• Cohort, name
    Babies After SCOPE: Evaluating the Longitudinal Impact using Neurological and Nutritional Endpoints

    Cohort, abbreviation
    BASELINE

    Cohort, country
    Ireland

    Cohort, website
    http://www.baselinestudy.net

    Cohort, facebook-site
    https://www.facebook.com/TheCorkBaselineBirthCohortStudy?

    Key reference
    O'Donovan SM, Murray DM, Hourihane J, Kenny LC, Irvine AD, Kiely M (2015) Cohort profile: The Cork BASELINE Birth Cohort Study: Babies after SCOPE: Evaluating the Longitudinal Impact on Neurological and Nutritional Endpoints. International Journal of Epidemiology; 44(3):764-75. PMID: 25102856https://academic.oup.com/ije/article/44/3/764/629555

    Date of filling in this questionnaire:
    2011-12-20

  • Principal investigator(s), name
    Deirdre Murray

    Principal investigator(s), e-mail address
    d.murray@ucc.ie

    Principal investigator(s), institution
    University College Cork

    Contact person(s), name
    Darina Sheehan

    Contact person(s), e-mail address
    darina.sheehan@ucc.ie

    Contact person(s), institution address
    University College Cork, Ireland

  • Main aim of cohort
    Our underlying aim is to establish a prospective paediatics birth cohort which will have access to detailed information on maternal health, fetal growth, and childhood nutrition, growth and development in the first 2 years of life. This cohort will have the advantage of a stored biobank of maternal and fetal plasma, serum and DNA. This cohort will allow us to monitor the effects of intrauterine growth and nutrition on early life illnesses. Our specific aims are: 1. To establish the fetal and early life growth trajectories which fortell later neuorcognitive disability and metabolic disorder. 2. To establish the incidence and prevalence of food allergy and eczema in Irish children and investigate the relationship between Vitamin D deficiency and allergic disorders in early childhood. 3. To establish the prevalence of maternal and neonatal Vitamin D deficicncy in an Irish paediatric population.

    Recruited number of:
    2185 children / 0 mothers / 0 fathers / 0 grand parents / 0 other family members

    Approximate proportion of source population included
    0

    Source population
    Region-based

  • Period of enrollment
    Start: 2008-08-01, End: 2011-10-31

    Enrollment period
    Pregnancy, week 15 to birth

    Planned age of children at end of follow-up
    15 years
General information ---------- Child age (years) at assessment ----------
<1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
Home address
School address
Birth outcomes
Birth weightX
Birth lengthX
Gestational age at birthX
Apgar scoreX
Congenital malformations
Stillbirth (>= 22 weeks)
Child’s sexX
Head circumference
Biparietal diameter
Child exposures ---------- Child age (years) at assessment ----------
<1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
Breast feedingXXX
DietXXX
Dietary supplementsXXXX
Childcare attendanceXXXX
Active smoking
Passive smokingXXXX
Alcohol consumption
Physical activityX
Substance use
Medicine intakeXXXX
VaccinationsXXXX
Psychological distress (e.g. bullying)
Air pollution
Access to green spaces
Built environment
Noise
Radiation, electromagnetic fields
Water contamination
PetsXXXX
Farm animal exposureXXXX
Biomarkers of exposure
Mercury
Lead
Cadmium
Arsenic
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds
Bisphenol A
Other bisphenols
Parabens
Benzophenones
Triclosan
Phthalates
Cotinine
Child development and health ---------- Child age (years) at assessment ----------
<1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
Anthropometry
WeightXXXX
HeightXXXX
Head circumferenceXXXX
Abdominal circumferenceXX
Arm circumference
Wrist circumferenceXX
Waist circumferenceXX
Clinical examinations
Blood pressureXX
Carotida intima media thickness
Pulse wave velocity
Cardiac ultrasound
Renal ultrasound
Brain MRI
Other MRI
DEXA‐scan resultsX
Skin folds
Bio impedence
Oscilometry
Spirometry
Skin prick testXX
Bronchial challenge test
Reversibility test
Dental observations
Mental and neurological development
Cognitive functionXX
School performance
LanguageXX
ADHDXX
AutismX
Sleep disturbances
Mental health
Respiratory health
AsthmaX
AllergyXXXX
Allergic rhinitisX
EczemaXXXX
Respiratory tract infections
Senses
Vision
Hearing
Musculo-skeletal health
Back pain
Neck pain
Growing pains
Sexual maturation
Tanner stage
Pubertal development stage
Age at menarche
Age at voice change
2D/4D digit ratio
Nocturnal ejaculation
Acne
Other health outcomes
Cancer
Diabetes
Congenital anomalies
Biomarkers of health
Nephrology (e.g. creatinine, albumin)
Thyroid hormones
Inflammatory markers (e.g. C-reactive protein cytokines)XX
Immunologic markers (e.g. immunoglobulines)
Cortisol
Vitamines and micronutrientsXXX
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)
Metabolomics
DNA methylation
Transcriptomics (mRNA, miRNA)
Genome-wide association study (GWAS)
Child biological samples ---------- Child age (years) at sampling ----------
At birth 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
Whole bloodXX
SerumXX
Plasma
Buffy coat
Urine
Hair
Teeth
Nails
SalivaXXXX
Purified DNAXX
Purified RNA
Red blood cells
Umbilical cord blood/tissueX
Blood smear
Faeces/meconium
Exhaled breathe condensate
Sputum induction
Placenta
General information
Pre-pregnancy During pregnancy <1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
Education
Income
Employment status
Job title
Single parenthood
Home address
Work address
Maternal characteristics related to the index pregnancy/child
Age at birth
Ethnicity
Country of birth
Planned pregnancy
Time to pregnancy
Fertility treatment
Prior spontaneous abortion (<22w)
Prior births
Ultrasound measurements
Doppler measurements
Preeclampsia
Gestational diabetes
Gestational hypertension
Gestational duration
Mode of delivery
Prenatal diagnostics
Medical termination of pregnancy
Maternal Exposures ---------- Timing of assessment ----------
Pre-pregnancy First trimester Second trimester Third trimester Post pregnancy
Diet
Dietary supplements
Active smokingX
Passive smokingX
Alcohol consumption
Physical activity
Substance use
Medicine intake
Coffee drinking
Psychological distress (e.g. life-events, health behaviors, perceived stress)
Occupational exposures
Heavy lifts
Work hours
Air pollution
Access to green spaces
Built environment
Noise
Radiation, electromagnetic fields
Water contamination
Binge drinking
Pets
Farm animal exposure
Biomarkers of exposure
Mercury
Lead
Cadmium
Arsenic
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds
Bisphenol A
Other bisphenols
Parabens
Benzophenones
Triclosan
Phthalates
Cotinine
Maternal health ---------- Timing of assessment ----------
Pre-pregnancy First trimester Second trimester Third trimester Post pregnancy
Anthropometry
Weight
Height
Waist circumference
Clinical examinations
Blood pressure
Carotida intima media thickness
Pulse wave velocity
DEXA scans
Bioimpedence
Mental and neurological development
Mental health
Cognitive function (e.g. intelligence quotient)
Respiratory health
Asthma
Allergy
Musculo‐skeletal disease
Back pain
Neck pain
Arthritis
Other health outcomes
Cancer
Diabetes
Cardio‐vascular disease
Family history of chronic disease
Infectious disease
Fever
Autoimmune disease
Urinary symptoms
Sexual problems
Sleep disturbance
Biomarkers of health
Nephrology (e.g. creatinine, albumin)
Thyroid hormones
Inflammatory markers (e.g. C-reactive protein cytokines)
Immunologic markers (e.g. immunoglobulines)
Cortisol
Vitamines and micronutrients
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)
Metabolomics
DNA methylation
Transcriptomics (mRNA, miRNA)
Genome-wide association study (GWAS)
Maternal biological samples ---------- Timing of sampling ----------
Pre-pregnancy First trimester Second trimester Third trimester Post pregnancy
Breast milk
Whole blood
Serum
Plasma
Buffy coat
Urine
Hair
Nails
Saliva
Purified DNA
Purified RNA
Red blood cells
Faeces
General information
Pre-pregnancy During pregnancy <1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
Education
Income
Employment status
Job title
Single parenthood
Home address
Work address
Paternal characteristics related to the index pregnancy/child
Fertility treatment
Age at child's birth
Ethnicity
Country of birth
Paternal exposures ---------- Timing of assessment ----------
Pre-pregnancy During pregnancy Post pregnancy
Diet
Dietary supplements
Active smokingX
Passive smoking
Alcohol consumption
Physical activity
Substance use
Medicine intake
Coffee drinking
Psychological distress (e.g. life-events, health behaviors, perceived stress)
Occupational exposures
Heavy lifts
Work hours
Air pollution
Access to green spaces
Built environment
Noise
Radiation, electromagnetic fields
Water contamination
Binge drinking
Pets
Farm animal exposure
Biomarkers of exposure
Mercury
Lead
Cadmium
Arsenic
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds
Bisphenol A
Other bisphenols
Parabens
Benzophenones
Triclosan
Phthalates
Cotinine
Paternal health ---------- Timing of assessment ----------
Pre-pregnancy During pregnancy Post pregnancy
Anthropometry
Weight
Height
Waist circumference
Clinical examinations
Blood pressure
Carotida intima media thickness
Pulse wave velocity
DEXA scans
Bio impedence
Mental and neurological development
Mental health
Cognitive function (e.g. intelligence quotient)
Respiratory health
Asthma
Allergy
Musculo‐skeletal disease
Back pain
Neck pain
Arthritis
Other health outcomes
Cancer
Diabetes
Cardio‐vascular disease
Family history of chronic disease
Infectious disease
Fever
Autoimmune disease
Urinary symptoms
Sexual problems
Sleep disturbance
Biomarkers of health
Nephrology (e.g. creatinine, albumin)
Thyroid hormones
Inflammatory markers (e.g. C-reactive protein cytokines)
Immunologic markers (e.g. immunoglobulines)
Cortisol
Vitamines and micronutrients
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)
Metabolomics
DNA methylation
Transcriptomics (mRNA, miRNA)
Genome-wide association study (GWAS)
Paternal biological samples ---------- Timing of sampling ----------
Pre-pregnancy During pregnancy Post pregnancy
Semen
Whole blood
Serum
Plasma
Buffy coat
Urine
Hair
Nails
Saliva
Purified DNA
Purified RNA
Red blood cells
Faeces
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