• Cohort, name
    Slovak PCB study

    Cohort, abbreviation


    Cohort, country
    Slovakia (Slovensko)

    Date of filling in this questionnaire:
    2012-05-10

  • Principal investigator(s), name
    Irva Hertz-Picciotto, Tomas Trnovec

    Principal investigator(s), e-mail address
    ihp@phs.ucdavis.edu; tomas.trnovec@szu.sk

    Principal investigator(s), institution
    University of California, Davis; Slovak Medical University, Bratislava

    Contact person(s), name
    Irva Hertz-Picciotto

    Contact person(s), e-mail address
    ihp@phs.ucdavis.edu

    Contact person(s), institution address
    University of California, Davis; National Insitute of Environmental Health Sciences, NIH

  • Main aim of cohort
    1- to describe the distributions in this population of concentrations of PCB congeners in cord and maternal serum collected at birth and in infant serum collected at 6 and 16 months of age, the distributions of PCDDs/PCDFs (polychlorinated dibenzo-dioxins and –furans) and coplanar PCBs in serum/breastmilk, and the distributions of PCB-OH metabolites and PCB-MeSO2 metabolites in maternal serum/breastmilk; 2- to examine the hypothesis that higher exposures to PCB/PCDF/PCDDs or metabolites of PCBs in the prenatal period are associated with alterations in cellular immune parameters (immunophenotypes of lymphocytes including B, T, NK, CD4+ and CD8+ cells) measured in cord blood, and with reduced thymic size at birth; 3- to examine the hypothesis that higher exposures to PCB/PCDF/PCDDs or metabolites of PCBs in the prenatal or postnatal period are associated with: (a) lymphocyte subset alterations in the child at 6 and 16 months; (b) post-vaccination antibody titers to diphtheria and tetanus at 6 months; (c) general immunoglobulins at 16 months; and (d) reduced thymic size at 6 months and 16 months; 4- to examine the hypothesis that higher exposures to PCB/PCDF/PCDDs or metabolites of PCBs in the prenatal or postnatal period are associated with increased incidence of childhood morbidity from otitis media and from lower respiratory infections between birth and 16 months of age; 5- to examine the hypothesis that higher exposures to PCB/PCDF/PCDDs or metabolites of PCBs in the prenatal or postnatal period are associated with deficits in neurodevelopment, including hearing, motor, and cognitive impairment (relating measurements at birth to prenatal exposures, and later measurements to prenatal or postnatal exposures); 6- to examine the hypothesis that higher exposures to PCB/PCDF/PCDDs or metabolites of PCBs in the prenatal period are associated with intrauterine growth retardation, and in the prenatal or postnatal period, with deficits in early childhood growth, particularly in males, and whether growth deficit at birth is a marker for greater susceptibility to organochlorine induced effects on other outcomes listed above; 7- to examine the hypothesis that higher exposures to PCB/PCDF/PCDDs or metabolites of PCBs in the prenatal period are associated with alterations in thyroid hormones in early life.

    Recruited number of:
    1134 children / 1134 mothers / 0 fathers / 0 grand parents / 0 other family members

    Approximate proportion of source population included
    0

    Source population
    Region-based

  • Period of enrollment
    Start: 2002-00-00, End: 2004-00-00

    Enrollment period
    At birth  to

    Enrollment criteria, please specify
    Pregnant women were recruited for this study at the time of their admittance to the hospital for delivery. Recruitment occurred between 2002 and 2004 in two districts of eastern Slovakia: Michalovce, a region with substantial environmental contamination due to past manufacturing; and Svidnik, a region located approximately 70 km to the northwest, with less environmental contamination and lower serum PCB concentrations among inhabitants. Because each district has only one hospital, the vast majority of births to residents in these two districts occur in these hospitals.

    Exclusion criteria, please specify
    We excluded mothers who had more than four previous births, who were < 18 years of age at the time of delivery, who reported residing < 5 years in either district, or who had a major illness during pregnancy. Infants with severe birth defects were also excluded.

    Planned age of children at end of follow-up
General information ---------- Child age (years) at assessment ----------
<1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
Home address
School address
Birth outcomes
Birth weightX
Birth lengthX
Gestational age at birthX
Apgar scoreX
Congenital malformations
Stillbirth (>= 22 weeks)
Child’s sexX
Head circumference
Biparietal diameter
Child exposures ---------- Child age (years) at assessment ----------
<1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
Breast feedingXXXX
DietXXXX
Dietary supplements
Childcare attendanceXXXXXX
Active smoking
Passive smokingXXXXXXX
Alcohol consumption
Physical activityX
Substance use
Medicine intake
VaccinationsXXX
Psychological distress (e.g. bullying)
Air pollution
Access to green spaces
Built environment
Noise
Radiation, electromagnetic fields
Water contamination
Pets
Farm animal exposure
Biomarkers of exposure
Mercury
Lead
Cadmium
Arsenic
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds
Bisphenol A
Other bisphenols
Parabens
Benzophenones
Triclosan
Phthalates
Cotinine
Child development and health ---------- Child age (years) at assessment ----------
<1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
Anthropometry
WeightXXXXXX
HeightXXXXXX
Head circumferenceXX
Abdominal circumference
Arm circumference
Wrist circumference
Waist circumference
Clinical examinations
Blood pressureX
Carotida intima media thickness
Pulse wave velocity
Cardiac ultrasound
Renal ultrasound
Brain MRI
Other MRI
DEXA‐scan results
Skin folds
Bio impedence
Oscilometry
Spirometry
Skin prick test
Bronchial challenge test
Reversibility test
Dental observations
Mental and neurological development
Cognitive functionXXX
School performance
Language
ADHD
Autism
Sleep disturbances
Mental health
Respiratory health
Asthma
Allergy
Allergic rhinitis
Eczema
Respiratory tract infections
Senses
Vision
Hearing
Musculo-skeletal health
Back pain
Neck pain
Growing pains
Sexual maturation
Tanner stage
Pubertal development stage
Age at menarche
Age at voice change
2D/4D digit ratio
Nocturnal ejaculation
Acne
Other health outcomes
Cancer
Diabetes
Congenital anomalies
Biomarkers of health
Nephrology (e.g. creatinine, albumin)
Thyroid hormones
Inflammatory markers (e.g. C-reactive protein cytokines)
Immunologic markers (e.g. immunoglobulines)
Cortisol
Vitamines and micronutrients
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)
Metabolomics
DNA methylation
Transcriptomics (mRNA, miRNA)
Genome-wide association study (GWAS)
Child biological samples ---------- Child age (years) at sampling ----------
At birth 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
Whole bloodX
SerumXXXXXXX
Plasma
Buffy coat
UrineX
Hair
Teeth
Nails
Saliva
Purified DNA
Purified RNA
Red blood cells
Umbilical cord blood/tissueX
Blood smear
Faeces/meconium
Exhaled breathe condensate
Sputum induction
Placenta
General information
Pre-pregnancy During pregnancy <1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
EducationXX
Income
Employment status
Job title
Single parenthoodX
Home address
Work address
Maternal characteristics related to the index pregnancy/child
Age at birthX
EthnicityX
Country of birth
Planned pregnancy
Time to pregnancy
Fertility treatment
Prior spontaneous abortion (<22w)
Prior birthsX
Ultrasound measurements
Doppler measurements
Preeclampsia
Gestational diabetes
Gestational hypertension
Gestational durationX
Mode of deliveryX
Prenatal diagnostics
Medical termination of pregnancy
Maternal Exposures ---------- Timing of assessment ----------
Pre-pregnancy First trimester Second trimester Third trimester Post pregnancy
DietXXX
Dietary supplementsXXX
Active smokingXXXX
Passive smokingXXXX
Alcohol consumptionXXXX
Physical activity
Substance use
Medicine intakeXXX
Coffee drinking
Psychological distress (e.g. life-events, health behaviors, perceived stress)
Occupational exposuresXXXXX
Heavy lifts
Work hours
Air pollution
Access to green spaces
Built environment
Noise
Radiation, electromagnetic fields
Water contamination
Binge drinking
Pets
Farm animal exposure
Biomarkers of exposure
Mercury
Lead
Cadmium
Arsenic
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds
Bisphenol A
Other bisphenols
Parabens
Benzophenones
Triclosan
Phthalates
Cotinine
Maternal health ---------- Timing of assessment ----------
Pre-pregnancy First trimester Second trimester Third trimester Post pregnancy
Anthropometry
WeightXXXX
HeightX
Waist circumference
Clinical examinations
Blood pressure
Carotida intima media thickness
Pulse wave velocity
DEXA scans
Bioimpedence
Mental and neurological development
Mental health
Cognitive function (e.g. intelligence quotient)
Respiratory health
Asthma
Allergy
Musculo‐skeletal disease
Back pain
Neck pain
Arthritis
Other health outcomes
Cancer
Diabetes
Cardio‐vascular disease
Family history of chronic disease
Infectious disease
Fever
Autoimmune disease
Urinary symptoms
Sexual problems
Sleep disturbance
Biomarkers of health
Nephrology (e.g. creatinine, albumin)
Thyroid hormones
Inflammatory markers (e.g. C-reactive protein cytokines)
Immunologic markers (e.g. immunoglobulines)
Cortisol
Vitamines and micronutrients
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)
Metabolomics
DNA methylation
Transcriptomics (mRNA, miRNA)
Genome-wide association study (GWAS)
Maternal biological samples ---------- Timing of sampling ----------
Pre-pregnancy First trimester Second trimester Third trimester Post pregnancy
Breast milkX
Whole bloodX
SerumX
Plasma
Buffy coat
Urine
Hair
Nails
Saliva
Purified DNA
Purified RNA
Red blood cells
Faeces
General information
Pre-pregnancy During pregnancy <1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
EducationXX
Income
Employment status
Job title
Single parenthood
Home address
Work address
Paternal characteristics related to the index pregnancy/child
Fertility treatment
Age at child's birth
EthnicityX
Country of birth
Paternal exposures ---------- Timing of assessment ----------
Pre-pregnancy During pregnancy Post pregnancy
Diet
Dietary supplements
Active smokingXXX
Passive smokingXX
Alcohol consumptionXX
Physical activity
Substance use
Medicine intake
Coffee drinking
Psychological distress (e.g. life-events, health behaviors, perceived stress)
Occupational exposures
Heavy lifts
Work hours
Air pollution
Access to green spaces
Built environment
Noise
Radiation, electromagnetic fields
Water contamination
Binge drinking
Pets
Farm animal exposure
Biomarkers of exposure
Mercury
Lead
Cadmium
Arsenic
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds
Bisphenol A
Other bisphenols
Parabens
Benzophenones
Triclosan
Phthalates
Cotinine
Paternal health ---------- Timing of assessment ----------
Pre-pregnancy During pregnancy Post pregnancy
Anthropometry
Weight
Height
Waist circumference
Clinical examinations
Blood pressure
Carotida intima media thickness
Pulse wave velocity
DEXA scans
Bio impedence
Mental and neurological development
Mental health
Cognitive function (e.g. intelligence quotient)
Respiratory health
Asthma
Allergy
Musculo‐skeletal disease
Back pain
Neck pain
Arthritis
Other health outcomes
Cancer
Diabetes
Cardio‐vascular disease
Family history of chronic disease
Infectious disease
Fever
Autoimmune disease
Urinary symptoms
Sexual problems
Sleep disturbance
Biomarkers of health
Nephrology (e.g. creatinine, albumin)
Thyroid hormones
Inflammatory markers (e.g. C-reactive protein cytokines)
Immunologic markers (e.g. immunoglobulines)
Cortisol
Vitamines and micronutrients
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)
Metabolomics
DNA methylation
Transcriptomics (mRNA, miRNA)
Genome-wide association study (GWAS)
Paternal biological samples ---------- Timing of sampling ----------
Pre-pregnancy During pregnancy Post pregnancy
Semen
Whole blood
Serum
Plasma
Buffy coat
Urine
Hair
Nails
Saliva
Purified DNA
Purified RNA
Red blood cells
Faeces
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