• Cohort, name
    LiNA

    Cohort, abbreviation
    Lifestyle and environmental factors and their Influence on Newborns Allergy risk

    Cohort, country
    Germany (Deutschland)

    Cohort, website
    https://www.ufz.de/index.php?de=37715

    Cohort, facebook-site
    none

    Key reference
    mother-child birth cohort, environmental exposure, chemicals, epigenetics, immune system, allergic diseases, obesity

    Date of filling in this questionnaire:
    2019-05-06

  • Principal investigator(s), name
    Gunda Herberth

    Principal investigator(s), e-mail address
    gunda.herberth@uz.de

    Principal investigator(s), institution
    Helmholtz Centre for Environmental Research

    Contact person(s), name
    Stefan Roeder, Gunda Herberth

    Contact person(s), e-mail address
    stefan.roeder@ufz.de, gunda.herberth@uz.de

    Contact person(s), institution address
    Helmholtz Centre for Environmental Research

  • Main aim of cohort
    The mother-child study LINA (Lifestyle and Environmental factors and their Influence on Newborns Allergy risk) is a birth cohort study designed to investigate the influence of prenatal life style and environmental factors on newborn allergy risk. Six hundred and twenty-two mother-child pairs were recruited from May 2006 to December 2008 in Leipzig, Germany. Maternal blood samples were collected during pregnancy at week 34 of gestation. Venous umbilical cord blood was obtained at delivery. Children and mothers were followed up every year thereafter. Exposure under investigation includes: * chemicals in the environment, * social and life style factors (social economic status, parental education, living conditions, renovation actvities, pet ownership, nutrition, mode of transportation, screen time) Assesed outcomes are: * development of the immune system (IgE, immune parameters, cytokines, chemokines, regulatory T cells) * metabolomics (endogenous metabolites, chemical metabolites) * allergic disorders (atopic dermatitis, hay fever, asthma, allergic sensitisation), * obesity, * behaviour, * respiratory disorders (wheezing, bronchitis, obstructive bronchitis, rhinitis)

    Recruited number of:
    629 children / 622 mothers / 0 fathers / 0 grand parents / 0 other family members

    Approximate proportion of source population included
    0

    Source population
    Region-based

  • Period of enrollment
    Start: 2006-01-01, End: 2008-12-31

    Enrollment period
    Pregnancy, week 20 to 34

    Enrollment criteria, please specify
    healthy mothers (caucasian), birth weight >=2500 g, gestational age > 36 wk

    Exclusion criteria, please specify
    non communicable diseases

    Planned age of children at end of follow-up
    Life-long / unrestricted
General information ---------- Child age (years) at assessment ----------
<1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
Home addressXXXXXXXXXXX
School addressXXXXXXXX
Birth outcomes
Birth weightX
Birth lengthX
Gestational age at birthX
Apgar scoreX
Congenital malformations
Stillbirth (>= 22 weeks)
Child’s sexX
Head circumferenceX
Biparietal diameter
Child exposures ---------- Child age (years) at assessment ----------
<1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
Breast feedingXXXX
DietXXXX
Dietary supplementsXXXXXXXXXXX
Childcare attendanceXXXXXXX
Active smoking
Passive smokingXXXXXXXXXXX
Alcohol consumption
Physical activityXXX
Substance use
Medicine intake
Vaccinations
Psychological distress (e.g. bullying)X
Air pollutionXXXXXXXXX
Access to green spacesXXXXXXXXX
Built environmentXXXXXXXXX
NoiseXXXXXXXXX
Radiation, electromagnetic fields
Water contamination
PetsXXXXXXXXX
Farm animal exposure
Biomarkers of exposure
Mercury
Lead
Cadmium
Arsenic
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
HexachlorobenzeneXX
Brominated flame retardants
Perflouralkyl compounds
Bisphenol AX
Other bisphenols
ParabensX
Benzophenones
Triclosan
PhthalatesX
CotinineXXXXXXXXX
Child development and health ---------- Child age (years) at assessment ----------
<1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
Anthropometry
WeightXXXXXXXX
HeightXXXXXXXX
Head circumferenceXXXXXXXX
Abdominal circumference
Arm circumference
Wrist circumference
Waist circumference
Clinical examinations
Blood pressure
Carotida intima media thickness
Pulse wave velocity
Cardiac ultrasound
Renal ultrasound
Brain MRI
Other MRI
DEXA‐scan results
Skin folds
Bio impedenceXXX
Oscilometry
SpirometryXXX
Skin prick test
Bronchial challenge test
Reversibility test
Dental observationsX
Mental and neurological development
Cognitive function
School performance
Language
ADHDXX
Autism
Sleep disturbances
Mental health
Respiratory health
AsthmaXXXXXXXX
AllergyXXXXXXXX
Allergic rhinitisXXXXXXXX
EczemaXXXXXXXX
Respiratory tract infectionsXXXXXXXX
Senses
Vision
Hearing
Musculo-skeletal health
Back pain
Neck pain
Growing pains
Sexual maturation
Tanner stage
Pubertal development stage
Age at menarche
Age at voice change
2D/4D digit ratio
Nocturnal ejaculation
Acne
Other health outcomes
Cancer
Diabetes
Congenital anomalies
Biomarkers of health
Nephrology (e.g. creatinine, albumin)
Thyroid hormones
Inflammatory markers (e.g. C-reactive protein cytokines)XXXXXXXXX
Immunologic markers (e.g. immunoglobulines)XXXXXXXXX
Cortisol
Vitamines and micronutrientsXXX
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)X
MetabolomicsXX
DNA methylationX
Transcriptomics (mRNA, miRNA)XXX
Genome-wide association study (GWAS)
Child biological samples ---------- Child age (years) at sampling ----------
At birth 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
Whole bloodXXXXXXXXX
SerumXXXXXXXXX
PlasmaXXXXXXXXX
Buffy coat
UrineXXXXX
Hair
TeethXXX
Nails
Saliva
Purified DNAXXXXXXXXX
Purified RNAXXXXXXXXX
Red blood cells
Umbilical cord blood/tissue
Blood smear
Faeces/meconiumX
Exhaled breathe condensate
Sputum induction
Placenta
General information
Pre-pregnancy During pregnancy <1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
EducationX
IncomeXXXXXXXXX
Employment statusX
Job title
Single parenthoodX
Home addressX
Work address
Maternal characteristics related to the index pregnancy/child
Age at birthX
EthnicityX
Country of birthX
Planned pregnancy
Time to pregnancy
Fertility treatment
Prior spontaneous abortion (<22w)
Prior birthsX
Ultrasound measurements
Doppler measurements
Preeclampsia
Gestational diabetes
Gestational hypertension
Gestational duration
Mode of deliveryX
Prenatal diagnostics
Medical termination of pregnancy
Maternal Exposures ---------- Timing of assessment ----------
Pre-pregnancy First trimester Second trimester Third trimester Post pregnancy
DietXXX
Dietary supplementsXXX
Active smokingXXX
Passive smokingXXX
Alcohol consumptionXXX
Physical activity
Substance use
Medicine intakeXXX
Coffee drinking
Psychological distress (e.g. life-events, health behaviors, perceived stress)XXX
Occupational exposures
Heavy lifts
Work hoursXXX
Air pollutionXXX
Access to green spacesXXX
Built environmentXXX
NoiseXXX
Radiation, electromagnetic fields
Water contamination
Binge drinking
PetsXXX
Farm animal exposure
Biomarkers of exposure
Mercury
Lead
Cadmium
Arsenic
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds
Bisphenol AXXX
Other bisphenols
ParabensXXX
Benzophenones
Triclosan
PhthalatesXXX
CotinineXXX
Maternal health ---------- Timing of assessment ----------
Pre-pregnancy First trimester Second trimester Third trimester Post pregnancy
Anthropometry
Weight
Height
Waist circumference
Clinical examinations
Blood pressure
Carotida intima media thickness
Pulse wave velocity
DEXA scans
Bioimpedence
Mental and neurological development
Mental health
Cognitive function (e.g. intelligence quotient)
Respiratory health
AsthmaXXX
AllergyXXX
Musculo‐skeletal disease
Back pain
Neck pain
Arthritis
Other health outcomes
Cancer
Diabetes
Cardio‐vascular disease
Family history of chronic disease
Infectious disease
Fever
Autoimmune disease
Urinary symptoms
Sexual problems
Sleep disturbance
Biomarkers of health
Nephrology (e.g. creatinine, albumin)
Thyroid hormones
Inflammatory markers (e.g. C-reactive protein cytokines)X
Immunologic markers (e.g. immunoglobulines)X
Cortisol
Vitamines and micronutrientsXXX
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)
MetabolomicsX
DNA methylationX
Transcriptomics (mRNA, miRNA)X
Genome-wide association study (GWAS)
Maternal biological samples ---------- Timing of sampling ----------
Pre-pregnancy First trimester Second trimester Third trimester Post pregnancy
Breast milk
Whole bloodX
SerumX
PlasmaX
Buffy coat
UrineX
Hair
Nails
Saliva
Purified DNAX
Purified RNAX
Red blood cells
Faeces
General information
Pre-pregnancy During pregnancy <1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
Education
Income
Employment status
Job title
Single parenthood
Home address
Work address
Paternal characteristics related to the index pregnancy/child
Fertility treatment
Age at child's birth
Ethnicity
Country of birth
Paternal exposures ---------- Timing of assessment ----------
Pre-pregnancy During pregnancy Post pregnancy
Diet
Dietary supplements
Active smoking
Passive smoking
Alcohol consumption
Physical activity
Substance use
Medicine intake
Coffee drinking
Psychological distress (e.g. life-events, health behaviors, perceived stress)
Occupational exposures
Heavy lifts
Work hours
Air pollution
Access to green spaces
Built environment
Noise
Radiation, electromagnetic fields
Water contamination
Binge drinking
Pets
Farm animal exposure
Biomarkers of exposure
Mercury
Lead
Cadmium
Arsenic
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds
Bisphenol A
Other bisphenols
Parabens
Benzophenones
Triclosan
Phthalates
Cotinine
Paternal health ---------- Timing of assessment ----------
Pre-pregnancy During pregnancy Post pregnancy
Anthropometry
Weight
Height
Waist circumference
Clinical examinations
Blood pressure
Carotida intima media thickness
Pulse wave velocity
DEXA scans
Bio impedence
Mental and neurological development
Mental health
Cognitive function (e.g. intelligence quotient)
Respiratory health
AsthmaXX
AllergyXX
Musculo‐skeletal disease
Back pain
Neck pain
Arthritis
Other health outcomes
Cancer
Diabetes
Cardio‐vascular disease
Family history of chronic disease
Infectious disease
Fever
Autoimmune disease
Urinary symptoms
Sexual problems
Sleep disturbance
Biomarkers of health
Nephrology (e.g. creatinine, albumin)
Thyroid hormones
Inflammatory markers (e.g. C-reactive protein cytokines)
Immunologic markers (e.g. immunoglobulines)
Cortisol
Vitamines and micronutrients
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)
Metabolomics
DNA methylation
Transcriptomics (mRNA, miRNA)
Genome-wide association study (GWAS)
Paternal biological samples ---------- Timing of sampling ----------
Pre-pregnancy During pregnancy Post pregnancy
Semen
Whole blood
Serum
Plasma
Buffy coat
Urine
Hair
Nails
Saliva
Purified DNA
Purified RNA
Red blood cells
Faeces
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