• Cohort, name
    ECLIPSES

    Cohort, abbreviation
    ECLIPSES

    Cohort, country
    Spain (Espa

    Date of filling in this questionnaire:
    2019-02-11

  • Principal investigator(s), name
    Victoria Arija Val

    Principal investigator(s), e-mail address
    carmen.hernandez@urv.cat

    Principal investigator(s), institution
    Rovira i Virgili University, Medicine and Health Sciences Faculty, C/ Sant Llorenç, 21, 43201, Reus (Tarragona, Spain)

    Contact person(s), name
    Carmen Hernández-Martínez

    Contact person(s), e-mail address
    carmen.hernandez@urv.cat

    Contact person(s), institution address
    Rovira i Virgili University, Edication and Psychology Faculty, Campus Sescelades, Ctra. Valls S/N, 43007, Tarragona (Spain)

  • Main aim of cohort
    To assess the impact of prenatal environmental factors, including nutritional habits, environmental pollution and emotional status exposure during pregnancy on newborn cognitive development assessed at 40 days and on executive functions and intelligence at 4 years after birth

    Recruited number of:
    400 children / 700 mothers / 500 fathers / 0 grand parents / 0 other family members

    Approximate proportion of source population included
    0

    Source population
    Region-based

  • Period of enrollment
    Start: 2013-09-01, End: 2018-04-01

    Enrollment period
    Pregnancy, week 8 to 12

    Enrollment criteria, please specify
    Inclusion criteria: Adult female older than 18 years of age with ≤ 12 weeks gestation without anemia (Hb >110 g/L), capable of understanding the official State languages (Castilian or Catalan), who can understand the characteristics of the study, and who sign the informed consent form.

    Exclusion criteria, please specify
    Exclusion criteria: Multiple pregnancy, taking >10 mg iron during the months prior to week 12, hypersensitivity to egg protein (due to the iron prescription formula contains ovalbumin), previous serious illness (immunosuppressed status) or chronic illness that could affect the nutritional development (e.g. cancer, diabetes), malabsorption, and liver disease such as chronic hepatitis or cirrhosis. The risk factors of pregnancy to be considered as exclusion criteria are: adverse obstetric history, previous uterine surgery, heart disease grade 2, 3 or 4, endocrinopathy, suspected fetal malformation, morbid obesity, preeclampsia, maternal infection, uterine malformation, perinatal recurrent death, alcoholism, diabetes 1 and 2, uterine cervical incompetence.

    Planned age of children at end of follow-up
    4 years
General information ---------- Child age (years) at assessment ----------
<1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
Home addressX
School address
Birth outcomes
Birth weightX
Birth lengthX
Gestational age at birthX
Apgar scoreX
Congenital malformations
Stillbirth (>= 22 weeks)
Child’s sexX
Head circumferenceX
Biparietal diameter
Child exposures ---------- Child age (years) at assessment ----------
<1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
Breast feedingXXXX
DietXX
Dietary supplementsX
Childcare attendanceXXXXX
Active smoking
Passive smokingX
Alcohol consumption
Physical activityX
Substance use
Medicine intakeX
VaccinationsXXXXX
Psychological distress (e.g. bullying)
Air pollutionX
Access to green spaces
Built environment
Noise
Radiation, electromagnetic fields
Water contamination
Pets
Farm animal exposure
Biomarkers of exposure
Mercury
Lead
Cadmium
Arsenic
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds
Bisphenol A
Other bisphenols
Parabens
Benzophenones
Triclosan
Phthalates
Cotinine
Child development and health ---------- Child age (years) at assessment ----------
<1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
Anthropometry
WeightX
HeightX
Head circumference
Abdominal circumference
Arm circumference
Wrist circumference
Waist circumference
Clinical examinations
Blood pressure
Carotida intima media thickness
Pulse wave velocity
Cardiac ultrasound
Renal ultrasound
Brain MRI
Other MRI
DEXA‐scan results
Skin folds
Bio impedenceX
Oscilometry
Spirometry
Skin prick test
Bronchial challenge test
Reversibility test
Dental observations
Mental and neurological development
Cognitive functionX
School performance
LanguageX
ADHDX
AutismX
Sleep disturbancesX
Mental healthX
Respiratory health
AsthmaX
AllergyX
Allergic rhinitisX
EczemaX
Respiratory tract infectionsX
Senses
Vision
Hearing
Musculo-skeletal health
Back pain
Neck pain
Growing pains
Sexual maturation
Tanner stage
Pubertal development stage
Age at menarche
Age at voice change
2D/4D digit ratio
Nocturnal ejaculation
Acne
Other health outcomes
Cancer
Diabetes
Congenital anomalies
Biomarkers of health
Nephrology (e.g. creatinine, albumin)
Thyroid hormones
Inflammatory markers (e.g. C-reactive protein cytokines)
Immunologic markers (e.g. immunoglobulines)
Cortisol
Vitamines and micronutrients
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)
MetabolomicsX
DNA methylation
Transcriptomics (mRNA, miRNA)
Genome-wide association study (GWAS)
Child biological samples ---------- Child age (years) at sampling ----------
At birth 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
Whole blood
Serum
Plasma
Buffy coat
UrineX
Hair
Teeth
Nails
Saliva
Purified DNA
Purified RNA
Red blood cells
Umbilical cord blood/tissue
Blood smear
Faeces/meconium
Exhaled breathe condensate
Sputum induction
Placenta
General information
Pre-pregnancy During pregnancy <1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
EducationXX
IncomeXX
Employment statusXX
Job titleXX
Single parenthoodXX
Home addressXXX
Work address
Maternal characteristics related to the index pregnancy/child
Age at birthX
EthnicityX
Country of birthX
Planned pregnancy
Time to pregnancy
Fertility treatment
Prior spontaneous abortion (<22w)X
Prior birthsX
Ultrasound measurements
Doppler measurements
PreeclampsiaX
Gestational diabetesX
Gestational hypertensionX
Gestational durationX
Mode of deliveryX
Prenatal diagnosticsX
Medical termination of pregnancy
Maternal Exposures ---------- Timing of assessment ----------
Pre-pregnancy First trimester Second trimester Third trimester Post pregnancy
DietXXXX
Dietary supplementsXXXX
Active smokingXXXXX
Passive smoking
Alcohol consumptionXXXXX
Physical activityXXXX
Substance use
Medicine intakeXXXX
Coffee drinkingXXXX
Psychological distress (e.g. life-events, health behaviors, perceived stress)XXXX
Occupational exposures
Heavy lifts
Work hours
Air pollutionXXXX
Access to green spaces
Built environment
Noise
Radiation, electromagnetic fields
Water contamination
Binge drinking
Pets
Farm animal exposure
Biomarkers of exposure
Mercury
Lead
Cadmium
Arsenic
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds
Bisphenol A
Other bisphenols
Parabens
Benzophenones
Triclosan
Phthalates
Cotinine
Maternal health ---------- Timing of assessment ----------
Pre-pregnancy First trimester Second trimester Third trimester Post pregnancy
Anthropometry
WeightXXXX
HeightXXXX
Waist circumference
Clinical examinations
Blood pressureXXXX
Carotida intima media thickness
Pulse wave velocity
DEXA scans
Bioimpedence
Mental and neurological development
Mental healthXXXX
Cognitive function (e.g. intelligence quotient)X
Respiratory health
Asthma
Allergy
Musculo‐skeletal disease
Back pain
Neck pain
Arthritis
Other health outcomes
Cancer
Diabetes
Cardio‐vascular disease
Family history of chronic disease
Infectious disease
Fever
Autoimmune disease
Urinary symptoms
Sexual problems
Sleep disturbance
Biomarkers of health
Nephrology (e.g. creatinine, albumin)
Thyroid hormones
Inflammatory markers (e.g. C-reactive protein cytokines)XXXX
Immunologic markers (e.g. immunoglobulines)
CortisolXXXX
Vitamines and micronutrientsXX
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)
Metabolomics
DNA methylation
Transcriptomics (mRNA, miRNA)
Genome-wide association study (GWAS)
Maternal biological samples ---------- Timing of sampling ----------
Pre-pregnancy First trimester Second trimester Third trimester Post pregnancy
Breast milk
Whole blood
SerumXXXX
PlasmaXXXX
Buffy coat
UrineXXXX
Hair
Nails
Saliva
Purified DNAXXXX
Purified RNA
Red blood cells
Faeces
General information
Pre-pregnancy During pregnancy <1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
EducationXXXX
IncomeXXXX
Employment statusXXXX
Job titleXXXX
Single parenthoodXXXX
Home addressXXXX
Work address
Paternal characteristics related to the index pregnancy/child
Fertility treatment
Age at child's birthX
EthnicityX
Country of birthX
Paternal exposures ---------- Timing of assessment ----------
Pre-pregnancy During pregnancy Post pregnancy
Diet
Dietary supplements
Active smoking
Passive smoking
Alcohol consumption
Physical activity
Substance use
Medicine intake
Coffee drinking
Psychological distress (e.g. life-events, health behaviors, perceived stress)
Occupational exposures
Heavy lifts
Work hours
Air pollution
Access to green spaces
Built environment
Noise
Radiation, electromagnetic fields
Water contamination
Binge drinking
Pets
Farm animal exposure
Biomarkers of exposure
Mercury
Lead
Cadmium
Arsenic
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds
Bisphenol A
Other bisphenols
Parabens
Benzophenones
Triclosan
Phthalates
Cotinine
Paternal health ---------- Timing of assessment ----------
Pre-pregnancy During pregnancy Post pregnancy
Anthropometry
Weight
Height
Waist circumference
Clinical examinations
Blood pressure
Carotida intima media thickness
Pulse wave velocity
DEXA scans
Bio impedence
Mental and neurological development
Mental healthX
Cognitive function (e.g. intelligence quotient)X
Respiratory health
Asthma
Allergy
Musculo‐skeletal disease
Back pain
Neck pain
Arthritis
Other health outcomes
Cancer
Diabetes
Cardio‐vascular disease
Family history of chronic disease
Infectious disease
Fever
Autoimmune disease
Urinary symptoms
Sexual problems
Sleep disturbance
Biomarkers of health
Nephrology (e.g. creatinine, albumin)
Thyroid hormones
Inflammatory markers (e.g. C-reactive protein cytokines)
Immunologic markers (e.g. immunoglobulines)
Cortisol
Vitamines and micronutrients
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)
Metabolomics
DNA methylation
Transcriptomics (mRNA, miRNA)
Genome-wide association study (GWAS)
Paternal biological samples ---------- Timing of sampling ----------
Pre-pregnancy During pregnancy Post pregnancy
Semen
Whole blood
Serum
Plasma
Buffy coat
Urine
Hair
Nails
Saliva
Purified DNA
Purified RNA
Red blood cells
Faeces
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