Indentification |
Cohort name:
Rhea study - Mother Child Cohort in Crete
|
Institution:
University of Crete, and CREAL
|
Principal investigator:
Manolis Kogevinas
|
Institution address and additional researchers:
|
E-mail address:
kogevinas@creal.cat
|
Key Reference:
|
Cohort website:
http://rhea.med.uoc.gr/
|
Basic description |
The aims of the Mother-Child cohort in Crete (Rhea study) are:
1.The evaluation of nutritional, environmental, biological and psychosocial exposures in the prenatal period and in early childhood.
2.The evaluation of the association of these exposures with the development of the fetus and the child, reproductive outcomes, endocrine related outcomes, neurodevelopment, obesity and with the occurrence of chronic diseases including asthma and allergies, metabolic syndrome and endocrine disorders that appear first in childhood but that may perpetuate to adulthood.
3.The evaluation of mother’s health during and after pregnancy.
4.The evaluation of genetic susceptibility and the interactions between genetic and environmental factors affecting child health.
|
|
Enrolment: 2007
- 2008
Status: Completed |
Gestational age at enrolment:
week 13-18
|
|
Source population: Region-based |
Country: Greece |
No. of participants:
1500 mothers,
0 fathers,
1500 children |
Expected time of follow-up:
2012 (if additional funding becomes available, follow-up will continue)
|
Type of data collection |
| | Pregnancy | Birth | Post Natal |
| First
trimester | Second
trimester | Third
trimester | | 0-6
months | 7-18
months | 18-60
months | 5+
years |
| Questionnaire data | | Maternal exposures | x | x | x | x | - | - | - | - |
| Paternal exposures | x | x | - | - | - | - | - | - |
| Offspring exposures | - | - | - | x | x | x | x | - |
| Maternal outcomes | - | x | x | x | x | - | - | - |
| Paternal outcomes | - | - | - | - | - | - | - | - |
| Offspring outcomes | - | - | - | x | x | x | x | - |
| Biological samples | | Maternal blood | x | - | - | x | - | - | - | - |
| Paternal blood | - | - | - | - | - | - | - | - |
| Cord blood | - | - | - | x | - | - | - | - |
| Offspring blood | - | - | - | - | - | - | x | - |
| Maternal other (urine, hair etc.) | x | x | - | - | - | - | - | - |
| Paternal other (urine, hair etc.) | - | - | - | - | - | - | - | - |
| Offspring other (urine, hair etc.) | - | - | - | - | - | x | x | - |
|
Amount and
storage of bio samples
About 30ml blood mother (EDTA and heparin), complex processing, serum, plasma, whole blood, DNA extracted, RNA; cord blood quantity variable, complex processing;
|
Exposures and outcomes
available in the cohort |
Exposures: medication, air pollution, water quality, occupation, tobacco, alcohol, social position, nutrition, pregnancy, nutrition, child, health services, other,
|
Outcomes: milestones, birth defects, infections, growth/obesity, neurodevelopment, asthma/allergies, immunity,
|
Data planned to be collected |
Enrollment at 3rd wk of pregnancy and follow-up until 4 years of age is funded. This includes repeated contacts of the mother in pregnancy and first days after birth, and of the mother and child in early childohhd, with close contact of the children to evaluate growth and obesity, anogential dsistance, neurodevelopment, asthma and allergies. Collection of genetic material from the father is planned.
|
Register-based follow-up
|
Not available
|
Additional information about the cohort |
|
