsenic
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds
Bisphenol A
Other bisphenols
Parabens
Benzophenones
Triclosan
Phthalates
Cotinine
Maternal health ---------- Timing of assessment ----------
Pre-pregnancy First trimester Second trimester Third trimester Post pregnancy
Anthropometry
WeightX
HeightX
Waist circumference
Clinical examinations
Blood pressureX
Carotida intima media thickness
Pulse wave velocity
DEXA scans
Bioimpedence
Mental and neurological development
Mental health
Cognitive function (e.g. intelligence quotient)
Respiratory health
Asthma
Allergy
Musculo‐skeletal diseaseX
Back pain
Neck pain
Arthritis
Other health outcomes
CancerX
DiabetesX
Cardio‐vascular diseaseX
Family history of chronic disease
Infectious diseaseX
Fever
Autoimmune diseaseX
Urinary symptoms
Sexual problems
Sleep disturbance
Biomarkers of health
Nephrology (e.g. creatinine, albumin)
Thyroid hormones
Inflammatory markers (e.g. C-reactive protein cytokines)
Immunologic markers (e.g. immunoglobulines)
Cortisol
Vitamines and micronutrients
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)
Metabolomics
DNA methylation
Transcriptomics (mRNA, miRNA)
Genome-wide association study (GWAS)
Maternal biological samples ---------- Timing of sampling ----------
Pre-pregnancy First trimester Second trimester Third trimester Post pregnancy
Breast milk
Whole blood
Serum
Plasma
Buffy coat
Urine
Hair
Nails
Saliva
Purified DNA
Purified RNA
Red blood cells
Faeces
General information
Pre-pregnancy During pregnancy <1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
Education
Income
Employment status
Job title
Single parenthood
Home address
Work address
Paternal characteristics related to the index pregnancy/child
Fertility treatment
Age at child's birthX
Ethnicity
Country of birth
Paternal exposures ---------- Timing of assessment ----------
Pre-pregnancy During pregnancy Post pregnancy
DietX
Dietary supplements
Active smokingX
Passive smokingX
Alcohol consumption
Physical activityX
Substance use
Medicine intake
Coffee drinking
Psychological distress (e.g. life-events, health behaviors, perceived stress)
Occupational exposuresX
Heavy lifts
Work hours
Air pollution
Access to green spaces
Built environment
Noise
Radiation, electromagnetic fields
Water contamination
Binge drinking
Pets
Farm animal exposure
Biomarkers of exposure
Mercury
Lead
Cadmium
Arsenic
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds
Bisphenol A
Other bisphenols
Parabens
Benzophenones
Triclosan
Phthalates
Cotinine
Paternal health ---------- Timing of assessment ----------
Pre-pregnancy During pregnancy Post pregnancy
Anthropometry
WeightX
HeightX
Waist circumference
Clinical examinations
Blood pressureX
Carotida intima media thickness
Pulse wave velocity
DEXA scans
Bio impedence
Mental and neurological development
Mental health
Cognitive function (e.g. intelligence quotient)
Respiratory health
Asthma
Allergy
Musculo‐skeletal diseaseX
Back pain
Neck pain
Arthritis
Other health outcomes
CancerX
DiabetesX
Cardio‐vascular diseaseX
Family history of chronic disease
Infectious diseaseX
Fever
Autoimmune diseaseX
Urinary symptoms
Sexual problems
Sleep disturbance
Biomarkers of health
Nephrology (e.g. creatinine, albumin)
Thyroid hormones
Inflammatory markers (e.g. C-reactive protein cytokines)
Immunologic markers (e.g. immunoglobulines)
Cortisol
Vitamines and micronutrients
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)
Metabolomics
DNA methylation
Transcriptomics (mRNA, miRNA)
Genome-wide association study (GWAS)
Paternal biological samples ---------- Timing of sampling ----------
Pre-pregnancy During pregnancy Post pregnancy
Semen
Whole blood
Serum
Plasma
Buffy coat
Urine
Hair
Nails
Saliva
Purified DNA
Purified RNA
Red blood cells
Faeces
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