• Cohort, name
    Children's Health and the Environment in the Faroes - Cohort 3

    Cohort, abbreviation
    CHEF 3

    Cohort, country
    Faroe Islands

    Cohort, website
    http://www.chef-project.dk/

    Key reference
    Weihe P, Steuerwald U, Taheri S, Faeroe O, Veyhe AS, Nicolajsen D. Chapter 6: The Human Health programme in the Faroe Islands 1985-2001. In: B. Deutch and J.C. Hansen (Eds). Amap Greenland and the Faroe Islands 1997-2001. Vol. 1: Human Health. Ministry of Environment, Denmark. 2003.

    Date of filling in this questionnaire:
    2011-10-14

  • Principal investigator(s), name
    Philippe Grandjean ; Pál Weihe

    Principal investigator(s), e-mail address
    PGrandjean@health.sdu.dk ; pal@health.fo

    Principal investigator(s), institution
    Institute of Public Health ; The Faroes Hospital System

    Contact person(s), name
    Maria Skaalum Petersen

    Contact person(s), e-mail address
    maria@health.fo

    Contact person(s), institution address
    Institute of Public Health ; The Faroes Hospital System

  • Main aim of cohort
    Prenatal and postnatal exposure to methylmercury and organochlorines related to neurodevelopment, hormonal dysruption and immunresponse.

    Recruited number of:
    656 children / 656 mothers / 0 fathers / 0 grand parents / 0 other family members

    Approximate proportion of source population included
    0

    Source population
    Region-based

  • Period of enrollment
    Start: 1998-04-24, End: 2000-02-29

    Enrollment period
    Pregnancy, week 34 to

    Enrollment criteria, please specify
    All children born in Tórshavn between 24 April, 1998 and 29 February, 2000.

    Planned age of children at end of follow-up
    Life-long / unrestricted
General information ---------- Child age (years) at assessment ----------
<1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
Home address
School address
Birth outcomes
Birth weightX
Birth lengthX
Gestational age at birthX
Apgar scoreX
Congenital malformationsX
Stillbirth (>= 22 weeks)
Child’s sexX
Head circumference
Biparietal diameter
Child exposures ---------- Child age (years) at assessment ----------
<1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
Breast feedingX
DietX
Dietary supplements
Childcare attendanceX
Active smoking
Passive smokingX
Alcohol consumption
Physical activity
Substance use
Medicine intakeXX
VaccinationsXX
Psychological distress (e.g. bullying)
Air pollution
Access to green spaces
Built environment
Noise
Radiation, electromagnetic fields
Water contamination
Pets
Farm animal exposure
Biomarkers of exposure
Mercury
Lead
Cadmium
Arsenic
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds
Bisphenol A
Other bisphenols
Parabens
Benzophenones
Triclosan
Phthalates
Cotinine
Child development and health ---------- Child age (years) at assessment ----------
<1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
Anthropometry
WeightXXX
HeightXXX
Head circumferenceXXX
Abdominal circumference
Arm circumference
Wrist circumference
Waist circumference
Clinical examinations
Blood pressureXX
Carotida intima media thickness
Pulse wave velocity
Cardiac ultrasound
Renal ultrasound
Brain MRI
Other MRI
DEXA‐scan results
Skin folds
Bio impedence
Oscilometry
Spirometry
Skin prick test
Bronchial challenge test
Reversibility test
Dental observations
Mental and neurological development
Cognitive functionX
School performance
LanguageX
ADHD
Autism
Sleep disturbances
Mental healthXX
Respiratory health
Asthma
Allergy
Allergic rhinitis
Eczema
Respiratory tract infections
Senses
Vision
Hearing
Musculo-skeletal health
Back pain
Neck pain
Growing pains
Sexual maturation
Tanner stage
Pubertal development stage
Age at menarche
Age at voice change
2D/4D digit ratio
Nocturnal ejaculation
Acne
Other health outcomes
CancerXX
DiabetesXX
Congenital anomaliesX
Biomarkers of health
Nephrology (e.g. creatinine, albumin)
Thyroid hormones
Inflammatory markers (e.g. C-reactive protein cytokines)
Immunologic markers (e.g. immunoglobulines)
Cortisol
Vitamines and micronutrients
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)
Metabolomics
DNA methylation
Transcriptomics (mRNA, miRNA)
Genome-wide association study (GWAS)
Child biological samples ---------- Child age (years) at sampling ----------
At birth 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
Whole bloodXXXX
SerumXXXX
Plasma
Buffy coat
UrineXX
HairXX
Teeth
Nails
Saliva
Purified DNA
Purified RNA
Red blood cells
Umbilical cord blood/tissueX
Blood smear
Faeces/meconium
Exhaled breathe condensate
Sputum induction
Placenta
General information
Pre-pregnancy During pregnancy <1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
EducationX
Income
Employment status
Job title
Single parenthood
Home address
Work address
Maternal characteristics related to the index pregnancy/child
Age at birthX
EthnicityX
Country of birth
Planned pregnancy
Time to pregnancy
Fertility treatment
Prior spontaneous abortion (<22w)
Prior birthsX
Ultrasound measurements
Doppler measurements
PreeclampsiaX
Gestational diabetes
Gestational hypertension
Gestational durationX
Mode of deliveryX
Prenatal diagnosticsX
Medical termination of pregnancyX
Maternal Exposures ---------- Timing of assessment ----------
Pre-pregnancy First trimester Second trimester Third trimester Post pregnancy
DietX
Dietary supplements
Active smokingXXXX
Passive smoking
Alcohol consumptionX
Physical activity
Substance use
Medicine intakeXXX
Coffee drinking
Psychological distress (e.g. life-events, health behaviors, perceived stress)
Occupational exposures
Heavy lifts
Work hours
Air pollutionX
Access to green spaces
Built environment
Noise
Radiation, electromagnetic fields
Water contamination
Binge drinking
Pets
Farm animal exposure
Biomarkers of exposure
MercuryX
LeadX
Cadmium
Arsenic
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
HexachlorobenzeneX
Brominated flame retardants
Perflouralkyl compounds
Bisphenol A
Other bisphenols
Parabens
BenzophenonesX
Triclosan
Phthalates
Cotinine
Maternal health ---------- Timing of assessment ----------
Pre-pregnancy First trimester Second trimester Third trimester Post pregnancy
Anthropometry
WeightXX
HeightXX
Waist circumference
Clinical examinations
Blood pressure
Carotida intima media thickness
Pulse wave velocity
DEXA scans
Bioimpedence
Mental and neurological development
Mental health
Cognitive function (e.g. intelligence quotient)
Respiratory health
Asthma
Allergy
Musculo‐skeletal diseaseX
Back pain
Neck pain
Arthritis
Other health outcomes
CancerX
DiabetesX
Cardio‐vascular diseaseX
Family history of chronic disease
Infectious disease
Fever
Autoimmune diseaseX
Urinary symptoms
Sexual problems
Sleep disturbance
Biomarkers of health
Nephrology (e.g. creatinine, albumin)
Thyroid hormones
Inflammatory markers (e.g. C-reactive protein cytokines)
Immunologic markers (e.g. immunoglobulines)
Cortisol
Vitamines and micronutrients
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)
Metabolomics
DNA methylation
Transcriptomics (mRNA, miRNA)
Genome-wide association study (GWAS)
Maternal biological samples ---------- Timing of sampling ----------
Pre-pregnancy First trimester Second trimester Third trimester Post pregnancy
Breast milkX
Whole bloodX
SerumX
Plasma
Buffy coat
Urine
HairX
Nails
Saliva
Purified DNA
Purified RNA
Red blood cells
Faeces
General information
Pre-pregnancy During pregnancy <1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
EducationX
Income
Employment status
Job title
Single parenthood
Home address
Work address
Paternal characteristics related to the index pregnancy/child
Fertility treatment
Age at child's birth
Ethnicity
Country of birth
Paternal exposures ---------- Timing of assessment ----------
Pre-pregnancy During pregnancy Post pregnancy
Diet
Dietary supplements
Active smokingXX
Passive smoking
Alcohol consumption
Physical activity
Substance use
Medicine intake
Coffee drinking
Psychological distress (e.g. life-events, health behaviors, perceived stress)
Occupational exposuresXX
Heavy lifts
Work hours
Air pollution
Access to green spaces
Built environment
Noise
Radiation, electromagnetic fields
Water contamination
Binge drinking
Pets
Farm animal exposure
Biomarkers of exposure
Mercury
Lead
Cadmium
Arsenic
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds
Bisphenol A
Other bisphenols
Parabens
Benzophenones
Triclosan
Phthalates
Cotinine
Paternal health ---------- Timing of assessment ----------
Pre-pregnancy During pregnancy Post pregnancy
Anthropometry
WeightX
HeightX
Waist circumference
Clinical examinations
Blood pressure
Carotida intima media thickness
Pulse wave velocity
DEXA scans
Bio impedence
Mental and neurological development
Mental health
Cognitive function (e.g. intelligence quotient)
Respiratory health
Asthma
Allergy
Musculo‐skeletal disease
Back pain
Neck pain
Arthritis
Other health outcomes
Cancer
Diabetes
Cardio‐vascular disease
Family history of chronic disease
Infectious disease
Fever
Autoimmune disease
Urinary symptoms
Sexual problems
Sleep disturbance
Biomarkers of health
Nephrology (e.g. creatinine, albumin)
Thyroid hormones
Inflammatory markers (e.g. C-reactive protein cytokines)
Immunologic markers (e.g. immunoglobulines)
Cortisol
Vitamines and micronutrients
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)
Metabolomics
DNA methylation
Transcriptomics (mRNA, miRNA)
Genome-wide association study (GWAS)
Paternal biological samples ---------- Timing of sampling ----------
Pre-pregnancy During pregnancy Post pregnancy
Semen
Whole blood
Serum
Plasma
Buffy coat
Urine
Hair
Nails
Saliva
Purified DNA
Purified RNA
Red blood cells
Faeces
Comments and ideas
Follow up of this cohort will begin in Nov 2011.