• Cohort, name
    PIAMA (Prevention and Incidence of Asthma and Mite Allergy)

    Cohort, abbreviation
    PIAMA

    Cohort, country
    Netherlands (Nederland)

    Cohort, website
    http://piama.iras.uu.nl/index-en.php

    Key reference
    Brunekreef B, Smit J, de Jongste J, Neijens H, Gerritsen J, Postma D, et al. 2002. The prevention and incidence of asthma and mite allergy (piama) birth cohort study: Design and first results. Pediatr Allergy Immunol 13 Suppl 15:55-60. Wijga AH, Kerkhof M, Gehring U, de Jongste JC, Postma DS, Aalberse RC, et al. 2014. Cohort profile: The prevention and incidence of asthma and mite allergy (piama) birth cohort. Int J Epidemiol 43:527-535.

    Date of filling in this questionnaire:
    2018-06-21

  • Principal investigator(s), name
    Bert Brunekreef; Jet Smit

    Principal investigator(s), e-mail address
    b.brunekreef@uu.nl; H.A.Smit@umcutrecht.nl

    Principal investigator(s), institution
    Utrecht University; University Medical Center Utrecht

    Contact person(s), name
    Alet Wijga; Ulrike Gehring

    Contact person(s), e-mail address
    alet.wijga@rivm.nl; u.gehring@uu.nl

    Contact person(s), institution address
    Centre for Prevention and Health Services, National Institute for Public Health and the Environment, Bilthoven, The Netherlands; Institute for Risk Assessment Sciences (IRAS), Utrecht University, The Netherlands

  • Main aim of cohort
    The PIAMA study was set up (1) To investigate the effect of mite-allergen avoidance on the incidence of asthma in childhood (Intervention Study); and (2) To investigate the incidence of asthma in children from 0 to 8 years of age (Natural History Study). Main outcomes: IgE, BHR, eNO, SPT, asthma & allergy symptoms & diagnosis Main exposures: allergens, endotoxin, mould components, indoor air pollution (ETS & NO2), outdoor air pollution (from traffic), nutrition (allergens, antioxidants, fatty acids, breast feeding etc). In addition, anthropometric data have been collected since birth. In the course of the study genetic and genomic studies were incorporated also. When the study was extended beyond the originally planned 8 years, into adolescence, early markers of cardiometabolic risk were included in the study as additional health outcomes.

    Recruited number of:
    3963 children / 4146 mothers / 4116 fathers / 0 grand parents / 0 other family members

    Approximate proportion of source population included
    0

    Source population
    Region-based

  • Period of enrollment
    Start: 1996-03-01, End: 1997-05-31

    Enrollment period
    Pregnancy, week  to

    Enrollment criteria, please specify
    PIAMA is a population-based birth cohort. Pregnant women were recruited during their second trimester from the general population through 52 antenatal clinics located in the North, West and Center of the Netherlands, resulting in a baseline study population of 3963 children born in 1996 and 1997.

    Planned age of children at end of follow-up
    Life-long / unrestricted
General information ---------- Child age (years) at assessment ----------
<1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
Home addressXXXXXXXXXXXXXXXXXXX
School addressXXXXXXX
Birth outcomes
Birth weightX
Birth lengthX
Gestational age at birthX
Apgar scoreX
Congenital malformations
Stillbirth (>= 22 weeks)
Child’s sexX
Head circumferenceX
Biparietal diameter
Child exposures ---------- Child age (years) at assessment ----------
<1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
Breast feedingXX
DietXXXXXXXXXXXX
Dietary supplements
Childcare attendanceXXXXX
Active smokingXXX
Passive smokingXXXXXXXXXXXX
Alcohol consumptionXXX
Physical activityXXXXX
Substance useXXX
Medicine intakeXXXXXXXXXXX
VaccinationsXXX
Psychological distress (e.g. bullying)XX
Air pollutionXXXXXXXXXXXXXXXXXXX
Access to green spacesXXXXXXXXXXXXXXXXXXX
Built environment
NoiseXXXXXXXXXXXXXXXXXXX
Radiation, electromagnetic fields
Water contamination
PetsXXXXXXXXXXXX
Farm animal exposureXXXXX
Biomarkers of exposure
Mercury
Lead
Cadmium
Arsenic
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds
Bisphenol A
Other bisphenols
Parabens
Benzophenones
Triclosan
Phthalates
Cotinine
Child development and health ---------- Child age (years) at assessment ----------
<1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
Anthropometry
WeightXXXXXXXXXXXX
HeightXXXXXXXXXXXX
Head circumferenceX
Abdominal circumference
Arm circumferenceXX
Wrist circumference
Waist circumferenceXXX
Clinical examinations
Blood pressureXX
Carotida intima media thicknessX
Pulse wave velocity
Cardiac ultrasound
Renal ultrasound
Brain MRI
Other MRI
DEXA‐scan results
Skin folds
Bio impedence
Oscilometry
SpirometryXXX
Skin prick testX
Bronchial challenge testXX
Reversibility test
Dental observations
Mental and neurological development
Cognitive function
School performanceXX
Language
ADHDXXX
AutismX
Sleep disturbancesXXX
Mental healthXXX
Respiratory health
AsthmaXXXXXXXXXXX
AllergyXXXXXXXXXXX
Allergic rhinitisXXXXXXXXXXX
EczemaXXXXXXXXXXX
Respiratory tract infectionsXXXXXXXXXXX
Senses
Vision
Hearing
Musculo-skeletal health
Back painXXX
Neck painXXX
Growing pains
Sexual maturation
Tanner stage
Pubertal development stageXXX
Age at menarcheXXX
Age at voice change
2D/4D digit ratio
Nocturnal ejaculation
Acne
Other health outcomes
Cancer
DiabetesXXXX
Congenital anomalies
Biomarkers of health
Nephrology (e.g. creatinine, albumin)
Thyroid hormones
Inflammatory markers (e.g. C-reactive protein cytokines)X
Immunologic markers (e.g. immunoglobulines)XXXXX
CortisolX
Vitamines and micronutrients
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)XX
Metabolomics
DNA methylationXXX
Transcriptomics (mRNA, miRNA)X
Genome-wide association study (GWAS)XX
Child biological samples ---------- Child age (years) at sampling ----------
At birth 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
Whole blood
SerumXXXX
PlasmaXX
Buffy coat
Urine
Hair
Teeth
Nails
SalivaX
Purified DNA
Purified RNA
Red blood cells
Umbilical cord blood/tissue
Blood smear
Faeces/meconium
Exhaled breathe condensate
Sputum induction
Placenta
General information
Pre-pregnancy During pregnancy <1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
Education
Income
Employment status
Job title
Single parenthood
Home address
Work address
Maternal characteristics related to the index pregnancy/child
Age at birth
Ethnicity
Country of birth
Planned pregnancy
Time to pregnancy
Fertility treatment
Prior spontaneous abortion (<22w)
Prior births
Ultrasound measurements
Doppler measurements
Preeclampsia
Gestational diabetes
Gestational hypertension
Gestational duration
Mode of delivery
Prenatal diagnostics
Medical termination of pregnancy
Maternal Exposures ---------- Timing of assessment ----------
Pre-pregnancy First trimester Second trimester Third trimester Post pregnancy
Diet
Dietary supplements
Active smoking
Passive smoking
Alcohol consumption
Physical activity
Substance use
Medicine intake
Coffee drinking
Psychological distress (e.g. life-events, health behaviors, perceived stress)
Occupational exposures
Heavy lifts
Work hours
Air pollution
Access to green spaces
Built environment
Noise
Radiation, electromagnetic fields
Water contamination
Binge drinking
Pets
Farm animal exposure
Biomarkers of exposure
Mercury
Lead
Cadmium
Arsenic
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds
Bisphenol A
Other bisphenols
Parabens
Benzophenones
Triclosan
Phthalates
Cotinine
Maternal health ---------- Timing of assessment ----------
Pre-pregnancy First trimester Second trimester Third trimester Post pregnancy
Anthropometry
Weight
Height
Waist circumference
Clinical examinations
Blood pressure
Carotida intima media thickness
Pulse wave velocity
DEXA scans
Bioimpedence
Mental and neurological development
Mental health
Cognitive function (e.g. intelligence quotient)
Respiratory health
Asthma
Allergy
Musculo‐skeletal disease
Back pain
Neck pain
Arthritis
Other health outcomes
Cancer
Diabetes
Cardio‐vascular disease
Family history of chronic disease
Infectious disease
Fever
Autoimmune disease
Urinary symptoms
Sexual problems
Sleep disturbance
Biomarkers of health
Nephrology (e.g. creatinine, albumin)
Thyroid hormones
Inflammatory markers (e.g. C-reactive protein cytokines)
Immunologic markers (e.g. immunoglobulines)
Cortisol
Vitamines and micronutrients
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)
Metabolomics
DNA methylation
Transcriptomics (mRNA, miRNA)
Genome-wide association study (GWAS)
Maternal biological samples ---------- Timing of sampling ----------
Pre-pregnancy First trimester Second trimester Third trimester Post pregnancy
Breast milk
Whole blood
Serum
Plasma
Buffy coat
Urine
Hair
Nails
Saliva
Purified DNA
Purified RNA
Red blood cells
Faeces
General information
Pre-pregnancy During pregnancy <1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
Education
Income
Employment status
Job title
Single parenthood
Home address
Work address
Paternal characteristics related to the index pregnancy/child
Fertility treatment
Age at child's birth
Ethnicity
Country of birth
Paternal exposures ---------- Timing of assessment ----------
Pre-pregnancy During pregnancy Post pregnancy
Diet
Dietary supplements
Active smoking
Passive smoking
Alcohol consumption
Physical activity
Substance use
Medicine intake
Coffee drinking
Psychological distress (e.g. life-events, health behaviors, perceived stress)
Occupational exposures
Heavy lifts
Work hours
Air pollution
Access to green spaces
Built environment
Noise
Radiation, electromagnetic fields
Water contamination
Binge drinking
Pets
Farm animal exposure
Biomarkers of exposure
Mercury
Lead
Cadmium
Arsenic
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds
Bisphenol A
Other bisphenols
Parabens
Benzophenones
Triclosan
Phthalates
Cotinine
Paternal health ---------- Timing of assessment ----------
Pre-pregnancy During pregnancy Post pregnancy
Anthropometry
Weight
Height
Waist circumference
Clinical examinations
Blood pressure
Carotida intima media thickness
Pulse wave velocity
DEXA scans
Bio impedence
Mental and neurological development
Mental health
Cognitive function (e.g. intelligence quotient)
Respiratory health
Asthma
Allergy
Musculo‐skeletal disease
Back pain
Neck pain
Arthritis
Other health outcomes
Cancer
Diabetes
Cardio‐vascular disease
Family history of chronic disease
Infectious disease
Fever
Autoimmune disease
Urinary symptoms
Sexual problems
Sleep disturbance
Biomarkers of health
Nephrology (e.g. creatinine, albumin)
Thyroid hormones
Inflammatory markers (e.g. C-reactive protein cytokines)
Immunologic markers (e.g. immunoglobulines)
Cortisol
Vitamines and micronutrients
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)
Metabolomics
DNA methylation
Transcriptomics (mRNA, miRNA)
Genome-wide association study (GWAS)
Paternal biological samples ---------- Timing of sampling ----------
Pre-pregnancy During pregnancy Post pregnancy
Semen
Whole blood
Serum
Plasma
Buffy coat
Urine
Hair
Nails
Saliva
Purified DNA
Purified RNA
Red blood cells
Faeces
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