• Cohort, name
    The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study

    Cohort, abbreviation
    The TMM BirThree Cohort Study

    Cohort, country
    Japan (日本)

    Date of filling in this questionnaire:
    2018-04-23

  • Principal investigator(s), name
    Professor Shinichi Kuriyama

    Principal investigator(s), e-mail address
    birthree@sansedai.megabank.tohoku.ac.jp

    Principal investigator(s), institution
    Tohoku Medical Megabank Organization, Tohoku University

    Contact person(s), name
    Associate Professor Taku Obara

    Contact person(s), e-mail address
    birthree@sansedai.megabank.tohoku.ac.jp

  • Main aim of cohort
    The aims of our study are to monitor persons’ health status and implement suitable intervention after a big disaster and to challenge missing heritability by considering relatively sufficient required factors, including familial genetic information, exposures in early life, and life-course environmental factors.

    Recruited number of:
    24000 children / 22000 mothers / 9000 fathers / 8000 grand parents / 11000 other family members

    Approximate proportion of source population included
    0

    Source population
    Other, please describePopulation-based

  • Period of enrollment
    Start: 2013-07-19, End: 2017-03-31

    Enrollment period
    Pregnancy, week  to

    Enrollment criteria, please specify
    recruited from pregnancy to a month after delivery

    Planned age of children at end of follow-up
General information ---------- Child age (years) at assessment ----------
<1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
Home addressXXXXXXXXXXXXXXXXXXX
School address
Birth outcomes
Birth weightX
Birth lengthX
Gestational age at birthX
Apgar scoreX
Congenital malformationsX
Stillbirth (>= 22 weeks)X
Child’s sexX
Head circumferenceX
Biparietal diameter
Child exposures ---------- Child age (years) at assessment ----------
<1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
Breast feedingXXXX
DietXXXXXXXXXXXXXXXXXXX
Dietary supplementsXXXXXXXXXXXXXXXXXXX
Childcare attendanceXXXXXX
Active smokingXXXXXX
Passive smokingXXXXXXXXXXXXXXXXXXX
Alcohol consumptionXXXXXX
Physical activityXXXXXXXXXXXXXXXXXXX
Substance use
Medicine intakeXXXXXXXXXXXXXXXXXXX
VaccinationsX
Psychological distress (e.g. bullying)XXXXXXXXXXXXXXX
Air pollution
Access to green spaces
Built environmentXXXXXXXXXXXXXXXXXXX
Noise
Radiation, electromagnetic fields
Water contamination
PetsXXXXXXXXXXXXXXXXXXX
Farm animal exposure
Biomarkers of exposure
Mercury
Lead
Cadmium
Arsenic
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds
Bisphenol A
Other bisphenols
Parabens
Benzophenones
Triclosan
Phthalates
Cotinine
Child development and health ---------- Child age (years) at assessment ----------
<1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
Anthropometry
WeightXXXXXXXXXXXXXXXXXXX
HeightXXXXXXXXXXXXXXXXXXX
Head circumferenceXXXX
Abdominal circumference
Arm circumference
Wrist circumference
Waist circumference
Clinical examinations
Blood pressureXX
Carotida intima media thickness
Pulse wave velocity
Cardiac ultrasound
Renal ultrasound
Brain MRI
Other MRI
DEXA‐scan results
Skin folds
Bio impedenceXX
Oscilometry
SpirometryXX
Skin prick test
Bronchial challenge test
Reversibility test
Dental observationsXXX
Mental and neurological development
Cognitive function
School performance
Language
ADHD
AutismX
Sleep disturbancesXXXXXXXXXXXXXXXXXXX
Mental healthXXXXXXXXXXXXXXXXXXX
Respiratory health
AsthmaXXXXXXXXXXXXXXXXXXX
AllergyXXXXXXXXXXXXXXXXXXX
Allergic rhinitisXXXXXXXXXXXXXXXXXXX
EczemaXXXXXXXXXXXXXXXXXXX
Respiratory tract infectionsXXXXXXXXXXXXXXXXXXX
Senses
VisionXXX
HearingXXX
Musculo-skeletal health
Back pain
Neck pain
Growing pains
Sexual maturation
Tanner stage
Pubertal development stage
Age at menarche
Age at voice change
2D/4D digit ratio
Nocturnal ejaculation
Acne
Other health outcomes
CancerXXXXXXXXXXXXXXXXXXX
DiabetesXXXXXXXXXXXXXXXXXXX
Congenital anomaliesX
Biomarkers of health
Nephrology (e.g. creatinine, albumin)
Thyroid hormonesXX
Inflammatory markers (e.g. C-reactive protein cytokines)
Immunologic markers (e.g. immunoglobulines)
Cortisol
Vitamines and micronutrients
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)
Metabolomics
DNA methylation
Transcriptomics (mRNA, miRNA)
Genome-wide association study (GWAS)
Child biological samples ---------- Child age (years) at sampling ----------
At birth 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
Whole blood
SerumX
PlasmaXXXX
Buffy coatXXXX
UrineXXX
Hair
Teeth
Nails
Saliva
Purified DNAXXXX
Purified RNA
Red blood cells
Umbilical cord blood/tissue
Blood smear
Faeces/meconium
Exhaled breathe condensate
Sputum induction
Placenta
General information
Pre-pregnancy During pregnancy <1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
EducationX
IncomeX
Employment statusXXXXXXX
Job titleXXX
Single parenthood
Home addressXXXXXXX
Work address
Maternal characteristics related to the index pregnancy/child
Age at birth
Ethnicity
Country of birthX
Planned pregnancy
Time to pregnancyX
Fertility treatmentX
Prior spontaneous abortion (<22w)
Prior birthsX
Ultrasound measurementsX
Doppler measurements
PreeclampsiaX
Gestational diabetesX
Gestational hypertensionX
Gestational durationX
Mode of deliveryX
Prenatal diagnosticsX
Medical termination of pregnancyX
Maternal Exposures ---------- Timing of assessment ----------
Pre-pregnancy First trimester Second trimester Third trimester Post pregnancy
DietXX
Dietary supplementsXX
Active smokingXXX
Passive smokingXXX
Alcohol consumptionXXX
Physical activityXX
Substance use
Medicine intakeXX
Coffee drinkingXX
Psychological distress (e.g. life-events, health behaviors, perceived stress)XX
Occupational exposuresXX
Heavy liftsXX
Work hoursXX
Air pollution
Access to green spaces
Built environment
NoiseXXX
Radiation, electromagnetic fields
Water contamination
Binge drinking
PetsXX
Farm animal exposure
Biomarkers of exposure
Mercury
Lead
Cadmium
Arsenic
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds
Bisphenol A
Other bisphenols
Parabens
Benzophenones
Triclosan
Phthalates
Cotinine
Maternal health ---------- Timing of assessment ----------
Pre-pregnancy First trimester Second trimester Third trimester Post pregnancy
Anthropometry
WeightXXX
HeightXXX
Waist circumferenceXXX
Clinical examinations
Blood pressureXXX
Carotida intima media thicknessXXX
Pulse wave velocity
DEXA scans
BioimpedenceXXX
Mental and neurological development
Mental healthXXX
Cognitive function (e.g. intelligence quotient)
Respiratory health
Asthma
Allergy
Musculo‐skeletal disease
Back pain
Neck pain
Arthritis
Other health outcomes
Cancer
Diabetes
Cardio‐vascular disease
Family history of chronic disease
Infectious diseaseXX
Fever
Autoimmune disease
Urinary symptoms
Sexual problems
Sleep disturbanceXXX
Biomarkers of health
Nephrology (e.g. creatinine, albumin)XXX
Thyroid hormones
Inflammatory markers (e.g. C-reactive protein cytokines)
Immunologic markers (e.g. immunoglobulines)
Cortisol
Vitamines and micronutrients
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)
MetabolomicsXXX
DNA methylation
Transcriptomics (mRNA, miRNA)XXX
Genome-wide association study (GWAS)XXX
Maternal biological samples ---------- Timing of sampling ----------
Pre-pregnancy First trimester Second trimester Third trimester Post pregnancy
Breast milkX
Whole blood
SerumXXX
PlasmaXXX
Buffy coatXXX
UrineXXX
Hair
Nails
Saliva
Purified DNAXXX
Purified RNA
Red blood cells
Faeces
General information
Pre-pregnancy During pregnancy <1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
EducationX
IncomeX
Employment statusXXXXXX
Job titleX
Single parenthood
Home addressXXXXXXX
Work address
Paternal characteristics related to the index pregnancy/child
Fertility treatment
Age at child's birth
Ethnicity
Country of birthX
Paternal exposures ---------- Timing of assessment ----------
Pre-pregnancy During pregnancy Post pregnancy
DietXX
Dietary supplementsXX
Active smokingX
Passive smokingX
Alcohol consumptionX
Physical activityXX
Substance use
Medicine intakeXX
Coffee drinkingXX
Psychological distress (e.g. life-events, health behaviors, perceived stress)XX
Occupational exposuresX
Heavy liftsX
Work hoursX
Air pollution
Access to green spacesX
Built environmentXX
NoiseX
Radiation, electromagnetic fields
Water contamination
Binge drinking
PetsX
Farm animal exposure
Biomarkers of exposure
Mercury
Lead
Cadmium
Arsenic
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds
Bisphenol A
Other bisphenols
Parabens
Benzophenones
Triclosan
Phthalates
Cotinine
Paternal health ---------- Timing of assessment ----------
Pre-pregnancy During pregnancy Post pregnancy
Anthropometry
WeightXX
HeightXX
Waist circumferenceXX
Clinical examinations
Blood pressureXX
Carotida intima media thicknessXX
Pulse wave velocity
DEXA scans
Bio impedenceXX
Mental and neurological development
Mental healthXX
Cognitive function (e.g. intelligence quotient)XX
Respiratory health
AsthmaXX
AllergyXX
Musculo‐skeletal disease
Back pain
Neck pain
Arthritis
Other health outcomes
CancerXX
DiabetesXX
Cardio‐vascular diseaseXX
Family history of chronic diseaseXX
Infectious diseaseXX
Fever
Autoimmune diseaseXX
Urinary symptoms
Sexual problems
Sleep disturbanceXX
Biomarkers of health
Nephrology (e.g. creatinine, albumin)XX
Thyroid hormonesX
Inflammatory markers (e.g. C-reactive protein cytokines)X
Immunologic markers (e.g. immunoglobulines)
Cortisol
Vitamines and micronutrients
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)
MetabolomicsX
DNA methylation
Transcriptomics (mRNA, miRNA)X
Genome-wide association study (GWAS)X
Paternal biological samples ---------- Timing of sampling ----------
Pre-pregnancy During pregnancy Post pregnancy
Semen
Whole blood
SerumX
PlasmaX
Buffy coatX
UrineX
Hair
Nails
Saliva
Purified DNA
Purified RNA
Red blood cells
Faeces
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