• Cohort, name
    Steps to the Healthy Development and Well-being of Children

    Cohort, abbreviation
    STEPS Study

    Cohort, country
    Finland (Suomi)

    Cohort, website
    http://www3.utu.fi/cyri/en/research/steps/

    Key reference
    Int J Epidemiol. 2013 Oct;42(5):1273-84. doi: 10.1093/ije/dys150

    Date of filling in this questionnaire:
    2013-03-12

  • Principal investigator(s), name
    Hanna Lagström

    Principal investigator(s), e-mail address
    hanlag@utu.fi

    Principal investigator(s), institution
    University of Turku, The Discipline of Public Health, 20014 Turun yliopisto

    Contact person(s), name
    Hanna Lagström

    Contact person(s), e-mail address
    hanlag@utu.fi

    Contact person(s), institution address
    Turku Institute for Child and Youth Research, 20014 Univeristy of Turku

  • Main aim of cohort
    The overall objective is to contribute to a comprehensive, integrated view of healthy development: to improve the understanding of the early development of children, and their health and well-being beginning from the prenatal period up to school age; and also to determine the long-term effects of their early development later on in life. The STEPS Study endeavours to especially shed light on how various areas of development are interrelated during the first years of life. MAIN OUTCOMES Postnatal growth patterns, owerweigh and obesity Recurrent (respiratory) infections Asthma and allergy Chronic diseases Neurological disorders, cognition Normative picture of typical development and difficulties Mono- and bilingual development Child’s emotional and social development Child’s (early) peer relations MAIN EXPOSURES: Biological determinants - Foetal and postnatal growth characteristics - Parental anthropometrics - Genetic variants in the child and parents - Prevalence and incidence of diseases - Information from registers Psychosocial determinants - Child temperament - Relationships between the child and parent(s) - Parenting self-efficacy, maternal and paternal depression, social phobia, anxiety, loneliness, dyadic and triadic relationships Social and demographic determinants - Parental education, employment and household income - Parental marital status, etc. Environmental determinants - Parental life style habits - Housing conditions - Health and social care utilization system - Early child care contexts (home and day care)

    Recruited number of:
    1827 children / 1797 mothers / 1658 fathers / 0 grand parents / 0 other family members

    Approximate proportion of source population included
    20

    Source population
    Region-based

  • Period of enrollment
    Start: 2007-09-01, End: 2010-03-31

    Enrollment period
    Pregnancy, week 10 to 15

    Enrollment criteria, please specify
    The cohort group (SFBC) consist of all children born in the Hospital District of Southwest Finland in years 2008-2010 (n=14,946) and their mothers (n=13,436). The mothers were recruited to the STEPS Study from that cohort during the first trimester of pregnancy or after delivery.

    Planned age of children at end of follow-up
    Life-long / unrestricted
General information ---------- Child age (years) at assessment ----------
<1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
Home addressXXXXXXXXXXX
School address
Birth outcomes
Birth weightX
Birth lengthX
Gestational age at birthX
Apgar scoreX
Congenital malformationsX
Stillbirth (>= 22 weeks)X
Child’s sexX
Head circumferenceX
Biparietal diameter
Child exposures ---------- Child age (years) at assessment ----------
<1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
Breast feedingXXX
DietXXXXXX
Dietary supplements
Childcare attendanceXXXXXXX
Active smoking
Passive smoking
Alcohol consumption
Physical activityXXXXX
Substance use
Medicine intakeXXXXXXXXX
VaccinationsXXXXXXXXX
Psychological distress (e.g. bullying)
Air pollution
Access to green spacesXXXXXXXXX
Built environmentXXXXXXXXX
Noise
Radiation, electromagnetic fields
Water contamination
PetsXXXXX
Farm animal exposure
Biomarkers of exposure
Mercury
Lead
Cadmium
Arsenic
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds
Bisphenol A
Other bisphenols
Parabens
Benzophenones
Triclosan
Phthalates
Cotinine
Child development and health ---------- Child age (years) at assessment ----------
<1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
Anthropometry
WeightXXXXXXXXX
HeightXXXXXXXXX
Head circumferenceX
Abdominal circumference
Arm circumference
Wrist circumference
Waist circumferenceXXX
Clinical examinations
Blood pressureXXXX
Carotida intima media thickness
Pulse wave velocity
Cardiac ultrasound
Renal ultrasound
Brain MRI
Other MRI
DEXA‐scan results
Skin folds
Bio impedenceXXX
Oscilometry
Spirometry
Skin prick test
Bronchial challenge test
Reversibility test
Dental observations
Mental and neurological development
Cognitive function
School performance
LanguageXXXXX
ADHD
Autism
Sleep disturbances
Mental healthXXXXX
Respiratory health
AsthmaXXXXX
AllergyXXXXX
Allergic rhinitisXXXXX
EczemaXXXXX
Respiratory tract infectionsXXXXXX
Senses
Vision
Hearing
Musculo-skeletal health
Back pain
Neck pain
Growing pains
Sexual maturation
Tanner stage
Pubertal development stage
Age at menarche
Age at voice change
2D/4D digit ratio
Nocturnal ejaculation
Acne
Other health outcomes
CancerXXXXX
DiabetesXXXXX
Congenital anomalies
Biomarkers of health
Nephrology (e.g. creatinine, albumin)
Thyroid hormones
Inflammatory markers (e.g. C-reactive protein cytokines)
Immunologic markers (e.g. immunoglobulines)XXX
Cortisol
Vitamines and micronutrients
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)
Metabolomics
DNA methylation
Transcriptomics (mRNA, miRNA)
Genome-wide association study (GWAS)
Child biological samples ---------- Child age (years) at sampling ----------
At birth 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
Whole bloodXXXX
SerumXXXX
PlasmaXXXX
Buffy coatX
Urine
Hair
Teeth
Nails
SalivaX
Purified DNAX
Purified RNA
Red blood cells
Umbilical cord blood/tissueX
Blood smear
Faeces/meconium
Exhaled breathe condensate
Sputum induction
Placenta
General information
Pre-pregnancy During pregnancy <1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
EducationXX
IncomeXX
Employment status
Job title
Single parenthoodX
Home address
Work address
Maternal characteristics related to the index pregnancy/child
Age at birthX
EthnicityX
Country of birth
Planned pregnancyX
Time to pregnancyX
Fertility treatmentX
Prior spontaneous abortion (<22w)X
Prior birthsX
Ultrasound measurements
Doppler measurements
Preeclampsia
Gestational diabetes
Gestational hypertension
Gestational durationX
Mode of deliveryX
Prenatal diagnosticsX
Medical termination of pregnancyX
Maternal Exposures ---------- Timing of assessment ----------
Pre-pregnancy First trimester Second trimester Third trimester Post pregnancy
DietXX
Dietary supplements
Active smokingXXX
Passive smoking
Alcohol consumptionXX
Physical activityXX
Substance useXX
Medicine intakeXX
Coffee drinking
Psychological distress (e.g. life-events, health behaviors, perceived stress)XX
Occupational exposures
Heavy lifts
Work hours
Air pollution
Access to green spaces
Built environment
Noise
Radiation, electromagnetic fields
Water contamination
Binge drinkingXX
Pets
Farm animal exposure
Biomarkers of exposure
Mercury
Lead
Cadmium
Arsenic
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds
Bisphenol A
Other bisphenols
Parabens
Benzophenones
Triclosan
Phthalates
Cotinine
Maternal health ---------- Timing of assessment ----------
Pre-pregnancy First trimester Second trimester Third trimester Post pregnancy
Anthropometry
WeightXXXXX
HeightXXXXX
Waist circumference
Clinical examinations
Blood pressureXX
Carotida intima media thickness
Pulse wave velocity
DEXA scans
Bioimpedence
Mental and neurological development
Mental healthXX
Cognitive function (e.g. intelligence quotient)
Respiratory health
Asthma
Allergy
Musculo‐skeletal diseaseXX
Back pain
Neck pain
Arthritis
Other health outcomes
CancerXX
DiabetesXXX
Cardio‐vascular diseaseXX
Family history of chronic disease
Infectious diseaseXX
Fever
Autoimmune diseaseXX
Urinary symptoms
Sexual problems
Sleep disturbance
Biomarkers of health
Nephrology (e.g. creatinine, albumin)
Thyroid hormones
Inflammatory markers (e.g. C-reactive protein cytokines)
Immunologic markers (e.g. immunoglobulines)
Cortisol
Vitamines and micronutrients
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)
Metabolomics
DNA methylation
Transcriptomics (mRNA, miRNA)
Genome-wide association study (GWAS)
Maternal biological samples ---------- Timing of sampling ----------
Pre-pregnancy First trimester Second trimester Third trimester Post pregnancy
Breast milkX
Whole bloodX
SerumX
Plasma
Buffy coat
Urine
Hair
Nails
SalivaX
Purified DNAX
Purified RNA
Red blood cells
Faeces
General information
Pre-pregnancy During pregnancy <1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
EducationX
IncomeX
Employment status
Job title
Single parenthood
Home address
Work address
Paternal characteristics related to the index pregnancy/child
Fertility treatment
Age at child's birthX
EthnicityX
Country of birth
Paternal exposures ---------- Timing of assessment ----------
Pre-pregnancy During pregnancy Post pregnancy
DietXX
Dietary supplements
Active smokingXX
Passive smoking
Alcohol consumptionXX
Physical activityXX
Substance useXX
Medicine intake
Coffee drinking
Psychological distress (e.g. life-events, health behaviors, perceived stress)XX
Occupational exposuresXX
Heavy lifts
Work hours
Air pollution
Access to green spaces
Built environment
Noise
Radiation, electromagnetic fields
Water contamination
Binge drinking
Pets
Farm animal exposure
Biomarkers of exposure
Mercury
Lead
Cadmium
Arsenic
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds
Bisphenol A
Other bisphenols
Parabens
Benzophenones
Triclosan
Phthalates
Cotinine
Paternal health ---------- Timing of assessment ----------
Pre-pregnancy During pregnancy Post pregnancy
Anthropometry
WeightXX
HeightXX
Waist circumference
Clinical examinations
Blood pressureXX
Carotida intima media thickness
Pulse wave velocity
DEXA scans
Bio impedence
Mental and neurological development
Mental healthXX
Cognitive function (e.g. intelligence quotient)
Respiratory health
Asthma
Allergy
Musculo‐skeletal diseaseXX
Back pain
Neck pain
Arthritis
Other health outcomes
CancerXX
DiabetesXX
Cardio‐vascular diseaseXX
Family history of chronic disease
Infectious diseaseXX
Fever
Autoimmune diseaseXX
Urinary symptoms
Sexual problems
Sleep disturbance
Biomarkers of health
Nephrology (e.g. creatinine, albumin)
Thyroid hormones
Inflammatory markers (e.g. C-reactive protein cytokines)
Immunologic markers (e.g. immunoglobulines)
Cortisol
Vitamines and micronutrients
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)
Metabolomics
DNA methylation
Transcriptomics (mRNA, miRNA)
Genome-wide association study (GWAS)
Paternal biological samples ---------- Timing of sampling ----------
Pre-pregnancy During pregnancy Post pregnancy
Semen
Whole bloodX
SerumX
Plasma
Buffy coat
Urine
Hair
Nails
SalivaX
Purified DNAX
Purified RNA
Red blood cells
Faeces
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