• Cohort, name
    LoewenKIDS

    Cohort, abbreviation


    Cohort, country
    Germany (Deutschland)

    Date of filling in this questionnaire:
    2018-03-23

  • Principal investigator(s), name
    Rafael Mikolajczyk

    Principal investigator(s), e-mail address
    Rafael.Mikolajczyk@uk-halle.de

    Principal investigator(s), institution
    Institute of Medical Epidemiology, Biometry and Informatics, Magdeburger Str. 8, 06112 Halle (Saale), Germany

    Contact person(s), name
    Cornelia Gottschick

    Contact person(s), e-mail address
    cornelia.gottschick@uk-halle.de

    Contact person(s), institution address
    Institute of Medical Epidemiology, Biometry and Informatics, Magdeburger Str. 8, 06112 Halle (Saale), Germany

  • Main aim of cohort
    The purpose of this study is to determine in what way infections, microbiome, and vaccinations during childhood interact in shaping the development of immunity and tolerance. The investigators collect and use data from a birth cohort focusing on infectious diseases during childhood and apply a life course perspective.

    Recruited number of:
    783 children / 0 mothers / 0 fathers / 0 grand parents / 0 other family members

    Approximate proportion of source population included
    0

    Source population
    Region-based

  • Period of enrollment
    Start: 2015-02-01, End: 2018-02-09

    Enrollment period
    Pregnancy, week 25 to 40

    Enrollment criteria, please specify
    Healthy Newborns in the Studyregions: Braunschweig, Hannover, Bremen, München, Halle (Saale), Germany

    Exclusion criteria, please specify
    Parents < 18 years old and insufficient knowledge of the German language (parents)

    Planned age of children at end of follow-up
    6 years
General information ---------- Child age (years) at assessment ----------
<1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
Home addressXXXXXXX
School address
Birth outcomes
Birth weightX
Birth lengthX
Gestational age at birthX
Apgar score
Congenital malformations
Stillbirth (>= 22 weeks)
Child’s sexX
Head circumference
Biparietal diameter
Child exposures ---------- Child age (years) at assessment ----------
<1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
Breast feedingXXX
DietXXXXXXX
Dietary supplementsXX
Childcare attendanceXXXXXX
Active smoking
Passive smokingX
Alcohol consumption
Physical activityXXXXXXX
Substance use
Medicine intakeXXXXXXX
VaccinationsXXXXXXX
Psychological distress (e.g. bullying)
Air pollution
Access to green spacesXX
Built environment
Noise
Radiation, electromagnetic fields
Water contamination
PetsXXXXXXX
Farm animal exposure
Biomarkers of exposure
Mercury
Lead
Cadmium
Arsenic
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds
Bisphenol A
Other bisphenols
Parabens
Benzophenones
Triclosan
Phthalates
Cotinine
Child development and health ---------- Child age (years) at assessment ----------
<1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
Anthropometry
Weight
Height
Head circumference
Abdominal circumference
Arm circumference
Wrist circumference
Waist circumference
Clinical examinations
Blood pressure
Carotida intima media thickness
Pulse wave velocity
Cardiac ultrasound
Renal ultrasound
Brain MRI
Other MRI
DEXA‐scan results
Skin folds
Bio impedence
Oscilometry
Spirometry
Skin prick test
Bronchial challenge test
Reversibility test
Dental observations
Mental and neurological development
Cognitive functionXXXXXX
School performance
LanguageXXXXXX
ADHD
Autism
Sleep disturbancesXXXXXX
Mental health
Respiratory health
AsthmaX
AllergyXXXXXX
Allergic rhinitisXXXXXX
EczemaXXXXXX
Respiratory tract infectionsXXXXXXX
Senses
Vision
Hearing
Musculo-skeletal health
Back pain
Neck pain
Growing pains
Sexual maturation
Tanner stage
Pubertal development stage
Age at menarche
Age at voice change
2D/4D digit ratio
Nocturnal ejaculation
Acne
Other health outcomes
Cancer
Diabetes
Congenital anomalies
Biomarkers of health
Nephrology (e.g. creatinine, albumin)
Thyroid hormones
Inflammatory markers (e.g. C-reactive protein cytokines)
Immunologic markers (e.g. immunoglobulines)
Cortisol
Vitamines and micronutrients
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)
Metabolomics
DNA methylation
Transcriptomics (mRNA, miRNA)XXXXXXX
Genome-wide association study (GWAS)
Child biological samples ---------- Child age (years) at sampling ----------
At birth 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
Whole bloodXXX
SerumXXX
Plasma
Buffy coat
Urine
Hair
Teeth
Nails
SalivaX
Purified DNA
Purified RNA
Red blood cells
Umbilical cord blood/tissueX
Blood smear
Faeces/meconiumXXXXXXX
Exhaled breathe condensate
Sputum induction
Placenta
General information
Pre-pregnancy During pregnancy <1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
EducationX
IncomeX
Employment statusXXXXXX
Job titleX
Single parenthoodX
Home addressX
Work address
Maternal characteristics related to the index pregnancy/child
Age at birthX
Ethnicity
Country of birthX
Planned pregnancy
Time to pregnancy
Fertility treatment
Prior spontaneous abortion (<22w)
Prior birthsX
Ultrasound measurements
Doppler measurements
Preeclampsia
Gestational diabetesX
Gestational hypertensionX
Gestational durationX
Mode of deliveryX
Prenatal diagnostics
Medical termination of pregnancy
Maternal Exposures ---------- Timing of assessment ----------
Pre-pregnancy First trimester Second trimester Third trimester Post pregnancy
DietXXXXX
Dietary supplementsXXX
Active smokingXXXXX
Passive smoking
Alcohol consumptionXXXX
Physical activity
Substance use
Medicine intakeXXX
Coffee drinking
Psychological distress (e.g. life-events, health behaviors, perceived stress)
Occupational exposures
Heavy lifts
Work hours
Air pollution
Access to green spaces
Built environment
Noise
Radiation, electromagnetic fields
Water contamination
Binge drinking
Pets
Farm animal exposure
Biomarkers of exposure
Mercury
Lead
Cadmium
Arsenic
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds
Bisphenol A
Other bisphenols
Parabens
Benzophenones
Triclosan
Phthalates
Cotinine
Maternal health ---------- Timing of assessment ----------
Pre-pregnancy First trimester Second trimester Third trimester Post pregnancy
Anthropometry
Weight
Height
Waist circumference
Clinical examinations
Blood pressure
Carotida intima media thickness
Pulse wave velocity
DEXA scans
Bioimpedence
Mental and neurological development
Mental health
Cognitive function (e.g. intelligence quotient)
Respiratory health
AsthmaX
AllergyX
Musculo‐skeletal disease
Back pain
Neck pain
ArthritisX
Other health outcomes
Cancer
Diabetes
Cardio‐vascular disease
Family history of chronic disease
Infectious diseaseXXX
Fever
Autoimmune diseaseX
Urinary symptoms
Sexual problems
Sleep disturbance
Biomarkers of health
Nephrology (e.g. creatinine, albumin)
Thyroid hormones
Inflammatory markers (e.g. C-reactive protein cytokines)
Immunologic markers (e.g. immunoglobulines)
Cortisol
Vitamines and micronutrients
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)
Metabolomics
DNA methylation
Transcriptomics (mRNA, miRNA)
Genome-wide association study (GWAS)
Maternal biological samples ---------- Timing of sampling ----------
Pre-pregnancy First trimester Second trimester Third trimester Post pregnancy
Breast milk
Whole blood
Serum
Plasma
Buffy coat
Urine
Hair
Nails
Saliva
Purified DNA
Purified RNA
Red blood cells
Faeces
General information
Pre-pregnancy During pregnancy <1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
EducationX
IncomeX
Employment statusXXXXXX
Job titleX
Single parenthoodX
Home addressX
Work address
Paternal characteristics related to the index pregnancy/child
Fertility treatment
Age at child's birthX
Ethnicity
Country of birthX
Paternal exposures ---------- Timing of assessment ----------
Pre-pregnancy During pregnancy Post pregnancy
Diet
Dietary supplements
Active smokingXXX
Passive smoking
Alcohol consumption
Physical activity
Substance use
Medicine intake
Coffee drinking
Psychological distress (e.g. life-events, health behaviors, perceived stress)
Occupational exposures
Heavy lifts
Work hours
Air pollution
Access to green spaces
Built environment
Noise
Radiation, electromagnetic fields
Water contamination
Binge drinking
Pets
Farm animal exposure
Biomarkers of exposure
Mercury
Lead
Cadmium
Arsenic
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds
Bisphenol A
Other bisphenols
Parabens
Benzophenones
Triclosan
Phthalates
Cotinine
Paternal health ---------- Timing of assessment ----------
Pre-pregnancy During pregnancy Post pregnancy
Anthropometry
Weight
Height
Waist circumference
Clinical examinations
Blood pressure
Carotida intima media thickness
Pulse wave velocity
DEXA scans
Bio impedence
Mental and neurological development
Mental health
Cognitive function (e.g. intelligence quotient)
Respiratory health
AsthmaX
AllergyX
Musculo‐skeletal disease
Back pain
Neck pain
ArthritisX
Other health outcomes
Cancer
Diabetes
Cardio‐vascular disease
Family history of chronic disease
Infectious diseaseXXX
Fever
Autoimmune diseaseX
Urinary symptoms
Sexual problems
Sleep disturbance
Biomarkers of health
Nephrology (e.g. creatinine, albumin)
Thyroid hormones
Inflammatory markers (e.g. C-reactive protein cytokines)
Immunologic markers (e.g. immunoglobulines)
Cortisol
Vitamines and micronutrients
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)
Metabolomics
DNA methylation
Transcriptomics (mRNA, miRNA)
Genome-wide association study (GWAS)
Paternal biological samples ---------- Timing of sampling ----------
Pre-pregnancy During pregnancy Post pregnancy
Semen
Whole blood
Serum
Plasma
Buffy coat
Urine
Hair
Nails
Saliva
Purified DNA
Purified RNA
Red blood cells
Faeces
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