• Cohort, name
    Lifelines NEXT

    Cohort, abbreviation


    Cohort, country
    Netherlands (Nederland)

    Cohort, website
    www.lifelines.nl/lifelines-next-2

    Date of filling in this questionnaire:
    2017-06-23

  • Principal investigator(s), name
    Prof. Dr. S.A. Scherjon

    Principal investigator(s), e-mail address
    s.a.scherjon@umcg.nl

    Principal investigator(s), institution
    University Medical Center Groningen (UMCG)

    Contact person(s), name
    Jackie Dekens

    Contact person(s), e-mail address
    j.a.m.dekens@umcg.nl

    Contact person(s), institution address
    Universitiy Medical Center Groningen (UMCG)

  • Main aim of cohort
    To investigate the effects of early life factors and pre-conceptional transgenerational events on healthy ageing and chronic disease in (early) childhood. To relate immunological, metabolic, environmental, (epi)genomic and social factors in early life development to microbiome.

    Recruited number of:
    0 children / 0 mothers / 0 fathers / 0 grand parents / 0 other family members

    Approximate proportion of source population included
    0

    Source population
    Nation-based

  • Period of enrollment
    Start: 2016-10-01, End: 0000-00-00

    Enrollment period
    Pre pregnancy  to

    Enrollment criteria, please specify
    pregnant Lifelines participant

    Planned age of children at end of follow-up
General information ---------- Child age (years) at assessment ----------
<1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
Home address
School address
Birth outcomes
Birth weightX
Birth lengthX
Gestational age at birthX
Apgar scoreX
Congenital malformations
Stillbirth (>= 22 weeks)
Child’s sexX
Head circumferenceX
Biparietal diameter
Child exposures ---------- Child age (years) at assessment ----------
<1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
Breast feedingXXXX
DietXXXXXX
Dietary supplementsXXXXXX
Childcare attendanceX
Active smoking
Passive smokingX
Alcohol consumption
Physical activity
Substance use
Medicine intakeXXXXXX
VaccinationsX
Psychological distress (e.g. bullying)
Air pollution
Access to green spaces
Built environment
Noise
Radiation, electromagnetic fields
Water contamination
PetsXXX
Farm animal exposureXXXXXX
Biomarkers of exposure
Mercury
Lead
Cadmium
Arsenic
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds
Bisphenol A
Other bisphenols
Parabens
Benzophenones
Triclosan
Phthalates
Cotinine
Child development and health ---------- Child age (years) at assessment ----------
<1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
Anthropometry
WeightXXX
HeightXXX
Head circumference
Abdominal circumference
Arm circumference
Wrist circumference
Waist circumference
Clinical examinations
Blood pressure
Carotida intima media thickness
Pulse wave velocity
Cardiac ultrasound
Renal ultrasound
Brain MRI
Other MRI
DEXA‐scan results
Skin folds
Bio impedence
Oscilometry
SpirometryX
Skin prick test
Bronchial challenge test
Reversibility test
Dental observations
Mental and neurological development
Cognitive functionXX
School performance
Language
ADHD
Autism
Sleep disturbances
Mental healthX
Respiratory health
AsthmaX
AllergyXX
Allergic rhinitis
EczemaX
Respiratory tract infections
Senses
Vision
Hearing
Musculo-skeletal health
Back pain
Neck pain
Growing pains
Sexual maturation
Tanner stage
Pubertal development stage
Age at menarche
Age at voice change
2D/4D digit ratio
Nocturnal ejaculation
Acne
Other health outcomes
Cancer
Diabetes
Congenital anomalies
Biomarkers of health
Nephrology (e.g. creatinine, albumin)
Thyroid hormones
Inflammatory markers (e.g. C-reactive protein cytokines)
Immunologic markers (e.g. immunoglobulines)
Cortisol
Vitamines and micronutrients
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)
Metabolomics
DNA methylation
Transcriptomics (mRNA, miRNA)
Genome-wide association study (GWAS)
Child biological samples ---------- Child age (years) at sampling ----------
At birth 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
Whole bloodXX
Serum
Plasma
Buffy coat
UrineX
Hair
Teeth
Nails
Saliva
Purified DNA
Purified RNA
Red blood cells
Umbilical cord blood/tissueX
Blood smear
Faeces/meconiumXXXXXXX
Exhaled breathe condensate
Sputum induction
PlacentaX
General information
Pre-pregnancy During pregnancy <1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
EducationX
IncomeX
Employment statusX
Job titleX
Single parenthoodX
Home address
Work address
Maternal characteristics related to the index pregnancy/child
Age at birthX
EthnicityX
Country of birthX
Planned pregnancy
Time to pregnancy
Fertility treatment
Prior spontaneous abortion (<22w)
Prior birthsX
Ultrasound measurements
Doppler measurements
Preeclampsia
Gestational diabetesX
Gestational hypertensionX
Gestational durationX
Mode of deliveryX
Prenatal diagnostics
Medical termination of pregnancy
Maternal Exposures ---------- Timing of assessment ----------
Pre-pregnancy First trimester Second trimester Third trimester Post pregnancy
DietXXXX
Dietary supplementsX
Active smokingX
Passive smokingX
Alcohol consumptionX
Physical activityX
Substance useX
Medicine intakeXXX
Coffee drinkingX
Psychological distress (e.g. life-events, health behaviors, perceived stress)XX
Occupational exposuresX
Heavy liftsX
Work hoursX
Air pollutionX
Access to green spaces
Built environment
Noise
Radiation, electromagnetic fields
Water contamination
Binge drinking
PetsXXX
Farm animal exposureXX
Biomarkers of exposure
Mercury
Lead
Cadmium
Arsenic
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds
Bisphenol A
Other bisphenols
Parabens
Benzophenones
Triclosan
Phthalates
Cotinine
Maternal health ---------- Timing of assessment ----------
Pre-pregnancy First trimester Second trimester Third trimester Post pregnancy
Anthropometry
WeightX
HeightX
Waist circumferenceX
Clinical examinations
Blood pressureX
Carotida intima media thickness
Pulse wave velocityX
DEXA scans
Bioimpedence
Mental and neurological development
Mental healthXXX
Cognitive function (e.g. intelligence quotient)X
Respiratory health
AsthmaX
AllergyX
Musculo‐skeletal disease
Back painX
Neck painX
ArthritisX
Other health outcomes
CancerX
DiabetesX
Cardio‐vascular diseaseX
Family history of chronic diseaseX
Infectious diseaseX
FeverX
Autoimmune diseaseX
Urinary symptomsX
Sexual problemsX
Sleep disturbanceX
Biomarkers of health
Nephrology (e.g. creatinine, albumin)X
Thyroid hormonesX
Inflammatory markers (e.g. C-reactive protein cytokines)
Immunologic markers (e.g. immunoglobulines)
Cortisol
Vitamines and micronutrients
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)
Metabolomics
DNA methylation
Transcriptomics (mRNA, miRNA)
Genome-wide association study (GWAS)
Maternal biological samples ---------- Timing of sampling ----------
Pre-pregnancy First trimester Second trimester Third trimester Post pregnancy
Breast milkX
Whole blood
SerumX
PlasmaX
Buffy coat
UrineX
HairX
Nails
Saliva
Purified DNAX
Purified RNAX
Red blood cells
FaecesXXX
General information
Pre-pregnancy During pregnancy <1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
EducationX
IncomeX
Employment statusX
Job titleX
Single parenthood
Home address
Work address
Paternal characteristics related to the index pregnancy/child
Fertility treatment
Age at child's birthX
EthnicityX
Country of birthX
Paternal exposures ---------- Timing of assessment ----------
Pre-pregnancy During pregnancy Post pregnancy
DietX
Dietary supplementsX
Active smokingX
Passive smokingX
Alcohol consumptionX
Physical activityX
Substance useX
Medicine intakeX
Coffee drinkingX
Psychological distress (e.g. life-events, health behaviors, perceived stress)X
Occupational exposuresX
Heavy liftsX
Work hoursX
Air pollutionX
Access to green spaces
Built environment
Noise
Radiation, electromagnetic fields
Water contamination
Binge drinking
PetsX
Farm animal exposureX
Biomarkers of exposure
Mercury
Lead
Cadmium
Arsenic
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds
Bisphenol A
Other bisphenols
Parabens
Benzophenones
Triclosan
Phthalates
Cotinine
Paternal health ---------- Timing of assessment ----------
Pre-pregnancy During pregnancy Post pregnancy
Anthropometry
WeightX
HeightX
Waist circumferenceX
Clinical examinations
Blood pressureX
Carotida intima media thickness
Pulse wave velocityX
DEXA scans
Bio impedence
Mental and neurological development
Mental healthX
Cognitive function (e.g. intelligence quotient)X
Respiratory health
AsthmaX
AllergyX
Musculo‐skeletal disease
Back painX
Neck painX
ArthritisX
Other health outcomes
CancerX
DiabetesX
Cardio‐vascular diseaseX
Family history of chronic diseaseX
Infectious diseaseX
FeverX
Autoimmune diseaseX
Urinary symptomsX
Sexual problemsX
Sleep disturbanceX
Biomarkers of health
Nephrology (e.g. creatinine, albumin)X
Thyroid hormonesX
Inflammatory markers (e.g. C-reactive protein cytokines)
Immunologic markers (e.g. immunoglobulines)
Cortisol
Vitamines and micronutrients
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)X
Metabolomics
DNA methylation
Transcriptomics (mRNA, miRNA)
Genome-wide association study (GWAS)
Paternal biological samples ---------- Timing of sampling ----------
Pre-pregnancy During pregnancy Post pregnancy
Semen
Whole blood
SerumX
PlasmaX
Buffy coat
UrineX
HairX
Nails
Saliva
Purified DNAX
Purified RNAX
Red blood cells
Faeces
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