• Cohort, name
    BaBi study, Bielefeld Birth cohort study

    Cohort, abbreviation
    BaBi

    Cohort, country
    Germany (Deutschland)

    Cohort, website
    www.uni-bielefeld.de/babi-studie

    Cohort, facebook-site
    -

    Key reference
    Spallek, Jacob; Razum, Oliver (2012): Gesundheitschancen: Frühzeitige Weichenstellung. Dtsch Ärztebl 109 (46), A2298-A2301.

    Date of filling in this questionnaire:
    2017-04-04

  • Principal investigator(s), name
    Angelique Grosser

    Principal investigator(s), e-mail address
    angelique.grosser@uni-bielefeld.de

    Principal investigator(s), institution
    Bielefeld University

    Contact person(s), name
    Angelique Grosser, Jacob Spallek, Oliver Razum,

    Contact person(s), e-mail address
    angelique.grosser@uni-bielefeld.de, Jacob.spallek@b-tu.de, oliver.razum@uni-bielefeld.de

    Contact person(s), institution address
    Dept. of Epidemiology & International Public Health, School of Public Health, Bielefeld University, Universitätsstr. 25, 33615 Bielefeld, Germany; Department of Public Health, Brandenburg University of Technology, Universitätsplatz 1, 01968 Senftenbe

  • Main aim of cohort
    Main aim of the cohort: The BaBi study is a prospective cohort study examining the health of 1,000 mother-and-child-pairs in Bielefeld, Germany. The aim is to disentangle the effects of individual and contextual factors among the offspring of migrants and non-migrant. The BaBi-study will help to untangle the underlying reasons for health inequalities between different population groups in Germany under a life course perspective with a focus on the contribution of individual and contextual factors during pregnancy and childhood. Health inequalities will be analyzed in the areas of physical and mental/cognitive development (child), the development of allergies (child), and access to and use of health care (mother and child)

    Recruited number of:
    978 children / 970 mothers / 0 fathers / 0 grand parents / 0 other family members

    Approximate proportion of source population included
    11

    Source population
    Region-based

  • Period of enrollment
    Start: 2013-10-01, End: 2017-01-17

    Enrollment period
    Pregnancy, week  to

    Enrollment criteria, please specify
    pregnancy, as from week 14, up to 8 weeks after birth, all pregnant women aged 18 or older living in Bielefeld at time of childbirth

    Exclusion criteria, please specify
    unable to understand German, Turkish, Polish, and English

    Planned age of children at end of follow-up
    6 years
General information ---------- Child age (years) at assessment ----------
<1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
Home addressX
School address
Birth outcomes
Birth weightX
Birth lengthX
Gestational age at birthX
Apgar scoreX
Congenital malformationsX
Stillbirth (>= 22 weeks)X
Child’s sexX
Head circumferenceX
Biparietal diameterX
Child exposures ---------- Child age (years) at assessment ----------
<1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
Breast feedingXX
DietXXX
Dietary supplements
Childcare attendanceXXX
Active smoking
Passive smokingX
Alcohol consumption
Physical activity
Substance use
Medicine intakeX
VaccinationsX
Psychological distress (e.g. bullying)
Air pollution
Access to green spaces
Built environment
Noise
Radiation, electromagnetic fields
Water contamination
PetsXXXX
Farm animal exposure
Biomarkers of exposure
Mercury
Lead
Cadmium
Arsenic
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds
Bisphenol A
Other bisphenols
Parabens
Benzophenones
Triclosan
Phthalates
Cotinine
Child development and health ---------- Child age (years) at assessment ----------
<1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
Anthropometry
WeightXXXX
HeightXXXX
Head circumference
Abdominal circumference
Arm circumference
Wrist circumference
Waist circumference
Clinical examinations
Blood pressure
Carotida intima media thickness
Pulse wave velocity
Cardiac ultrasound
Renal ultrasound
Brain MRI
Other MRI
DEXA‐scan results
Skin folds
Bio impedence
Oscilometry
Spirometry
Skin prick test
Bronchial challenge test
Reversibility test
Dental observations
Mental and neurological development
Cognitive function
School performance
LanguageX
ADHD
Autism
Sleep disturbancesX
Mental healthX
Respiratory health
AsthmaX
AllergyX
Allergic rhinitisX
Eczema
Respiratory tract infections
Senses
Vision
Hearing
Musculo-skeletal health
Back pain
Neck pain
Growing pains
Sexual maturation
Tanner stage
Pubertal development stage
Age at menarche
Age at voice change
2D/4D digit ratio
Nocturnal ejaculation
Acne
Other health outcomes
Cancer
DiabetesX
Congenital anomaliesX
Biomarkers of health
Nephrology (e.g. creatinine, albumin)
Thyroid hormones
Inflammatory markers (e.g. C-reactive protein cytokines)
Immunologic markers (e.g. immunoglobulines)
Cortisol
Vitamines and micronutrients
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)
Metabolomics
DNA methylation
Transcriptomics (mRNA, miRNA)
Genome-wide association study (GWAS)
Child biological samples ---------- Child age (years) at sampling ----------
At birth 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
Whole blood
Serum
Plasma
Buffy coat
Urine
Hair
Teeth
Nails
Saliva
Purified DNA
Purified RNA
Red blood cells
Umbilical cord blood/tissue
Blood smear
Faeces/meconium
Exhaled breathe condensate
Sputum induction
Placenta
General information
Pre-pregnancy During pregnancy <1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
EducationXX
IncomeXX
Employment statusXX
Job titleXX
Single parenthoodX
Home addressXX
Work address
Maternal characteristics related to the index pregnancy/child
Age at birthX
Ethnicity
Country of birthX
Planned pregnancyX
Time to pregnancyX
Fertility treatmentX
Prior spontaneous abortion (<22w)X
Prior birthsX
Ultrasound measurements
Doppler measurements
PreeclampsiaX
Gestational diabetesX
Gestational hypertensionX
Gestational durationX
Mode of deliveryX
Prenatal diagnostics
Medical termination of pregnancyX
Maternal Exposures ---------- Timing of assessment ----------
Pre-pregnancy First trimester Second trimester Third trimester Post pregnancy
DietXXX
Dietary supplementsXXX
Active smokingXXX
Passive smokingXX
Alcohol consumptionXXX
Physical activityXXXX
Substance useXXXX
Medicine intakeXXX
Coffee drinking
Psychological distress (e.g. life-events, health behaviors, perceived stress)XXX
Occupational exposuresXXX
Heavy liftsXXX
Work hours
Air pollutionXXX
Access to green spacesXXX
Built environmentXXX
NoiseXXX
Radiation, electromagnetic fields
Water contamination
Binge drinking
PetsXXX
Farm animal exposure
Biomarkers of exposure
Mercury
Lead
Cadmium
Arsenic
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds
Bisphenol A
Other bisphenols
Parabens
Benzophenones
Triclosan
Phthalates
Cotinine
Maternal health ---------- Timing of assessment ----------
Pre-pregnancy First trimester Second trimester Third trimester Post pregnancy
Anthropometry
WeightXXXX
HeightXXXX
Waist circumference
Clinical examinations
Blood pressureXXX
Carotida intima media thicknessXXX
Pulse wave velocity
DEXA scans
Bioimpedence
Mental and neurological development
Mental health
Cognitive function (e.g. intelligence quotient)
Respiratory health
AsthmaXXXX
AllergyXXXX
Musculo‐skeletal disease
Back pain
Neck pain
Arthritis
Other health outcomes
CancerXXXX
DiabetesXXXX
Cardio‐vascular diseaseXXXX
Family history of chronic disease
Infectious diseaseXXXX
Fever
Autoimmune disease
Urinary symptoms
Sexual problems
Sleep disturbance
Biomarkers of health
Nephrology (e.g. creatinine, albumin)
Thyroid hormones
Inflammatory markers (e.g. C-reactive protein cytokines)
Immunologic markers (e.g. immunoglobulines)
Cortisol
Vitamines and micronutrients
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)
Metabolomics
DNA methylation
Transcriptomics (mRNA, miRNA)
Genome-wide association study (GWAS)
Maternal biological samples ---------- Timing of sampling ----------
Pre-pregnancy First trimester Second trimester Third trimester Post pregnancy
Breast milk
Whole blood
Serum
Plasma
Buffy coat
Urine
Hair
Nails
Saliva
Purified DNA
Purified RNA
Red blood cells
Faeces
General information
Pre-pregnancy During pregnancy <1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
EducationXX
IncomeXX
Employment statusXX
Job titleXX
Single parenthood
Home addressXX
Work address
Paternal characteristics related to the index pregnancy/child
Fertility treatmentX
Age at child's birthX
Ethnicity
Country of birthX
Paternal exposures ---------- Timing of assessment ----------
Pre-pregnancy During pregnancy Post pregnancy
Diet
Dietary supplements
Active smokingXX
Passive smoking
Alcohol consumptionX
Physical activity
Substance useX
Medicine intake
Coffee drinking
Psychological distress (e.g. life-events, health behaviors, perceived stress)
Occupational exposures
Heavy lifts
Work hours
Air pollution
Access to green spaces
Built environment
Noise
Radiation, electromagnetic fields
Water contamination
Binge drinking
Pets
Farm animal exposure
Biomarkers of exposure
Mercury
Lead
Cadmium
Arsenic
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds
Bisphenol A
Other bisphenols
Parabens
Benzophenones
Triclosan
Phthalates
Cotinine
Paternal health ---------- Timing of assessment ----------
Pre-pregnancy During pregnancy Post pregnancy
Anthropometry
WeightX
HeightX
Waist circumference
Clinical examinations
Blood pressure
Carotida intima media thickness
Pulse wave velocity
DEXA scans
Bio impedence
Mental and neurological development
Mental health
Cognitive function (e.g. intelligence quotient)
Respiratory health
AsthmaX
AllergyX
Musculo‐skeletal disease
Back pain
Neck pain
Arthritis
Other health outcomes
CancerX
DiabetesX
Cardio‐vascular diseaseX
Family history of chronic disease
Infectious disease
Fever
Autoimmune disease
Urinary symptoms
Sexual problems
Sleep disturbance
Biomarkers of health
Nephrology (e.g. creatinine, albumin)
Thyroid hormones
Inflammatory markers (e.g. C-reactive protein cytokines)
Immunologic markers (e.g. immunoglobulines)
Cortisol
Vitamines and micronutrients
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)
Metabolomics
DNA methylation
Transcriptomics (mRNA, miRNA)
Genome-wide association study (GWAS)
Paternal biological samples ---------- Timing of sampling ----------
Pre-pregnancy During pregnancy Post pregnancy
Semen
Whole blood
Serum
Plasma
Buffy coat
Urine
Hair
Nails
Saliva
Purified DNA
Purified RNA
Red blood cells
Faeces
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