• Cohort, name
    LIFE Child

    Cohort, abbreviation


    Cohort, country
    Germany (Deutschland)

    Cohort, website
    http://www.life.uni-leipzig.de/

    Date of filling in this questionnaire:
    2012-01-12

  • Principal investigator(s), name
    Wieland Kiess, Antje Körner

    Principal investigator(s), e-mail address
    wieland.kiess@medizin.uni-leipzig.de

    Principal investigator(s), institution
    University of Leipzig, Germany

    Contact person(s), name
    Anne Jurkutat

    Contact person(s), e-mail address
    ajurkutat@life.uni-leipzig.de

    Contact person(s), institution address
    Leipzig Research Center for Civilization Diseases, Philipp-Rosenthal-Str. 27, 04103 Leipzig, Germany

  • Main aim of cohort
    healthy child development from pregnancy to adulthood + development of civilization diseases (e.g. obesity)

    Recruited number of:
    3500 children / 2500 mothers / 1000 fathers / 0 grand parents / 0 other family members

    Approximate proportion of source population included
    0

    Source population
    Region-based

  • Period of enrollment
    Start: 2011-08-01, End: 0000-00-00

    Enrollment period
    Pregnancy, week 24 to 36

    Exclusion criteria, please specify
    severe chronic, chromosomal, or syndromal diseases

    Planned age of children at end of follow-up
    18 years
General information ---------- Child age (years) at assessment ----------
<1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
Home address
School address
Birth outcomes
Birth weightX
Birth lengthX
Gestational age at birthX
Apgar scoreX
Congenital malformationsX
Stillbirth (>= 22 weeks)
Child’s sexX
Head circumferenceX
Biparietal diameterX
Child exposures ---------- Child age (years) at assessment ----------
<1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
Breast feedingX
DietXXXXXXXXXXXXXXXXXXX
Dietary supplements
Childcare attendanceXXXXXXX
Active smokingXXXXXXXX
Passive smokingX
Alcohol consumptionXXXXXXXX
Physical activityXXXXXXXXXXXXXXXXXXX
Substance useXXXXXXXX
Medicine intakeXXXXXXXXXXXXXXXXXXX
VaccinationsXXXXXXXXXXXXXXXXXXX
Psychological distress (e.g. bullying)
Air pollution
Access to green spaces
Built environment
Noise
Radiation, electromagnetic fields
Water contamination
PetsXXXXXXXXXXXXXXXXXXX
Farm animal exposure
Biomarkers of exposure
Mercury
Lead
Cadmium
Arsenic
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds
Bisphenol A
Other bisphenols
Parabens
Benzophenones
Triclosan
Phthalates
Cotinine
Child development and health ---------- Child age (years) at assessment ----------
<1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
Anthropometry
WeightXXXXXXXXXXXXXXXXXXX
HeightXXXXXXXXXXXXXXXXXXX
Head circumferenceXXXXXXXXXXXXXXXXXXX
Abdominal circumferenceXXXXXXXXXXXXXXXXXXX
Arm circumferenceXXXXXXXXXXXX
Wrist circumferenceXXXXXXXXXXXX
Waist circumferenceXXXXXXXXXXXX
Clinical examinations
Blood pressureXXXXXXXXXXXXXXXXXXX
Carotida intima media thickness
Pulse wave velocity
Cardiac ultrasound
Renal ultrasound
Brain MRI
Other MRI
DEXA‐scan results
Skin foldsXXXXXXXXXXXXXXXXXXX
Bio impedenceXXXXXXXXXXXXX
Oscilometry
SpirometryXXXXXXXXXXXXX
Skin prick test
Bronchial challenge test
Reversibility test
Dental observationsXXXXXXXXXXXXXXXXXX
Mental and neurological development
Cognitive functionXXXXXX
School performanceXXXXXXXXXXX
LanguageXXXXX
ADHD
Autism
Sleep disturbancesXXXXXXXXXXXXXXXXXXX
Mental healthXXXXXXXXXXXXXXXXXXX
Respiratory health
AsthmaXXXXXXXXXXXXXXXXXXX
AllergyXXXXXXXXXXXXXXXXXXX
Allergic rhinitisXXXXXXXXXXXXXXXXXXX
EczemaXXXXXXXXXXXXXXXXXXX
Respiratory tract infectionsXXXXXXXXXXXXXXXXXXX
Senses
VisionXXXXXXXXXXXXXXXX
Hearing
Musculo-skeletal health
Back pain
Neck pain
Growing pains
Sexual maturation
Tanner stageXXXXXXXXXXXXXXXXXXX
Pubertal development stage
Age at menarcheX
Age at voice change
2D/4D digit ratioXXXXXXXXXXXXXXXXX
Nocturnal ejaculation
Acne
Other health outcomes
CancerXXXXXXXXXXXXXXXXXXX
DiabetesXXXXXXXXXXXXXXXXXXX
Congenital anomaliesX
Biomarkers of health
Nephrology (e.g. creatinine, albumin)XXXXXXXXXXXXXXXXXXX
Thyroid hormonesXXXXXXXXXXXXXXXXXXX
Inflammatory markers (e.g. C-reactive protein cytokines)XXXXXXXXXXXXXXXXXXX
Immunologic markers (e.g. immunoglobulines)XXXXXXXXXXXXXXXXXXX
Cortisol
Vitamines and micronutrientsXXXXXXXXXXXXXXXXXXX
Gonadal axis hormones (e.g. testosterone, estradiol)XXXXXXXXXXXXXXXXXX
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)XXXXXXXXXXXXXXXXXXX
Metabolomics
DNA methylation
Transcriptomics (mRNA, miRNA)
Genome-wide association study (GWAS)
Child biological samples ---------- Child age (years) at sampling ----------
At birth 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
Whole blood
SerumXXXXXXXXXXXXXXXXXXXX
PlasmaXXXXXXXXXXXXXXXXXXXX
Buffy coat
UrineXXXXXXXXXXXXXXXXXXX
HairXXXXXXXXXXXXXXXXXXX
Teeth
Nails
Saliva
Purified DNAXXXXXXXXXXXXXXXXXXX
Purified RNAXXXXXXXXXXXXXXXXXXX
Red blood cellsXXXXXXXXXXXXXXXXXXX
Umbilical cord blood/tissueX
Blood smear
Faeces/meconiumXXXXXX
Exhaled breathe condensate
Sputum induction
PlacentaX
General information
Pre-pregnancy During pregnancy <1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
EducationX
IncomeX
Employment status
Job title
Single parenthood
Home address
Work address
Maternal characteristics related to the index pregnancy/child
Age at birthX
EthnicityX
Country of birth
Planned pregnancyX
Time to pregnancyX
Fertility treatment
Prior spontaneous abortion (<22w)X
Prior birthsX
Ultrasound measurements
Doppler measurements
PreeclampsiaX
Gestational diabetes
Gestational hypertension
Gestational durationX
Mode of delivery
Prenatal diagnosticsX
Medical termination of pregnancyX
Maternal Exposures ---------- Timing of assessment ----------
Pre-pregnancy First trimester Second trimester Third trimester Post pregnancy
DietX
Dietary supplementsX
Active smokingX
Passive smokingX
Alcohol consumptionX
Physical activity
Substance useX
Medicine intakeX
Coffee drinkingX
Psychological distress (e.g. life-events, health behaviors, perceived stress)X
Occupational exposures
Heavy lifts
Work hours
Air pollution
Access to green spaces
Built environment
Noise
Radiation, electromagnetic fields
Water contamination
Binge drinking
Pets
Farm animal exposure
Biomarkers of exposure
Mercury
Lead
Cadmium
Arsenic
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds
Bisphenol A
Other bisphenols
Parabens
Benzophenones
Triclosan
Phthalates
Cotinine
Maternal health ---------- Timing of assessment ----------
Pre-pregnancy First trimester Second trimester Third trimester Post pregnancy
Anthropometry
WeightXXX
HeightXXX
Waist circumference
Clinical examinations
Blood pressureXX
Carotida intima media thickness
Pulse wave velocity
DEXA scans
Bioimpedence
Mental and neurological development
Mental healthXXX
Cognitive function (e.g. intelligence quotient)
Respiratory health
Asthma
Allergy
Musculo‐skeletal diseaseX
Back pain
Neck pain
Arthritis
Other health outcomes
CancerXXX
DiabetesXXX
Cardio‐vascular diseaseXXX
Family history of chronic disease
Infectious diseaseXXX
Fever
Autoimmune diseaseX
Urinary symptoms
Sexual problems
Sleep disturbance
Biomarkers of health
Nephrology (e.g. creatinine, albumin)
Thyroid hormones
Inflammatory markers (e.g. C-reactive protein cytokines)
Immunologic markers (e.g. immunoglobulines)
Cortisol
Vitamines and micronutrients
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)
Metabolomics
DNA methylation
Transcriptomics (mRNA, miRNA)
Genome-wide association study (GWAS)
Maternal biological samples ---------- Timing of sampling ----------
Pre-pregnancy First trimester Second trimester Third trimester Post pregnancy
Breast milkX
Whole blood
SerumXX
Plasma
Buffy coat
UrineXX
HairXX
Nails
Saliva
Purified DNAXX
Purified RNA
Red blood cells
Faeces
General information
Pre-pregnancy During pregnancy <1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
Education
Income
Employment status
Job title
Single parenthood
Home address
Work address
Paternal characteristics related to the index pregnancy/child
Fertility treatment
Age at child's birthX
EthnicityX
Country of birth
Paternal exposures ---------- Timing of assessment ----------
Pre-pregnancy During pregnancy Post pregnancy
Diet
Dietary supplements
Active smoking
Passive smoking
Alcohol consumption
Physical activity
Substance use
Medicine intake
Coffee drinking
Psychological distress (e.g. life-events, health behaviors, perceived stress)
Occupational exposures
Heavy lifts
Work hours
Air pollution
Access to green spaces
Built environment
Noise
Radiation, electromagnetic fields
Water contamination
Binge drinking
Pets
Farm animal exposure
Biomarkers of exposure
Mercury
Lead
Cadmium
Arsenic
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds
Bisphenol A
Other bisphenols
Parabens
Benzophenones
Triclosan
Phthalates
Cotinine
Paternal health ---------- Timing of assessment ----------
Pre-pregnancy During pregnancy Post pregnancy
Anthropometry
WeightX
HeightX
Waist circumference
Clinical examinations
Blood pressureX
Carotida intima media thickness
Pulse wave velocity
DEXA scans
Bio impedence
Mental and neurological development
Mental healthX
Cognitive function (e.g. intelligence quotient)
Respiratory health
Asthma
Allergy
Musculo‐skeletal diseaseX
Back pain
Neck pain
Arthritis
Other health outcomes
CancerX
DiabetesX
Cardio‐vascular disease
Family history of chronic disease
Infectious diseaseX
Fever
Autoimmune diseaseX
Urinary symptoms
Sexual problems
Sleep disturbance
Biomarkers of health
Nephrology (e.g. creatinine, albumin)
Thyroid hormones
Inflammatory markers (e.g. C-reactive protein cytokines)
Immunologic markers (e.g. immunoglobulines)
Cortisol
Vitamines and micronutrients
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)
Metabolomics
DNA methylation
Transcriptomics (mRNA, miRNA)
Genome-wide association study (GWAS)
Paternal biological samples ---------- Timing of sampling ----------
Pre-pregnancy During pregnancy Post pregnancy
Semen
Whole blood
SerumX
Plasma
Buffy coat
UrineX
HairX
Nails
Saliva
Purified DNAX
Purified RNA
Red blood cells
Faeces
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