• Cohort, name
    All Our Families Study

    Cohort, abbreviation
    AOF

    Cohort, country
    Canada

    Cohort, website
    http://allourfamiliesstudy.com/

    Cohort, facebook-site
    https://www.facebook.com/allourfamiliesstudy/

    Date of filling in this questionnaire:
    2018-05-22

  • Principal investigator(s), name
    Suzanne Tough

    Principal investigator(s), e-mail address
    stough@ucalgary.ca

    Principal investigator(s), institution
    Owerko Centre | Child Development Centre | #389, 3820 - 24 Avenue NW | Calgary, AB | T3B 2X9

    Contact person(s), name
    Nikki Stephenson

    Contact person(s), e-mail address
    nstephe@ucalgary.ca

    Contact person(s), institution address
    Owerko Centre | Child Development Centre | #389, 3820 - 24 Avenue NW | Calgary, AB | T3B 2X9

  • Main aim of cohort
    All Our Families (AOF) is a community-based, longitudinal pregnancy cohort (n=3387) developed to investigate the relationships between the prenatal and early life periods and outcomes for infants, children and mothers. AOF spans pregnancy, birth and early postpartum through childhood, and therefore provides the unique opportunity to describe the relations between prenatal events and early life development and to examine key factors that influence child and mother well-being over time. Through recognition of the unique opportunity to continue to collect relevant life course information on a large cohort of families, the main objectives of AOF have evolved to include the following: 1. Investigate maternal and infant outcomes during the perinatal period, with a particular emphasis on barriers and facilitators to accessing health care services in Calgary, Alberta; 2. Examine biological and environmental determinants of adverse birth outcomes, specifically spontaneous preterm birth; 3. Further investigate risk and protective factors for optimal child development, and to understand the trajectory and impact of poor maternal mental health over time. To date, mothers have completed two questionnaires during pregnancy, and then follow ups at 4 months, 1, 2, 3 and 5 years postpartum. Data collection for an 8-year follow-up questionnaire is ongoing. A subgroup within the cohort (n=1800) participated in the ‘prediction of preterm birth’ component and provided blood samples during pregnancy and an umbilical cord blood sample. The continuation of follow-up to 12 years is in development.

    Recruited number of:
    3387 children / 3387 mothers / 0 fathers / 0 grand parents / 0 other family members

    Approximate proportion of source population included
    0

    Source population
    Region-based

  • Period of enrollment
    Start: 2008-05-01, End: 2011-05-31

    Enrollment period
    Pregnancy, week 20 to 24

    Enrollment criteria, please specify
    Women were eligible if they were less than 24 weeks and 6 days gestation age at the time of recruitment, at least 18 years of age, receiving prenatal care in Calgary, and able to complete the questionnaires in English.

    Planned age of children at end of follow-up
    Life-long / unrestricted
General information ---------- Child age (years) at assessment ----------
<1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
Home address
School addressX
Birth outcomes
Birth weightX
Birth lengthX
Gestational age at birthX
Apgar scoreX
Congenital malformationsX
Stillbirth (>= 22 weeks)X
Child’s sexX
Head circumference
Biparietal diameter
Child exposures ---------- Child age (years) at assessment ----------
<1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
Breast feedingXX
DietXXXXXX
Dietary supplements
Childcare attendanceXXXXX
Active smoking
Passive smokingXXXXXX
Alcohol consumption
Physical activityXXX
Substance use
Medicine intakeXXXX
VaccinationsXXXXXX
Psychological distress (e.g. bullying)X
Air pollution
Access to green spaces
Built environment
Noise
Radiation, electromagnetic fields
Water contamination
PetsXX
Farm animal exposure
Biomarkers of exposure
Mercury
Lead
Cadmium
Arsenic
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds
Bisphenol A
Other bisphenols
Parabens
Benzophenones
Triclosan
Phthalates
Cotinine
Child development and health ---------- Child age (years) at assessment ----------
<1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
Anthropometry
WeightXXXXXX
HeightXXXXX
Head circumference
Abdominal circumference
Arm circumference
Wrist circumference
Waist circumference
Clinical examinations
Blood pressure
Carotida intima media thickness
Pulse wave velocity
Cardiac ultrasound
Renal ultrasound
Brain MRI
Other MRI
DEXA‐scan results
Skin folds
Bio impedence
Oscilometry
Spirometry
Skin prick test
Bronchial challenge test
Reversibility test
Dental observationsXX
Mental and neurological development
Cognitive functionXXXXX
School performanceXX
LanguageXXXX
ADHDXXX
AutismXXX
Sleep disturbancesXXXXX
Mental healthXXXX
Respiratory health
AsthmaXXX
AllergyXXX
Allergic rhinitis
EczemaXX
Respiratory tract infections
Senses
VisionXX
HearingX
Musculo-skeletal health
Back painX
Neck painX
Growing painsX
Sexual maturation
Tanner stage
Pubertal development stage
Age at menarche
Age at voice change
2D/4D digit ratio
Nocturnal ejaculation
Acne
Other health outcomes
Cancer
Diabetes
Congenital anomaliesXX
Biomarkers of health
Nephrology (e.g. creatinine, albumin)
Thyroid hormones
Inflammatory markers (e.g. C-reactive protein cytokines)
Immunologic markers (e.g. immunoglobulines)
Cortisol
Vitamines and micronutrients
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)
Metabolomics
DNA methylation
Transcriptomics (mRNA, miRNA)
Genome-wide association study (GWAS)
Child biological samples ---------- Child age (years) at sampling ----------
At birth 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
Whole blood
Serum
Plasma
Buffy coat
Urine
Hair
Teeth
Nails
Saliva
Purified DNA
Purified RNA
Red blood cells
Umbilical cord blood/tissueX
Blood smear
Faeces/meconium
Exhaled breathe condensate
Sputum induction
Placenta
General information
Pre-pregnancy During pregnancy <1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
EducationXXXXX
IncomeXXXX
Employment statusXXXXXX
Job titleX
Single parenthoodXXXXXX
Home address
Work address
Maternal characteristics related to the index pregnancy/child
Age at birthX
EthnicityX
Country of birthX
Planned pregnancyX
Time to pregnancyX
Fertility treatmentX
Prior spontaneous abortion (<22w)X
Prior birthsX
Ultrasound measurements
Doppler measurements
PreeclampsiaX
Gestational diabetesX
Gestational hypertensionX
Gestational durationX
Mode of deliveryX
Prenatal diagnostics
Medical termination of pregnancyX
Maternal Exposures ---------- Timing of assessment ----------
Pre-pregnancy First trimester Second trimester Third trimester Post pregnancy
DietXX
Dietary supplements
Active smokingXXXXX
Passive smokingXXX
Alcohol consumptionXXXXX
Physical activityXXXX
Substance useXXXXX
Medicine intakeXXX
Coffee drinking
Psychological distress (e.g. life-events, health behaviors, perceived stress)XXX
Occupational exposuresX
Heavy lifts
Work hoursXX
Air pollution
Access to green spaces
Built environment
Noise
Radiation, electromagnetic fields
Water contamination
Binge drinkingXXXXX
PetsX
Farm animal exposure
Biomarkers of exposure
Mercury
Lead
Cadmium
Arsenic
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds
Bisphenol A
Other bisphenols
Parabens
Benzophenones
Triclosan
Phthalates
Cotinine
Maternal health ---------- Timing of assessment ----------
Pre-pregnancy First trimester Second trimester Third trimester Post pregnancy
Anthropometry
WeightXXXX
HeightXX
Waist circumference
Clinical examinations
Blood pressureX
Carotida intima media thickness
Pulse wave velocity
DEXA scans
Bioimpedence
Mental and neurological development
Mental healthXXXX
Cognitive function (e.g. intelligence quotient)
Respiratory health
Asthma
Allergy
Musculo‐skeletal disease
Back painX
Neck painX
ArthritisX
Other health outcomes
CancerX
DiabetesXX
Cardio‐vascular diseaseX
Family history of chronic disease
Infectious disease
Fever
Autoimmune disease
Urinary symptomsX
Sexual problems
Sleep disturbanceX
Biomarkers of health
Nephrology (e.g. creatinine, albumin)
Thyroid hormones
Inflammatory markers (e.g. C-reactive protein cytokines)
Immunologic markers (e.g. immunoglobulines)
Cortisol
Vitamines and micronutrients
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)
Metabolomics
DNA methylation
Transcriptomics (mRNA, miRNA)
Genome-wide association study (GWAS)
Maternal biological samples ---------- Timing of sampling ----------
Pre-pregnancy First trimester Second trimester Third trimester Post pregnancy
Breast milk
Whole bloodXX
SerumXX
PlasmaXX
Buffy coat
Urine
Hair
Nails
Saliva
Purified DNA
Purified RNA
Red blood cells
Faeces
General information
Pre-pregnancy During pregnancy <1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
Education
Income
Employment status
Job title
Single parenthood
Home address
Work address
Paternal characteristics related to the index pregnancy/child
Fertility treatment
Age at child's birthX
EthnicityX
Country of birth
Paternal exposures ---------- Timing of assessment ----------
Pre-pregnancy During pregnancy Post pregnancy
Diet
Dietary supplements
Active smoking
Passive smoking
Alcohol consumption
Physical activity
Substance use
Medicine intake
Coffee drinking
Psychological distress (e.g. life-events, health behaviors, perceived stress)
Occupational exposures
Heavy lifts
Work hours
Air pollution
Access to green spaces
Built environment
Noise
Radiation, electromagnetic fields
Water contamination
Binge drinking
Pets
Farm animal exposure
Biomarkers of exposure
Mercury
Lead
Cadmium
Arsenic
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds
Bisphenol A
Other bisphenols
Parabens
Benzophenones
Triclosan
Phthalates
Cotinine
Paternal health ---------- Timing of assessment ----------
Pre-pregnancy During pregnancy Post pregnancy
Anthropometry
Weight
Height
Waist circumference
Clinical examinations
Blood pressure
Carotida intima media thickness
Pulse wave velocity
DEXA scans
Bio impedence
Mental and neurological development
Mental health
Cognitive function (e.g. intelligence quotient)
Respiratory health
Asthma
Allergy
Musculo‐skeletal disease
Back pain
Neck pain
Arthritis
Other health outcomes
Cancer
Diabetes
Cardio‐vascular disease
Family history of chronic disease
Infectious disease
Fever
Autoimmune disease
Urinary symptoms
Sexual problems
Sleep disturbance
Biomarkers of health
Nephrology (e.g. creatinine, albumin)
Thyroid hormones
Inflammatory markers (e.g. C-reactive protein cytokines)
Immunologic markers (e.g. immunoglobulines)
Cortisol
Vitamines and micronutrients
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)
Metabolomics
DNA methylation
Transcriptomics (mRNA, miRNA)
Genome-wide association study (GWAS)
Paternal biological samples ---------- Timing of sampling ----------
Pre-pregnancy During pregnancy Post pregnancy
Semen
Whole blood
Serum
Plasma
Buffy coat
Urine
Hair
Nails
Saliva
Purified DNA
Purified RNA
Red blood cells
Faeces
Comments and ideas
AOF participants reflect the pregnant and parenting population at local and provincial levels, and perinatal indicators from the study are comparable to perinatal surveillance data. Overall, AOF has collected detailed data on a vast array of domains including mental health, lifestyle, neighborhood, pregnancy, parenting, child development, family life, recreation, screen time, sleep and use of services. AOF variables are available to access for secondary data analysis. AOF data is stored through the Secondary Analysis to Generate Evidence (SAGE) repository, an initiative which seeks to deposit datasets in the areas of social, health, human ecology, and other related fields, and make it available for other researchers to access. Researchers interested in accessing the AOF dataset can contact AOF for more information, or visit the SAGE website directly at https://policywise.com/initiatives/sage/.