• Cohort, name
    KOALA Birth Cohort Study

    Cohort, abbreviation
    KOALA

    Cohort, country
    Netherlands (Nederland)

    Cohort, website
    http://www.koala-study.nl/researchers.html

    Key reference
    Kummeling et al. Pediatr Allergy Immunol 2005: 16: 679–684

    Date of filling in this questionnaire:
    2012-05-24

  • Principal investigator(s), name
    Carel Thijs

    Principal investigator(s), e-mail address
    c.thijs at maastrichtuniversity.nl

    Principal investigator(s), institution
    Maastricht University, PO box 616, NL-6200 Maastricht, the Netherlands

    Contact person(s), name
    Carel Thijs

    Contact person(s), e-mail address
    c.thijs at maastrichtuniversity.nl

    Contact person(s), institution address
    Maastricht University, PO box 616, NL-6200 Maastricht, the Netherlands

  • Main aim of cohort
    Main outcomes: 1. Allergy and asthma development, 2. Growth and overweight development (inflammatory, immunological, metabolic, cardiorespiratory and cardiovascular aspects) Main exposures: microbial (infections, gut microbiota), breastfeeding and breast milk composition, nutrition, physical activity, parenting practices and parenting styles; home, neighbourhood and childcare environment

    Recruited number of:
    2843 children / 2900 mothers / 2900 fathers / 0 grand parents / 0 other family members

    Approximate proportion of source population included
    0

    Source population
    Region-based

  • Period of enrollment
    Start: 2000-01-01, End: 2002-10-01

    Enrollment period
    Pregnancy, week 14 to

    Enrollment criteria, please specify
    1. General population: healthy pregnant women, participating to a study of etiology of pelvic pain in pregnancy, recruited from the general population via obstetric practices (conventional recruitmentment group); 2. Alternative lifestyle: healthy pregnant women, recruited via anthroposophic obstetric practices, Steiner schools, organic food shops and magazines targeted at these groups (alternative recruitment group).

    Exclusion criteria, please specify
    No general exclusion criteria (depend on the study question)

    Planned age of children at end of follow-up
General information ---------- Child age (years) at assessment ----------
<1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
Home addressXXXXXXXXXXXXXXX
School addressXX
Birth outcomes
Birth weightX
Birth lengthX
Gestational age at birthX
Apgar scoreX
Congenital malformationsX
Stillbirth (>= 22 weeks)
Child’s sexX
Head circumferenceX
Biparietal diameter
Child exposures ---------- Child age (years) at assessment ----------
<1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
Breast feedingXXX
DietXXXXXXXX
Dietary supplementsXXXXX
Childcare attendanceXXXXX
Active smoking
Passive smokingXXXXXXXX
Alcohol consumption
Physical activityXXXXXXX
Substance use
Medicine intakeXXXXXXXXXX
VaccinationsXXXX
Psychological distress (e.g. bullying)
Air pollution
Access to green spacesX
Built environmentX
Noise
Radiation, electromagnetic fields
Water contamination
PetsXXXX
Farm animal exposureXXXX
Biomarkers of exposure
Mercury
Lead
Cadmium
Arsenic
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds
Bisphenol A
Other bisphenols
Parabens
Benzophenones
Triclosan
Phthalates
Cotinine
Child development and health ---------- Child age (years) at assessment ----------
<1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
Anthropometry
WeightXXXXXXXXXX
HeightXXXXXXXXXX
Head circumferenceX
Abdominal circumference
Arm circumference
Wrist circumference
Waist circumferenceXXXXXXX
Clinical examinations
Blood pressureX
Carotida intima media thickness
Pulse wave velocity
Cardiac ultrasound
Renal ultrasound
Brain MRI
Other MRI
DEXA‐scan results
Skin foldsX
Bio impedence
Oscilometry
SpirometryX
Skin prick test
Bronchial challenge test
Reversibility testX
Dental observations
Mental and neurological development
Cognitive function
School performance
Language
ADHDXXXXX
Autism
Sleep disturbancesXXX
Mental healthXX
Respiratory health
AsthmaXXXXXX
AllergyXXXXX
Allergic rhinitisXXXXXX
EczemaXXXXXXXXX
Respiratory tract infectionsXXXX
Senses
Vision
Hearing
Musculo-skeletal health
Back pain
Neck pain
Growing pains
Sexual maturation
Tanner stage
Pubertal development stageX
Age at menarche
Age at voice change
2D/4D digit ratio
Nocturnal ejaculation
Acne
Other health outcomes
Cancer
Diabetes
Congenital anomalies
Biomarkers of health
Nephrology (e.g. creatinine, albumin)
Thyroid hormones
Inflammatory markers (e.g. C-reactive protein cytokines)X
Immunologic markers (e.g. immunoglobulines)XXX
Cortisol
Vitamines and micronutrientsX
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)XX
Metabolomics
DNA methylation
Transcriptomics (mRNA, miRNA)
Genome-wide association study (GWAS)X
Child biological samples ---------- Child age (years) at sampling ----------
At birth 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
Whole bloodXXX
SerumXXX
Plasma
Buffy coatXXX
Urine
Hair
Teeth
Nails
Saliva
Purified DNAX
Purified RNA
Red blood cells
Umbilical cord blood/tissue
Blood smear
Faeces/meconiumXX
Exhaled breathe condensate
Sputum induction
Placenta
General information
Pre-pregnancy During pregnancy <1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
EducationX
Income
Employment status
Job title
Single parenthood
Home address
Work address
Maternal characteristics related to the index pregnancy/child
Age at birthX
EthnicityX
Country of birth
Planned pregnancy
Time to pregnancyX
Fertility treatment
Prior spontaneous abortion (<22w)
Prior birthsX
Ultrasound measurements
Doppler measurements
PreeclampsiaX
Gestational diabetes
Gestational hypertension
Gestational durationX
Mode of deliveryX
Prenatal diagnostics
Medical termination of pregnancy
Maternal Exposures ---------- Timing of assessment ----------
Pre-pregnancy First trimester Second trimester Third trimester Post pregnancy
DietXX
Dietary supplementsXXXX
Active smokingXXXX
Passive smokingXXX
Alcohol consumptionXXX
Physical activityXX
Substance use
Medicine intakeXX
Coffee drinkingXXX
Psychological distress (e.g. life-events, health behaviors, perceived stress)XXX
Occupational exposures
Heavy liftsXXX
Work hours
Air pollution
Access to green spaces
Built environment
Noise
Radiation, electromagnetic fields
Water contaminationXX
Binge drinking
Pets
Farm animal exposure
Biomarkers of exposure
Mercury
Lead
Cadmium
Arsenic
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds
Bisphenol A
Other bisphenols
Parabens
Benzophenones
Triclosan
Phthalates
Cotinine
Maternal health ---------- Timing of assessment ----------
Pre-pregnancy First trimester Second trimester Third trimester Post pregnancy
Anthropometry
WeightXXX
HeightXXX
Waist circumference
Clinical examinations
Blood pressureXX
Carotida intima media thickness
Pulse wave velocity
DEXA scans
Bioimpedence
Mental and neurological development
Mental healthXXX
Cognitive function (e.g. intelligence quotient)
Respiratory health
Asthma
Allergy
Musculo‐skeletal diseaseXXX
Back pain
Neck pain
Arthritis
Other health outcomes
Cancer
DiabetesXX
Cardio‐vascular diseaseX
Family history of chronic disease
Infectious diseaseXX
FeverXX
Autoimmune diseaseXX
Urinary symptoms
Sexual problems
Sleep disturbance
Biomarkers of health
Nephrology (e.g. creatinine, albumin)
Thyroid hormones
Inflammatory markers (e.g. C-reactive protein cytokines)
Immunologic markers (e.g. immunoglobulines)
Cortisol
Vitamines and micronutrients
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)
Metabolomics
DNA methylation
Transcriptomics (mRNA, miRNA)
Genome-wide association study (GWAS)
Maternal biological samples ---------- Timing of sampling ----------
Pre-pregnancy First trimester Second trimester Third trimester Post pregnancy
Breast milkX
Whole bloodX
SerumX
Plasma
Buffy coat
Urine
Hair
Nails
Saliva
Purified DNAX
Purified RNA
Red blood cells
Faeces
General information
Pre-pregnancy During pregnancy <1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
Education
Income
Employment status
Job title
Single parenthood
Home address
Work address
Paternal characteristics related to the index pregnancy/child
Fertility treatment
Age at child's birthX
EthnicityX
Country of birth
Paternal exposures ---------- Timing of assessment ----------
Pre-pregnancy During pregnancy Post pregnancy
Diet
Dietary supplements
Active smokingX
Passive smoking
Alcohol consumption
Physical activity
Substance use
Medicine intake
Coffee drinking
Psychological distress (e.g. life-events, health behaviors, perceived stress)
Occupational exposures
Heavy lifts
Work hours
Air pollution
Access to green spaces
Built environment
Noise
Radiation, electromagnetic fields
Water contamination
Binge drinking
Pets
Farm animal exposure
Biomarkers of exposure
Mercury
Lead
Cadmium
Arsenic
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds
Bisphenol A
Other bisphenols
Parabens
Benzophenones
Triclosan
Phthalates
Cotinine
Paternal health ---------- Timing of assessment ----------
Pre-pregnancy During pregnancy Post pregnancy
Anthropometry
WeightX
HeightX
Waist circumference
Clinical examinations
Blood pressureX
Carotida intima media thickness
Pulse wave velocity
DEXA scans
Bio impedence
Mental and neurological development
Mental healthX
Cognitive function (e.g. intelligence quotient)
Respiratory health
Asthma
Allergy
Musculo‐skeletal diseaseX
Back pain
Neck pain
Arthritis
Other health outcomes
Cancer
DiabetesX
Cardio‐vascular diseaseX
Family history of chronic disease
Infectious disease
Fever
Autoimmune diseaseX
Urinary symptoms
Sexual problems
Sleep disturbance
Biomarkers of health
Nephrology (e.g. creatinine, albumin)
Thyroid hormones
Inflammatory markers (e.g. C-reactive protein cytokines)
Immunologic markers (e.g. immunoglobulines)
Cortisol
Vitamines and micronutrients
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)
Metabolomics
DNA methylation
Transcriptomics (mRNA, miRNA)
Genome-wide association study (GWAS)
Paternal biological samples ---------- Timing of sampling ----------
Pre-pregnancy During pregnancy Post pregnancy
Semen
Whole blood
Serum
Plasma
Buffy coat
Urine
Hair
Nails
Saliva
Purified DNAX
Purified RNA
Red blood cells
Faeces
Comments and ideas
We are specially interested in gut microbiota. If you have biobanked faecal samples, or if you have ideas for measurements in such samples or follow-up, please contact me (also when you know of other such biobanks): c.thijs(at)maastrichtuniversity.nl (we have gut microbiota determined in 900 children at age 1 months and biobanked faecal samples in 600 at age 7 years). See KOALA publications at http://www.koala-study.nl/researchers.html