• Cohort, name
    Children (Barn), Allergy, Milieu, Stockholm, Epidemiological study

    Cohort, abbreviation
    BAMSE

    Cohort, country
    Sweden (Sverige)

    Cohort, website
    http://www.ki.se/BAMSE

    Key reference
    Wickman M, Kull I, Pershagen G, Nordvall SL. The BAMSE Project: presentation of a prospective longitudinal birth cohort study. Pediatr Allergy Immunol 2002: 13 (Suppl. 15): 11–13.

    Date of filling in this questionnaire:
    2018-09-27

  • Principal investigator(s), name
    Erik Melén

    Principal investigator(s), e-mail address
    erik.melen@ki.se

    Principal investigator(s), institution
    Karolinska Institutet, PO.Box 2010, 171 76 Stockholm, Sweden

    Contact person(s), name
    Anna Bergstrom

    Contact person(s), e-mail address
    Anna.Bergstrom@ki.se

    Contact person(s), institution address
    Karolinska Institutet, PO.Box 2010, 171 76 Stockholm, Sweden

  • Main aim of cohort
    The main aim of this Swedish population-based birth cohort is to study risk factors for asthma, allergic diseases and lung function and to study factors of importance for prognosis at already established disease. Main exposures: Allergens, nutrients/foods, air pollution, tobacco smoke, indoor environment, lifestyle, genetics Main outcomes: Asthma, eczema, allergic rhinitis, food allergy, lung function, dermatology, functional gastro intestinal disorders

    Recruited number of:
    4089 children / 4089 mothers / 4089 fathers / 0 grand parents / 0 other family members

    Approximate proportion of source population included
    75

    Source population
    Region-based

  • Period of enrollment
    Start: 1994-00-00, End: 1996-00-00

    Enrollment period
    At birth  to

    Enrollment criteria, please specify
    All eligible children born during the enrolment period in the predefined areas of the central and north-western parts of Stockholm, representative for Sweden

    Exclusion criteria, please specify
    Insufficient knowledge in Swedish, planned to move within one year, child seriously ill

    Planned age of children at end of follow-up
    unrestricted years
General information ---------- Child age (years) at assessment ----------
<1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
Home addressXXXXXXX
School addressXXX
Birth outcomes
Birth weightX
Birth lengthX
Gestational age at birthX
Apgar score
Congenital malformations
Stillbirth (>= 22 weeks)
Child’s sexX
Head circumference
Biparietal diameter
Child exposures ---------- Child age (years) at assessment ----------
<1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
Breast feedingXX
DietXXXXX
Dietary supplementsXXXX
Childcare attendanceXX
Active smokingXX
Passive smokingXXXXXXX
Alcohol consumption
Physical activityXXX
Substance use
Medicine intakeXXXXXX
VaccinationsX
Psychological distress (e.g. bullying)
Air pollutionXX
Access to green spaces
Built environment
NoiseX
Radiation, electromagnetic fields
Water contamination
PetsXXXXXXX
Farm animal exposureXXX
Biomarkers of exposure
Mercury
Lead
Cadmium
Arsenic
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds
Bisphenol AX
Other bisphenolsX
Parabens
Benzophenones
Triclosan
PhthalatesX
CotinineX
Child development and health ---------- Child age (years) at assessment ----------
<1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
Anthropometry
WeightXXXXX
HeightXXXX
Head circumferenceX
Abdominal circumference
Arm circumference
Wrist circumference
Waist circumference
Clinical examinations
Blood pressureX
Carotida intima media thickness
Pulse wave velocity
Cardiac ultrasound
Renal ultrasound
Brain MRI
Other MRI
DEXA‐scan results
Skin folds
Bio impedence
OscilometryX
SpirometryXX
Skin prick testX
Bronchial challenge test
Reversibility test
Dental observations
Mental and neurological development
Cognitive function
School performance
Language
ADHDX
Autism
Sleep disturbancesX
Mental health
Respiratory health
AsthmaXXXXXX
AllergyXXXXXX
Allergic rhinitisXXXXXX
EczemaXXXXXX
Respiratory tract infectionsXXXX
Senses
Vision
HearingX
Musculo-skeletal health
Back pain
Neck pain
Growing pains
Sexual maturation
Tanner stage
Pubertal development stageXX
Age at menarcheXX
Age at voice change
2D/4D digit ratio
Nocturnal ejaculation
AcneXX
Other health outcomes
Cancer
DiabetesX
Congenital anomalies
Biomarkers of health
Nephrology (e.g. creatinine, albumin)
Thyroid hormones
Inflammatory markers (e.g. C-reactive protein cytokines)X
Immunologic markers (e.g. immunoglobulines)
CortisolX
Vitamines and micronutrientsX
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)
MetabolomicsXX
DNA methylationXXX
Transcriptomics (mRNA, miRNA)X
Genome-wide association study (GWAS)XXX
Child biological samples ---------- Child age (years) at sampling ----------
At birth 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
Whole blood
Serum
PlasmaXXX
Buffy coat
UrineX
Hair
Teeth
Nails
SalivaX
Purified DNAXXX
Purified RNAX
Red blood cells
Umbilical cord blood/tissue
Blood smear
Faeces/meconium
Exhaled breathe condensate
Sputum induction
Placenta
General information
Pre-pregnancy During pregnancy <1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
EducationX
Income
Employment statusX
Job titleXX
Single parenthood
Home addressXXXXXXX
Work address
Maternal characteristics related to the index pregnancy/child
Age at birthX
Ethnicity
Country of birthX
Planned pregnancy
Time to pregnancy
Fertility treatment
Prior spontaneous abortion (<22w)
Prior births
Ultrasound measurements
Doppler measurements
Preeclampsia
Gestational diabetes
Gestational hypertension
Gestational durationX
Mode of delivery
Prenatal diagnostics
Medical termination of pregnancy
Maternal Exposures ---------- Timing of assessment ----------
Pre-pregnancy First trimester Second trimester Third trimester Post pregnancy
Diet
Dietary supplements
Active smokingXXXX
Passive smokingX
Alcohol consumption
Physical activity
Substance use
Medicine intakeX
Coffee drinking
Psychological distress (e.g. life-events, health behaviors, perceived stress)
Occupational exposures
Heavy lifts
Work hours
Air pollution
Access to green spaces
Built environment
Noise
Radiation, electromagnetic fields
Water contamination
Binge drinking
PetsX
Farm animal exposureX
Biomarkers of exposure
Mercury
Lead
Cadmium
Arsenic
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds
Bisphenol A
Other bisphenols
Parabens
Benzophenones
Triclosan
Phthalates
Cotinine
Maternal health ---------- Timing of assessment ----------
Pre-pregnancy First trimester Second trimester Third trimester Post pregnancy
Anthropometry
Weight
Height
Waist circumference
Clinical examinations
Blood pressure
Carotida intima media thickness
Pulse wave velocity
DEXA scans
Bioimpedence
Mental and neurological development
Mental health
Cognitive function (e.g. intelligence quotient)
Respiratory health
AsthmaX
AllergyX
Musculo‐skeletal disease
Back pain
Neck pain
Arthritis
Other health outcomes
Cancer
DiabetesX
Cardio‐vascular diseaseX
Family history of chronic disease
Infectious disease
Fever
Autoimmune disease
Urinary symptoms
Sexual problems
Sleep disturbance
Biomarkers of health
Nephrology (e.g. creatinine, albumin)
Thyroid hormones
Inflammatory markers (e.g. C-reactive protein cytokines)
Immunologic markers (e.g. immunoglobulines)
Cortisol
Vitamines and micronutrients
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)
Metabolomics
DNA methylation
Transcriptomics (mRNA, miRNA)
Genome-wide association study (GWAS)
Maternal biological samples ---------- Timing of sampling ----------
Pre-pregnancy First trimester Second trimester Third trimester Post pregnancy
Breast milk
Whole blood
Serum
Plasma
Buffy coat
Urine
Hair
Nails
Saliva
Purified DNA
Purified RNA
Red blood cells
Faeces
General information
Pre-pregnancy During pregnancy <1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
EducationX
Income
Employment statusX
Job titleXX
Single parenthood
Home addressXXXXXXX
Work address
Paternal characteristics related to the index pregnancy/child
Fertility treatment
Age at child's birthX
Ethnicity
Country of birthX
Paternal exposures ---------- Timing of assessment ----------
Pre-pregnancy During pregnancy Post pregnancy
Diet
Dietary supplements
Active smokingXX
Passive smokingXX
Alcohol consumption
Physical activity
Substance use
Medicine intakeX
Coffee drinking
Psychological distress (e.g. life-events, health behaviors, perceived stress)
Occupational exposures
Heavy lifts
Work hours
Air pollution
Access to green spaces
Built environment
Noise
Radiation, electromagnetic fields
Water contamination
Binge drinking
PetsX
Farm animal exposureX
Biomarkers of exposure
Mercury
Lead
Cadmium
Arsenic
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds
Bisphenol A
Other bisphenols
Parabens
Benzophenones
Triclosan
Phthalates
Cotinine
Paternal health ---------- Timing of assessment ----------
Pre-pregnancy During pregnancy Post pregnancy
Anthropometry
Weight
Height
Waist circumference
Clinical examinations
Blood pressure
Carotida intima media thickness
Pulse wave velocity
DEXA scans
Bio impedence
Mental and neurological development
Mental health
Cognitive function (e.g. intelligence quotient)
Respiratory health
AsthmaX
AllergyX
Musculo‐skeletal disease
Back pain
Neck pain
Arthritis
Other health outcomes
Cancer
DiabetesX
Cardio‐vascular diseaseX
Family history of chronic disease
Infectious disease
Fever
Autoimmune disease
Urinary symptoms
Sexual problems
Sleep disturbance
Biomarkers of health
Nephrology (e.g. creatinine, albumin)
Thyroid hormones
Inflammatory markers (e.g. C-reactive protein cytokines)
Immunologic markers (e.g. immunoglobulines)
Cortisol
Vitamines and micronutrients
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)
Metabolomics
DNA methylation
Transcriptomics (mRNA, miRNA)
Genome-wide association study (GWAS)
Paternal biological samples ---------- Timing of sampling ----------
Pre-pregnancy During pregnancy Post pregnancy
Semen
Whole blood
Serum
Plasma
Buffy coat
Urine
Hair
Nails
Saliva
Purified DNA
Purified RNA
Red blood cells
Faeces
Comments and ideas