• Cohort, name
    The Prospective Epidemiological Research Studies in Iran Birth Cohort

    Cohort, abbreviation
    PERSIAN Birth Cohort

    Cohort, country
    Iran (ایران)

    Cohort, website
    http://persian-bc.cfamily

    Key reference
    Prevention, Epigenetic, Neurodevelopment, Environmental Exposure, Growth

    Date of filling in this questionnaire:
    2018-12-11

  • Principal investigator(s), name
    Professor. Roya Kelishadi

    Principal investigator(s), e-mail address
    roya.kelishadi@gmail.com

    Principal investigator(s), institution
    Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-Communicable Disease, Isfah

    Contact person(s), name
    Prof. Roya Kelishadi

    Contact person(s), e-mail address
    roya.kelishadi@gmail.com

    Contact person(s), institution address
    Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non Communicable Disease, Isfahan University of Medical Sciences, Hezar Jerib Ave, Isfahan, Iran

  • Main aim of cohort
    The overarching aim of this project is to study the factors related to the Developmental Origins of Health and Diseases (DOHaD) in Iranian population. Towards this aim, we will evaluate the impact of socioenvironmental, psychological and genetic factors on pregnancy outcomes, child mental and physical health, growth, and development, and early- and late-onset chronic non-communicable diseases.

    Recruited number of:
    15000 children / 15000 mothers / 15000 fathers / 0 grand parents / 0 other family members

    Approximate proportion of source population included
    10

    Source population
    Nation-based

  • Period of enrollment
    Start: 2016-01-01, End: 2019-03-20

    Enrollment period
    Pregnancy, week 0 to 12

    Enrollment criteria, please specify
    We enroll pregnant women with Iranian nationality, reside in the catchment area of the study center, plan to give birth in the hospitals located in the city where the cohort is undergoing, natural pregnancy or with history of using assisted reproductive techniques for treating infertility, and do not have any communication problems. Pregnancies ending in both natural vaginal delivery and Cesarean section are included in the study.

    Exclusion criteria, please specify
    Those women who would migrate from the city of the ongoing cohort, Give birth in not a reference hospital, and those without compliance to follow the study will be excluded from the study.

    Planned age of children at end of follow-up
    10 years
General information ---------- Child age (years) at assessment ----------
<1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
Home addressX
School addressX
Birth outcomes
Birth weightX
Birth lengthX
Gestational age at birthX
Apgar scoreX
Congenital malformationsX
Stillbirth (>= 22 weeks)X
Child’s sexX
Head circumferenceX
Biparietal diameterX
Child exposures ---------- Child age (years) at assessment ----------
<1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
Breast feedingXXX
DietXXXXXXXXXXX
Dietary supplementsXXXXXXXXXXX
Childcare attendanceXXXXXXX
Active smokingX
Passive smokingXXXXXXXXXXX
Alcohol consumption
Physical activityXXXXXXXXX
Substance use
Medicine intakeXXXXXXXXXX
VaccinationsXXXX
Psychological distress (e.g. bullying)XXXXXX
Air pollutionXXXXXXXXXXX
Access to green spacesXXXXXXXXXXX
Built environmentXXXXXXXXXXX
NoiseXXXXXXXXXXX
Radiation, electromagnetic fieldsXXXXXXXXXXX
Water contaminationXXXXXXXXXXX
PetsXXXXXXXXXXX
Farm animal exposureXXXXXXXXXXX
Biomarkers of exposure
MercuryXX
Lead
Cadmium
ArsenicXX
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds
Bisphenol A
Other bisphenols
ParabensX
Benzophenones
Triclosan
PhthalatesXX
Cotinine
Child development and health ---------- Child age (years) at assessment ----------
<1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
Anthropometry
WeightXXXXXXXXXXX
HeightXXXXXXXXXXX
Head circumferenceXXXX
Abdominal circumferenceXXXXXXXXX
Arm circumferenceXXXXXXXXXX
Wrist circumferenceX
Waist circumferenceXXXXXXXXX
Clinical examinations
Blood pressureXXXXXXXXXX
Carotida intima media thickness
Pulse wave velocity
Cardiac ultrasound
Renal ultrasound
Brain MRI
Other MRI
DEXA‐scan results
Skin folds
Bio impedence
Oscilometry
Spirometry
Skin prick test
Bronchial challenge test
Reversibility test
Dental observationsXXX
Mental and neurological development
Cognitive functionX
School performance
LanguageXX
ADHDX
AutismXX
Sleep disturbancesXX
Mental healthXXXXXXXX
Respiratory health
AsthmaXXX
AllergyXXX
Allergic rhinitisXXX
EczemaXXX
Respiratory tract infectionsXXX
Senses
VisionXXXXX
HearingXXXX
Musculo-skeletal health
Back pain
Neck pain
Growing painsXXXX
Sexual maturation
Tanner stageXXXXX
Pubertal development stageXXXXX
Age at menarcheXXXX
Age at voice changeXX
2D/4D digit ratio
Nocturnal ejaculationX
AcneX
Other health outcomes
CancerXXXXXXXXXX
DiabetesXXXXXXXXX
Congenital anomaliesXX
Biomarkers of health
Nephrology (e.g. creatinine, albumin)
Thyroid hormonesX
Inflammatory markers (e.g. C-reactive protein cytokines)
Immunologic markers (e.g. immunoglobulines)
Cortisol
Vitamines and micronutrientsX
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)XX
Metabolomics
DNA methylationX
Transcriptomics (mRNA, miRNA)
Genome-wide association study (GWAS)
Child biological samples ---------- Child age (years) at sampling ----------
At birth 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
Whole blood
Serum
Plasma
Buffy coatX
UrineXX
HairXX
TeethXX
NailsX
Saliva
Purified DNA
Purified RNA
Red blood cells
Umbilical cord blood/tissueX
Blood smear
Faeces/meconiumXX
Exhaled breathe condensate
Sputum induction
Placenta
General information
Pre-pregnancy During pregnancy <1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
EducationXX
IncomeXX
Employment statusXXXX
Job titleXXXX
Single parenthoodXXXXX
Home addressXXXXX
Work addressXX
Maternal characteristics related to the index pregnancy/child
Age at birthX
EthnicityX
Country of birthX
Planned pregnancyX
Time to pregnancyX
Fertility treatmentX
Prior spontaneous abortion (<22w)X
Prior birthsX
Ultrasound measurementsX
Doppler measurements
PreeclampsiaX
Gestational diabetesX
Gestational hypertensionX
Gestational durationX
Mode of deliveryX
Prenatal diagnosticsX
Medical termination of pregnancyX
Maternal Exposures ---------- Timing of assessment ----------
Pre-pregnancy First trimester Second trimester Third trimester Post pregnancy
DietXXXX
Dietary supplementsXXXX
Active smokingXXX
Passive smokingXXXX
Alcohol consumptionXXX
Physical activityXXX
Substance useXXX
Medicine intakeXXXX
Coffee drinkingXXXX
Psychological distress (e.g. life-events, health behaviors, perceived stress)X
Occupational exposuresXXXX
Heavy liftsXXX
Work hoursXXXX
Air pollutionXXX
Access to green spacesXXX
Built environmentXXXX
NoiseXXX
Radiation, electromagnetic fieldsXXX
Water contaminationXXX
Binge drinkingXXX
PetsXXX
Farm animal exposureXX
Biomarkers of exposure
MercuryXXX
Lead
CadmiumX
ArsenicXXX
Other metals
Polychlorinated biphenyl estersXXX
Dicloro difenil tricloroetanoXXX
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds
Bisphenol AX
Other bisphenols
ParabensX
Benzophenones
Triclosan
PhthalatesXXX
Cotinine
Maternal health ---------- Timing of assessment ----------
Pre-pregnancy First trimester Second trimester Third trimester Post pregnancy
Anthropometry
WeightXXXX
HeightXXXX
Waist circumferenceXXXX
Clinical examinations
Blood pressureXXXX
Carotida intima media thickness
Pulse wave velocity
DEXA scans
Bioimpedence
Mental and neurological development
Mental healthX
Cognitive function (e.g. intelligence quotient)X
Respiratory health
AsthmaXXXX
AllergyXXXX
Musculo‐skeletal disease
Back painXXXX
Neck painXXXX
ArthritisXXXX
Other health outcomes
CancerXXXX
DiabetesXXXX
Cardio‐vascular diseaseXXXX
Family history of chronic diseaseXXXX
Infectious diseaseXXXX
FeverXXXX
Autoimmune diseaseXXXX
Urinary symptomsXXXX
Sexual problemsXXXX
Sleep disturbanceXXXX
Biomarkers of health
Nephrology (e.g. creatinine, albumin)X
Thyroid hormonesX
Inflammatory markers (e.g. C-reactive protein cytokines)X
Immunologic markers (e.g. immunoglobulines)
Cortisol
Vitamines and micronutrientsX
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)X
Metabolomics
DNA methylation
Transcriptomics (mRNA, miRNA)
Genome-wide association study (GWAS)
Maternal biological samples ---------- Timing of sampling ----------
Pre-pregnancy First trimester Second trimester Third trimester Post pregnancy
Breast milkX
Whole blood
SerumXXX
Plasma
Buffy coat
UrineXXX
HairXXX
NailsXXX
Saliva
Purified DNA
Purified RNA
Red blood cells
Faeces
General information
Pre-pregnancy During pregnancy <1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
EducationX
IncomeX
Employment statusX
Job titleX
Single parenthoodX
Home addressX
Work addressX
Paternal characteristics related to the index pregnancy/child
Fertility treatmentX
Age at child's birthX
EthnicityX
Country of birthX
Paternal exposures ---------- Timing of assessment ----------
Pre-pregnancy During pregnancy Post pregnancy
DietX
Dietary supplementsX
Active smokingX
Passive smokingX
Alcohol consumption
Physical activity
Substance useX
Medicine intakeX
Coffee drinking
Psychological distress (e.g. life-events, health behaviors, perceived stress)
Occupational exposures
Heavy lifts
Work hoursX
Air pollution
Access to green spaces
Built environment
Noise
Radiation, electromagnetic fieldsX
Water contamination
Binge drinking
Pets
Farm animal exposure
Biomarkers of exposure
Mercury
Lead
Cadmium
Arsenic
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds
Bisphenol A
Other bisphenols
Parabens
Benzophenones
Triclosan
Phthalates
Cotinine
Paternal health ---------- Timing of assessment ----------
Pre-pregnancy During pregnancy Post pregnancy
Anthropometry
WeightX
HeightX
Waist circumferenceX
Clinical examinations
Blood pressure
Carotida intima media thickness
Pulse wave velocity
DEXA scans
Bio impedence
Mental and neurological development
Mental healthX
Cognitive function (e.g. intelligence quotient)
Respiratory health
AsthmaX
AllergyX
Musculo‐skeletal disease
Back pain
Neck pain
Arthritis
Other health outcomes
CancerX
DiabetesX
Cardio‐vascular diseaseX
Family history of chronic diseaseX
Infectious diseaseX
FeverX
Autoimmune diseaseX
Urinary symptomsX
Sexual problemsX
Sleep disturbanceX
Biomarkers of health
Nephrology (e.g. creatinine, albumin)
Thyroid hormones
Inflammatory markers (e.g. C-reactive protein cytokines)
Immunologic markers (e.g. immunoglobulines)
Cortisol
Vitamines and micronutrients
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)
Metabolomics
DNA methylation
Transcriptomics (mRNA, miRNA)
Genome-wide association study (GWAS)
Paternal biological samples ---------- Timing of sampling ----------
Pre-pregnancy During pregnancy Post pregnancy
Semen
Whole blood
Serum
Plasma
Buffy coat
Urine
Hair
Nails
Saliva
Purified DNA
Purified RNA
Red blood cells
Faeces
Comments and ideas
Some variables are being checked in sub-samples of the cohort. Some items will be added during the cohort period.