• Cohort, name
    Kuopio Birth Cohort

    Cohort, abbreviation
    KuBiCo

    Cohort, country
    Finland (Suomi)

    Cohort, website
    http://www.kubico.fi/

    Date of filling in this questionnaire:
    2017-11-21

  • Principal investigator(s), name
    Leea Keski-Nisula

    Principal investigator(s), e-mail address
    leea.keski-nisula@kuh.fi

    Principal investigator(s), institution
    Kuopio University Hospital

    Contact person(s), name
    Anne Karvonen

    Contact person(s), e-mail address
    anne.karvonen@thl.fi

    Contact person(s), institution address
    National Institute for Health and Welfare (THL), P.O.Box 95, FIN-70701 Kuopio, Finland

  • Main aim of cohort
    The KuBiCo is aimed to resolve effects of genetics and different stress factors (medicines, nutrition, lifestyle factors and environmental aspects) during pregnancy on health status of the mother and the child.

    Recruited number of:
    4700 children / 4700 mothers / 0 fathers / 0 grand parents / 0 other family members

    Approximate proportion of source population included
    0

    Source population
    Region-based

  • Period of enrollment
    Start: 2012-06-01, End: 0000-00-00

    Enrollment period
    Pregnancy, week  to

    Enrollment criteria, please specify
    All pregnant women who will give a birth at Kuopio University Hospital can participate in the KuBiCo project.

    Planned age of children at end of follow-up
General information ---------- Child age (years) at assessment ----------
<1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
Home addressXX
School address
Birth outcomes
Birth weight
Birth length
Gestational age at birth
Apgar score
Congenital malformations
Stillbirth (>= 22 weeks)
Child’s sex
Head circumference
Biparietal diameter
Child exposures ---------- Child age (years) at assessment ----------
<1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
Breast feedingXXX
DietX
Dietary supplementsXXXX
Childcare attendanceXXXXX
Active smoking
Passive smokingXXXX
Alcohol consumption
Physical activityXX
Substance use
Medicine intakeXXXXX
VaccinationsXXXX
Psychological distress (e.g. bullying)
Air pollution
Access to green spaces
Built environmentXXX
Noise
Radiation, electromagnetic fields
Water contamination
PetsXXX
Farm animal exposureXXX
Biomarkers of exposure
Mercury
Lead
Cadmium
Arsenic
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds
Bisphenol A
Other bisphenols
Parabens
Benzophenones
Triclosan
Phthalates
Cotinine
Child development and health ---------- Child age (years) at assessment ----------
<1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
Anthropometry
WeightXXXXX
HeightXXXXX
Head circumferenceXXXXX
Abdominal circumference
Arm circumference
Wrist circumference
Waist circumference
Clinical examinations
Blood pressure
Carotida intima media thickness
Pulse wave velocity
Cardiac ultrasound
Renal ultrasound
Brain MRI
Other MRI
DEXA‐scan results
Skin folds
Bio impedence
Oscilometry
Spirometry
Skin prick test
Bronchial challenge test
Reversibility test
Dental observations
Mental and neurological development
Cognitive function
School performance
Language
ADHD
Autism
Sleep disturbances
Mental health
Respiratory health
AsthmaXXXXX
AllergyXXXXX
Allergic rhinitisXXXXX
EczemaXXXXX
Respiratory tract infectionsXXXXX
Senses
Vision
Hearing
Musculo-skeletal health
Back pain
Neck pain
Growing pains
Sexual maturation
Tanner stage
Pubertal development stage
Age at menarche
Age at voice change
2D/4D digit ratio
Nocturnal ejaculation
Acne
Other health outcomes
Cancer
Diabetes
Congenital anomalies
Biomarkers of health
Nephrology (e.g. creatinine, albumin)
Thyroid hormones
Inflammatory markers (e.g. C-reactive protein cytokines)
Immunologic markers (e.g. immunoglobulines)
Cortisol
Vitamines and micronutrients
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)
Metabolomics
DNA methylation
Transcriptomics (mRNA, miRNA)
Genome-wide association study (GWAS)
Child biological samples ---------- Child age (years) at sampling ----------
At birth 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
Whole blood
Serum
Plasma
Buffy coat
Urine
Hair
Teeth
Nails
SalivaX
Purified DNA
Purified RNA
Red blood cells
Umbilical cord blood/tissueX
Blood smear
Faeces/meconium
Exhaled breathe condensate
Sputum induction
PlacentaX
General information
Pre-pregnancy During pregnancy <1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
EducationX
Income
Employment statusX
Job titleX
Single parenthoodXXXXX
Home addressXXX
Work address
Maternal characteristics related to the index pregnancy/child
Age at birthX
Ethnicity
Country of birth
Planned pregnancy
Time to pregnancy
Fertility treatmentX
Prior spontaneous abortion (<22w)X
Prior birthsX
Ultrasound measurementsX
Doppler measurements
PreeclampsiaX
Gestational diabetesX
Gestational hypertensionX
Gestational durationX
Mode of delivery
Prenatal diagnostics
Medical termination of pregnancy
Maternal Exposures ---------- Timing of assessment ----------
Pre-pregnancy First trimester Second trimester Third trimester Post pregnancy
DietXXX
Dietary supplementsXX
Active smokingXXXXX
Passive smokingXXXXX
Alcohol consumptionXXXXX
Physical activityXXXX
Substance useXXXX
Medicine intakeXXXX
Coffee drinkingXX
Psychological distress (e.g. life-events, health behaviors, perceived stress)X
Occupational exposures
Heavy lifts
Work hours
Air pollution
Access to green spaces
Built environmentX
NoiseX
Radiation, electromagnetic fieldsXXX
Water contamination
Binge drinkingXX
PetsXX
Farm animal exposureXX
Biomarkers of exposure
Mercury
Lead
Cadmium
Arsenic
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds
Bisphenol A
Other bisphenols
Parabens
Benzophenones
Triclosan
Phthalates
Cotinine
Maternal health ---------- Timing of assessment ----------
Pre-pregnancy First trimester Second trimester Third trimester Post pregnancy
Anthropometry
WeightXX
HeightXX
Waist circumference
Clinical examinations
Blood pressureXXX
Carotida intima media thickness
Pulse wave velocity
DEXA scans
Bioimpedence
Mental and neurological development
Mental healthXXX
Cognitive function (e.g. intelligence quotient)
Respiratory health
AsthmaXXXX
AllergyXXXX
Musculo‐skeletal disease
Back pain
Neck pain
ArthritisXX
Other health outcomes
CancerXX
DiabetesXX
Cardio‐vascular diseaseXX
Family history of chronic diseaseXX
Infectious diseaseXX
FeverXXX
Autoimmune diseaseXX
Urinary symptoms
Sexual problems
Sleep disturbanceX
Biomarkers of health
Nephrology (e.g. creatinine, albumin)
Thyroid hormones
Inflammatory markers (e.g. C-reactive protein cytokines)
Immunologic markers (e.g. immunoglobulines)
Cortisol
Vitamines and micronutrients
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)
Metabolomics
DNA methylation
Transcriptomics (mRNA, miRNA)
Genome-wide association study (GWAS)
Maternal biological samples ---------- Timing of sampling ----------
Pre-pregnancy First trimester Second trimester Third trimester Post pregnancy
Breast milk
Whole bloodX
SerumX
Plasma
Buffy coat
Urine
Hair
Nails
Saliva
Purified DNA
Purified RNA
Red blood cells
Faeces
General information
Pre-pregnancy During pregnancy <1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
EducationX
Income
Employment statusX
Job titleX
Single parenthood
Home address
Work address
Paternal characteristics related to the index pregnancy/child
Fertility treatment
Age at child's birthX
Ethnicity
Country of birth
Paternal exposures ---------- Timing of assessment ----------
Pre-pregnancy During pregnancy Post pregnancy
Diet
Dietary supplements
Active smokingXX
Passive smoking
Alcohol consumptionXX
Physical activity
Substance useXX
Medicine intake
Coffee drinking
Psychological distress (e.g. life-events, health behaviors, perceived stress)
Occupational exposures
Heavy lifts
Work hours
Air pollution
Access to green spaces
Built environment
Noise
Radiation, electromagnetic fields
Water contamination
Binge drinkingXX
Pets
Farm animal exposureXX
Biomarkers of exposure
Mercury
Lead
Cadmium
Arsenic
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds
Bisphenol A
Other bisphenols
Parabens
Benzophenones
Triclosan
Phthalates
Cotinine
Paternal health ---------- Timing of assessment ----------
Pre-pregnancy During pregnancy Post pregnancy
Anthropometry
WeightX
HeightX
Waist circumference
Clinical examinations
Blood pressure
Carotida intima media thickness
Pulse wave velocity
DEXA scans
Bio impedence
Mental and neurological development
Mental healthXX
Cognitive function (e.g. intelligence quotient)
Respiratory health
AsthmaXX
AllergyXX
Musculo‐skeletal disease
Back pain
Neck pain
ArthritisXX
Other health outcomes
CancerXX
DiabetesXX
Cardio‐vascular diseaseXX
Family history of chronic diseaseXX
Infectious diseaseXX
Fever
Autoimmune diseaseXX
Urinary symptoms
Sexual problems
Sleep disturbance
Biomarkers of health
Nephrology (e.g. creatinine, albumin)
Thyroid hormones
Inflammatory markers (e.g. C-reactive protein cytokines)
Immunologic markers (e.g. immunoglobulines)
Cortisol
Vitamines and micronutrients
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)
Metabolomics
DNA methylation
Transcriptomics (mRNA, miRNA)
Genome-wide association study (GWAS)
Paternal biological samples ---------- Timing of sampling ----------
Pre-pregnancy During pregnancy Post pregnancy
Semen
Whole blood
Serum
Plasma
Buffy coat
Urine
Hair
Nails
Saliva
Purified DNA
Purified RNA
Red blood cells
Faeces
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