• Cohort, name
    GECKO Drenthe cohort

    Cohort, abbreviation
    GECKO Drenthe

    Cohort, country
    Netherlands (Nederland)

    Cohort, website
    www.geckodrenthe.umcg.nl

    Key reference
    L’Abée C, Sauer PJJ, Damen M, Rake JP, Cats H, Stolk RP. Cohort Profile: The GECKO Drenthe study; overweight programming during early childhood. Int J Epidemiol 2008; 37: 486-9

    Date of filling in this questionnaire:
    2017-07-25

  • Principal investigator(s), name
    Eva Corpeleijn

    Principal investigator(s), e-mail address
    e.corpeleijn@umcg.nl

    Principal investigator(s), institution
    University Medical Center Groningen

    Contact person(s), name
    Eva Corpeleijn

    Contact person(s), e-mail address
    e.corpeleijn@umcg.nl

    Contact person(s), institution address
    University Medical Center Groningen

  • Main aim of cohort
    The overall aim of the GECKO Drenthe cohort is to study the prevalence and early risk factors for the development of childhood overweight and fat distribution at very young age. Within this birth cohort the growth of the children is closely followed, starting at birth until adulthood. The children are followed using questionnaires that the parents have to answer and the regular visits to the Well Baby Clinics, where length, weight, head circumference and hip and waist circumference are measured. Furthermore, physical activity is measured using accelerometers. At birth, cord blood was sampled and stored for (epi)genetic analysis and biomarkers. During the first 9 months of life, the children were measured every month (incl. questionnaire), thereafter this frequency decreased until once every 2 years from 3 years onwards. The children are now 5 years old. As risk factors nutrition, physical activity, biological, epigenetic, social and environmental factors are monitored. The children are followed using questionnaires that the parents have to answer and the regular visits to the Well Baby Clinics, where length, weight, head circumference and hip and waist circumference are measured. Furthermore, physical activity is measured using accelerometers. At birth, cord blood was sampled and stored for (epi)genetic analysis and biomarkers. As risk factors nutrition, physical activity, biological, epigenetic, social and environmental factors are monitored.

    Recruited number of:
    2997 children / 0 mothers / 0 fathers / 0 grand parents / 0 other family members

    Approximate proportion of source population included
    63

    Source population
    Region-based

  • Period of enrollment
    Start: 2006-04-01, End: 2007-04-01

    Enrollment period
    Pregnancy, week  to

    Enrollment criteria, please specify
    All children born from April 2006 to April 2007 and living in Drenthe (a northern province of the Netherlands) at the time of birth were allowed to participate. All pregnant women in this province were invited to participate in the third trimester of their pregnancy. Recruitment took place by obstetricians, midwives and general practitioners, supported by a media campaign. If for any reason a child was not included in the GECKO Drenthe cohort before birth, a nurse from the Well Baby Clinic invited the parents of the newborn to participate.

    Exclusion criteria, please specify
    No exclusion criteria.

    Planned age of children at end of follow-up
General information ---------- Child age (years) at assessment ----------
<1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
Home addressXXXXXXXXXXX
School addressX
Birth outcomes
Birth weightX
Birth lengthX
Gestational age at birthX
Apgar scoreX
Congenital malformationsX
Stillbirth (>= 22 weeks)X
Child’s sexX
Head circumferenceX
Biparietal diameter
Child exposures ---------- Child age (years) at assessment ----------
<1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
Breast feedingXX
DietXXXXXX
Dietary supplementsXXXXXX
Childcare attendanceXX
Active smoking
Passive smokingXXXX
Alcohol consumption
Physical activityXXXXXX
Substance use
Medicine intakeXXXXXX
Vaccinations
Psychological distress (e.g. bullying)X
Air pollution
Access to green spacesX
Built environmentXX
Noise
Radiation, electromagnetic fields
Water contamination
PetsX
Farm animal exposure
Biomarkers of exposure
Mercury
Lead
Cadmium
Arsenic
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds
Bisphenol A
Other bisphenols
Parabens
Benzophenones
Triclosan
Phthalates
Cotinine
Child development and health ---------- Child age (years) at assessment ----------
<1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
Anthropometry
WeightXXXXXX
HeightXXXXXX
Head circumferenceXXXXX
Abdominal circumference
Arm circumference
Wrist circumference
Waist circumferenceXXXXXXX
Clinical examinations
Blood pressureXX
Carotida intima media thickness
Pulse wave velocity
Cardiac ultrasound
Renal ultrasound
Brain MRI
Other MRI
DEXA‐scan results
Skin folds
Bio impedence
Oscilometry
Spirometry
Skin prick test
Bronchial challenge test
Reversibility test
Dental observations
Mental and neurological development
Cognitive functionXX
School performance
Language
ADHD
Autism
Sleep disturbancesXXXXX
Mental health
Respiratory health
AsthmaXXX
AllergyX
Allergic rhinitis
EczemaXXX
Respiratory tract infections
Senses
Vision
Hearing
Musculo-skeletal health
Back painX
Neck painX
Growing pains
Sexual maturation
Tanner stage
Pubertal development stage
Age at menarche
Age at voice change
2D/4D digit ratio
Nocturnal ejaculation
AcneX
Other health outcomes
Cancer
Diabetes
Congenital anomaliesX
Biomarkers of health
Nephrology (e.g. creatinine, albumin)X
Thyroid hormones
Inflammatory markers (e.g. C-reactive protein cytokines)
Immunologic markers (e.g. immunoglobulines)
Cortisol
Vitamines and micronutrients
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)
Metabolomics
DNA methylationX
Transcriptomics (mRNA, miRNA)
Genome-wide association study (GWAS)
Child biological samples ---------- Child age (years) at sampling ----------
At birth 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
Whole bloodX
SerumX
PlasmaX
Buffy coatX
UrineX
Hair
Teeth
Nails
Saliva
Purified DNAX
Purified RNA
Red blood cells
Umbilical cord blood/tissueX
Blood smear
Faeces/meconium
Exhaled breathe condensate
Sputum induction
Placenta
General information
Pre-pregnancy During pregnancy <1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
EducationX
IncomeX
Employment status
Job title
Single parenthoodX
Home address
Work address
Maternal characteristics related to the index pregnancy/child
Age at birthX
EthnicityX
Country of birth
Planned pregnancyX
Time to pregnancyX
Fertility treatmentX
Prior spontaneous abortion (<22w)X
Prior birthsX
Ultrasound measurements
Doppler measurements
PreeclampsiaX
Gestational diabetes
Gestational hypertension
Gestational durationX
Mode of deliveryX
Prenatal diagnosticsX
Medical termination of pregnancyX
Maternal Exposures ---------- Timing of assessment ----------
Pre-pregnancy First trimester Second trimester Third trimester Post pregnancy
Diet
Dietary supplementsX
Active smokingXX
Passive smokingXX
Alcohol consumptionXX
Physical activityXX
Substance useX
Medicine intakeXX
Coffee drinking
Psychological distress (e.g. life-events, health behaviors, perceived stress)
Occupational exposures
Heavy lifts
Work hours
Air pollution
Access to green spaces
Built environment
Noise
Radiation, electromagnetic fields
Water contamination
Binge drinking
Pets
Farm animal exposure
Biomarkers of exposure
Mercury
Lead
Cadmium
Arsenic
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds
Bisphenol A
Other bisphenols
Parabens
Benzophenones
Triclosan
Phthalates
Cotinine
Maternal health ---------- Timing of assessment ----------
Pre-pregnancy First trimester Second trimester Third trimester Post pregnancy
Anthropometry
WeightXX
HeightXX
Waist circumference
Clinical examinations
Blood pressureX
Carotida intima media thickness
Pulse wave velocity
DEXA scans
Bioimpedence
Mental and neurological development
Mental healthX
Cognitive function (e.g. intelligence quotient)
Respiratory health
Asthma
Allergy
Musculo‐skeletal disease
Back pain
Neck pain
Arthritis
Other health outcomes
Cancer
DiabetesXX
Cardio‐vascular disease
Family history of chronic disease
Infectious disease
Fever
Autoimmune disease
Urinary symptoms
Sexual problems
Sleep disturbance
Biomarkers of health
Nephrology (e.g. creatinine, albumin)
Thyroid hormones
Inflammatory markers (e.g. C-reactive protein cytokines)
Immunologic markers (e.g. immunoglobulines)
Cortisol
Vitamines and micronutrients
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)
Metabolomics
DNA methylation
Transcriptomics (mRNA, miRNA)
Genome-wide association study (GWAS)
Maternal biological samples ---------- Timing of sampling ----------
Pre-pregnancy First trimester Second trimester Third trimester Post pregnancy
Breast milk
Whole blood
Serum
Plasma
Buffy coat
Urine
Hair
Nails
Saliva
Purified DNA
Purified RNA
Red blood cells
Faeces
General information
Pre-pregnancy During pregnancy <1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
EducationX
IncomeX
Employment status
Job title
Single parenthood
Home address
Work address
Paternal characteristics related to the index pregnancy/child
Fertility treatment
Age at child's birthX
EthnicityX
Country of birth
Paternal exposures ---------- Timing of assessment ----------
Pre-pregnancy During pregnancy Post pregnancy
Diet
Dietary supplements
Active smokingXX
Passive smokingXX
Alcohol consumptionXX
Physical activityXX
Substance useX
Medicine intake
Coffee drinking
Psychological distress (e.g. life-events, health behaviors, perceived stress)
Occupational exposuresXX
Heavy lifts
Work hours
Air pollution
Access to green spaces
Built environment
Noise
Radiation, electromagnetic fields
Water contamination
Binge drinking
Pets
Farm animal exposure
Biomarkers of exposure
Mercury
Lead
Cadmium
Arsenic
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds
Bisphenol A
Other bisphenols
Parabens
Benzophenones
Triclosan
Phthalates
Cotinine
Paternal health ---------- Timing of assessment ----------
Pre-pregnancy During pregnancy Post pregnancy
Anthropometry
WeightXX
HeightXX
Waist circumference
Clinical examinations
Blood pressureX
Carotida intima media thickness
Pulse wave velocity
DEXA scans
Bio impedence
Mental and neurological development
Mental healthX
Cognitive function (e.g. intelligence quotient)
Respiratory health
Asthma
Allergy
Musculo‐skeletal disease
Back pain
Neck pain
Arthritis
Other health outcomes
Cancer
DiabetesX
Cardio‐vascular disease
Family history of chronic disease
Infectious disease
Fever
Autoimmune disease
Urinary symptoms
Sexual problems
Sleep disturbance
Biomarkers of health
Nephrology (e.g. creatinine, albumin)
Thyroid hormones
Inflammatory markers (e.g. C-reactive protein cytokines)
Immunologic markers (e.g. immunoglobulines)
Cortisol
Vitamines and micronutrients
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)
Metabolomics
DNA methylation
Transcriptomics (mRNA, miRNA)
Genome-wide association study (GWAS)
Paternal biological samples ---------- Timing of sampling ----------
Pre-pregnancy During pregnancy Post pregnancy
Semen
Whole blood
Serum
Plasma
Buffy coat
Urine
Hair
Nails
Saliva
Purified DNA
Purified RNA
Red blood cells
Faeces
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